Focal adhesion kinase with the interacting proteins and signaling in cancer

Cell-Extracellular Matrix Interactions in Cancer

Volumn , Issue , 2010, Pages 275-305

  Golubovskaya, Vita M ^a   Beierle, Elizabeth A ^b   Hochwald, Steven N ^c,d   Kurenova, Elena V ^a   Cance, William G ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF FLORIDA   (United States)

Author keywords

Apoptosis; Cancer; Focal adhesion Kinase; Tumorigenesis

Indexed keywords

EID: 84900212667     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-0814-8_12     Document Type: Chapter

References (208)

1. Aarts M, Liu Y, Liu L, Besshoh S, Arundine M, Gurd JW, Wang YT, Salter MW, Tymianski M (2002) Treatment of ischemic brain Damage by perturbing NMDA receptor-PSD-95 protein interactions. Science 298:846-850
2. Abedi H, Zachary I (1997) Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J Biol Chem 272:15442-15451
3. Achen MG, Stacker SA (2006) Tumor lymphangiogenesis and metastatic spread-new players begin to emerge. Int J Cancer 119:1755-1760
4. Adhikary S, Eilers M (2005) Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cel Biol 6:635-645
5. Agochiya M, Brunton VG, Owens DW, Parkinson EK, Paraskeva C, Keith WN, Frame MC (1999) Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells. Oncogene 18:5646-5653
6. Akhter SA, Luttrell LM, Rockman HA, Iaccarino G, Lefkowitz RJ, Koch WJ (1998) Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science 280:574-577
7. Alex R, Sozeri O, Meyer S, Dildrop R (1992) Determination of the DNA sequence recognized by the bHLH-zip domain of the N-Myc protein. Nucleic Acids Res 20:2257-2263
8. Alitalo K, Carmeliet P (2002) Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell 1:219-224
9. Aprelikova O, Pajusola K, Partanen J, Armstrong E, Alitalo R, Bailey SK, McMahon J, Wasmuth J, Huebner K, Alitalo K (1992) FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter. Cancer Res 52:746-748
10. Aramburu J, Yaffe MB, Lopez-Rodriguez C, Cantley LC, Hogan PG, Rao A (1999) Affinitydriven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 285:2129-2133
11. Arbet-Engels C, Janknecht R, Eckhart W (1999) Role of focal adhesion kinase in MAP kinase activation by insulin-like growth factor-I or insulin. FEBS Lett 454:252-256
12. Arold ST, Hoellerer MK, Noble ME (2002) The structural basis of localization and signaling by the focal adhesion targeting domain. Structure 10:319-327
13. Avraham HK, Jiang S, Lee TH, Prakash O, Avraham S (2004) HIV-1 Tat-mediated effects on focal adhesion assembly and permeability in brain microvascular endothelial cells. J Immunol 173:6228-6233
14. Avraham HK, Lee TH, Koh Y, Kim TA, Jiang S, Sussman M, Samarel AM, Avraham S (2003) Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase. J Biol Chem 278:36661-36668
15. Bagi CM, Roberts GW, Andresen CJ (2008) Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors: Implications for bone metastases. Cancer 112:2313-2321
16. Baker SJ, Preisinger AC, Jessup JM, Paraskeva C, Markowitz S, Willson JK, Hamilton S, Vogelstein B (1990) P53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 50:7717-7722
17. Barcia RN, Valle NS, McLeod JD (2003) Caspase involvement in RIP-Associated CD95-induced T cell apoptosis. Cell Immunol 226:78-85
18. Baron V, Calleja V, Ferrari P, Alengrin F, Van Obberghen E (1998) p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors. J Biol Chem 273:7162-7168
19. Baud V, Karin M (2001) Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol 11:372-377
20. Beierle EA, Massoll NA, Hartwich J, Kurenova EV, Golubovskaya VM, Cance WG, McGrady P, London WB (2008a) Focal adhesion kinase expression in human neuroblastoma: Immunohistochemical and real-Time PCR analyses. Clin Cancer Res 14:3299-3305
21. Beierle EA, Trujillo A, Nagaram A, Golubovskaya VM, Cance WG, Kurenova EV (2008b) TAE226 inhibits human neuroblastoma cell survival. Cancer Invest 26:145-151
22. Beierle EA, Trujillo A, Nagaram A, Kurenova EV, Finch R, Ma X, Vella J, Cance WG, Golubovskaya VM (2007) N-MYC regulates focal adhesion kinase expression in human neuroblastoma. J Biol Chem 282:12503-12516
23. Benlimame N, He Q, Jie S, Xiao D, Xu YJ, Loignon M, Schlaepfer DD, Alaoui-And Jamali MA (2005) FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion. J Cell Biol 171:505-516
24. Benoit V, de Moraes E, Dar NA, Taranchon E, Bours V, Hautefeuille A, Taniere P, Chariot A, Scoazec JY, de Moura Gallo CV, Merville MP, Hainaut P (2006) Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kB. Oncogene 25:5708-5718
