메뉴 건너뛰기




Volumn 68, Issue , 2014, Pages 181-208

The potential antitumor effects of capsaicin

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE MONOPHOSPHATE DEPENDENT KINASE; CAPSAICIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHOSPHOTRANSFERASE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STAT PROTEIN; TRPV1 RECEPTOR; UNCLASSIFIED DRUG; VANILLOID RECEPTOR;

EID: 84901233786     PISSN: 0071786X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-0348-0828-6_8     Document Type: Review
Times cited : (87)

References (123)
  • 1
    • 84856800302 scopus 로고    scopus 로고
    • Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: Cross talk, shortcuts, and feedbacks
    • Alers S, Loffler AS, Wesselborg S, Stork B (2012) Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: Cross talk, shortcuts, and feedbacks. Mol Cell Biol 32:2-111
    • (2012) Mol Cell Biol , vol.32 , pp. 2-111
    • Alers, S.1    Loffler, A.S.2    Wesselborg, S.3    Stork, B.4
  • 2
    • 84867880761 scopus 로고    scopus 로고
    • Determination of capsaicinoids in Capsicum species using ultra performance liquid chromatography-mass spectrometry
    • Alothman ZA, Wabaidur SM, Khan MR, Abdel Ghafar A, Habila MA, Ahmed YB (2012) Determination of capsaicinoids in Capsicum species using ultra performance liquid chromatography-mass spectrometry. J Sep Sci 35:2892-28966
    • (2012) J Sep Sci , vol.35 , pp. 2892-2896
    • Alothman, Z.A.1    Wabaidur, S.M.2    Khan, M.R.3    Abdel Ghafar, A.4    Habila, M.A.5    Ahmed, Y.B.6
  • 3
    • 33846281508 scopus 로고    scopus 로고
    • Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: How vanilloids cause non-vanilloid receptor mediated cell death
    • Athanasiou A, Smith PA, Vakilpour S, Kumaran NM, Turner AE, Bagiokou D et al (2007) Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: How vanilloids cause non-vanilloid receptor mediated cell death. Biochem Biophys Res Commun 354:50-555
    • (2007) Biochem Biophys Res Commun , vol.354 , pp. 50-55
    • Athanasiou, A.1    Smith, P.A.2    Vakilpour, S.3    Kumaran, N.M.4    Turner, A.E.5    Bagiokou, D.6
  • 4
    • 78249268846 scopus 로고    scopus 로고
    • Inhibition and induction of human cytochrome P450 enzymes in vitro by capsaicin
    • Babbar S, Chanda S, Bley K (2010) Inhibition and induction of human cytochrome P450 enzymes in vitro by capsaicin. Xenobiotica 40:807-8166
    • (2010) Xenobiotica , vol.40 , pp. 807-816
    • Babbar, S.1    Chanda, S.2    Bley, K.3
  • 5
    • 77955228300 scopus 로고    scopus 로고
    • The involvement of smac diablo, p53, nf-kb, and mapk pathways in apoptosis of keratinocytes from perilesional vitiligo skin: Protective effects of curcumin and capsaicin
    • Becatti M, Prignano F, Fiorillo C, Pescitelli L, Nassi P, Lotti T et al (2010) The involvement of Smac DIABLO, p53, NF-kB, and MAPK pathways in apoptosis of keratinocytes from perilesional vitiligo skin: Protective effects of curcumin and capsaicin. Antioxid Redox Signal 13:1309-13211
    • (2010) Antioxid Redox Signal , vol.13 , pp. 1309-1321
    • Becatti, M.1    Prignano, F.2    Fiorillo, C.3    Pescitelli, L.4    Nassi, P.5    Lotti, T.6
  • 6
    • 33845186328 scopus 로고    scopus 로고
    • Vanilloid receptor 1 (TRPV1) expression in lingual nerve neuromas from patients with or without symptoms of burning pain
    • Biggs JE, Yates JM, Loescher AR, Clayton NM, Boissonade FM, Robinson PP (2007) Vanilloid receptor 1 (TRPV1) expression in lingual nerve neuromas from patients with or without symptoms of burning pain. Brain Res 1127:59-655
    • (2007) Brain Res , vol.1127 , pp. 59-65
    • Biggs, J.E.1    Yates, J.M.2    Loescher, A.R.3    Clayton, N.M.4    Boissonade, F.M.5    Robinson, P.P.6
  • 7
    • 77951340037 scopus 로고
    • To the 50th anniversary of death of rudolf wirchow
    • Bochalli R (1952) To the 50th anniversary of death of Rudolf Wirchow. Hippokrates 23:647-6499
    • (1952) Hippokrates , vol.23 , pp. 647-649
    • Bochalli, R.1
  • 8
    • 70249098477 scopus 로고    scopus 로고
    • ECTO-NOX (ENOX) proteins of the cell surface lack thioredoxin reductase activity
    • Bosneaga E, Kim C, Shen B, Watanabe T, Morre DM, Morre DJ (2008) ECTO-NOX (ENOX) proteins of the cell surface lack thioredoxin reductase activity. BioFactors 34:245-2511
    • (2008) BioFactors , vol.34 , pp. 245-251
    • Bosneaga, E.1    Kim, C.2    Shen, B.3    Watanabe, T.4    Morre, D.M.5    Morre, D.J.6
  • 9
    • 77956314277 scopus 로고    scopus 로고
    • Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway
    • Brown KC, Witte TR, Hardman WE, Luo H, Chen YC, Carpenter AB et al (2010) Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway. PLoS ONE 5:e102433
    • (2010) PLoS ONE , vol.5
    • Brown, K.C.1    Witte, T.R.2    Hardman, W.E.3    Luo, H.4    Chen, Y.C.5    Carpenter, A.B.6
  • 10
    • 33746125474 scopus 로고    scopus 로고
    • Delta9-Tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation
    • Caffarel MM, Sarrio D, Palacios J, Guzman M, Sanchez C (2006) Delta9-Tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Res 66:6615-66211
    • (2006) Cancer Res , vol.66 , pp. 6615-6621
    • Caffarel, M.M.1    Sarrio, D.2    Palacios, J.3    Guzman, M.4    Sanchez, C.5
  • 11
    • 79955749422 scopus 로고    scopus 로고
    • Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells
    • Caprodossi S, Amantini C, Nabissi M, Morelli MB, Farfariello V, Santoni M et al (2011) Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis 32:686-6944
    • (2011) Carcinogenesis , vol.32 , pp. 686-694
    • Caprodossi, S.1    Amantini, C.2    Nabissi, M.3    Morelli, M.B.4    Farfariello, V.5    Santoni, M.6
  • 12
    • 84862849835 scopus 로고    scopus 로고
    • Redox implications of AMPK-mediated signal transduction beyond energetic clues
    • Cardaci S, Filomeni G, Ciriolo MR (2012) Redox implications of AMPK-mediated signal transduction beyond energetic clues. J Cell Sci 125:2115-21255
    • (2012) J Cell Sci , vol.125 , pp. 2115-2125
    • Cardaci, S.1    Filomeni, G.2    Ciriolo, M.R.3
  • 15
    • 50949132714 scopus 로고    scopus 로고
    • Reactive oxygen species generation at the plasma membrane for antibody control
    • Crane FL, Low H (2008) Reactive oxygen species generation at the plasma membrane for antibody control. Autoimmun Rev 7:518-5222
