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Volumn 78, Issue 1, 2010, Pages 114-125

Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; BAFILOMYCIN A1; CAPSAICIN; MICROTUBULE ASSOCIATED PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38;

EID: 77953763757     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.063495     Document Type: Article
Times cited : (118)

References (49)
  • 1
    • 0023031060 scopus 로고
    • Tumour-promoting effect of chili extract in BALB/c mice
    • Agrawal RC, Wiessler M, Hecker E, and Bhide SV (1986) Tumour-promoting effect of chili extract in BALB/c mice. Int J Cancer 38:689-695.
    • (1986) Int J Cancer , vol.38 , pp. 689-695
    • Agrawal, R.C.1    Wiessler, M.2    Hecker, E.3    Bhide, S.V.4
  • 2
    • 38349050159 scopus 로고    scopus 로고
    • PKR is a novel functional direct player that coordinates skeletal muscle differentiation via p38MAPK/AKT pathways
    • Alisi A, Spaziani A, Anticoli S, Ghidinelli M, and Balsano C (2008) PKR is a novel functional direct player that coordinates skeletal muscle differentiation via p38MAPK/AKT pathways. Cell Signal 20:534-542.
    • (2008) Cell Signal , vol.20 , pp. 534-542
    • Alisi, A.1    Spaziani, A.2    Anticoli, S.3    Ghidinelli, M.4    Balsano, C.5
  • 3
    • 34347238938 scopus 로고    scopus 로고
    • Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: Role of Akt and extracellular signal-regulated kinase signaling pathways
    • Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, and Kondo Y (2007) Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol 72:29-39.
    • (2007) Mol Pharmacol , vol.72 , pp. 29-39
    • Aoki, H.1    Takada, Y.2    Kondo, S.3    Sawaya, R.4    Aggarwal, B.B.5    Kondo, Y.6
  • 4
    • 20344387475 scopus 로고    scopus 로고
    • Autophagy: Dual roles in life and death?
    • Baehrecke EH (2005) Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol 6:505-510.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 505-510
    • Baehrecke, E.H.1
  • 5
    • 33845480131 scopus 로고    scopus 로고
    • Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response
    • Bernales S, McDonald KL, and Walter P (2006) Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol 4:e423.
    • (2006) PLoS Biol , vol.4
    • Bernales, S.1    McDonald, K.L.2    Walter, P.3
  • 6
    • 4644310423 scopus 로고    scopus 로고
    • The p38 pathway regulates Akt both at the protein and transcriptional activation levels during myogenesis
    • Cabane C, Coldefy AS, Yeow K, and Derijard B (2004) The p38 pathway regulates Akt both at the protein and transcriptional activation levels during myogenesis. Cell Signal 16:1405-1415.
    • (2004) Cell Signal , vol.16 , pp. 1405-1415
    • Cabane, C.1    Coldefy, A.S.2    Yeow, K.3    Derijard, B.4
  • 8
    • 66349090851 scopus 로고    scopus 로고
    • Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K/Akt and ERK1/2 signaling pathways
    • Chiu HW, Ho SY, Guo HR, and Wang YJ (2009) Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K/Akt and ERK1/2 signaling pathways. Autophagy 5:472-483.
    • (2009) Autophagy , vol.5 , pp. 472-483
    • Chiu, H.W.1    Ho, S.Y.2    Guo, H.R.3    Wang, Y.J.4
  • 11
    • 33746166864 scopus 로고    scopus 로고
    • Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/ extracellular signal-regulated kinase activity
    • Corcelle E, Nebout M, Bekri S, Gauthier N, Hofman P, Poujeol P, Fénichel P, and Mograbi B (2006) Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/ extracellular signal-regulated kinase activity. Cancer Res 66:6861-6870.
    • (2006) Cancer Res , vol.66 , pp. 6861-6870
    • Corcelle, E.1    Nebout, M.2    Bekri, S.3    Gauthier, N.4    Hofman, P.5    Poujeol, P.6    Fénichel, P.7    Mograbi, B.8
  • 12
    • 34248158083 scopus 로고    scopus 로고
    • Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells
    • Cui Q, Tashiro S, Onodera S, Minami M, and Ikejima T (2007) Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells. Biol Pharm Bull 30:859-864.