25. Bergmann U, Funatomi H, Kornmann M, Beger HG, Korc M (1996) Increased expression of insulin receptor substrate-1 in human pancreatic cancer. Biochem Biophys Res Commun 220:886-890
26. Bergmann U, Funatomi H, Yokoyama M, Beger HG, Korc M (1995) Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles. Cancer Res 55:2007-2011
27. Beviglia L, Golubovskaya V, Xu L, Yang X, Craven RJ, Cance WG (2003) Focal adhesion kinase N-Terminus in breast carcinoma cells induces rounding, detachment and apoptosis. Biochem J 373:201-210
28. Blonska M, You Y, Geleziunas R, Lin X (2004) Restoration of NF-{k}B activation by tumor necrosis factor alpha receptor complex-Targeted MEKK3 in receptor-interacting protein-deficient cells. Mol Cell Biol 24:10757-10765
29. Bouchet BP, de Fromentel CC, Puisieux A, Galmarini CM (2006) P53 as a target for anti-cancer drug development. Crit Rev Oncol Hematol 58:190-207
30. Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM (1984) Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 224:1121-1124
31. Calalb MB, Polte TR, Hanks SK (1995) Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src family kinases. Mol Cell Biol 15:954-963
32. Cance WG, Golubovskaya VM (2008) Focal adhesion kinase versus p53: Apoptosis or survival?. Sci Signal 1:pe22
33. Cance WG, Harris JE, Iacocca MV, Roche E, Yang X, Chang J, Simkins S, Xu L (2000) Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: Correlation with preinvasive and invasive phenotypes. Clin Cancer Res 6:2417-2423
34. Ceccarelli DF, Song HK, Poy F, Schaller MD, Eck MJ (2006) Crystal structure of the FERM domain of focal adhesion kinase. J Biol Chem 281:252-259
35. Chen G, Goeddel DV (2002) TNF-R1 signaling: A beautiful pathway. Science 296:1634-1635
36. Chen YN, Sharma SK, Ramsey TM, Jiang L, Martin MS, Baker K, Adams PD, Bair KW, Kaelin WG Jr (1999) Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists. Proc Natl Acad Sci USA 96:4325-4329
37. Chinnaiyan AM, Tepper CG, Seldin MF, O'Rourke K, Kischkel FC, Hellbardt S, Krammer PH, Peter ME, Dixit VM (1996) FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem 271:4961-4965
38. Chipuk JE, Green DR (2004) Cytoplasmic p53: Bax and forward. Cell Cycle 3:429-431
39. Choi HS, Wang Z, Richmond W, He X, Yang K, Jiang T, Karanewsky D, Gu XJ, Zhou V, Liu Y, Che J, Lee CC, Caldwell J, Kanazawa T, Umemura I, Matsuura N, Ohmori O, Honda T, Gray N, He Y (2006) Design and synthesis of 7H-pyrrolo[2, 3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2. Bioorg Med Chem Lett 16:2689-2692
40. Cooper LA, Shen TL, Guan JL (2003) Regulation of focal adhesion kinase by its amino-Terminal domain through an autoinhibitory interaction. Mol Cell Biol 23:8030-8041
41. Corsi JM, Rouer E, Girault JA, Enslen H (2006) Organization and post-Transcriptional processing of focal adhesion kinase gene. BMC Genomics 7:198
42. Devin A, Cook A, Lin Y, Rodriguez Y, Kelliher M, Liu Z (2000) The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity 12:419-429
43. Devin A, Lin Y, Liu ZG (2003) The role of the death-domain kinase RIP in tumour-necrosisfactor-induced activation of mitogen-Activated protein kinases. EMBO Rep 4:623-627
44. Dews M, Prisco M, Peruzzi F, Romano G, Morrione A, Baserga R (2000) Domains of the insulinlike growth factor I receptor required for the activation of extracellular signal-regulated kinases. Endocrinology 141:1289-1300
45. Douma S, Van Laar T, Zevenhoven J, Meuwissen R, Van Garderen E, Peeper DS (2004) Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature 430:1034-1039
46. Duan H, Dixit VM (1997) RAIDD is a new 'death' adaptor molecule. Nature 385:86-89
47. El Annabi S, Gautier N, Baron V (2001) Focal adhesion kinase and Src mediate integrin regulation of insulin receptor phosphorylation. FEBS Lett 507:247-252
48. Farmer G, Bargonetti J, Zhu H, Friedman P, Prywes R, Prives C (1992) Wild-Type p53 activates transcription in vitro. Nature 358:83-86
49. Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759-767
50. Fiedorek FT Jr, Kay ES (1995) Mapping of the focal adhesion kinase (Fadk) gene to mouse chromosome 15 and human chromosome 8. Mammalian Genome 6:123-126
51. Fournier E, Dubreuil P, Birnbaum D, Borg JP (1995) Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor. Oncogene 11:921-931
52. Fournier E, Rosnet O, Marchetto S, Turck CW, Rottapel R, Pelicci PG, Birnbaum D, Borg JP (1996) Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase. J Biol Chem 271:12956-12963
53. Frisch SM (1999) Evidence for a function of death-receptor-related, death-domain- containing proteins in anoikis. Curr Biol 9:1047-1049