    • (2008) Autoimmun Rev , vol.7 , pp. 518-522
    • Crane, F.L.1    Low, H.2
  • 16
    • 84861217903 scopus 로고    scopus 로고
    • Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations
    • Cui Y, Yang F, Cao X, Yarov-Yarovoy V, Wang K, Zheng J (2012) Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. J Gen Physiol 139:273-2833
    • (2012) J Gen Physiol , vol.139 , pp. 273-283
    • Cui, Y.1    Yang, F.2    Cao, X.3    Yarov-Yarovoy, V.4    Wang, K.5    Zheng, J.6
  • 17
    • 61449211120 scopus 로고    scopus 로고
    • Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma
    • Czifra G, Varga A, Nyeste K, Marincsak R, Toth BI, Kovacs I et al (2009) Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma. J Cancer Res Clin Oncol 135:507-5144
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 507-514
    • Czifra, G.1    Varga, A.2    Nyeste, K.3    Marincsak, R.4    Toth, B.I.5    Kovacs, I.6
  • 18
    • 80054869554 scopus 로고    scopus 로고
    • Capsaicin may induce breast cancer cell death through apoptosis-inducing factor involving mitochondrial dysfunction
    • Chang HC, Chen ST, Chien SY, Kuo SJ, Tsai HT, Chen DR (2011) Capsaicin may induce breast cancer cell death through apoptosis-inducing factor involving mitochondrial dysfunction. Hum Exp Toxicol 30:1657-16655
    • (2011) Hum Exp Toxicol , vol.30 , pp. 1657-1665
    • Chang, H.C.1    Chen, S.T.2    Chien, S.Y.3    Kuo, S.J.4    Tsai, H.T.5    Chen, D.R.6
  • 19
    • 77953763757 scopus 로고    scopus 로고
    • Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-Activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis
    • Choi CH, Jung YK, Oh SH (2010a) Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-Activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis. Mol Pharmacol 78:114-1255
    • (2010) Mol Pharmacol , vol.78 , pp. 114-125
    • Choi, C.H.1    Jung, Y.K.2    Oh, S.H.3
  • 20
    • 77953541592 scopus 로고    scopus 로고
    • Selective induction of catalase-mediated autophagy by dihydrocapsaicin in lung cell lines
    • Choi CH, Jung YK, Oh SH (2010b) Selective induction of catalase-mediated autophagy by dihydrocapsaicin in lung cell lines. Free Radic Biol Med 49:245-2577
    • (2010) Free Radic Biol Med , vol.49 , pp. 245-257
    • Choi, C.H.1    Jung, Y.K.2    Oh, S.H.3
  • 21
    • 79960235582 scopus 로고    scopus 로고
    • Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells
    • Choi SE, Kim TH, Yi SA, Hwang YC, Hwang WS, Choe SJ et al (2011) Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells. Nutr Res 31:468-4788
    • (2011) Nutr Res , vol.31 , pp. 468-478
    • Choi, S.E.1    Kim, T.H.2    Yi, S.A.3    Hwang, Y.C.4    Hwang, W.S.5    Choe, S.J.6
  • 22
    • 64849094943 scopus 로고    scopus 로고
    • Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway
    • Chou CC, Wu YC, Wang YF, Chou MJ, Kuo SJ, Chen DR (2009) Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway. Oncol Rep 21:665-6711
    • (2009) Oncol Rep , vol.21 , pp. 665-671
    • Chou, C.C.1    Wu, Y.C.2    Wang, Y.F.3    Chou, M.J.4    Kuo, S.J.5    Chen, D.R.6
  • 23
    • 13444304185 scopus 로고    scopus 로고
    • TNOX is both necessary and sufficient as a cellular target for the anticancer actions of capsaicin and the green tea catechin (-)-epigallocatechin- 3-gallate
    • Chueh PJ, Wu LY, Morre DM, Morre DJ (2004) tNOX is both necessary and sufficient as a cellular target for the anticancer actions of capsaicin and the green tea catechin (-)-epigallocatechin-3-gallate. BioFactors 20:235-2499
    • (2004) BioFactors , vol.20 , pp. 235-249
    • Chueh, P.J.1    Wu, L.Y.2    Morre, D.M.3    Morre, D.J.4
  • 24
    • 84871898027 scopus 로고    scopus 로고
    • RPF101, a new capsaicin-like analogue, disrupts the microtubule network accompanied by arrest in the G2/M phase, inducing apoptosis and mitotic catastrophe in the MCF-77 breast cancer cells
    • de Sa Junior PL, Pasqualoto KF, Ferreira AK, Tavares MT, Damiao MC, de Azevedo RA et al (2013) RPF101, a new capsaicin-like analogue, disrupts the microtubule network accompanied by arrest in the G2/M phase, inducing apoptosis and mitotic catastrophe in the MCF-77 breast cancer cells. Toxicol Appl Pharmacol 266:385-3988
    • (2013) Toxicol Appl Pharmacol , vol.266 , pp. 385-398
    • De Sa Junior, P.L.1    Pasqualoto, K.F.2    Ferreira, A.K.3    Tavares, M.T.4    Damiao, M.C.5    De Azevedo, R.A.6
  • 25
    • 77951750296 scopus 로고    scopus 로고
    • Selective autophagy in cancer development and therapy
    • Dikic I, Johansen T, Kirkin V (2010) Selective autophagy in cancer development and therapy. Cancer Res 70:3431-34344
    • (2010) Cancer Res , vol.70 , pp. 3431-3434
    • Dikic, I.1    Johansen, T.2    Kirkin, V.3
  • 26
    • 79951907445 scopus 로고    scopus 로고
    • Tumor cell growth inhibition is correlated with levels of capsaicin present in hot peppers
    • Dou D, Ahmad A, Yang H, Sarkar FH (2011) Tumor cell growth inhibition is correlated with levels of capsaicin present in hot peppers. Nutr Cancer 63:272-2811
    • (2011) Nutr Cancer , vol.63 , pp. 272-281
    • Dou, D.1    Ahmad, A.2    Yang, H.3    Sarkar, F.H.4
  • 27
    • 62449287501 scopus 로고    scopus 로고
    • The paradox of autophagy and its implication in cancer etiology and therapy
    • Eisenberg-Lerner A, Kimchi A (2009) The paradox of autophagy and its implication in cancer etiology and therapy. Apoptosis 14:376-3911
    • (2009) Apoptosis , vol.14 , pp. 376-391
    • Eisenberg-Lerner, A.1    Kimchi, A.2
  • 28
    • 77950994646 scopus 로고    scopus 로고
    • Autophagy: Cellular and molecular mechanisms
    • Glick D, Barth S, Macleod KF (2010) Autophagy: Cellular and molecular mechanisms. J Pathol 221:3-122
    • (2010) J Pathol , vol.221 , pp. 3-122
    • Glick, D.1    Barth, S.2    Macleod, K.F.3
  • 30
    • 0037560833 scopus 로고    scopus 로고
    • Mechanisms of vanilloid-induced apoptosis
    • Hail N Jr (2003) Mechanisms of vanilloid-induced apoptosis. Apoptosis 8:251-2622
    • (2003) Apoptosis , vol.8 , pp. 251-262
    • Hail Jr., N.1
  • 31
    • 0037019765 scopus 로고    scopus 로고
    • Examining the role of mitochondrial respiration in vanilloid-induced apoptosis
