Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors

Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2003, Pages 1153-1164

  Parkes, Kevin E B ^a,c   Ermert, Philipp ^b   Fässler, Jürg ^b   Ives, Jane ^a   Martin, Joseph A ^a,d   Merrett, John H ^a   Obrecht, Daniel ^b   Williams, Glyn ^a   Klumpp, Klaus ^a,d  

^a ROCHE PRODUCTS LTD   (United Kingdom)

^b Polyphor Ltd   (Switzerland)

^c MEDIVIR AB   (Sweden)

^d ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIKETOBUTANOIC ACID DERIVATIVE; 3 [3 [1 HYDROXY 3 (1 HYDROXYBENZYLIDENE) 2 OXO 2,3 DIHYDRO 1H INDOL 6 YL]UREIDO]BENZOIC ACID; ANTIVIRUS AGENT; COBALT; ENDONUCLEASE; ENZYME INHIBITOR; FERROUS ION; FLUTAMIDE; HYDROXAMIC ACID DERIVATIVE; MAGNESIUM ION; MANGANESE; N HYDROXYIMIDE DERIVATIVE; NAPHTHALENE 2 CARBOXYLIC ACID [1 HYDROXY 3 (1 HYDROXYETHYLIDENE) 2 OXO 2,3 DIHYDRO 1H INDOL 6 YL]AMIDE; NICKEL; RIBONUCLEOPROTEIN; RNA POLYMERASE; TETRAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ZINC ION;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DEPOLYMERIZATION; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HYDROLYSIS; INFLUENZA VIRUS; METAL BINDING; NONHUMAN; PH; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIVIRAL AGENTS; BINDING SITES; BUTYRIC ACIDS; CELL LINE; COMBINATORIAL CHEMISTRY TECHNIQUES; DATABASES, FACTUAL; DNA-DIRECTED RNA POLYMERASES; DOGS; ENDONUCLEASES; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HETEROCYCLIC COMPOUNDS, 3-RING; INFLUENZA A VIRUS; INFLUENZA B VIRUS; KETO ACIDS; MODELS, MOLECULAR; PHTHALIMIDES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0344453794     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020334u     Document Type: Article

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