Expression and function of TRP channels in liver cells

Advances in Experimental Medicine and Biology

Volumn 704, Issue , 2011, Pages 667-686

  Rychkov, Grigori Y ^a   Barritt, Gregory J ^b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b FLINDERS UNIVERSITY   (Australia)

Author keywords

Ca 2+ channel; Hepatocyte; Hormone; Liver; Plasma membrane; TRP channel

Indexed keywords

CALCIUM ION; NITRIC OXIDE; POLYCYSTIN 2; REACTIVE OXYGEN METABOLITE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; TRANSIENT RECEPTOR POTENTIAL CHANNEL M7; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 4; CALCIUM;

CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL MEMBRANE TRANSPORT; CELL MIGRATION; CELL PROLIFERATION; CELL VOLUME; CONFERENCE PAPER; ENDOPLASMIC RETICULUM; EXTRACELLULAR SIGNAL; HUMAN; INTRACELLULAR SIGNALING; LIVER CELL; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TUMOR DIFFERENTIATION; CELL LINE; ION TRANSPORT; LIVER; LIVER TUMOR; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; TUMOR CELL LINE;

CALCIUM; CELL LINE; CELL LINE, TUMOR; HUMANS; ION TRANSPORT; LIVER; LIVER NEOPLASMS; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 79959792142     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-94-007-0265-3_35     Document Type: Conference Paper

References (105)