    • Hail N Jr, Lotan R (2002) Examining the role of mitochondrial respiration in vanilloid-induced apoptosis. J Natl Cancer Inst 94:1281-12922
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1281-1292
    • Hail Jr., N.1    Lotan, R.2
  • 32
    • 84876320551 scopus 로고    scopus 로고
    • LKB1 and AMPK and the cancer-metabolism link-Ten years after
    • Hardie DG, Alessi DR (2013) LKB1 and AMPK and the cancer-metabolism link-Ten years after. BMC Biol 11:366
    • (2013) BMC Biol , vol.11 , pp. 366
    • Hardie, D.G.1    Alessi, D.R.2
  • 33
    • 84868005485 scopus 로고    scopus 로고
    • AMP-Activated protein kinase: A target for drugs both ancient and modern
    • Hardie DG, Ross FA, Hawley SA (2012) AMP-Activated protein kinase: A target for drugs both ancient and modern. Chem Biol 19:1222-12366
    • (2012) Chem Biol , vol.19 , pp. 1222-1236
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 35
    • 33947596710 scopus 로고    scopus 로고
    • Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells
    • Hsu CL, Yen GC (2007) Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells. J Agric Food Chem 55:1730-17366
    • (2007) J Agric Food Chem , vol.55 , pp. 1730-1736
    • Hsu, C.L.1    Yen, G.C.2
  • 37
    • 84861799499 scopus 로고    scopus 로고
    • Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress
    • Ip SW, Lan SH, Lu HF, Huang AC, Yang JS, Lin JP et al (2012) Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress. Hum Exp Toxicol 31:539-5499
    • (2012) Hum Exp Toxicol , vol.31 , pp. 539-549
    • Ip, S.W.1    Lan, S.H.2    Lu, H.F.3    Huang, A.C.4    Yang, J.S.5    Lin, J.P.6
  • 38
    • 0842304283 scopus 로고    scopus 로고
    • Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: Implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species
    • Ito K, Nakazato T, Yamato K, Miyakawa Y, Yamada T, Hozumi N et al (2004) Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: Implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res 64:1071-10788
    • (2004) Cancer Res , vol.64 , pp. 1071-1078
    • Ito, K.1    Nakazato, T.2    Yamato, K.3    Miyakawa, Y.4    Yamada, T.5    Hozumi, N.6
  • 39
    • 0031933189 scopus 로고    scopus 로고
    • Establishment and characterization of immortalized human cell lines from prostatic carcinoma and benign prostatic hyperplasia
    • Iype PT, Iype LE, Verma M, Kaighn ME (1998) Establishment and characterization of immortalized human cell lines from prostatic carcinoma and benign prostatic hyperplasia. Int J Oncol 12:257-2633
    • (1998) Int J Oncol , vol.12 , pp. 257-263
    • Iype, P.T.1    Iype, L.E.2    Verma, M.3    Kaighn, M.E.4
  • 40
    • 76149122154 scopus 로고    scopus 로고
    • Capsaicin may slow PSA doubling time: Case report and literature review
    • Jankovic B, Loblaw DA, Nam R (2010) Capsaicin may slow PSA doubling time: Case report and literature review. Can Urol Assoc J 4:E9-E111
    • (2010) Can Urol Assoc J , vol.4
    • Jankovic, B.1    Loblaw, D.A.2    Nam, R.3
  • 41
    • 58849123372 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a candidate human growth-related and time-keeping constitutive cell surface hydroquinone (NADH) oxidase
    • Jiang Z, Gorenstein NM, Morre DM, Morre DJ (2008) Molecular cloning and characterization of a candidate human growth-related and time-keeping constitutive cell surface hydroquinone (NADH) oxidase. Biochemistry 47:14028-140388
    • (2008) Biochemistry , vol.47 , pp. 14028-14038
    • Jiang, Z.1    Gorenstein, N.M.2    Morre, D.M.3    Morre, D.J.4
  • 42
    • 0036183319 scopus 로고    scopus 로고
    • Molecular basis for species-specific sensitivity to hot chili peppers
    • Jordt SE, Julius D (2002) Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell 108:421-4300
    • (2002) Cell , vol.108 , pp. 421-430
    • Jordt, S.E.1    Julius, D.2
  • 43
    • 35848954977 scopus 로고    scopus 로고
    • Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3 K-Nrf2 signaling: NAD(P) H:quinone oxidoreductase as a potential target
    • Joung EJ, Li MH, Lee HG, Somparn N, Jung YS, Na HK et al (2007) Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3 K-Nrf2 signaling: NAD(P) H:quinone oxidoreductase as a potential target. Antioxid Redox Signal 9:2087-20988
    • (2007) Antioxid Redox Signal , vol.9 , pp. 2087-2098
    • Joung, E.J.1    Li, M.H.2    Lee, H.G.3    Somparn, N.4    Jung, Y.S.5    Na, H.K.6
  • 44
    • 77950187437 scopus 로고    scopus 로고
    • Dietary capsaicin reduces obesityinduced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet
    • Kang JH, Goto T, Han IS, Kawada T, Kim YM, Yu R (2010) Dietary capsaicin reduces obesityinduced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet. Obesity (Silver Spring) 18:780-7877
    • (2010) Obesity (Silver Spring , vol.18 , pp. 780-787
    • Kang, J.H.1    Goto, T.2    Han, I.S.3    Kawada, T.4    Kim, Y.M.5    Yu, R.6
  • 45
    • 4644295000 scopus 로고    scopus 로고
    • Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-Activated receptor gamma in HT-29 human colon cancer cells
    • Kim CS, Park WH, Park JY, Kang JH, Kim MO, Kawada T et al (2004) Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-Activated receptor gamma in HT-29 human colon cancer cells. J Med Food 7:267-2733
    • (2004) J Med Food , vol.7 , pp. 267-273
    • Kim, C.S.1    Park, W.H.2    Park, J.Y.3    Kang, J.H.4    Kim, M.O.5    Kawada, T.6
  • 46
    • 84862945998 scopus 로고    scopus 로고
    • Nitric oxide triggers apoptosis in A375 human melanoma cells treated with capsaicin and resveratrol
    • Kim MY (2012) Nitric oxide triggers apoptosis in A375 human melanoma cells treated with capsaicin and resveratrol. Mol Med Rep 5:585-5911
    • (2012) Mol Med Rep , vol.5 , pp. 585-591
    • Kim, M.Y.1
  • 47
    • 71949091112 scopus 로고    scopus 로고
    • Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation
    • Kim MY, Trudel LJ, Wogan GN (2009) Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation. Anticancer Res 29:3733-37400
    • (2009) Anticancer Res , vol.29 , pp. 3733-3740
    • Kim, M.Y.1    Trudel, L.J.2    Wogan, G.N.3
  • 48
    • 34247898927 scopus 로고    scopus 로고
    • Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cells
    • Kim YM, Hwang JT, Kwak DW, Lee YK, Park OJ (2007) Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cells. Ann N Y Acad Sci 1095:496-5033