54. Frisch SM, Ruoslahti E (1997) Integrins and anoikis. Curr Opin Cell Biol 9:701-706
55. Frisch SM, Screaton RA (2001) Anoikis mechanisms. Curr Opin Cell Biol 13:555-562
56. Frisch SM, Vuori K, Ruoslahti E, Chan-Hui PY (1996) Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol 134:793-799
57. Funakoshi-Tago M, Sonoda Y, Tanaka S, Hashimoto K, Tago K, Tominaga S, Kasahara T (2003) Tumor necrosis factor-induced nuclear factor kB activation is impaired in focal adhesion kinase-deficient fibroblasts. J Biol Chem 278:29359-29365
58. Gabarra-Niecko V, Schaller MD, Dunty JM (2003) FAK regulates biological processes important for the pathogenesis of cancer. Cancer Metastasis Rev 22:359-374
59. Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D (1992) Chromosomal localization of FLT4, a novel receptor-Type tyrosine kinase gene. Genomics 13:475-478
60. Garces CA, Kurenova EV, Golubovskaya VM, Cance WG (2006) Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells. Cancer Res 66:1446-1454
61. Giaccia AJ, Kastan MB (1998) The complexity of p53 modulation: Emerging patterns from divergent signals. Genes Dev 12:2973-2983
62. Giannini G, Cerignoli F, Mellone M, Massimi I, Ambrosi C, Rinaldi C, Gulino A (2005) Molecular mechanism of HMGA1 deregulation in human neuroblastoma. Cancer Lett 228:97-104
63. Golubovskaya V, Beviglia L, Xu LH, Earp HS 3rd, Craven R, Cance W (2002) Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. J Biol Chem 277:38978-38987
64. Golubovskaya V, Finch R, Zheng M, Kurenova EV, Cance WG (2008a) The 7 amino-Acid site in the proline-rich region of the N-Terminal domain of p53 is involved in interaction with FAK and is critical for p53 functioning. Biochem J 411:151-160
65. Golubovskaya VM, Conway-Dorsey K, Edmiston SN, Tse CK, Lark AA, Livasy CA, Moore D, Millikan RC, Cance WG (2009) FAK overexpression and p53 mutations are highly correlated in human breast cancer. Int J Cancer 125:1735-1738
66. Golubovskaya V, Kaur A, Cance W (2004) Cloning and characterization of the promoter region of human focal adhesion kinase gene: Nuclear factor k B and p53 binding sites 1. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1678:111-125
67. Golubovskaya VM, Cance WG (2007) Focal adhesion kinase and p53 signaling in cancer cells. Int Rev Cytol 263:103-153
68. Golubovskaya VM, Finch R, Cance WG (2005) Direct interaction of the N-Terminal domain of focal adhesion kinase with the N-Terminal transactivation Domain of p53. J Biol Chem 280:25008-25021
69. Golubovskaya VM, Finch R, Kweh F, Massoll NA, Campbell-Thompson M, Wallace MR, Cance WG (2008b) P53 regulates FAK expression in human tumor cells. Mol Carcinog 47:373-382
70. Golubovskaya VM, Gross S, Kaur AS, Wilson RI, Xu LH, Yang XH, Cance WG (2003) Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. Mol Cancer Res 1:755-764
71. Golubovskaya VM, Virnig C, Cance WG (2007) TAE226-Induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Mol Carcinog 47:222-234
72. Golubovskaya VM, Nyberg C, Zheng M, Kweh F, Magis A, Ostrov, Cance W (2009) A small molecule inhibitor 1,2,4,5-Benzenetetraamine tetrahydrochloride, targeting the Y397 site of Focal Adhesion Kinase decreases tumor growth. J Med Chem 51:7405-7416
73. Grossmann J (2002) Molecular mechanisms of 'detachment-induced apoptosis-Anoikis'. Apoptosis 7:247-260
74. Golubovskaya VM, Zheng M., Zhang L, Li J-L, Cance WG (2009) The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAKsiRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis. BMC Cancer 9:208-212
75. Han EK, McGonigal T, Wang J, Giranda VL, Luo Y (2004) Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs. Anticancer Res 24:3899-3905
76. Hanada M, Tanaka K, Matsumoto Y, Nakatani F, Sakimura R, Matsunobu T, Li X, Okada T, Nakamura T, Takasaki M, Iwamoto Y (2005) Focal adhesion kinase is activated in invading fibrosarcoma cells and regulates metastasis. Clin Exp Metastasis 22:485-494
77. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70
78. Hanks SK, Polte TR (1997) Signaling through focal adhesion kinase. Bioessays 19:137-145
79. Hanks SK, Ryzhova L, Shin NY, Brabek J (2003) Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. Front Biosci 8:d982-d996
80. Harris RG, White E, Phillips ES, Lillycrop KA (2002) The expression of the developmentally regulated proto-oncogene Pax-3 is modulated by N-Myc. J Biol Chem 277:34815-34825
81. Hatzi E, Murphy C, Zoephel A, Ahorn H, Tontsch U, Bamberger AM, Yamauchi-Takihara K, Schweigerer L, Fotsis T (2002) N-myc oncogene overexpression Down-regulates leukemia inhibitory factor in neuroblastoma. Eur J Biochem 269:3732-3741