1. Boyer JL (2002) Bile formation and cholestasis. In: Schiffs diseases of the liver, 9th ed. Lippincott, Williams & Wilkins, Philadelphia, PA, pp 135-165
2. Leite MF, Nathanson MH (2001) In: The liver biology and pathobiology. Lippincott, Williams & Wilkiins, Philadelphia, PA, pp 537-554
3. Mohammed FF, Khokha R (2005) Thinking outside the cell: Proteases regulate hepatocyte division. Trends Cell Biol 15: 555-563
4. Young B, Heath JW (2000) Liver and pancreas. In: Wheater's functional histology, 4th ed. Churchill Livingstone, Edinburgh, pp 274-275
5. Wakabayashi Y, Kipp H, Arias IM (2006) Transporters on demand: Intracellular reservoirs and cycling of bile canalicular ABC transporters. J Biol Chem 281: 27669-27673
6. Hubbard AL, Barr VA, Scott LJ (1994) Hepatocyte surface polarity. In: The liver: Biology and pathobiology. Raven Press Ltd, New York, NY, pp 189-214
7. Zegers MM, Hoekstra D (1998) Mechanisms and functional features of polarized membrane traffic in epithelial and hepatic cells. Biochem J 336:257-269
8. Berry MN, Edwards AM, Barritt G (1991) Assessment of integrity of isolated hepatocytes. In: Isolated hepatocytes - preparation, properties and applications. Elsevier, Amsterdam, pp 83-98
9. Dixon CJ, White PJ, Hall JF, Kingston S, Boarder MR (2005) Regulation of human hepatocytes by P2Y receptors: Control of glycogen phosphorylase, Ca2+, and mitogen-activated protein kinases. J Pharmacol Exp Ther 313:1305-1313
10. O'Brien EM, Gomes DA, Sehgal S, Nathanson MH (2007) Hormonal regulation of nuclear permeability. J Biol Chem 282:4210-4217
11. Nieuwenhuijs VB, De Bruijn MT, Padbury RT, Barritt GJ (2006) Hepatic ischemiareperfusion injury: Roles of Ca2+ and other intracellular mediators of impaired bile flow and hepatocyte damage. Dig Dis Sci 51:1087-1102
12. Enfissi A, Prigent S, Colosetti P, Capiod T (2004) The blocking of capacitative calcium entry by 2-aminoethyl diphenylborate (2-APB) and carboxyamidotriazole (CAI) inhibits proliferation in Hep G2 and Huh-7 human hepatoma cells. Cell Calcium 36:459-467
13. Robb-Gaspers LD, Burnett P, Rutter GA, Denton RM, Rizzuto R, Thomas AP (1998) Integrating cytosolic calcium signals into mitochondrial metabolic responses. EMBO J 17:4987-5000
14. Berridge MJ (2002) The endoplasmic reticulum: A multifunctional signaling organelle. Cell Calcium 32:235-249
15. Rodrigues MA, Gomes DA, Leite MF, Grant W, Zhang L, Lam W, Cheng YC, Bennett AM, NathansonMH (2007) Nucleoplasmic calcium is required for cell proliferation. J Biol Chem 282:17061-17068
16. Barritt GJ, Parker JC, Wadsworth JC (1981) A kinetic analysis of the effects of adrenaline on calcium distribution in isolated rat liver parenchymal cells. J Physiol 312:29-55
17. Canaff L, Petit JL, Kisiel M, Watson PH, Gascon-Barre M, Hendy GN (2001) Extracellular calcium-sensing receptor is expressed in rat hepatocytes. coupling to intracellular calcium mobilization and stimulation of bile flow. J Biol Chem 276:4070-4079
18. Lesurtel M, Graf R, Aleil B, Walther DJ, Tian Y, Jochum W, Gachet C, Bader M, Clavien PA (2006) Platelet-derived serotonin mediates liver regeneration. Science 312:104-107
19. Patel S, Robb-Gaspers LD, Stellato KA, Shon M, Thomas AP (1999) Coordination of calcium signalling by endothelial-derived nitric oxide in the intact liver. Nat Cell Biol 1:467-471
20. Schofl C, Ponczek M, Mader T, Waring M, Benecke H, von zur Muhlen A, Mix H, Cornberg M, Boker KH, Manns MP, Wagner S (1999) Regulation of cytosolic free calcium concentration by extracellular nucleotides in human hepatocytes. Am J Physiol 276:G164-G172
21. Barros LF, Stutzin A, Calixto A, Catalan M, Castro J, Hetz C, Hermosilla T (2001) Nonselective cation channels as effectors of free radical-induced rat liver cell necrosis. Hepatology 33:114-122
