Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress

Human and Experimental Toxicology

Volumn 31, Issue 6, 2012, Pages 539-549

  Ip, S W ^a   Lan, S H ^a   Lu, H F ^b,c   Huang, A C ^d   Yang, J S ^a   Lin, J P ^a   Huang, H Y ^a   Lien, J C ^a   Ho, C C ^e   Chiu, C F ^f   Wood, W G ^g   Chung, J G ^a,h  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHENG HSIN GENERAL HOSPITAL   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^d St Mary's Medicine Nursing and Management College   (Taiwan)

^e CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^f CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^g UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^h ASIA UNIVERSITY   (Taiwan)

Author keywords

apoptosis; capsaicin; caspases 3 activation; human nasopharyngeal carcinoma NPC TW 039 cells; mitochondria

Indexed keywords

APOPTOSIS INDUCING FACTOR; CALCIUM ION; CAPSAICIN; CASPASE 3; CASPASE 9; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INOSITOL; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL CYCLE G0 PHASE; CELL GROWTH; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN TISSUE; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CAPSAICIN; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NASOPHARYNGEAL NEOPLASMS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TRPV CATION CHANNELS;

CAPSICUM FRUTESCENS;

EID: 84861799499     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327111417269     Document Type: Article

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