Inhibitory effects of quinones on RNase H activity associated with HIV-1 reverse transcriptase

Phytotherapy Research

Volumn 16, Issue SUPPL. 1, 2002, Pages

  Min, Byung Sun ^a   Miyashiro, Hirotsugu ^a   Hattori, Masao ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

1,4 naphthoquinone; HIV 1, reverse transcriptase; Juglone; Naphthazarin; Naphthoquinone; RNase H

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; ANTHRAQUINONE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZOQUINONE DERIVATIVE; JUGLONE; MENADIONE; NAPHTHAZARIN; PLUMBAGIN; QUINONE DERIVATIVE; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; SHIKONIN DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG POTENCY; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0036221012     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.808     Document Type: Article

References (30)

1. Enzymatic kinetic studies with the non-nucleoside HIV reverse transcriptase inhibitor U-9843
2. The amphiphilic properties of novenamines determine their activity as inhibitors of HIV-1 RNase H
3. Inhibition of HIV-1 reverse transcriptase by pyridinone derivatives (potency, binding characteristics, and effect of template sequence)
4. Toward improved anti-HIV chemotherapy: Therapeutic strategies for intervention with HIV infections
5. Human immunodeficiency virus reverse transcriptase displays a partially processive 3′ to 5′ endonuclease activity
6. The human immunodeficiency virus: Infectivity and mechanism of pathogenesis
7. Retroviral reverse transcriptase: Synthesis, structure, and function
8. HP 0.35, a cephalosporin degradation product is a specific inhibitor of lentiviral RNase H
9. Screening of various Ayurvedic medicines for their inhibitory activities on reverse transcriptase and identification of arecatannins and embelin as major inhibitory substances from Areca chatechu and Embelia ribes
10. Inhibitory effects of Sudanese medicinal plant extract on hepatitis C virus (HCV) protease
11. Inhibitory effect of tannins on reverse transcriptase from RNA tumor virus
12. Effect of condensed tannins and related compounds on reverse transcriptase
13. Screening of Egyptian folk medicinal plant extracts for anti-human immunodeficiency virus type-1 (HIV-1) activity
14. Searching for anti-HIV agents among the traditional medicines
15. Effects of flavonoids and alkaloids on reverse transcriptase
16. Screening of various plants extracts used in Ayurvedic medicine for inhibitory effects on human immunodeficiency virus type 1 (HIV-1) protease
17. Diterpenoids from the roots of Agastache rugosa and their cytotoxic activities
18. Agastaquinone, a new cytotoxic diterpenoid quinone from Agastache rugosa
19. The inhibition of human immunodeficiency virus type 1 reverse transcriptase by avarol and avarone derivatives
20. Illimaquinone, a selective inhibitors of the RNase H activity of human immunodeficiency virus type 1 reverse transcriptase
21. The interaction of illimaguinone, a selective inhibitor of the RNase H activity, with the reverse transcriptases of human immunodeficiency and murine leukemia retroviruses
22. A human immuno-deficiency virus protease inhibitory substance from Swietenia mahagoni
23. Biotransformation of shikonin by human intestinal bacteria
24. Inhibition of human immunodeficiency virus type 1 RNase H by sulfated polyanions
25. Nevirapine alters the cleavage specificity of ribonuclease H of human immunodeficiency virus 1 reverse transcriptase
26. Purification and characterization of an active human immunodeficiency virus type 1 RNase H domain
27. Human immunodeficiency virus reverse transcriptase-associated RNase H activity
28. Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase
29. Inhibition of the RNase H activity of HIV reverse transcriptase by azidothymidylate
30. Catalytically distinct conformations of the ribonuclease H of HIV-1 reversetranscriptase by substrate cleavage patterns and inhibition by azidothymidylate and N-ethylmaleimide