Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo

Journal of Asian Natural Products Research

Volumn 14, Issue 4, 2012, Pages 382-395

  Zhang, Qing Hao ^a   Hu, Jin Ping ^a   Wang, Bao Lian ^a   Li, Yan ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Capsaicin; CYP450; Dihydrocapsaicin; Induction; Inhibition

Indexed keywords

CAPSAICIN; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DIHYDROCAPSAICIN; ISOENZYME; MESSENGER RNA; CHLORZOXAZONE 6 HYDROXYLASE, RAT; CHLORZOXAZONE 6-HYDROXYLASE, RAT; CYP2C19 PROTEIN, HUMAN; CYTOCHROME P450 3A; DRUG DERIVATIVE; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); DRUG EFFECT; DRUG STRUCTURE; ENZYME ACTIVITY; FOOD DRUG INTERACTION; HUMAN; HUMAN TISSUE; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MALE; NONHUMAN; RAT; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; ENZYMOLOGY; LIVER; WISTAR RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CAPSAICIN; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; FOOD-DRUG INTERACTIONS; HUMANS; INHIBITORY CONCENTRATION 50; LIVER; MALE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RATS; RATS, WISTAR;

EID: 84860251666     PISSN: 10286020     EISSN: 14772213     Source Type: Journal    
DOI: 10.1080/10286020.2012.656605     Document Type: Article

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