    • (2007) Ann N Y Acad Sci , vol.1095 , pp. 496-503
    • Kim, Y.M.1    Hwang, J.T.2    Kwak, D.W.3    Lee, Y.K.4    Park, O.J.5
  • 49
    • 84876294971 scopus 로고    scopus 로고
    • Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice
    • Lee GR, Shin MK, Yoon DJ, Kim AR, Yu R, Park NH et al (2013) Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice. Obesity (Silver Spring) 21:115-1222
    • (2013) Obesity (Silver Spring , vol.21 , pp. 115-122
    • Lee, G.R.1    Shin, M.K.2    Yoon, D.J.3    Kim, A.R.4    Yu, R.5    Park, N.H.6
  • 50
    • 70349200580 scopus 로고    scopus 로고
    • Capsaicin-induced apoptosis is regulated by endoplasmic reticulum stress-And calpain-mediated mitochondrial cell death pathways
    • Lee MJ, Kee KH, Suh CH, Lim SC, Oh SH (2009) Capsaicin-induced apoptosis is regulated by endoplasmic reticulum stress-And calpain-mediated mitochondrial cell death pathways. Toxicology 264:205-2144
    • (2009) Toxicology , vol.264 , pp. 205-214
    • Lee, M.J.1    Kee, K.H.2    Suh, C.H.3    Lim, S.C.4    Oh, S.H.5
  • 51
    • 84860887229 scopus 로고    scopus 로고
    • Capsaicin represses transcriptional activity of beta-catenin in human colorectal cancer cells
    • Lee SH, Richardson RL, Dashwood RH, Baek SJ (2012) Capsaicin represses transcriptional activity of beta-catenin in human colorectal cancer cells. J Nutr Biochem 23:646-6555
    • (2012) J Nutr Biochem , vol.23 , pp. 646-655
    • Lee, S.H.1    Richardson, R.L.2    Dashwood, R.H.3    Baek, S.J.4
  • 52
    • 1842431016 scopus 로고    scopus 로고
    • Involvement of NADPH oxidase-mediated generation of reactive oxygen species in the apototic cell death by capsaicin in HepG22 human hepatoma cells
    • Lee YS, Kang YS, Lee JS, Nicolova S, Kim JA (2004) Involvement of NADPH oxidase-mediated generation of reactive oxygen species in the apototic cell death by capsaicin in HepG22 human hepatoma cells. Free Radic Res 38:405-4122
    • (2004) Free Radic Res , vol.38 , pp. 405-412
    • Lee, Y.S.1    Kang, Y.S.2    Lee, J.S.3    Nicolova, S.4    Kim, J.A.5
  • 53
    • 79955766195 scopus 로고    scopus 로고
    • TRPV1-Antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling
    • Li S, Bode AM, Zhu F, Liu K, Zhang J, Kim MO et al (2011) TRPV1-Antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling. Carcinogenesis 32:779-7855
    • (2011) Carcinogenesis , vol.32 , pp. 779-785
    • Li, S.1    Bode, A.M.2    Zhu, F.3    Liu, K.4    Zhang, J.5    Kim, M.O.6
  • 55
    • 34250190946 scopus 로고    scopus 로고
    • The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity
    • Lishko PV, Procko E, Jin X, Phelps CB, Gaudet R (2007) The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron 54:905-9188
    • (2007) Neuron , vol.54 , pp. 905-918
    • Lishko, P.V.1    Procko, E.2    Jin, X.3    Phelps, C.B.4    Gaudet, R.5
  • 56
    • 84858308053 scopus 로고    scopus 로고
    • Capsaicin-mediated tnox (enox2) up-regulation enhances cell proliferation and migration in vitro and in vivo
    • Liu NC, Hsieh PF, Hsieh MK, Zeng ZM, Cheng HL, Liao JW et al (2012) Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo. J Agric Food Chem 60:2758-27655
    • (2012) J Agric Food Chem , vol.60 , pp. 2758-2765
    • Liu, N.C.1    Hsieh, P.F.2    Hsieh, M.K.3    Zeng, Z.M.4    Cheng, H.L.5    Liao, J.W.6
  • 57
    • 78650380318 scopus 로고    scopus 로고
    • Antitumor activity of capsaicin on human colon cancer cells in vitro and colo 205 tumor xenografts in vivo
    • Lu HF, Chen YL, Yang JS, Yang YY, Liu JY, Hsu SC et al (2010) Antitumor activity of capsaicin on human colon cancer cells in vitro and colo 205 tumor xenografts in vivo. J Agric Food Chem 58:12999-130055
    • (2010) J Agric Food Chem , vol.58 , pp. 12999-13005
    • Lu, H.F.1    Chen, Y.L.2    Yang, J.S.3    Yang, Y.Y.4    Liu, J.Y.5    Hsu, S.C.6
  • 58
    • 54449083925 scopus 로고    scopus 로고
    • Molecular targeted therapies in hepatocellular carcinoma
    • Llovet JM, Bruix J (2008) Molecular targeted therapies in hepatocellular carcinoma. Hepatology 48:1312-13277
    • (2008) Hepatology , vol.48 , pp. 1312-1327
    • Llovet, J.M.1    Bruix, J.2
  • 59
    • 0032997385 scopus 로고    scopus 로고
    • Selective induction of apoptosis by capsaicin in transformed cells: The role of reactive oxygen species and calcium
    • Macho A, Calzado MA, Munoz-Blanco J, Gomez-Diaz C, Gajate C, Mollinedo F et al (1999) Selective induction of apoptosis by capsaicin in transformed cells: The role of reactive oxygen species and calcium. Cell Death Differ 6:155-1655
    • (1999) Cell Death Differ , vol.6 , pp. 155-165
    • Macho, A.1    Calzado, M.A.2    Munoz-Blanco, J.3    Gomez-Diaz, C.4    Gajate, C.5    Mollinedo, F.6
  • 60
    • 0037613726 scopus 로고    scopus 로고
    • Involvement of reactive oxygen species in capsaicinoid-induced apoptosis in transformed cells
    • Macho A, Sancho R, Minassi A, Appendino G, Lawen A, Munoz E (2003) Involvement of reactive oxygen species in capsaicinoid-induced apoptosis in transformed cells. Free Radic Res 37:611-6199
    • (2003) Free Radic Res , vol.37 , pp. 611-619
    • Macho, A.1    Sancho, R.2    Minassi, A.3    Appendino, G.4    Lawen, A.5    Munoz, E.6
  • 61
    • 77950373388 scopus 로고    scopus 로고
    • Capsaicin induces apoptosis through ubiquitin-proteasome system dysfunction
    • Maity R, Sharma J, Jana NR (2010) Capsaicin induces apoptosis through ubiquitin-proteasome system dysfunction. J Cell Biochem 109:933-9422
    • (2010) J Cell Biochem , vol.109 , pp. 933-942
    • Maity, R.1    Sharma, J.2    Jana, N.R.3
  • 62
    • 57749188229 scopus 로고    scopus 로고
    • Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3 K and MAPK pathways in prostate LNCaP cells
    • Malagarie-Cazenave S, Olea-Herrero N, Vara D, Diaz-Laviada I (2009) Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3 K and MAPK pathways in prostate LNCaP cells. FEBS Lett 583:141-1477
    • (2009) FEBS Lett , vol.583 , pp. 141-147
    • Malagarie-Cazenave, S.1    Olea-Herrero, N.2    Vara, D.3    Diaz-Laviada, I.4
  • 63
    • 53049104152 scopus 로고    scopus 로고
    • Stress-induced down-regulation of tumor-Associated NADH oxidase during apoptosis in transformed cells