    • (2007) Biol Pharm Bull , vol.30 , pp. 859-864
    • Cui, Q.1    Tashiro, S.2    Onodera, S.3    Minami, M.4    Ikejima, T.5
  • 14
    • 34548299555 scopus 로고    scopus 로고
    • Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability
    • Ding WX, Ni HM, Gao W, Yoshimori T, Stolz DB, Ron D, and Yin XM (2007b) Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol 171:513-524.
    • (2007) Am J Pathol , vol.171 , pp. 513-524
    • Ding, W.X.1    Ni, H.M.2    Gao, W.3    Yoshimori, T.4    Stolz, D.B.5    Ron, D.6    Yin, X.M.7
  • 15
  • 16
    • 2442482810 scopus 로고    scopus 로고
    • Autophagy as a cell death and tumor suppressor mechanism
    • Gozuacik D and Kimchi A (2004) Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23:2891-2906.
    • (2004) Oncogene , vol.23 , pp. 2891-2906
    • Gozuacik, D.1    Kimchi, A.2
  • 17
    • 58849154467 scopus 로고    scopus 로고
    • Involvement of p38 MAPK in regulation of MMP13 mRNA in chondrocytes in response to surviving stress to endoplasmic reticulum
    • Hamamura K, Goldring MB, and Yokota H (2009) Involvement of p38 MAPK in regulation of MMP13 mRNA in chondrocytes in response to surviving stress to endoplasmic reticulum. Arch Oral Biol 54:279-286.
    • (2009) Arch Oral Biol , vol.54 , pp. 279-286
    • Hamamura, K.1    Goldring, M.B.2    Yokota, H.3
  • 18
    • 27144503701 scopus 로고    scopus 로고
    • Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death
    • Høyer-Hansen M, Bastholm L, Mathiasen IS, Elling F, and Jäättelä M (2005) Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ 12:1297-1309.
    • (2005) Cell Death Differ , vol.12 , pp. 1297-1309
    • Høyer-Hansen, M.1    Bastholm, L.2    Mathiasen, I.S.3    Elling, F.4    Jäättelä, M.5
  • 19
    • 10344253840 scopus 로고    scopus 로고
    • Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death
    • Hu P, Han Z, Couvillon AD, and Exton JH (2004) Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J Biol Chem 279:49420-49429.
    • (2004) J Biol Chem , vol.279 , pp. 49420-49429
    • Hu, P.1    Han, Z.2    Couvillon, A.D.3    Exton, J.H.4
  • 20
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • Klionsky DJ and Emr SD (2000) Autophagy as a regulated pathway of cellular degradation. Science 290:1717-1721.
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 22
    • 28544435485 scopus 로고    scopus 로고
    • Lysosomes and autophagy in cell death control
    • Kroemer G and Jäättelä M (2005) Lysosomes and autophagy in cell death control. Nat Rev Cancer 5:886-897.
    • (2005) Nat Rev Cancer , vol.5 , pp. 886-897
    • Kroemer, G.1    Jäättelä, M.2
  • 23
    • 70349200580 scopus 로고    scopus 로고
    • Capsaicin-induced apoptosis is regulated by endoplasmic reticulum stress- and calpain-mediated mitochondrial cell death pathways
    • Lee MJ, Kee KH, Suh CH, Lim SC, and Oh SH (2009) Capsaicin-induced apoptosis is regulated by endoplasmic reticulum stress- and calpain-mediated mitochondrial cell death pathways. Toxicology 264:205-214.
    • (2009) Toxicology , vol.264 , pp. 205-214
    • Lee, M.J.1    Kee, K.H.2    Suh, C.H.3    Lim, S.C.4    Oh, S.H.5
  • 24
    • 1842431016 scopus 로고    scopus 로고
    • Involvement of NADPH oxidase-mediated generation of reactive oxygen species in the apoptotic cell death by capsaicin in HepG2 human hepatoma cells
    • Lee YS, Kang YS, Lee JS, Nicolova S, and Kim JA (2004) Involvement of NADPH oxidase-mediated generation of reactive oxygen species in the apoptotic cell death by capsaicin in HepG2 human hepatoma cells. Free Radic Res 38:405-412.