82. Hauck CR, Sieg DJ, Hsia DA, Loftus JC, Gaarde WA, Monia BP, Schlaepfer DD (2001) Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells. Cancer Res 61:7079-7090
83. Hayashi I, Vuori K, Liddington RC (2002) The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin. Nat Struct Bio 9:101-106
84. Hildebrand JD, Schaller MD, Parsons JT (1993) Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions. J Cell Biol 123:993-1005
85. Hochwald S, Nyberg C, Zheng M., Cance W, Golubovskaya VM (2009) Small molecule inhibitor targeting Y397 site of FAK decreases pancreatic tumorigenesis. Cell Cycle 15:2435-2443
86. Hoffman WH, Biade S, Zilfou JT, Chen J, Murphy M (2002) Transcriptional repression of the anti-Apoptotic survivin gene by wild type p53. J Biol Chem 277:3247-3257
87. Hogarty MD (2003) The requirement for evasion of programmed cell death in neuroblastomas with MYCN amplification. Cancer Lett 197:173-179
88. Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, Bodmer JL, Schneider P, Seed B, Tschopp J (2000) Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 1:489-495
89. Hollstein M, Hergenhahn M, Yang Q, Bartsch H, Wang ZQ, Hainaut P (1999) New approaches to understanding p53 gene tumor mutation spectra. Mutat Res 431:199-209
90. Hosoi G, Hara J, Okamura T, Osugi Y, Ishihara S, Fukuzawa M, Okada A, Okada S, Tawa A (1994) Low frequency of the p53 gene mutations in neuroblastoma. Cancer 73:3087-3093
91. Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV (1996) TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4:387-396
92. Hur GM, Kim Y-S, Won M, Choksi S, Lu Z.-G. (2006) The death domain kinase RIP has an important role in DNA damage-induced, p53-independent cell death. J Biol Chem 281:25011-25017
93. Ilic D, Almeida EA, Schlaepfer DD, Dazin P, Aizawa S, Damsky CH (1998) Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. J Cell Biol 143:547-560
94. Illc D, Furuta Y, Kanazawa S, Takeda N, Sobue K, Nakatsuji N, Nomura S, Fujimoto J, Okada M, Yamamoto T (1995) Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377:539-544
95. Ishiwata T, Bergmann U, Kornmann M, Lopez M, Beger HG, Korc M (1997) Altered expression of insulin-like growth factor II receptor in human pancreatic cancer. Pancreas 15:367-373
96. Johnsen JI, Aurelio ON, Kwaja Z, Jorgensen GE, Pellegata NS, Plattner R, Stanbridge EJ, Cajot JF (2000) P53-mediated negative regulation of stathmin/Op18 expression is associated with G(2)/M cell-cycle arrest. Int J Cancer 88:685-691
97. Jones G, Stewart G (2004) Nuclear import of N-Terminal FAK by activation of the FcepsilonRI receptor in RBL-2H3 cells. Biochem Biophys Res Commun 314:39-45
98. Judson PL, He X, Cance WG, Van Le L (1999) Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Cancer 86:1551-1556
99. Kang JH, Rychahou PG, Ishola TA, Qiao J, Evers BM, Chung DH (2006) MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells. Biochem Biophys Res Commun 351:192-197
100. Karin M, Lin A (2002) NF-kB at the crossroads of life and death. Nat Immunol 3:221-227
101. Kasahara T, Koguchi E, Funakoshi M, Aizu-Yokota E, Sonod Y (2002) Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation. Antioxid Redox Signal 4:491-499
102. Kelliher MA, Grimm S, Ishida Y, Kuo F, Stanger BZ, Leder P (1998) The death domain kinase RIP mediates the TNF-induced NF-kB signal. Immunity 8:297-303
103. Kim B, Cheng HL, Margolis B, Feldman EL (1998) Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling. J Biol Chem 273:34543-34550
104. Kim JW, Choi EJ, Joe CO (2000) Activation of death-inducing signaling complex (DISC) by proapoptotic C-Terminal fragment of RIP. Oncogene 19:4491-4499
105. Kim JW, Joe CO, Choi EJ (2001) Role of receptor-interacting protein in tumor necrosis factoralpha -dependent MEKK1 activation. J Biol Chem 276:27064-27070
106. Kim YM, Hwang S, Kim YM, Pyun BJ, Kim TY, Lee ST, Gho YS, Kwon YG (2002) Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/ Flk-1. J Biol Chem 277:27872-27879
107. Korc M (1998) Role of growth factors in pancreatic cancer. Surg Oncol Clin N Am 7:25-41
108. Kornberg LJ, Shaw LC, Spoerri PE, Caballero S, Grant MB (2004) Focal adhesion kinase overexpression induces enhanced pathological retinal angiogenesis. Invest Ophthalmol Vis Sci 45:4463-4469
109. Krause K, Wasner M, Reinhard W, Haugwitz U, Dohna CL, Mossner J, Engeland K (2000) The tumour suppressor protein p53 can repress transcription of cyclin B. Nucleic Acids Res 28:4410-4418