    • Mao LC, Wang HM, Lin YY, Chang TK, Hsin YH, Chueh PJ (2008) Stress-induced down-regulation of tumor-Associated NADH oxidase during apoptosis in transformed cells. FEBS Lett 582:3445-34500
    • (2008) FEBS Lett , vol.582 , pp. 3445-3450
    • Mao, L.C.1    Wang, H.M.2    Lin, Y.Y.3    Chang, T.K.4    Hsin, Y.H.5    Chueh, P.J.6
  • 64
    • 84871781148 scopus 로고    scopus 로고
    • Worldwide relative burden of cancer death in 2008 extrapolated from the WHO mortality database
    • Matsuda A, Machii R (2013) Worldwide relative burden of cancer death in 2008 extrapolated from the WHO mortality database. Jpn J Clin Oncol 43:1022
    • (2013) Jpn J Clin Oncol , vol.43 , pp. 1022
    • Matsuda, A.1    Machii, R.2
  • 65
    • 84857121509 scopus 로고    scopus 로고
    • Capsaicin sensitizes TRAIL-induced apoptosis through Sp1-mediated DR5 up-regulation: Involvement of Ca 2+) influx
    • Moon DO, Kang CH, Kang SH, Choi YH, Hyun JW, Chang WY et al (2012) Capsaicin sensitizes TRAIL-induced apoptosis through Sp1-mediated DR5 up-regulation: Involvement of Ca(2+) influx. Toxicol Appl Pharmacol 259:87-955
    • (2012) Toxicol Appl Pharmacol , vol.259 , pp. 87-95
    • Moon, D.O.1    Kang, C.H.2    Kang, S.H.3    Choi, Y.H.4    Hyun, J.W.5    Chang, W.Y.6
  • 66
    • 33645533257 scopus 로고    scopus 로고
    • Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells
    • Mori A, Lehmann S, O'Kelly J, Kumagai T, Desmond JC, Pervan M et al (2006) Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells. Cancer Res 66:3222-32299
    • (2006) Cancer Res , vol.66 , pp. 3222-3229
    • Mori, A.1    Lehmann, S.2    O'Kelly, J.3    Kumagai, T.4    Desmond, J.C.5    Pervan, M.6
  • 67
    • 0031570783 scopus 로고    scopus 로고
    • NADH oxidase activity from sera altered by capsaicin is widely distributed among cancer patients
    • Morre DJ, Caldwell S, Mayorga A, Wu LY, Morre DM (1997) NADH oxidase activity from sera altered by capsaicin is widely distributed among cancer patients. Arch Biochem Biophys 342:224-2300
    • (1997) Arch Biochem Biophys , vol.342 , pp. 224-230
    • Morre, D.J.1    Caldwell, S.2    Mayorga, A.3    Wu, L.Y.4    Morre, D.M.5
  • 68
    • 0028925916 scopus 로고
    • Capsaicin inhibits preferentially the NADH oxidase and growth of transformed cells in culture
    • Morre DJ, Chueh PJ, Morre DM (1995) Capsaicin inhibits preferentially the NADH oxidase and growth of transformed cells in culture. Proc Natl Acad Sci U S A 92:1831-18355
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 1831-1835
    • Morre, D.J.1    Chueh, P.J.2    Morre, D.M.3
  • 69
    • 70349134341 scopus 로고    scopus 로고
    • Cancer type-specific tNOX isoforms: A putative family of redox protein splice variants with cancer diagnostic and prognostic potential
    • Morre DJ, Hostetler B, Weston N, Kim C, Morre DM (2008) Cancer type-specific tNOX isoforms: A putative family of redox protein splice variants with cancer diagnostic and prognostic potential. BioFactors 34:201-2077
    • (2008) BioFactors , vol.34 , pp. 201-207
    • Morre, D.J.1    Hostetler, B.2    Weston, N.3    Kim, C.4    Morre, D.M.5
  • 70
    • 0030272640 scopus 로고    scopus 로고
    • Capsaicin inhibits plasma membrane NADH oxidase and growth of human and mouse melanoma lines
    • Morre DJ, Sun E, Geilen C, Wu LY, de Cabo R, Krasagakis K et al (1996) Capsaicin inhibits plasma membrane NADH oxidase and growth of human and mouse melanoma lines. Eur J Cancer 32A:1995-20033
    • (1996) Eur J Cancer , vol.32 A , pp. 1995-2003
    • Morre, D.J.1    Sun, E.2    Geilen, C.3    Wu, L.Y.4    De Cabo, R.5    Krasagakis, K.6
  • 71
    • 79953024415 scopus 로고    scopus 로고
    • PPAR alpha activation by culinary herbs and spices
    • Mueller M, Beck V, Jungbauer A (2011) PPAR alpha activation by culinary herbs and spices. Planta Med 77:497-5044
    • (2011) Planta Med , vol.77 , pp. 497-504
    • Mueller, M.1    Beck, V.2    Jungbauer, A.3
  • 73
    • 58149086894 scopus 로고    scopus 로고
    • Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalaseregulated manner
    • Oh SH, Kim YS, Lim SC, Hou YF, Chang IY, You HJ (2008) Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalaseregulated manner. Autophagy 4:1009-10199
    • (2008) Autophagy , vol.4 , pp. 1009-1019
    • Oh, S.H.1    Kim, Y.S.2    Lim, S.C.3    Hou, Y.F.4    Chang, I.Y.5    You, H.J.6
  • 74
    • 77957909924 scopus 로고    scopus 로고
    • Lovastatin interacts with natural products to influence cultured hepatocarcinoma cell (hep-g2) growth
    • Popovich DG, Tiaras F, Yeo CR, Zhang W (2010) Lovastatin interacts with natural products to influence cultured hepatocarcinoma cell (hep-g2) growth. J Am Coll Nutr 29:204-2100
    • (2010) J Am Coll Nutr , vol.29 , pp. 204-210
    • Popovich, D.G.1    Tiaras, F.2    Yeo, C.R.3    Zhang, W.4
  • 75
    • 79957465966 scopus 로고    scopus 로고
    • Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells
    • Pramanik KC, Boreddy SR, Srivastava SK (2011) Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells. PLoS ONE 6:e201511
    • (2011) PLoS ONE , vol.6
    • Pramanik, K.C.1    Boreddy, S.R.2    Srivastava, S.K.3
  • 76
    • 84865417726 scopus 로고    scopus 로고
    • Apoptosis signal-regulating kinase 1-Thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis
    • Pramanik KC, Srivastava SK (2012) Apoptosis signal-regulating kinase 1-Thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis. Antioxid Redox Signal 17:1417-14322
    • (2012) Antioxid Redox Signal , vol.17 , pp. 1417-1432
    • Pramanik, K.C.1    Srivastava, S.K.2
  • 77
    • 0037799198 scopus 로고    scopus 로고
    • A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity
    • Prescott ED, Julius D (2003) A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science 300:1284-12888
    • (2003) Science , vol.300 , pp. 1284-1288
    • Prescott, E.D.1    Julius, D.2
  • 78
    • 84878885289 scopus 로고    scopus 로고
    • Incidence and mortality trends for four major cancers in the elderly and middle-Aged adults: An international comparison
    • Quaglia A, Lillini R, Crocetti E, Buzzoni C, and Vercelli M (2013) Incidence and mortality trends for four major cancers in the elderly and middle-Aged adults: An international comparison. Surg Oncol 22(2):e31-e388
