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Volumn 16, Issue 11, 1997, Pages 2985-2995

Targeted expression of MYCN causes neuroblastoma in transgenic mice

Author keywords

Comparative genomic hybridization; MYCN; N myc; Neuroblastoma; Transgenic

Indexed keywords

NUCLEAR FACTOR I; RETINOBLASTOMA PROTEIN;

EID: 0030999641     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.11.2985     Document Type: Article
Times cited : (696)

References (45)
  • 1
    • 0025002352 scopus 로고
    • Sympathetic hyperplasia and neuroblastomas in transgenic mice expressing polyoma middle T antigen
    • Aguzzi, A., Wagner, E.F., Williams, R.L. and Courtneidge, S.A. (1990) Sympathetic hyperplasia and neuroblastomas in transgenic mice expressing polyoma middle T antigen. The New Biologist, 2, 533-543.
    • (1990) The New Biologist , vol.2 , pp. 533-543
    • Aguzzi, A.1    Wagner, E.F.2    Williams, R.L.3    Courtneidge, S.A.4
  • 2
    • 0026541828 scopus 로고
    • 5′ Flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice
    • Banerjee, S.A., Hoppe, P., Brilliant, M. and Chikaraishi, D.M. (1992) 5′ Flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice. J. Neurosci., 12, 4460-4467.
    • (1992) J. Neurosci. , vol.12 , pp. 4460-4467
    • Banerjee, S.A.1    Hoppe, P.2    Brilliant, M.3    Chikaraishi, D.M.4
  • 3
    • 0002221849 scopus 로고
    • Neuroblastoma
    • Pizzo, P.A. and Poplack, D.G. (eds), J.B. Lippincott Co., Philadelphia, PA
    • Brodeur, G.M. and Castleberry, R.G. (1993) Neuroblastoma. In Pizzo, P.A. and Poplack, D.G. (eds), Principles and Practice of Pediatric Oncology. J.B. Lippincott Co., Philadelphia, PA, pp. 739-767.
    • (1993) Principles and Practice of Pediatric Oncology , pp. 739-767
    • Brodeur, G.M.1    Castleberry, R.G.2
  • 4
    • 0021261878 scopus 로고
    • Amplification of N-myc in untreated human neuroblastoma correlates with advanced disease stage
    • Brodeur, G.M., Seeger, R.C., Schwab, M., Varmus, H.E. and Bishop, J.M. (1984) Amplification of N-myc in untreated human neuroblastoma correlates with advanced disease stage. Science, 224, 1121-1124.
    • (1984) Science , vol.224 , pp. 1121-1124
    • Brodeur, G.M.1    Seeger, R.C.2    Schwab, M.3    Varmus, H.E.4    Bishop, J.M.5
  • 5
    • 84970049889 scopus 로고
    • Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with N-myc amplification
    • Caron, H. et al. (1993) Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with N-myc amplification. Nature Genet., 4, 187-190.
    • (1993) Nature Genet. , vol.4 , pp. 187-190
    • Caron, H.1
  • 6
    • 0021806364 scopus 로고
    • Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylation
    • Cole, C.N. and Stacy, T.P. (1985) Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylation. Mol. Cell. Biol., 5, 2104-2113.
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 2104-2113
    • Cole, C.N.1    Stacy, T.P.2
  • 7
    • 0027507490 scopus 로고
    • A genetic linkage map of the mouse: Current applications and future prospects
    • Copeland, N.G. et al. (1993) A genetic linkage map of the mouse: current applications and future prospects. Science, 262, 57-67.
    • (1993) Science , vol.262 , pp. 57-67
    • Copeland, N.G.1
  • 8
    • 0024456610 scopus 로고
    • IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: Generation of lymphoid neoplasias that lack c-myc expression
    • Dildrop, R., Ma, A., Zimmerman, K., Hsu, A., Tesfaye, A., DePinho, R. and Alt, F.W. (1989) IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression. EMBO J., 8, 1121-1128.
    • (1989) EMBO J. , vol.8 , pp. 1121-1128
    • Dildrop, R.1    Ma, A.2    Zimmerman, K.3    Hsu, A.4    Tesfaye, A.5    DePinho, R.6    Alt, F.W.7
  • 10
    • 0026769255 scopus 로고
    • Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas
    • Fong, C.T. et al. (1992) Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas. Cancer Res., 52, 1780-1785.