110. Kurenova E, Xu L-H, Yang X, Baldwin AS Jr, Craven RJ, Hanks SK, Z-g L, Cance WG (2004) Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Mol Cell Biol 24:4361-4371
111. Kurenova EV, Hunt DL, He D, Fu AD, Massoll NA, Golubovskaya VM, Garces CA, Cance WG (2009a) Vascular endothelial growth factor receptor-3 promotes breast cancer cell proliferation, motility and survival in vitro and tumor formation in vivo. Cell Cycle 8(14):2266-2280
112. Kurenova EV, Hunt DL, He D, Magis AT, Ostrov DA, Cance WG (2009b) Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo. J Med Chem 52(15):4716-4724
113. Lark AL, Livasy CA, Calvo B, Caskey L, Moore DT, Yang X, Cance WG (2003) Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: Immunohistochemistry and real-Time PCR analyses. Clin Cancer Res 9:215-222
114. Lark AL, Livasy CA, Dressler L, Moore DT, Millikan RC, Geradts J, Iacocca M, Cowan D, Little D, Craven RJ, Cance W (2005) High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype. Mod Path 18:1289-1294
115. Lebrun P, Baron V, Hauck CR, Schlaepfer DD, Van Obberghen E (2000) Cell adhesion and focal adhesion kinase regulate insulin receptor substrate-1 expression. J Biol Chem 275:38371-38377
116. Lebrun P, Mothe-Satney I, Delahaye L, Van Obberghen E, Baron V (1998) Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp 125(FAK) and pp60(src). J Biol Chem 273:32244-32253
117. Lee TH, Huang Q, Oikemus S, Shank J, Ventura JJ, Cusson N, Vaillancourt RR, Su B, Davis RJ, Kelliher MA (2003) The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-Activated protein kinase. Mol Cell Biol 23:8377-8385
118. Levine AJ (1997) P53, the cellular gatekeeper for growth and division. Cell 88:323-331
119. Li J, Kretzner L (2003) The growth-inhibitory Ndrg1 gene is a Myc negative target in human neuroblastomas and other cell types with overexpressed N- or c-myc. Mol Cell Biochem 250:91-105
120. Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ (2007) Structural basis for the autoinhibition of focal adhesion kinase. Cell 129:1177-1187
121. Lightfoot HM Jr, Lark A, Livasy CA, Moore DT, Cowan D, Dressler L, Craven RJ, Cance WG (2004) Upregulation of focal adhesion kinase (FAK) expression in Ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. Breast Cancer Res Treat 88:109-116
122. Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, Larocque N, Fisher SJ, Schlaepfer DD, Ilic D (2008) Nuclear FAK promotes cell proliferation and survival through FERMenhanced p53 degradation. Mol Cell 29:9-22
123. Lin Y, Choksi S, Shen HM, Yang QF, Hur GM, Kim YS, Tran JH, Nedospasov SA, Liu ZG (2004) Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting proteinmediated cellular reactive oxygen species accumulation. J Biol Chem 279:10822-10828
124. Lin Y, Devin A, Rodriguez Y, Liu ZG (1999) Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev 13:2514-2526
125. Liu W, Bloom DA, Cance WG, Kurenova EV, Golubovskaya VM, Hochwald SN (2008) Fak and Igf-Ir interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis 29(6):1096-107
126. Liu ZG, Hsu H, Goeddel DV, Karin M (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kB activation prevents cell death. Cell 87:565-576
127. Lobo M, Zachary I (2000) Nuclear localization and apoptotic regulation of an amino-Terminal domain focal adhesion kinase fragment in endothelial cells. Biochem Biophys Res Commun 276:1068-1074
128. Magis AT, Bailey KM, Kurenova EV, Hernández Prada JA, Cance WG, Ostrov DA (2008) Crystallization of the focal adhesion kinase targeting (FAT) domain in a primitive orthorhombic space group. Acta Crystallogr Sect F Struct Biol Cryst Commun 64(Pt 6):564-566
129. Manohar CF, Bray JA, Salwen HR, Madafiglio J, Cheng A, Flemming C, Marshall GM, Norris MD, Haber M, Cohn SL (2004) MYCN-mediated regulation of the MRP1 promoter in human neuroblastoma. Oncogene 23:753-762
130. Martinon F, Holler N, Richard C, Tschopp J (2000) Activation of a pro-Apoptotic amplification loop through inhibition of NF-kB-dependent survival signals by caspase-mediated inactivation of RIP. FEBS Lett 468:134-136
131. May MJ, D'Acquisto F, Madge LA, Glockner J, Pober JS, Ghosh S (2000) Selective inhibition of NF-kB activation by a peptide that blocks the interaction of NEMO with the IkB kinase complex. Science 289:1550-1554
132. McLean GW, Carragher NO, Avizienyte E, Evans J, Brunton VG, Frame MC (2005) The role of focal-Adhesion kinase in cancer - A new therapeutic opportunity. Nat Rev Cancer 5:505-515
133. Meylan E, Tschopp J (2005) The RIP kinases: Crucial integrators of cellular stress. Trends Biochem Sci 30:151-159
