Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by P450 enzymes

Chemical Research in Toxicology

Volumn 26, Issue 1, 2013, Pages 55-66

  Reilly, Christopher A ^a   Henion, Fred ^a   Bugni, Tim S ^a   Ethirajan, Manivannan ^a   Stockmann, Chris ^a   Pramanik, Kartick C ^b   Srivastava, Sanjay K ^b   Yost, Garold S ^a  

^a UNIVERSITY OF UTAH   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,5' DICAPSAICIN; ACETYLCYSTEINE; AROMATIC COMPOUND; CAPSAICIN; CAPSAICIN DERIVATIVE; CYTOCHROME P450; DRUG METABOLITE; ELECTROPHILE; GLUTATHIONE; MERCAPTOETHANOL; NONIVAMIDE; PEROXIDASE; QUINONE DERIVATIVE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONJUGATE; CROSS COUPLING REACTION; DEHYDROGENATION; DEMETHYLATION; DRUG DETERMINATION; DRUG METABOLISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; HYDROXYLATION; IN VIVO STUDY; LIVER MICROSOME; MOUSE; NONHUMAN; SUBSTITUTION REACTION;

ACETYLCYSTEINE; ANIMALS; CAPSAICIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DIMERIZATION; GLUTATHIONE; HUMANS; INDOLEQUINONES; LIVER; MICE; OXYGEN ISOTOPES; RECOMBINANT PROTEINS; TANDEM MASS SPECTROMETRY;

MUS;

EID: 84872550638     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx300366k     Document Type: Article

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