Focal adhesion kinase expression in human neuroblastoma: immunohistochemical and real-time PCR analyses

Clinical Cancer Research

Volumn 14, Issue 11, 2008, Pages 3299-3305

  Beierle, Elizabeth A ^a,d   Massoll, Nicole A ^b   Hartwich, Joseph ^a   Kurenova, Elena V ^a   Golubovskaya, Vita M ^a   Cance, William G ^a   McGrady, Patrick ^c   London, Wendy B ^c  

^a Departments of Surgery   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c CHILDREN S ONCOLOGY GROUP   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE 1; MESSENGER RNA; TUMOR MARKER;

ADVANCED CANCER; ARTICLE; CHILD; HUMAN; HUMAN TISSUE; INFANT; NEUROBLASTOMA; ONCOGENE C MYB; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR CELL; UPREGULATION; BIOSYNTHESIS; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; MALE; METABOLISM; MORTALITY; NEWBORN; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CHILD; CHILD, PRESCHOOL; FEMALE; FOCAL ADHESION KINASE 1; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; INFANT, NEWBORN; KAPLAN-MEIERS ESTIMATE; MALE; NEUROBLASTOMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL;

EID: 50349092365     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-07-1511     Document Type: Article

References (50)

1. Schaller MD, Borgman CA, Cobb BS, Vines RR, Reynolds AB, Parsons JT. pp125 fak a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci U S A1992;89:5192-6.
2. Hanks SK, PolteTR. Signaling through focal adhesion kinase. Bioessays 1997;19:137-45.
3. Schaller MD, Parsons JT. Focal adhesion kinase and associated proteins. Curr Opin Cell Biol 1994; 6:705-10
4. Xing A, Chen HC. Nowlen JK.Taylor S J, Shalloway D, Guan JL. Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. Mol Biol Cell 1994;5:413-21.
5. Calalb MB, PolteTR, Hanks SK. Tyrosine phosphorylation of focal adhesion kinase at site in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol 1995:15:954-63.
6. Chen HC, Guan JL. Association of focal adhesion kinase with its potential substrate phosphatidylssitol 3-kinase. Proc Natl Acad Sci U S A 1994:91 10148-52.
7. FAK) in invasive human tumors. Cancer Res 1995;55:2752-5.
8. Cance WG, Harris JE, lacocca MV, et al. Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res 2000;6:2417-23.
9. Watermann DO, Gabriel B, Jager M, et al. Specific induction of pp125 focal adhesion kinase in human breast cancer. Br J Cancer 2005;93:694-8.
10. Lark AL, Livasy CA, Dressier L, et al. High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype. Mod Pathol 2005;18:1289-94.
11. Oktay MH, Oktay K, Hamele-Bena D, Buyuk A, Koss LG. Focal adhesion kinase as a marker of malignant phenotype in breast and cervical carcinomas. Hum Pathol 2003;34:240-5.
12. Lark AL, Livasy CA, Calvo B, et al. Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses. Clin Cancer Res 2003;9:215-22.
13. Licato LL, Brenner DA. Analysis of signaling protein kinases in human colon or colorectal carcinomas. Dig Dis Sci 1998;43:1454-64.
14. Owens LV, Xu L, Dent GA, et al. Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer. Ann Surg Oncol 1996;3: 100-5.
15. Kim SJ, Park JW, Yoon JS, et al. Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study. J Korean Med Sci 2004;19: 710-15.
16. Judson PL, He X, CanceWG, Le LV. Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Cancer 1999;86:1551 -6.
17. Miyazaki T, Kato H, Nakajima M, et al. FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma. Br J Cancer 2003;89:140-5.
18. Aronsohn MS, Brown HM, Hauptman G, Kornberg LJ. Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in squamous cell carcinoma of the larynx. Laryngoscope 2003;113: 1944-8.
19. Akasaka T, van Leeuwen RL, Yoshinaga IG, Mihm MC, Byers HR. Focal adhesion kinase (p125FAK) expression correlates with motility of human melanoma cell lines. J Invest Dermatol 1995;105:104-8.
20. 20.WeinerTM, Liu ET, Craven RJ, CanceWG. Expression of focal adhesion kinase gene and invasive cancer. Lancet 1993;342:1024 - 5.