    • (1992) Cancer Res. , vol.52 , pp. 1780-1785
    • Fong, C.T.1
  • 11
    • 0029779280 scopus 로고    scopus 로고
    • Cdc25 cell-cycle phosphatase as a target of c-myc
    • Galaktionov, K., Chen, X. and Beach, D. (1996) Cdc25 cell-cycle phosphatase as a target of c-myc. Nature, 382, 511-517.
    • (1996) Nature , vol.382 , pp. 511-517
    • Galaktionov, K.1    Chen, X.2    Beach, D.3
  • 14
    • 0027274781 scopus 로고
    • Mutation of the p53 gene in neuroblastoma and its relationship with MYCN amplification
    • Imamura, J., Bartram, C.R., Berthold, F., Harms, D., Nakamura, H. and Koeffler, H.P. (1993) Mutation of the p53 gene in neuroblastoma and its relationship with MYCN amplification. Cancer Res., 53, 4053-4058.
    • (1993) Cancer Res. , vol.53 , pp. 4053-4058
    • Imamura, J.1    Bartram, C.R.2    Berthold, F.3    Harms, D.4    Nakamura, H.5    Koeffler, H.P.6
  • 15
    • 0027456950 scopus 로고
    • Neuroblastoma in a transgenic mouse carrying a metallothionein/ret fusion gene
    • Iwamoto, T., Taniguchi, M., Wajjwalku, W., Nakashima, I. and Takahashi, M. (1993) Neuroblastoma in a transgenic mouse carrying a metallothionein/ret fusion gene. Br. J. Cancer, 67, 504-507.
    • (1993) Br. J. Cancer , vol.67 , pp. 504-507
    • Iwamoto, T.1    Taniguchi, M.2    Wajjwalku, W.3    Nakashima, I.4    Takahashi, M.5
  • 18
    • 0027211048 scopus 로고
    • Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP·Ras
    • Johnson, M.R., Look, A.T., DeClue, J.E., Valentine, M.B. and Lowy, D.R. (1993) Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP·Ras. Proc. Natl Acad. Sci. USA, 90, 5539-5543.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 5539-5543
    • Johnson, M.R.1    Look, A.T.2    Declue, J.E.3    Valentine, M.B.4    Lowy, D.R.5
  • 19
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler, K.W. and Vogelstein, B. (1996) Lessons from hereditary colorectal cancer. Cell, 87, 159-170.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 20
    • 0021047844 scopus 로고
    • Transposition and amplification of oncogene related sequences in human neuroblastomas
    • Kohl, N.E., Kanda, N., Schreck, R.R., Bruns, G., Latt, S.A., Gilbert, F. and Alt, F.W. (1983) Transposition and amplification of oncogene related sequences in human neuroblastomas. Cell, 35, 359-367.
    • (1983) Cell , vol.35 , pp. 359-367
    • Kohl, N.E.1    Kanda, N.2    Schreck, R.R.3    Bruns, G.4    Latt, S.A.5    Gilbert, F.6    Alt, F.W.7
  • 21
    • 0021705664 scopus 로고
    • Activated expression of the N-myc gene in human neuroblastomas and related tumors
    • Kohl, N.E., Gee, C.E. and Alt, F.W. (1984) Activated expression of the N-myc gene in human neuroblastomas and related tumors. Science, 226, 1335-1337.
    • (1984) Science , vol.226 , pp. 1335-1337
    • Kohl, N.E.1    Gee, C.E.2    Alt, F.W.3
  • 22
    • 0025374984 scopus 로고
    • Activation of retrovirus in transgenic mice: Association with development of olfactory neuroblastoma
    • Koike, K., Jay, G., Hartley, J. Schrenzel, M.D., Higgins, R.J. and Hinrichs, S.H. (1990) Activation of retrovirus in transgenic mice: association with development of olfactory neuroblastoma. J. Virol., 64, 3988-3991.
    • (1990) J. Virol. , vol.64 , pp. 3988-3991
    • Koike, K.1    Jay, G.2    Hartley, J.3    Schrenzel, M.D.4    Higgins, R.J.5    Hinrichs, S.H.6
  • 23
    • 0028786697 scopus 로고
    • Co-amplification and concomitant high levels of expression of a DEAD box gene with MYCN in human neuroblastoma
    • Manohar, C.F., Salwen, H.R., Brodeur, G.M. and Cohn, S.L. (1995) Co-amplification and concomitant high levels of expression of a DEAD box gene with MYCN in human neuroblastoma. Genes, Chromosomes Cancer, 14, 196-203.
    • (1995) Genes, Chromosomes Cancer , vol.14 , pp. 196-203
    • Manohar, C.F.1    Salwen, H.R.2    Brodeur, G.M.3    Cohn, S.L.4
