Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt/mTOR and STAT-3 pathways

Neoplasma

Volumn 60, Issue 4, 2013, Pages 364-372

  Yang, J ^a   Li, T Z ^a   Xu, G H ^b   Luo, B B ^a   Chen, Y X ^a   Zhang, T ^a  

^a CHENGDU MEDICAL COLLEGE   (China)

^b General Surgery   (China)

Author keywords

Capsaicin; Colorectal cancer; EMT; Metastasis; ROS

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CAPSAICIN; GELATINASE A; GELATINASE B; MAMMALIAN TARGET OF RAPAMYCIN; N BENZYL 2 CYANO 3 (3, 4 DIHYDROXYPHENYL) ACRYLAMIDE; NERVE CELL ADHESION MOLECULE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; UDSA; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; MTOR PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; COLORECTAL CANCER; CONTROLLED STUDY; DRUG DOSE COMPARISON; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; HUMAN TISSUE; METASTASIS; NONHUMAN; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; CELL MOTION; COLORECTAL TUMOR; DRUG EFFECT; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR INVASION;

ANIMALS; CAPSAICIN; CELL LINE, TUMOR; CELL MOVEMENT; COLORECTAL NEOPLASMS; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED BALB C; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TOR SERINE-THREONINE KINASES;

MLCS; MLOWN;

EID: 84880399422     PISSN: 00282685     EISSN: 13384317     Source Type: Journal    
DOI: 10.4149/neo_2013_048     Document Type: Article

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