    • (2013) Surg Oncol , vol.22 , Issue.2
    • Quaglia, A.1    Lillini, R.2    Crocetti, E.3    Buzzoni, C.4    Vercelli, M.5
  • 79
    • 84858290396 scopus 로고    scopus 로고
    • Antitumor promoting potential of selected phytochemicals derived from spices: A review
    • Rajput S, Mandal M (2012) Antitumor promoting potential of selected phytochemicals derived from spices: A review. Eur J Cancer Prev 21:205-2155
    • (2012) Eur J Cancer Prev , vol.21 , pp. 205-215
    • Rajput, S.1    Mandal, M.2
  • 80
    • 0037348385 scopus 로고    scopus 로고
    • Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells
    • Reilly CA, Ehlhardt WJ, Jackson DA, Kulanthaivel P, Mutlib AE, Espina RJ et al (2003) Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol 16:336-3499
    • (2003) Chem Res Toxicol , vol.16 , pp. 336-349
    • Reilly, C.A.1    Ehlhardt, W.J.2    Jackson, D.A.3    Kulanthaivel, P.4    Mutlib, A.E.5    Espina, R.J.6
  • 81
    • 84872550638 scopus 로고    scopus 로고
    • Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by P450 enzymes
    • Reilly CA, Henion F, Bugni TS, Ethirajan M, Stockmann C, Pramanik KC et al (2013) Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by P450 enzymes. Chem Res Toxicol 26(1):55-666
    • (2013) Chem Res Toxicol , vol.26 , Issue.1 , pp. 55-66
    • Reilly, C.A.1    Henion, F.2    Bugni, T.S.3    Ethirajan, M.4    Stockmann, C.5    Pramanik, K.C.6
  • 82
    • 79959792142 scopus 로고    scopus 로고
    • Expression and function of TRP channels in liver cells
    • Rychkov GY, Barritt GJ (2011) Expression and function of TRP channels in liver cells. Adv Exp Med Biol 704:667-6866
    • (2011) Adv Exp Med Biol , vol.704 , pp. 667-686
    • Rychkov, G.1    Barritt, G.J.2
  • 83
    • 34848895758 scopus 로고    scopus 로고
    • Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation
    • Sanchez AM, Malagarie-Cazenave S, Olea N, Vara D, Chiloeches A, Diaz-Laviada I (2007) Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation. Apoptosis 12:2013-20244
    • (2007) Apoptosis , vol.12 , pp. 2013-2024
    • Sanchez, A.M.1    Malagarie-Cazenave, S.2    Olea, N.3    Vara, D.4    Chiloeches, A.5    Diaz-Laviada, I.6
  • 85
    • 31444437266 scopus 로고    scopus 로고
    • Induction of apoptosis in prostate tumor PC-3 cells and inhibition of xenograft prostate tumor growth by the vanilloid capsaicin
    • Sanchez AM, Sanchez MG, Malagarie-Cazenave S, Olea N, Diaz-Laviada I (2006) Induction of apoptosis in prostate tumor PC-3 cells and inhibition of xenograft prostate tumor growth by the vanilloid capsaicin. Apoptosis 11:89-999
    • (2006) Apoptosis , vol.11 , pp. 89-99
    • Sanchez, A.M.1    Sanchez, M.G.2    Malagarie-Cazenave, S.3    Olea, N.4    Diaz-Laviada, I.5
  • 86
    • 20344384533 scopus 로고    scopus 로고
    • Expression of the transient receptor potential vanilloid 1 (TRPV1 in LNCaP and PC-33 prostate cancer cells and in human prostate tissue
    • Sanchez MG, Sanchez AM, Collado B, Malagarie-Cazenave S, Olea N, Carmena MJ et al (2005) Expression of the transient receptor potential vanilloid 1 (TRPV1) in LNCaP and PC-33 prostate cancer cells and in human prostate tissue. Eur J Pharmacol 515:20-277
    • (2005) Eur J Pharmacol , vol.515 , pp. 20-27
    • Sanchez, M.G.1    Sanchez, A.M.2    Collado, B.3    Malagarie-Cazenave, S.4    Olea, N.5    Carmena, M.J.6
  • 87
    • 84874637703 scopus 로고    scopus 로고
    • Antioncogenic effects of transient receptor potential vanilloid 1 in the progression of transitional urothelial cancer of human bladder
    • Santoni G, Caprodossi S, Farfariello V, Liberati S, Gismondi A, Amantini C (2012) Antioncogenic effects of transient receptor potential vanilloid 1 in the progression of transitional urothelial cancer of human bladder. ISRN Urol 2012:4582388
    • (2012) ISRN Urol 2012 , pp. 4582388
    • Santoni, G.1    Caprodossi, S.2    Farfariello, V.3    Liberati, S.4    Gismondi, A.5    Amantini, C.6
  • 88
    • 84869009687 scopus 로고    scopus 로고
    • How cancer metabolism is tuned for proliferation and vulnerable to disruption
    • Schulze A, Harris AL (2012) How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 491:364-3733
    • (2012) Nature , vol.491 , pp. 364-373
    • Schulze, A.1    Harris, A.L.2
  • 89
    • 84879555144 scopus 로고    scopus 로고
    • Tumor regression with a combination of drugs interfering with the tumor metabolism: Efficacy of hydroxycitrate, lipoic acid and capsaicin
    • Schwartz L, Guais A, Israel M, Junod B, Steyaert JM, Crespi E et al (2013) Tumor regression with a combination of drugs interfering with the tumor metabolism: Efficacy of hydroxycitrate, lipoic acid and capsaicin. Invest New Drugs 31:256-2644
    • (2013) Invest New Drugs , vol.31 , pp. 256-264
    • Schwartz, L.1    Guais, A.2    Israel, M.3    Junod, B.4    Steyaert, J.M.5    Crespi, E.6
  • 91
    • 0030588541 scopus 로고    scopus 로고
    • Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents
    • Singh S, Natarajan K, Aggarwal BB (1996) Capsaicin (8-methyl-N-vanillyl- 6-nonenamide) is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents. J Immunol 157:4412-44200
    • (1996) J Immunol , vol.157 , pp. 4412-4420
    • Singh, S.1    Natarajan, K.2    Aggarwal, B.B.3
  • 92
    • 84879165160 scopus 로고    scopus 로고
    • Oxidative stress: The mitochondria-dependent and mitochondria-independent pathways of apoptosis
    • Sinha K, Das J, Pal PB, Sil PC (2013) Oxidative stress: The mitochondria-dependent and mitochondria-independent pathways of apoptosis. Arch Toxicol 87(7):1157-11800
    • (2013) Arch Toxicol , vol.87 , Issue.7 , pp. 1157-1180
    • Sinha, K.1    Das, J.2    Pal, P.B.3    Sil, P.C.4
  • 94
    • 84868551550 scopus 로고    scopus 로고
    • Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOPmediated upregulation of death receptors
    • Sung B, Prasad S, Ravindran J, Yadav VR, Aggarwal BB (2012) Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOPmediated upregulation of death receptors. Free Radic Biol Med 53:1977-19877
    • (2012) Free Radic Biol Med , vol.53 , pp. 1977-1987
    • Sung, B.1    Prasad, S.2    Ravindran, J.3    Yadav, V.R.4    Aggarwal, B.B.5
  • 95
    • 77952379134 scopus 로고    scopus 로고
    • Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats
    • Suresh D, Srinivasan K (2010) Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. Indian J Med Res 131:682-6911
    • (2010) Indian J Med Res , vol.131 , pp. 682-691
    • Suresh, D.1    Srinivasan, K.2
  • 96
    • 0037019748 scopus 로고    scopus 로고
    • More than spice: Capsaicin in hot chili peppers makes tumor cells commit suicide
    • Surh YJ (2002) More than spice: Capsaicin in hot chili peppers makes tumor cells commit suicide. J Natl Cancer Inst 94:1263-12655
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1263-1265
    • Surh, Y.J.1
  • 97
    • 0028913539 scopus 로고
    • Capsaicin, a double-edged sword: Toxicity, metabolism, and chemopreventive potential
    • Surh YJ, Lee SS (1995) Capsaicin, a double-edged sword: Toxicity, metabolism, and chemopreventive potential. Life Sci 56:1845-18555
    • (1995) Life Sci , vol.56 , pp. 1845-1855
    • Surh, Y.J.1    Lee, S.S.2
  • 98
    • 84881523670 scopus 로고    scopus 로고
    • Mechanisms of resistance to chemotherapeutic and anti-Angiogenic drugs as novel targets for pancreatic cancer therapy
    • Tamburrino A, Piro G, Carbone C, Tortora G, Melisi D (2013) Mechanisms of resistance to chemotherapeutic and anti-Angiogenic drugs as novel targets for pancreatic cancer therapy. Front Pharmacol 4:566
    • (2013) Front Pharmacol , vol.4 , pp. 566
    • Tamburrino, A.1    Piro, G.2    Carbone, C.3    Tortora, G.4    Melisi, D.5
  • 99
    • 74449084136 scopus 로고    scopus 로고
    • Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and-negative breast cancer cells by modulating the EGFR/HER-2 pathway
    • Thoennissen NH, O'Kelly J, Lu D, Iwanski GB, La DT, Abbassi S et al (2010) Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and-negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene 29:285-2966
    • (2010) Oncogene , vol.29 , pp. 285-296
    • Thoennissen, N.H.1    O'Kelly, J.2    Lu, D.3    Iwanski, G.B.4    La, D.T.5    Abbassi, S.6
  • 100
    • 33745621050 scopus 로고    scopus 로고
    • Involvement of Bax, Bcl-2, Ca2+ and caspase-3 in capsaicin-induced apoptosis of human leukemia HL-60 cells
    • Tsou MF, Lu HF, Chen SC, Wu LT, Chen YS, Kuo HM et al (2006) Involvement of Bax, Bcl-2, Ca2+ and caspase-3 in capsaicin-induced apoptosis of human leukemia HL-60 cells. Anticancer Res 26:1965-19711
    • (2006) Anticancer Res , vol.26 , pp. 1965-1971
    • Tsou, M.F.1    Lu, H.F.2    Chen, S.C.3    Wu, L.T.4    Chen, Y.S.5    Kuo, H.M.6
  • 102
    • 84929271083 scopus 로고    scopus 로고
    • Expression and functionality of TRPV1 receptor in human MCF-7 and canine CF.41 cells
    • doi:10.1111/vco.12028 [Epub ahead of print]]
    • Vercelli C, Barbero R, Cuniberti B, Odore R, Re G (2013) Expression and functionality of TRPV1 receptor in human MCF-7 and canine CF.41 cells. Vet Comp Oncol. doi:10.1111/vco.12028 [Epub ahead of print]]
    • (2013) Vet Comp Oncol
    • Vercelli, C.1    Barbero, R.2    Cuniberti, B.3    Odore, R.4    Re, G.5
  • 103
    • 84878298992 scopus 로고    scopus 로고
    • Strategy for detection of prostate cancer based on relation between prostate specific antigen at age 40-555 and long term risk of metastasis: Case-control study
    • Vickers AJ, Ulmert D, Sjoberg DD, Bennette CJ, Bjork T, Gerdtsson A et al (2013) Strategy for detection of prostate cancer based on relation between prostate specific antigen at age 40-555 and long term risk of metastasis: Case-control study. BMJ 346:f20233
    • (2013) BMJ , vol.346
    • Vickers, A.J.1    Ulmert, D.2    Sjoberg, D.D.3    Bennette, C.J.4    Bjork, T.5    Gerdtsson, A.6
  • 104
    • 2542452122 scopus 로고    scopus 로고
    • TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells
    • Vriens J, Janssens A, Prenen J, Nilius B, Wondergem R (2004) TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells. Cell Calcium 36:19-288
    • (2004) Cell Calcium , vol.36 , pp. 19-28
    • Vriens, J.1    Janssens, A.2    Prenen, J.3    Nilius, B.4    Wondergem, R.5
  • 105
    • 84876907236 scopus 로고    scopus 로고
    • Secondary metabolites of capsicum species and their importance in the human diet
    • Wahyuni Y, Ballester AR, Sudarmonowati E, Bino RJ, Bovy AG (2013) Secondary metabolites of capsicum species and their importance in the human diet. J Nat Prod 76(4):783-7933
    • (2013) J Nat Prod , vol.76 , Issue.4 , pp. 783-793
    • Wahyuni, Y.1    Ballester, A.R.2    Sudarmonowati, E.3    Bino, R.J.4    Bovy, A.G.5
  • 106
    • 0029898994 scopus 로고    scopus 로고
    • Similarities and differences in the structure-Activity relationships of capsaicin and resiniferatoxin analogues
    • Walpole CS, Bevan S, Bloomfield G, Breckenridge R, James IF, Ritchie T et al (1996) Similarities and differences in the structure-Activity relationships of capsaicin and resiniferatoxin analogues. J Med Chem 39:2939-29522
    • (1996) J Med Chem , vol.39 , pp. 2939-2952
    • Walpole, C.S.1    Bevan, S.2    Bloomfield, G.3    Breckenridge, R.4    James, I.F.5    Ritchie, T.6
  • 107
    • 0027270897 scopus 로고
    • Analogues of capsaicin with agonist activity as novel analgesic agents; structure-Activity studies 3 The hydrophobic side-chain C-region
    • Walpole CS, Wrigglesworth R, Bevan S, Campbell EA, Dray A, James IF et al (1993) Analogues of capsaicin with agonist activity as novel analgesic agents; structure-Activity studies. 3. The hydrophobic side-chain "C-region". J Med Chem 36:2381-23899
    • (1993) J Med Chem , vol.36 , pp. 2381-2389
    • Walpole, C.S.1    Wrigglesworth, R.2    Bevan, S.3    Campbell, E.A.4    Dray, A.5    James, I.F.6
  • 108
    • 77953387854 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress response in cancer: Molecular mechanism and therapeutic potential
    • Wang G, Yang ZQ, Zhang K (2010) Endoplasmic reticulum stress response in cancer: Molecular mechanism and therapeutic potential. Am J Transl Res 2:65-744
    • (2010) Am J Transl Res , vol.2 , pp. 65-74
    • Wang, G.1    Yang, Z.Q.2    Zhang, K.3
  • 109
    • 74049102383 scopus 로고    scopus 로고
    • Effect of Ccapsaicin on tNOX (ENOX2) protein expression in stomach cancer cells
    • Wang HM, Chueh PJ, Chang SP, Yang CL, Shao KN (2008) Effect of Ccapsaicin on tNOX (ENOX2) protein expression in stomach cancer cells. BioFactors 34:209-2177
