Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells

Chemical Research in Toxicology

Volumn 16, Issue 3, 2003, Pages 336-349

  Reilly, Christopher A ^a   Ehlhardt, William J ^b   Jackson, David A ^b   Kulanthaivel, Palaniappan ^b   Mutlib, Abdul E ^c   Espina, Robert J ^d   Moody, David E ^a   Crouch, Dennis J ^a   Yost, Garold S ^a  

^a UNIVERSITY OF UTAH   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c PFIZER INC   (United States)

^d BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DIHYDROCAPSAICIN; GLUTATHIONE; NONIVAMIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CYTOTOXICITY; DETOXIFICATION; ENZYME ACTIVITY; GOAT; HUMAN; HUMAN CELL; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIVER CELL; LUNG ALVEOLUS CELL; MASS SPECTROMETRY; METABOLITE; MOUSE; NONHUMAN; RAT; TOXICOKINETICS;

ANIMALS; BRONCHI; CAPSAICIN; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; GLUTATHIONE; GOATS; HEPATOCYTES; HUMANS; HYDROGENATION; MASS SPECTROMETRY; MICE; MICROSOMES, LIVER; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RABBITS; RATS; TRIAZOLES;

ANIMALIA; CAPRA HIRCUS;

EID: 0037348385     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx025599q     Document Type: Article

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