  • 24
    • 0029024453 scopus 로고
    • Neuroblastoma: A clinical challenge and biologic puzzle
    • Marthay, K.K. (1995) Neuroblastoma: a clinical challenge and biologic puzzle. Ca, Cancer J. Clin., 45, 179-192.
    • (1995) Ca, Cancer J. Clin. , vol.45 , pp. 179-192
    • Marthay, K.K.1
  • 25
    • 0029010921 scopus 로고
    • Detection of multiple gains and losses of genetic material in ten glioma cell lines by comparative genomic hybridization
    • Mohapatra, G., Kim, D.H. and Feuerstein, B.G. (1995) Detection of multiple gains and losses of genetic material in ten glioma cell lines by comparative genomic hybridization. Genes, Chromosomes Cancer, 13, 86-93.
    • (1995) Genes, Chromosomes Cancer , vol.13 , pp. 86-93
    • Mohapatra, G.1    Kim, D.H.2    Feuerstein, B.G.3
  • 26
    • 0344639482 scopus 로고    scopus 로고
    • Mouse Genome Database (MGD)
    • The Jackson Laboratory, Bar Harbor, ME 12/16/96
    • Mouse Genome Database (MGD), Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME. World Wide Web (URL: http:// www.informatics.jax.org/). 12/16/96).
    • Mouse Genome Informatics
  • 27
    • 0022801745 scopus 로고
    • Catecholaminergic differentiation associated with S100 protein-positive elements in human neuroblastoma
    • Nakagawara, A., Toyohara, T., Nada, O. and Ikeda, K. (1986) Catecholaminergic differentiation associated with S100 protein-positive elements in human neuroblastoma. Z. Kinderchir., 41, 275-278.
    • (1986) Z. Kinderchir. , vol.41 , pp. 275-278
    • Nakagawara, A.1    Toyohara, T.2    Nada, O.3    Ikeda, K.4
  • 28
    • 0026236567 scopus 로고
    • Deletions and rearrangements of the retinoblastoma gene in hepatocellular carcinoma, insulinoma and some neurogenic tumors as found in a study of 121 tumors
    • Nakamura, T., Iwamura, Y., Kaneko, M., Nakagawa, K., Kawai, K., Mitamura, K. Futagawa, T. and Hayashi, H. (1991) Deletions and rearrangements of the retinoblastoma gene in hepatocellular carcinoma, insulinoma and some neurogenic tumors as found in a study of 121 tumors. Jap. J. Clin. Oncol., 21, 325-329.
    • (1991) Jap. J. Clin. Oncol. , vol.21 , pp. 325-329
    • Nakamura, T.1    Iwamura, Y.2    Kaneko, M.3    Nakagawa, K.4    Kawai, K.5    Mitamura, K.6    Futagawa, T.7    Hayashi, H.8
  • 29
    • 0021270667 scopus 로고
    • Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15
    • Nusse, R., van Ooyen, A., Cox, D., Fung, Y.K. and Varmus, H. (1984) Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature, 307, 131-136.
    • (1984) Nature , vol.307 , pp. 131-136
    • Nusse, R.1    Van Ooyen, A.2    Cox, D.3    Fung, Y.K.4    Varmus, H.5
  • 30
    • 0019428314 scopus 로고
    • Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate reductase
    • O'Hare, K., Benoist, C. and Breathnach, R. (1981) Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate reductase. Proc. Natl Acad. Sci. USA, 78, 1527-1531.
    • (1981) Proc. Natl Acad. Sci. USA , vol.78 , pp. 1527-1531
    • O'Hare, K.1    Benoist, C.2    Breathnach, R.3
  • 32
    • 0031031692 scopus 로고    scopus 로고
    • Gain of chromosome 17 is the most frequent abnormality detected in neuroblastoma by comparative genomic hybridization
    • Plantaz, D., Mohapatra, G., Matthay, K.K., Pellarin, M., Seeger, R.C and Feuerstein, B.G. (1997) Gain of chromosome 17 is the most frequent abnormality detected in neuroblastoma by comparative genomic hybridization. Am. J. Pathol., 150, 81-89.
    • (1997) Am. J. Pathol. , vol.150 , pp. 81-89
    • Plantaz, D.1    Mohapatra, G.2    Matthay, K.K.3    Pellarin, M.4    Seeger, R.C.5    Feuerstein, B.G.6
  • 33
    • 0023009701 scopus 로고
    • Human proto-oncogene N-myc encodes nuclear proteins that bind DNA
    • Ramsay, G., Stanton, L., Schwab, M. and Bishop, J.M. (1986) Human proto-oncogene N-myc encodes nuclear proteins that bind DNA. Mol. Cell. Biol., 6, 4450-4457.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 4450-4457