134. Mitra SK, Mikolon D, Molina JE, Hsia DA, Hanson DA, Chi A, Lim ST, Bernard-Trifilo JA, Ilic D, Stupack DG, Cheresh DA, Schlaepfer DD (2006) Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors. Oncogene. 25:5969-5984
135. Mitra SK, Schlaepfer DD (2006) Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 18:516-523
136. Murphy M, Hinman A, Levine AJ (1996) Wild-Type p53 negatively regulates the expression of a microtubule-Associated protein. Genes Dev 10:2971-2980
137. Nara K, Kusafuka T, Yoneda A, Oue T, Sangkhathat S, Fukuzawa M (2007) Silencing of MYCN by RNA interference induces growth inhibition, apoptotic activity and cell differentiation in a neuroblastoma cell line with MYCN amplification. Int J Oncol 30:1189-1196
138. Negroni A, Scarpa S, Romeo A, Ferrari S, Modesti A, Raschella G (1991) Decrease of proliferation rate and induction of differentiation by a MYCN antisense DNA oligomer in a human neuroblastoma cell line. Cell Growth Differ 2:511-518
139. Nowakowski J, Cronin CN, McRee DE, Knuth MW, Nelson CG, Pavletich NP, Rogers J, Sang BC, Scheibe DN, Swanson RV, Thompson DA (2002) Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography. Structure 10:1659-1667
140. Otrock ZK, Makarem JA, Shamseddine AI (2007) Vascular endothelial growth factor family of ligands and receptors: Review. Blood Cells Mol Dis 38:258-268
141. Owens LV, Xu L, Craven RJ, Dent GA, Weiner TM, Kornberg L, Liu ET, Cance WG (1995) Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res 55:2752-2755
142. Owens LV, Xu L, Dent GA, Yang X, Sturge GC, Craven RJ, Cance WG (1996) Focal adhesion kinase as a marker of invasive potential in Differentiated human thyroid cancer. Ann Surg Oncol 3:100-105
143. Pajusola K, Aprelikova O, Korhonen J, Kaipainen A, Pertovaara L, Alitalo R, Alitalo K (1992) FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. Cancer Res 52:5738-5743
144. Park HB, Golubovskaya V, Xu L, Yang X, Lee JW, Scully S II, Craven RJ, Cance WG (2004) Activated Src increases adhesion, survival and alpha2-integrin expression in human breast cancer cells. Biochem J 378:559-567
145. Park HB, Xu L-H, Yang X, Cance WG (1999) Activated c-Src rescues cell rounding and loss of adhesion caused by attenuation of the focal adhesion kinase in human breast cancer cells. Surg Forum L:346-347
146. Parsons JT (2003) Focal adhesion kinase: The first ten years. J Cell Sci 116:1409-1416
147. Peng X, Ueda H, Zhou H, Stokol T, Shen TL, Alcaraz A, Nagy T, Vassalli JD, Guan JL (2004) Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice. Cardiovasc Res 64:421-430
148. Plate KH (2001) From angiogenesis to lymphangiogenesis. Nat Med 7:151-155
149. Reiske HR, Kao SC, Cary LA, Guan JL, Lai JF, Chen HC (1999) Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration. J Biol Chem 274: 12361-12366
150. Richardson A, Parsons JT (1995) Signal transduction through integrins: A central role for focal adhesion kinase?. Bioessays 17:229-236
151. Roberts WG, Ung E, Whalen P, Cooper B, Hulford C, Autry C, Richter D, Emerson E, Lin J, Kath J, Coleman K, Yao L, Martinez-Alsina L, Lorenzen M, Berliner M, Luzzio M, Patel N, Schmitt E, LaGreca S, Jani J, Wessel M, Marr E, Griffor M, Vajdos F (2008) Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562, 271. Cancer Res 68:1935-1944
152. Rytomaa M, Martins LM, Downward J (1999) Involvement of FADD and caspase-8 signalling in Detachment-induced apoptosis. Curr Biol 9:1043-1046
153. Salameh A, Galvagni F, Bardelli M, Bussolino F, Oliviero S (2005) Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways. Blood 106:3423-3431
154. Schaller MD (2001) Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochim Biophys Acta 1540:1-21
155. Schaller MD, Borgman CA, Cobb BS, Vines RR, Reynolds AB, Parsons J (1992) pp125fak a structurally distinctive protein-Tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci USA 89:5192-5519
156. Schaller MD, Hildebrand JD, Parsons JT (1999) Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases. Mol Biol Cell 10:3489-3505
157. Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, Parsons JT (1994) Autophosphorylation of the focal adhesion kinase, pp 125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol 14:1680-1688
158. Schaller MD, Otey CA, Hildebrand JD, Parsons JT (1995) Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J Cell Biol 130:1181-1187
159. Schaller MD, Parsons JT (1994) Focal adhesion kinase and associated proteins. Curr Opin Cell Biol 6:705-710