    • (2008) BioFactors , vol.34 , pp. 209-217
    • Wang, H.M.1    Chueh, P.J.2    Chang, S.P.3    Yang, C.L.4    Shao, K.N.5
  • 110
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate
    • Ward PS, Thompson CB (2012) Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate. Cancer Cell 21:297-3088
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 111
    • 0029845129 scopus 로고    scopus 로고
    • Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin
    • Wolvetang EJ, Larm JA, Moutsoulas P, Lawen A (1996) Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin. Cell Growth Differ 7:1315-13255
    • (1996) Cell Growth Differ , vol.7 , pp. 1315-1325
    • Wolvetang, E.J.1    Larm, J.A.2    Moutsoulas, P.3    Lawen, A.4
  • 112
    • 84880399422 scopus 로고    scopus 로고
    • Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt/mTOR and STAT-3 pathways
    • Yang J, Luo B, Xu G, Li T, Chen Y, Zhang T (2013) Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt/mTOR and STAT-3 pathways. Neoplasma 60(4):364-3722
    • (2013) Neoplasma , vol.60 , Issue.4 , pp. 364-372
    • Yang, J.1    Luo, B.2    Xu, G.3    Li, T.4    Chen, Y.5    Zhang, T.6
  • 113
    • 77649187285 scopus 로고    scopus 로고
    • Capsaicin mediates cell death in bladder cancer T24 cells through reactive oxygen species production and mitochondrial depolarization
    • Yang ZH, Wang XH, Wang HP, Hu LQ, Zheng XM, Li SW (2010) Capsaicin mediates cell death in bladder cancer T24 cells through reactive oxygen species production and mitochondrial depolarization. Urology 75:735-7411
    • (2010) Urology , vol.75 , pp. 735-741
    • Yang, Z.H.1    Wang, X.H.2    Wang, H.P.3    Hu, L.Q.4    Zheng, X.M.5    Li, S.W.6
  • 114
    • 84856008795 scopus 로고    scopus 로고
    • Multifaceted roles of peroxisome proliferator-Activated receptors (PPARs) at the cellular and whole organism levels
    • Yessoufou A, Wahli W (2010) Multifaceted roles of peroxisome proliferator-Activated receptors (PPARs) at the cellular and whole organism levels. Swiss Med Wkly 140:w130711
    • (2010) Swiss Med Wkly , vol.140
    • Yessoufou, A.1    Wahli, W.2
  • 115
    • 84862777879 scopus 로고    scopus 로고
    • Role of autophagy in chemoresistance: Regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNAPKcs and PARP-1
    • Yoon JH, Ahn SG, Lee BH, Jung SH, Oh SH (2012) Role of autophagy in chemoresistance: Regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNAPKcs and PARP-1. Biochem Pharmacol 83:747-7577
    • (2012) Biochem Pharmacol , vol.83 , pp. 747-757
    • Yoon, J.H.1    Ahn, S.G.2    Lee, B.H.3    Jung, S.H.4    Oh, S.H.5
  • 116
    • 0035513592 scopus 로고    scopus 로고
    • Chemoprevention of azoxymethaneinduced rat colon carcinogenesis by dietary capsaicin and rotenone
    • Yoshitani SI, Tanaka T, Kohno H, Takashima S (2001) Chemoprevention of azoxymethaneinduced rat colon carcinogenesis by dietary capsaicin and rotenone. Int J Oncol 19:929-9399
    • (2001) Int J Oncol , vol.19 , pp. 929-939
    • Yoshitani, S.I.1    Tanaka, T.2    Kohno, H.3    Takashima, S.4
  • 117
    • 79961244975 scopus 로고    scopus 로고
    • Peroxisome proliferator-Activated receptors and cancer challenges and opportunities
    • Youssef J, Badr M (2011) Peroxisome proliferator-Activated receptors and cancer challenges and opportunities. Br J Pharmacol 164(1):68-822
    • (2011) Br J Pharmacol , vol.164 , Issue.1 , pp. 68-82
    • Youssef, J.1    Badr, M.2
  • 118
    • 84871667873 scopus 로고    scopus 로고
    • Food-drug interactions: Effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats
    • Zhai XJ, Chen JG, Liu JM, Shi F, Lu YN (2013) Food-drug interactions: Effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats. Food Chem Toxicol 53:168-1733
    • (2013) Food Chem Toxicol , vol.53 , pp. 168-173
    • Zhai, X.J.1    Chen, J.G.2    Liu, J.M.3    Shi, F.4    Lu, Y.N.5
  • 119
    • 0037355052 scopus 로고    scopus 로고
    • Capsaicin inhibits growth of adult T-cell leukemia cells
    • Zhang J, Nagasaki M, Tanaka Y, Morikawa S (2003) Capsaicin inhibits growth of adult T-cell leukemia cells. Leuk Res 27:275-2833
    • (2003) Leuk Res , vol.27 , pp. 275-283
    • Zhang, J.1    Nagasaki, M.2    Tanaka, Y.3    Morikawa, S.4
  • 120
    • 84869053446 scopus 로고    scopus 로고
    • Involvement of the phosphoinositide 3-kinase/Akt pathway in apoptosis induced by capsaicin in the human pancreatic cancer cell line PANC-1
    • Zhang JH, Lai FJ, Chen H, Luo J, Zhang RY, Bu HQ et al (2013) Involvement of the phosphoinositide 3-kinase/Akt pathway in apoptosis induced by capsaicin in the human pancreatic cancer cell line PANC-1. Oncol Lett 5:43-488
    • (2013) Oncol Lett , vol.5 , pp. 43-48
    • Zhang, J.H.1    Lai, F.J.2    Chen, H.3    Luo, J.4    Zhang, R.Y.5    Bu, H.Q.6
  • 121
    • 84860251666 scopus 로고    scopus 로고
    • Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo
    • Zhang QH, Hu JP, Wang BL, Li Y (2012) Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res 14:382-3955
    • (2012) J Asian Nat Prod Res , vol.14 , pp. 382-395
    • Zhang, Q.H.1    Hu, J.P.2    Wang, B.L.3    Li, Y.4
  • 122
    • 56349151331 scopus 로고    scopus 로고
    • In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway
    • Zhang R, Humphreys I, Sahu RP, Shi Y, Srivastava SK (2008) In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. Apoptosis 13:1465-14788
    • (2008) Apoptosis , vol.13 , pp. 1465-1478
    • Zhang, R.1    Humphreys, I.2    Sahu, R.P.3    Shi, Y.4    Srivastava, S.K.5
  • 123
    • 0029102676 scopus 로고
    • Structural organization of mouse peroxisome proliferator-Activated receptor gamma (mPPAR gamma) gene: Alternative promoter use and different splicing yield two mPPAR gamma isoforms
    • Zhu Y, Qi C, Korenberg JR, Chen XN, Noya D, Rao MS et al (1995) Structural organization of mouse peroxisome proliferator-Activated receptor gamma (mPPAR gamma) gene: Alternative promoter use and different splicing yield two mPPAR gamma isoforms. Proc Natl Acad Sci U S A 92:7921-79255
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 7921-7925
    • Zhu, Y.1    Qi, C.2    Korenberg, J.R.3    Chen, X.N.4    Noya, D.5    Rao, M.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.