    • (2004) Free Radic Res , vol.38 , pp. 405-412
    • Lee, Y.S.1    Kang, Y.S.2    Lee, J.S.3    Nicolova, S.4    Kim, J.A.5
  • 25
    • 0034624342 scopus 로고    scopus 로고
    • Induction of apoptosis by capsaicin in A172 human glioblastoma cells
    • Lee YS, Nam DH, and Kim JA (2000) Induction of apoptosis by capsaicin in A172 human glioblastoma cells. Cancer Lett 161:121-130.
    • (2000) Cancer Lett , vol.161 , pp. 121-130
    • Lee, Y.S.1    Nam, D.H.2    Kim, J.A.3
  • 26
  • 30
    • 0037072937 scopus 로고    scopus 로고
    • An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12
    • Morishima N, Nakanishi K, Takenouchi H, Shibata T, and Yasuhiko Y (2002) An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 277:34287-34294.
    • (2002) J Biol Chem , vol.277 , pp. 34287-34294
    • Morishima, N.1    Nakanishi, K.2    Takenouchi, H.3    Shibata, T.4    Yasuhiko, Y.5
  • 32
    • 58149086894 scopus 로고    scopus 로고
    • Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalase-regulated manner
    • Oh SH, Kim YS, Lim SC, Hou YF, Chang IY, and You HJ (2008) Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalase-regulated manner. Autophagy 4:1009-1019.
    • (2008) Autophagy , vol.4 , pp. 1009-1019
    • Oh, S.H.1    Kim, Y.S.2    Lim, S.C.3    Hou, Y.F.4    Chang, I.Y.5    You, H.J.6
  • 33
    • 63849308518 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-mediated autophagy/ apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells
    • Oh SH and Lim SC (2009) Endoplasmic reticulum stress-mediated autophagy/ apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells. J Pharmacol Exp Ther 329:112-122.
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 112-122
    • Oh, S.H.1    Lim, S.C.2
  • 35
    • 0034685713 scopus 로고    scopus 로고
    • Implications of oxidative stress and inflammatory process in the cytotoxicity of capsaicin in human endothelial cells: Lack of DNA strand breakage
    • Richeux F, Cascante M, Ennamany R, Sanchez D, Sanni A, Saboureau D, and Creppy EE (2000) Implications of oxidative stress and inflammatory process in the cytotoxicity of capsaicin in human endothelial cells: lack of DNA strand breakage. Toxicology 147:41-49.
    • (2000) Toxicology , vol.147 , pp. 41-49
    • Richeux, F.1    Cascante, M.2    Ennamany, R.3    Sanchez, D.4    Sanni, A.5    Saboureau, D.6    Creppy, E.E.7
  • 36
    • 0035976991 scopus 로고    scopus 로고
    • CAD/DFF40 nuclease is dispensable for high molecular weight DNA cleavage and stage I chromatin condensation in apoptosis
    • Samejima K, Tone S, and Earnshaw WC (2001) CAD/DFF40 nuclease is dispensable for high molecular weight DNA cleavage and stage I chromatin condensation in apoptosis. J Biol Chem 276:45427-45432.
    • (2001) J Biol Chem , vol.276 , pp. 45427-45432
    • Samejima, K.1    Tone, S.2    Earnshaw, W.C.3
  • 37
    • 10444226462 scopus 로고    scopus 로고
    • ER stress and the unfolded protein response
    • Schröder M and Kaufman RJ (2005) ER stress and the unfolded protein response. Mutat Res 569:29-63.
    • (2005) Mutat Res , vol.569 , pp. 29-63
    • Schröder, M.1    Kaufman, R.J.2
  • 38
    • 0036581949 scopus 로고    scopus 로고
    • Phytochemicals as cell cycle modulators-A less toxic approach in halting human cancers
    • Singh RP, Dhanalakshmi S, and Agarwal R (2002) Phytochemicals as cell cycle modulators-a less toxic approach in halting human cancers. Cell Cycle 1:156-161.
    • (2002) Cell Cycle , vol.1 , pp. 156-161
    • Singh, R.P.1    Dhanalakshmi, S.2    Agarwal, R.3
  • 39
    • 0029928940 scopus 로고    scopus 로고
    • Capsaicin in hot chili pepper: Carcinogen, co-carcinogen or anticarcinogen?
    • Surh YJ and Lee SS (1996) Capsaicin in hot chili pepper: carcinogen, co-carcinogen or anticarcinogen? Food Chem Toxicol 34:313-316.