160. Schlaepfer DD, Hou S, Lim S-T, Tomar A, Yu H, Lim Y, Hanson DA, Uryu SA, Molina J, Mitra SK (2007) Tumor necrosis factor-{alpha} stimulates focal adhesion kinase activity required for mitogen-Activated kinase-Associated interleukin 6 expression. J Biol Chem 282:17450
161. Schlaepfer DD, Mitra SK (2004) Multiple connections link FAK to cell motility and invasion. Curr Opin Genet Dev 14:92-101
162. Schneider-Brachert W, Tchikov V, Neumeyer J, Jakob M, Winoto-Morbach S, Held-Feindt J, Heinrich M, Merkel O, Ehrenschwender M, Adam D, Mentlein R, Kabelitz D, Schutze S (2004) Compartmentalization of TNF receptor 1 signaling: Internalized TNF receptosomes as death signaling vesicles. Immunity 21:415-428
163. Schweigerer L, Breit S, Wenzel A, Tsunamoto K, Ludwig R, Schwab M (1990) Augmented MYCN expression advances the malignant phenotype of human neuroblastoma cells: Evidence for induction of autocrine growth factor activity. Cancer Res 50:4411-4416
164. Shen HM, Lin Y, Choksi S, Tran J, Jin T, Chang L, Karin M, Zhang J, Liu ZG (2004) Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol 24:5914-5922
165. Shi Q, Hjelmeland AB, Keir ST, Song L, Wickman S, Jackson D, Ohmori O, Bigner DD, Friedman HS, Rich JN (2007) A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth. Mol Carcinog 46(6)):488-496
166. Sidransky D, Mikkelsen T, Schwechheimer K, Rosenblum ML, Cavanee W, Vogelstein B (1992) Clonal expansion of p53 mutant cells is associated with brain tumour progression. Nature 355:846-847
167. Sieg DJ, Hauck CR, Schlaepfer DD (1999) Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. J Cell Sci 112:2677-2691
168. Skobe M, Hawighorst T, Jackson DG, Prevo R, Janes L, Velasco P, Riccardi L, Alitalo K, Claffey K, Detmar M (2001) Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med 7:192-194
169. Slack-Davis JK, Martin KH, Tilghman RW, Iwanicki M, Ung EJ, Autry C, Luzzio MJ, Cooper B, Kath JC, Roberts WG, Parsons JT (2007) Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem 282:14845-14852
170. Slack A, Chen Z, Tonelli R, Pule M, Hunt L, Pession A, Shohet JM (2005) The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma. Proc Natl Acad Sci USA 102:731-736
171. Slack AD, Chen Z, Ludwig AD, Hicks J, Shohet JM (2007) MYCN-directed centrosome amplification requires MDM2-mediated suppression of p53 activity in neuroblastoma cells. Cancer Res 67:2448-2455
172. Smith CS, Golubovskaya VM, Peck E, Xu LH, Monia BP, Yang X, Cance WG (2005) Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines. Melanoma Res 15:357-362
173. Sonoda Y, Matsumoto Y, Funakoshi M, Yamamoto D, Hanks SK, Kasahara T (2000) Antiapoptotic Role of Focal Adhesion Kinase (FAK). J Biol Chem 275:16309-16315
174. Stanger BZ, Leder P, Lee TH, Kim E, Seed B (1995) RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81:513-523
175. Stanton LW, Schwab M, Bishop JM (1986) Nucleotide sequence of the human N-myc gene. Proc Natl Acad Sci USA 83:1772-1776
176. Stewart A, Ham C, Zachary I (2002) The focal adhesion kinase amino-Terminal domain localises to nuclei and intercellular junctions in HEK 293 and MDCK cells independently of tyrosine 397 and the carboxy-Terminal domain. Biochem Biophys Res Commun 299:62-73
177. Takahashi N, Seko Y, Noiri E, Tobe K, Kadowaki T, Sabe H, Yazaki Y (1999) Vascular endothelial growth factor induces activation and subcellular translocation of focal adhesion kinase (p125FAK) in cultured rat cardiac myocytes. Circ Res 84:1194-1202
178. Takahashi R, Sonoda Y, Ichikawa D, Yoshida N, Eriko A-Y, Tadashi K (2007) Focal adhesion kinase determines the fate of death or survival of cells in response to TNF[alpha] in the presence of actinomycin D. Biochimica et Biophysica Acta (BBA) - General Subjects 1770:518
179. Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM (1999) PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem 274:20693-20703
180. Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM (1998) Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280:1614-1617
181. Taylor WR, Stark GR (2001) Regulation of the G2/M transition by p53. Oncogene 20:1803-1815
182. Thakar J, Schleinkofer K, Borner C, Dandekar T (2006) RIP death domain structural interactions implicated in TNF-mediated proliferation and survival. Proteins 63:413-423
183. Thomas SK, Messam CA, Spengler BA, Biedler JL, Ross RA (2004) Nestin is a potential mediator of malignancy in human neuroblastoma cells. J Biol Chem 279:27994-27999
184. Tilghman RW, Slack-Davis JK, Sergina N, Martin KH, Iwanicki M, Hershey ED, Beggs HE, Reichardt LF, Parsons JT (2005) Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells. J Cell Sci 118:2613-2623