    • Ramsay, G.1    Stanton, L.2    Schwab, M.3    Bishop, J.M.4
  • 34
    • 0029921469 scopus 로고    scopus 로고
    • High resolution mapping of a 130-kb core region of the MYCN amplicon in neuroblastomas
    • Reiter, J.L. and Brodeur, G.M. (1996) High resolution mapping of a 130-kb core region of the MYCN amplicon in neuroblastomas. Genomics, 32, 97-103.
    • (1996) Genomics , vol.32 , pp. 97-103
    • Reiter, J.L.1    Brodeur, G.M.2
  • 35
    • 0024436934 scopus 로고
    • N-myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross-regulation with c-myc
    • Rosenbaum, H., Webb, E., Adams, J.M., Cory, S. and Harris, A.W. (1989) N-myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross-regulation with c-myc. EMBO J., 8, 749-755.
    • (1989) EMBO J. , vol.8 , pp. 749-755
    • Rosenbaum, H.1    Webb, E.2    Adams, J.M.3    Cory, S.4    Harris, A.W.5
  • 36
    • 0021063273 scopus 로고
    • Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumor
    • Schwab, M., Alitalo, K., Klempnauer, K.H., Varmus, H.E., Bishop, J.M., Gilbert, F., Brodeur, G., Goldstein, M. and Trent, J. (1983) Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumor. Nature, 305, 245-248.
    • (1983) Nature , vol.305 , pp. 245-248
    • Schwab, M.1    Alitalo, K.2    Klempnauer, K.H.3    Varmus, H.E.4    Bishop, J.M.5    Gilbert, F.6    Brodeur, G.7    Goldstein, M.8    Trent, J.9
  • 37
    • 0021800964 scopus 로고
    • The human N-myc gene contributes to tumorigenic conversion of mammalian cells in culture
    • Schwab, M., Varmus, H.E. and Bishop, J.M. (1985) The human N-myc gene contributes to tumorigenic conversion of mammalian cells in culture. Nature, 316, 160-162.
    • (1985) Nature , vol.316 , pp. 160-162
    • Schwab, M.1    Varmus, H.E.2    Bishop, J.M.3
  • 38
    • 0025776414 scopus 로고
    • Restriction of neuroblastoma to the prostate gland in transgenic mice
    • Skalnik, D.G., Dorfman, D.M., Williams, D.A. and Orkin, S.H. (1991) Restriction of neuroblastoma to the prostate gland in transgenic mice. Mol. Cell. Biol., 11, 4518-4527.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 4518-4527
    • Skalnik, D.G.1    Dorfman, D.M.2    Williams, D.A.3    Orkin, S.H.4
  • 39
    • 0012084884 scopus 로고
    • Early regions of JC and BK virus induce distinct and tissue-specific tumors in transgenic mice
    • Small, J.A., Khoury, G., Jay, G., Howley, P. and Scangos, G. (1986) Early regions of JC and BK virus induce distinct and tissue-specific tumors in transgenic mice. Proc. Natl Acad. Sci. USA, 83, 8288-8292.
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 8288-8292
    • Small, J.A.1    Khoury, G.2    Jay, G.3    Howley, P.4    Scangos, G.5
  • 40
    • 0023148557 scopus 로고
    • Neoplastic transformation by the human gene N-myc
    • Small, M., Hay, N., Schwab, M. and Bishop, J.M. (1987) Neoplastic transformation by the human gene N-myc. Mol. Cell. Biol., 7, 1638-1645.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 1638-1645
    • Small, M.1    Hay, N.2    Schwab, M.3    Bishop, J.M.4
  • 42
    • 0025253116 scopus 로고
    • Normal diploid human and rodent cells lack a detectable frequency of gene amplification
    • Tlsty, T.D. (1990) Normal diploid human and rodent cells lack a detectable frequency of gene amplification. Proc. Natl Acad. Sci. USA, 87, 3132-3136.
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 3132-3136
    • Tlsty, T.D.1
  • 44
    • 0029049717 scopus 로고
    • A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3
    • White, P.S. et al. (1995) A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3. Proc. Natl Acad. Sci. USA, 92, 5520-5524.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 5520-5524
    • White, P.S.1


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