22. Barritt GJ, Chen J, Rychkov G (2008) Ca2+-permeable channels in the hepatocyte plasma membrane and their roles in hepatocyte physiology. Biochim Biophys Acta 1783: 651-672
23. El Boustany C, Bidaux G, Enfissi A, Delcourt P, Prevarskaya N, Capiod T (2008) Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation. Hepatology 47:2068-2077
24. Auld A, Chen J, Brereton HM, Wang YJ, Gregory RB, Barritt GJ (2000) Store-operated Ca(2+) inflow in reuber hepatoma cells is inhibited by voltage-operated Ca(2+) channel antagonists and, in contrast to freshly isolated hepatocytes, does not require a pertussis toxinsensitive trimeric GTP-binding protein. Biochim Biophys Acta 1497:11-26
25. Brereton HM, Harland ML, Froscio M, Petronijevic T, Barritt GJ (1997) Novel variants of voltage-operated calcium channel alpha 1-subunit transcripts in a rat liver-derived cell line: Deletion in the IVS4 voltage sensing region. Cell Calcium 22:39-52
26. Graf J, Haussinger D (1996) Ion transport in hepatocytes: Mechanisms and correlations to cell volume, hormone actions and metabolism. J Hepatol 24 (Suppl 1):53-77
27. Sawanobori T, Takanashi H, Hiraoka M, Iida Y, Kamisaka K, Maezawa H (1989) Electrophysiological properties of isolated rat liver cells. J Cell Physiol 139:580-585
28. Ong HL, Chen J, Chataway T, Brereton H, Zhang L, Downs T, Tsiokas L, Barritt G (2002) Specific detection of the endogenous transient receptor potential (TRP)-1 protein in liver and airway smooth muscle cells using immunoprecipitation and western-blot analysis. Biochem J 364:641-648
29. Altin JG, Bygrave FL (1987) The influx of Ca2+ induced by the administration of glucagon and Ca2+-mobilizing agents to the perfused rat liver could involve at least two separate pathways. Biochem J 242:43-50
30. Ikari A, Sakai H, Takeguchi N (1997) ATP thapsigargin and cAMP increase Ca2+ in rat hepatocytes by activating three different Ca2+ influx pathways. Jpn J Physiol 47:235-239
31. Llopis J, Kass GE, Gahm A, Orrenius S (1992) Evidence for two pathways of receptormediated Ca2+ entry in hepatocytes. Biochem J 284:243-247
32. Striggow F, Bohnensack R (1994) Inositol 1,4,5-trisphosphate activates receptor-mediated calcium entry by two different pathways in hepatocytes. Eur J Biochem 222:229-234
33. Litjens T, Harland ML, RobertsML, Barritt GJ, Rychkov GY (2004) Fast Ca(2+)-dependent inactivation of the store-operated Ca2+ current (ISOC) in liver cells: A role for calmodulin. J Physiol 558:85-97
34. Rychkov G, Brereton HM, Harland ML, Barritt GJ (2001) Plasma membrane Ca2+ releaseactivated Ca2+ channels with a high selectivity for Ca2+ identified by patch-clamp recording in rat liver cells. Hepatology 33:938-947
35. Rychkov GY, Litjens T, Roberts ML, Barritt GJ (2005) Arachidonic acid inhibits the storeoperated Ca2+ current in rat liver cells. Biochem J 385:551-556
36. Litjens T, Nguyen T, Castro J, Aromataris EC, Jones L, Barritt GJ, Rychkov GY (2007) Phospholipase C-gamma1 is required for the activation of store-operated Ca2+ channels in liver cells. Biochem J 405:269-276
37. Aromataris EC, Castro J, Rychkov GY, Barritt GJ (2008) Store-operated Ca(2+) channels and stromal interaction molecule 1 (STIM1) are targets for the actions of bile acids on liver cells. Biochim Biophys Acta 1783:874-885
38. Scrimgeour N, Litjens T, Ma L, Barritt GJ, Rychkov GY (2009) Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins. J Physiol 587:2903-2918
39. Parekh AB, Putney JWJr. (2005) Store-operated calcium channels. Physiol Rev 85:757-810
40. Rychkov G, Barritt GJ (2007) TRPC1 Ca(2+)-permeable channels in animal cells. Handb Exp Pharmacol 179:23-52
41. Yuan JP, Zeng W, Huang GN, Worley PF, Muallem S (2007) STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol 9: 636-645
