Induction of Apoptosis in Leukemic Cells by Homovanillic Acid Derivative, Capsaicin, through Oxidative Stress: Implication of Phosphorylation of p53 at Ser-15 Residue by Reactive Oxygen Species

Cancer Research

Volumn 64, Issue 3, 2004, Pages 1071-1078

  Ito, Keisuke ^a   Nakazato, Tomonori ^a   Yamato, Kenji ^b   Miyakawa, Yoshitaka ^a   Yamada, Taketo ^a   Hozumi, Nobumichi ^c   Segawa, Kaoru ^a   Ikeda, Yasuo ^a   Kizaki, Masahiro ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTISENSE OLIGONUCLEOTIDE; CAPSAICIN; CASPASE; CATALASE; HOMOVANILLIC ACID; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DRUG SELECTIVITY; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LEUKEMIA CELL; MONONUCLEAR CELL; MOUSE; MYELOID LEUKEMIA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; SEQUENCE ANALYSIS;

APOPTOSIS; CAPSAICIN; CELL DIVISION; CELL LINE, TUMOR; G0 PHASE; G1 PHASE; HUMANS; LEUKEMIA; MITOCHONDRIA; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SERINE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0842304283     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-1670     Document Type: Article

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