    • (1996) Food Chem Toxicol , vol.34 , pp. 313-316
    • Surh, Y.J.1    Lee, S.S.2
  • 40
    • 44349107112 scopus 로고    scopus 로고
    • Autophagy induced by Alexander disease-mutantGFAPaccumulation is regulated by p38/MAPK and mTOR signaling pathways
    • Tang G, Yue Z, Talloczy Z, Hagemann T, Cho W, Messing A, Sulzer DL, and Goldman JE (2008) Autophagy induced by Alexander disease-mutantGFAPaccumulation is regulated by p38/MAPK and mTOR signaling pathways. Hum Mol Genet 17:1540-1555.
    • (2008) Hum Mol Genet , vol.17 , pp. 1540-1555
    • Tang, G.1    Yue, Z.2    Talloczy, Z.3    Hagemann, T.4    Cho, W.5    Messing, A.6    Sulzer, D.L.7    Goldman, J.E.8
  • 41
    • 0021424057 scopus 로고
    • Tumorigenicity and mutagenicity studies with capsaicin of hot peppers
    • Toth B, Rogan E, and Walker B (1984) Tumorigenicity and mutagenicity studies with capsaicin of hot peppers. Anticancer Res 4:117-119.
    • (1984) Anticancer Res , vol.4 , pp. 117-119
    • Toth, B.1    Rogan, E.2    Walker, B.3
  • 42
    • 32544439717 scopus 로고    scopus 로고
    • Apoptosis induction by dohevanil, a DHA substitutive analog of capsaicin, in MCF-7 cells
    • Tuoya, Baba N, Shimoishi Y, Murata Y, Tada M, Koseki M, and Takahata K (2006) Apoptosis induction by dohevanil, a DHA substitutive analog of capsaicin, in MCF-7 cells. Life Sci 78:1515-1519.
    • (2006) Life Sci , vol.78 , pp. 1515-1519
    • Tuoya1    Baba, N.2    Shimoishi, Y.3    Murata, Y.4    Tada, M.5    Koseki, M.6    Takahata, K.7
  • 43
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, and Ron D (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287:664-666.
    • (2000) Science , vol.287 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3    Zhang, Y.4    Chung, P.5    Harding, H.P.6    Ron, D.7
  • 44
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden KH and Lu X (2002) Live or let die: the cell's response to p53. Nat Rev Cancer 2:594-604.
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 45
    • 0033575255 scopus 로고    scopus 로고
    • Suicidal tendencies: Apoptotic cell death by caspase family proteinases
    • Wolf BB and Green DR (1999) Suicidal tendencies: apoptotic cell death by caspase family proteinases. J Biol Chem 274:20049-20052.
    • (1999) J Biol Chem , vol.274 , pp. 20049-20052
    • Wolf, B.B.1    Green, D.R.2
  • 46
    • 0019225636 scopus 로고
    • Cell death: The significance of apoptosis
    • Wyllie AH, Kerr JF, and Currie AR (1980) Cell death: the significance of apoptosis. Int Rev Cytol 68:251-306.
    • (1980) Int Rev Cytol , vol.68 , pp. 251-306
    • Wyllie, A.H.1    Kerr, J.F.2    Currie, A.R.3
  • 47
    • 33749579383 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress triggers autophagy
    • Yorimitsu T, Nair U, Yang Z, and Klionsky DJ (2006) Endoplasmic reticulum stress triggers autophagy. J Biol Chem 281:30299-30304.
    • (2006) J Biol Chem , vol.281 , pp. 30299-30304
    • Yorimitsu, T.1    Nair, U.2    Yang, Z.3    Klionsky, D.J.4
  • 49
    • 0035824403 scopus 로고    scopus 로고
    • Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine
    • Zhang C, Kawauchi J, Adachi MT, Hashimoto Y, Oshiro S, Aso T, and Kitajima S (2001) Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine. Biochem Biophys Res Commun 289:718-724.
    • (2001) Biochem Biophys Res Commun , vol.289 , pp. 718-724
    • Zhang, C.1    Kawauchi, J.2    Adachi, M.T.3    Hashimoto, Y.4    Oshiro, S.5    Aso, T.6    Kitajima, S.7


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