42. Brereton HM, Chen J, Rychkov G, Harland ML, Barritt GJ (2001) Maitotoxin activates an endogenous non-selective cation channel and is an effective initiator of the activation of the heterologously expressed hTRPC-1 (transient receptor potential) non-selective cation channel in H4-IIE liver cells. Biochim Biophys Acta 1540:107-126
43. Chen J, Barritt GJ (2003) Evidence that TRPC1 (transient receptor potential canonical 1) forms a Ca(2+)-permeable channel linked to the regulation of cell volume in liver cells obtained using small interfering RNA targeted against TRPC1. Biochem J 373:327-336
44. Huang GN, Zeng W, Kim JY, Yuan JP, Han L, Muallem S, Worley PF (2006) STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol 8:1003-1010
45. Liao Y, Erxleben C, Yildirim E, Abramowitz J, Armstrong DL, Birnbaumer L (2007) Orai proteins interact with TRPC channels and confer responsiveness to store depletion. Proc Natl Acad Sci USA 104:4682-4687
46. Lopez JJ, Salido GM, Pariente JA, Rosado JA (2006) Interaction of STIM1 with endogenously expressed human canonical TRP1 upon depletion of intracellular Ca2+ stores. J Biol Chem 281:28254-28264
47. Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Ambudkar IS (2007) Dynamic assembly of TRPC1-STIM1- Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem 282:9105-9116
48. Ramsey IS, Delling M, Clapham DE (2006) An introduction to TRP channels. Annu Rev Physiol 68:619-647
49. Nilius B, Owsianik G, Voets T, Peters JA (2007) Transient receptor potential cation channels in disease. Physiol Rev 87:165-217
50. Castro J, Aromataris EC, Rychkov GY, Barritt GJ (2009) A small component of the endoplasmic reticulum is required for store-operated Ca2+ channel activation in liver cells: Evidence from studies using TRPV1 and taurodeoxycholic acid. Biochem J 418:553-566
51. Gregory RB, Wilcox RA, Berven LA, van Straten NC, van der Marel GA, van Boom JH, Barritt GJ (1999) Evidence for the involvement of a small subregion of the endoplasmic reticulum in the inositol trisphosphate receptor-induced activation of Ca2+ inflow in rat hepatocytes. Biochem J 341:401-408
52. Vriens J, Janssens A, Prenen J, Nilius B, Wondergem R (2004) TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells. Cell Calcium 36:19-28
53. Waning J, Vriens J, Owsianik G, Stuwe L, Mally S, Fabian A, Frippiat C, Nilius B, Schwab A (2007) A novel function of capsaicin-sensitive TRPV1 channels: Involvement in cell migration. Cell Calcium 42:17-25
54. ReuberMD (1961) A transplantable bile-secreting hepatocellular carcinoma in the rat. J Natl Cancer Inst 26:891-899
55. Zhang F, Li PL (2007) Reconstitution and characterization of a nicotinic acid adenine dinucleotide phosphate (NAADP)-sensitive Ca2+ release channel from liver lysosomes of rats. J Biol Chem 282:25259-25269
56. Ruas M, Rietdorf K, Arredouani A, Davis LC, Lloyd-Evans E, Koegel H, Funnell TM, Morgan AJ, Ward JA, Watanabe K, Cheng XT, Churchill GC, Zhu MX, Platt FM, Wessel GM, Parrington J, Galione A (2010) Purified TPC isoforms form NAADP receptors with distinct roles for Ca2+ signalling and endolysosomal trafficking. Curr Biol 20: 703-709
57. Lee WM (2003) Drug-induced hepatotoxicity. N Engl J Med 349:474-485
58. Vardanian AJ, Busuttil RW, Kupiec-Weglinski JW (2008) Molecular mediators of liver ischemia and reperfusion injury: A brief review. Mol Med 14:337-345
59. Dhar DK, Takemoto Y, Nagasue N, UchidaM, Ono T, Nakamura T (1996) FK506 maintains cellular calcium homeostasis in ischemia-reperfusion injury of the canine liver. J Surg Res 60:142-146
60. Isozaki H, Fujii K, Nomura E, Hara H (2000) Calcium concentration in hepatocytes during liver ischaemia-reperfusion injury and the effects of diltiazem and citrate on perfused rat liver. Eur J Gastroenterol Hepatol 12:291-297
61. Kurita K, Tanabe G, Aikou T, Shimazu H (1993) Ischemic liver cell damage and calcium accumulation in rats. J Hepatol 18:196-204