185. Ting AT, Pimentel-Muinos FX, Seed B (1996) RIP mediates tumor necrosis factor receptor 1 activation of NF-kB but not Fas/APO-1-initiated apoptosis. Embo J 15:6189-6196
186. Valentinis B, Morrione A, Peruzzi F, Prisco M, Reiss K, Baserga R (1999) Anti-Apoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion. Oncogene 18:1827-1836
187. van De Water B, Houtepen F, Huigsloot M, Tijdens IB (2001) Suppression of chemically induced apoptosis but not necrosis of renal proximal tubular epithelial (LLC-PK1) cells by focal adhesion kinase (FAK). Role of FAK in maintaining focal adhesion organization after acute renal cell injury. J Biol Chem 276:36183-36193
188. van Rooij E, Doevendans PA, de Theije CC, Babiker FA, Molkentin JD, de Windt LJ (2002) Requirement of nuclear factor of activated T-cells in calcineurin-mediated cardiomyocyte hypertrophy. J Biol Chem 277:48617-48626
189. Vanden Berghe T, van Loo G, Saelens X, Van Gurp M, Brouckaert G, Kalai M, Declercq W, Vandenabeele P (2004) Differential signaling to apoptotic and necrotic cell death by Fasassociated death domain protein FADD. J Biol Chem 279:7925-7933
190. Vassilev LT (2005) P53 Activation by small molecules: Application in oncology. J Med Chem 48:4491-4499
191. Vincent AM, Feldman EL (2002) Control of cell survival by IGF signaling pathways. Growth Horm IGF Res 12:193-197
192. Wang W, Rastinejad F, El-Deiry WS (2003) Restoring p53-dependent tumor suppression. Cancer Biol Ther 2:S55-S63
193. Wei CL, Wu Q, Vega VB, Chiu KP, Ng P, Zhang T, Shahab A, Yong HC, Fu Y, Weng Z, Liu J, Zhao XD, Chew JL, Lee YL, Kuznetsov VA, Sung WK, Miller LD, Lim B, Liu ET, Yu Q, Ng HH, Ruan Y (2006) A global map of p53 transcription-factor binding sites in the human genome. Cell 124:207-219
194. Weiner TM, Liu ET, Craven RJ, Cance WG (1993) Expression of focal adhesion kinase gene and invasive cancer. Lancet 342:1024-1025
195. Weiss WA, Aldape K, Mohapatra G, Feuerstein BG, Bishop JM (1997) Targeted expression of MYCN causes neuroblastoma in transgenic mice. Embo J 16:2985-2995
196. Whitney GS, Chan PY, Blake J, Cosand WL, Neubauer MG, Aruffo A, Kanner SB (1993) Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK. DNA Cell Biology 12:823-830
197. Willis AC, Chen X (2002) The promise and obstacle of p53 as a cancer therapeutic agent. Curr Mol Med 2:329-345
198. Windham TC, Parikh NU, Siwak DR, Summy JM, McConkey DJ, Kraker AJ, Gallick GE (2002) Src activation regulates anoikis in human colon tumor cell lines. Oncogene 21:7797-7807
199. Woo CW, Tan F, Cassano H, Lee J, Lee KC, Thiele C (2008) Use of RNA interference to elucidate the effect of MYCN on cell cycle in neuroblastoma. Pediatr Blood Cancer 50:208-212
200. Wu L, Bernard-Trifilo JA, Lim Y, Lim ST, Mitra SK, Uryu S, Chen M, Pallen CJ, Cheung NK, Mikolon D, Mielgo A, Stupack DG, Schlaepfer DD (2008) Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility. Oncogene 27:1439-1448
201. Wu Y, Mehew JW, Heckman CA, Arcinas M, Boxer LM (2001) Negative regulation of bcl-2 expression by p53 in hematopoietic cells. Oncogene 20:240-251
202. Xu L-h, Yang X-h, Bradham CA, Brenner DA, Baldwin AS, Craven RJ, Cance WG (2000) The focal adhesion kinase suppresses transformation-Associated, anchorage-Independent apoptosis in human breast cancer cells. J Biol Chem 275:30597-30604
203. Xu LH, Owens LV, Sturge GC, Yang X, Liu ET, Craven RJ, Cance WG (1996) Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells. Cell Growth Differ 7:413-418
204. Xu LH, Yang X, Craven RJ, Cance WG (1998) The COOH-Terminal domain of the focal adhesion kinase induces loss of adhesion and cell death in human tumor cells. Cell Growth Differ 9:999-1005
205. Yamamoto D, Sonoda Y, Hasegawa M, Funakoshi-Tago M, Aizu-Yokota E, Kasahara T (2003) FAK overexpression upregulates cyclin D3 and enhances cell proliferation via the PKC and PI3-kinase-Akt pathways. Cell Signal 15:575-583
206. Yeo MG, Partridge MA, Ezratty EJ, Shen Q, Gundersen GG, Marcantonio EE (2006) Src SH2 arginine 175 is required for cell motility: Specific focal adhesion kinase targeting and focal adhesion assembly function. Mol Cell Biol 26:4399-4409
207. Yujiri T, Nawata R, Takahashi T, Sato Y, Tanizawa Y, Kitamura T, Oka Y (2003) MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor substrate-1 expression. J Biol Chem 278:3846-3851
208. Zheng D, Kurenova E, Ucar D, Golubovskaya V, Magis A, Ostrov D, Cance WG, Hochwald SN (2009) Targeting of the protein interaction site between FAK and IGF-1R. Biochem Biophys Res Commun 388(2):301-305