62. Takemoto Y, Uchida M, Nagasue N, Ohiwa K, Kimoto T, Dhar DK, Nakamura T (1994) Changes in calcium content of the liver during hepatic ischemia-reperfusion in dogs. J Hepatol 21:743-747
63. Carini R, Castino R, De Cesaris MG, Splendore R, Demoz M, Albano E, Isidoro C (2004) Preconditioning-induced cytoprotection in hepatocytes requires Ca(2+)-dependent exocytosis of lysosomes. J Cell Sci 117:1065-1077
64. Crenesse D, Hugues M, Ferre C, Poiree JC, Benoliel J, Dolisi C, Gugenheim J (1999) Inhibition of calcium influx during hypoxia/reoxygenation in primary cultured rat hepatocytes. Pharmacology 58:160-170
65. Gasbarrini A, Borle AB, Farghali H, Bender C, Francavilla A, Van Thiel D (1992) Effect of anoxia on intracellular ATP, Na+i, Ca2+i, Mg2+i, and cytotoxicity in rat hepatocytes. J Biol Chem 267:6654-6663 [erratum appears in J Biol Chem 1992 Jun 25;267(18): 13114]
66. Glantzounis GK, Salacinski HJ, Yang W, Davidson BR, Seifalian AM (2005) The contemporary role of antioxidant therapy in attenuating liver ischemia-reperfusion injury: A review. Liver Transpl 11:1031-1047
67. Aarts M, Iihara K, Wei WL, Xiong ZG, Arundine M, Cerwinski W, MacDonald JF, Tymianski M (2003) A key role for TRPM7 channels in anoxic neuronal death. Cell 115:863-877
68. Bari MR, Akbar S, Eweida M, Kuhn FJP, Gustafsson AJ, Luckhoff A, Islam MS (2009) H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the beta-cells: Involement of TRPM2 channels. J Cell Mol Med 13: 3260-3267
69. Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K, Mori Y (2002) LTRPC2 Ca2+ permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9:163-173
70. Lin MJ, Yang XR, Cao YN, Sham JS (2007) Hydrogen peroxide-induced Ca2+ mobilization in pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 292: L1598-L1608
71. Miller BA (2006) The role of TRP channels in oxidative stress-induced cell death. J Membr Biol 209:31-41
72. Suzuki Y, Yoshimaru T, Inoue T, Ra C (2009) Discrete generations of intracellular hydrogen peroxide and superoxide in antigen-stimulated mast cells: Reciprocal regulation of storeoperated Ca2+ channel activity. Mol Immunol 46:2200-2209
73. Yoshida T, Inoue R, Morii T, Takahashi N, Yamamoto S, Hara Y, Tominaga M, Shimizu S, Sato Y, Mori Y (2006) Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol 2:596-607
74. Gao H, Wang Y, Wegierski T, Skouloudaki K, Putz M, Fu X, Engel C, Boehlke C, Peng H, Kuhn EW, Kim E, Kramer-Zucker A,Walz G (2010) PRKCSH/80 K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation. Hum Mol Genet 19:16-24
75. Gkika D, Prevarskaya N (2009) Molecular mechanisms of TRP regulation in tumor growth and metastasis. Biochim Biophys Acta 1793:953-958
76. Prevarskaya N, Zhang L, Barritt G (2007) TRP channels in cancer. Biochim Biophys Acta 1772:937-946
77. Llovet JM, Bruix J (2008) Molecular targeted therapies in hepatocellular carcinoma. Hepatology 48:1312-1327
78. Capiod T (1998) ATP-activated cation currents in single guinea-pig hepatocytes. J Physiol 507:795-805
79. Howard A, Barley NF, Legon S, Walters JR (1994) Plasma-membrane calcium-pump isoforms in human and rat liver. Biochem J 303:275-279
80. Gasbarrini A, Borle AB, Van Thiel DH (1993) Ca2+ antagonists do not protect isolated perfused rat hepatocytes from anoxic injury. Biochim Biophys Acta 1177:1-7
81. Studer RK, Borle AB (1992) Na(+)-Ca2+ antiporter activity of rat hepatocytes. Effect of adrenalectomy on Ca2+ uptake and release from plasma membrane vesicles. Biochim Biophys Acta 1134:7-16
82. Delgado-Coello B, Trejo R, Mas-Oliva J (2006) Is there a specific role for the plasma membrane Ca2+-ATPase in the hepatocyte? Mol Cell Biochem 285:1-15
83. Hirata K, Pusl T, O'Neill AF, Dranoff JA, Nathanson MH (2002) The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes. Gastroenterology 122:1088-1100
84. Wojcikiewicz RJ (1995) Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell types. J Biol Chem 270:11678-11683
85. Pierobon N, Renard-Rooney DC, Gaspers LD, Thomas AP (2006) Ryanodine receptors in liver. J Biol Chem 281:34086-34095
86. Barritt GJ (2000) Calcium signalling in liver cells. In: Pochet R, Donato R, Haiech J, Heizmann CW, Gerke V (eds) Calcium: The molecular basis of calcium action in biology and medicine. Kluwer Academic Publishers, The Netherlands, pp 73-94
87. Gaspers LD, Thomas AP (2005) Calcium signaling in liver. Cell Calcium 38:329-342
88. Missiaen L, Dode L, Vanoevelen J, Raeymaekers L,Wuytack F (2007) Calcium in the Golgi apparatus. Cell Calcium 41:405-416
89. Liu G, Xie C, Sun F, Xu X, Yang Y, Zhang T, Deng Y, Wang D, Huang Z, Yang L, Huang S, Wang Q, Liu G, Zhong D, Miao X (2010) Clinical significance of transient receptor potential vanilloid 2 expression in human hepatocellular carcinoma. Cancer Genet Cytogenet 197: 54-59
90. Brereton HM, Harland ML, Auld AM, Barritt GJ (2000) Evidence that the TRP-1 protein in unlikely to account for store-operated Ca2+ inflow in Xenopus laevis oocytes. Mol Cell Biochem 214:63-74
91. Riccio A, Medhurst AD, Mattei C, Kelsell RE, Calver AR, Randall AD, Benham CD (2002) mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. Brain Res Mol Brain Res 109:95-104
92. Reilly CA, Taylor JL, Lanza DL, Carr BA, Crouch DJ, Yost GS (2003) Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors. Toxicol Sci 73:170-181
93. Peng JB, HedigerMA(2002) A family of calcium-permeable channels in the kidney: Distinct roles in renal calcium handling. Curr Opin Nephrol Hypertens 11:555-561
94. Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2:695-702
95. Peng JB, Chen XZ, Berger UV,Weremowicz S, Morton CC, Vassilev PM, Brown EM(2000) Human calcium transport protein CaT1. Biochem Biophys Res Commun 278:326-332
96. Pan TC, Liao BK, Huang CJ, Lin LY, Hwang PP (2005) Epithelial Ca(2+) channel expression and Ca(2+) uptake in developing zebrafish. Am J Physiol Regul Integr Comp Physiol 289:R1202-R1211
97. Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP (2002) TRPM4 is a Ca2+-activated non-selective cation channel mediating cell membrane depolarization. Cell 109:397-407
98. Enklaar T, Esswein M, Oswald M, Hilbert K, Winterpacht A, Higgins M, Zabel B (2000) MTR1, a novel biallelically expressed gene in the centre of the mouse distal chromosome 7 imprinting cluster, is a member of the TRP gene family. Genomics 67:179-197
99. Prawitt D, Enklaar T, Klemm G, Gartner B, Spangenberg C, Winterpacht A, Higgins M (2000) Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the TRP gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression. Hum Mol Genet 9: 203-216
100. Runnels LW, Yue L, Clapham DE (2001) TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science 291:1043-1047
101. Elizondo MR, Arduini BL, Paulsen J, MacDonald EL, Sabel JL, Henion PD, Cornell RA, Parichy DM (2005) Defective skeletogenesis with kidney stone formation in dwarf zebrafish mutant for trpm7. Curr Biol 15:667-671
102. Ong ACM, Ward CJ, Butler RJ, Biddolph S, Bowker C, Torra R, Pei Y (1999) Coordinate expression of the autosomal dominant polycystic kidney disease proteins, polycystin-2 and polycystin-1, in normal and cystic tissue. Am J Pathol 154:1721-1729
103. Tsiokas L, Arnould T, Zhu CW, Kim E,Walz G, Sukhatme VP (1999) Specific association of the gene product of PKD2 with the TRPC1 channel. Proc Natl Acad Sci USA 96:3934-3939
104. Veldhuisen B, Spruit L, Dauwerde HG, Breuning MH, Peters DJ (1999) Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2). Eur J Hum Genet 7:860-872
105. Mishra R, Rao V, Ta R, Shobeiri N, Hill CE (2009) Mg2+ and MgATP-inhibited and Ca2+ colmodulin-sensitive TRPM7-like current in hepatoma and hepatocytes. Am J Physiol Gastrointest Liver Physiol 297:G687-94