21. Agochiya M, Brunton VG, Owens DW, et al. Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells. Oncogene 1999;18:5646-53.
22. Canel M, Secades P, Rodrigo JP, et al. Overexpression of focal adhesion kinase in head and neck squamous cell carcinoma is independent of fak gene copy number. Clin Cancer Res 2006;12:3272-9.
23. Cotterill SJ, Parker L, More L, Craft AW. Neuroblastoma: changing incidence and survival in young people aged 0-24 years. A report from the North of England Young Persons' Malignant Disease Registry. Med Pediatr Oncol 2001;36:231 -4.
24. Beierle EA.Trujillo A, Nagaram A, et al. N-MYC regulates focal adhesion kinase expression in neuroblastoma. J Biol Chem 2007;282:12503-16.
25. Kaplan EL, Meier P. Non parametric estimation from incomplete observations. J Am Stat Assoc 1958;53: 457-81.
26. Peto R, Peto J. Asymptotically efficient rank invariant test procedures. J R Stat Soc A 1972;135: 185-98.
27. Frisch SM.Vuori K, Ruoslahti E, Chan-Hui PY. Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol 1996;134:793-9.
28. Ilic D, Almeida EAC, Schlaepfer DD, et al. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. J Cell Biol 1998;143:547-60.
29. Frisch SM, Screaton RA. Anoikis mechanisms. Curr Opin Cell Biol 2001;13:555-62.
30. Sonoda Y Watanabe S, Matsumoto Y, Aizu-Yokota E, KasaharaT. FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line. J Biol Chem 1999;274: 10566-70.
31. Sonoda Y, Matsumoto Y, Funakoshi M.Yamamoto D, Hanks SK, KasaharaT. Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor of apoptosis proteins and apoptosis suppression by the overexpression of Fak in a human leukemic cell line, HL60. J Biol Chem 2000;275:16309-15.
32. Liao CH, Sang S, Ho CT, Lin JK. Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. J Cell Biochem 2005;96:155-69.
33. Krajewski S, Krajewska M, Ehrmann J, et al. Immunohistochemical analysis of Bcl-2, Bcl-X, Mcl-1, and Bax in tumors of central and peripheral nervous system origin. Am J Pathol 1997;150:805-14.
34. Gallo G, Giarnieri E, Bosco S, et al. Aberrant bcl-2 and bax protein expression related to chemotherapy response in neuroblastoma. Anticancer Res 2003;23: 777-84.
35. McPake CR.Tillman DM, Poquette CA, George EO, Houghton JA, Harris LC. Bax is an important determinant of chemosensitivity in pediatric tumor cell lines independent of Bcl-2 expression and p53 status. Oncol Res 1998;10:235-44.
36. Lightfoot HM, Lark A., Livasy CA, et al. Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. Breast Cancer Res Treat 2004;88: 109-16.
37. FAK) in node- negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome. Br Cancer Res 2005;7:R194-203.
38. GolubovskayaVM, Gross S, Kaur AS, et al. Simultaneous inhibition of focal adhesion kinase and Src enhances detachment and apoptosis in colon cancer cell lines. Mol Cancer Res 2003;1:755-64.
39. GolubovskayaVM, Bevliglia L, Earp HS, Craven RJ, Cance WG. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells, J Biol Chem 2002:277: 38978-87.
40. Garces CA, Kurenova EV, GolubovskayaVM, Cance WG. Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells. Cancer Res 2006;66:1446-54.
41. Beviglia L, Golubovskaya V, Xu L,Yang X, Craven RJ, CanceWG. Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis. Biochem J 2003:373:201 -10.
42. Xu LH.Yang H, Craven RJ, CanceWG.The COOH- terminal domain of the focal adhesion kinase induces loss of adhesion and death in human tumor cells. Cell Growth Differ1998;9:999-1005.
43. Xu LH.Yang H, Bradham CA, et al. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. J Biol Chem 2000;275:30597-604.
44. Xu LH, Owens LV, Sturge GC, et al. Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells. Cell Growth Differ 1996;7: 413-8.
45. Smith CS, Golubovskaya VM, Peck E, etal. Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cells. Melanoma Res 2005; 15:357-62.
46. Xiong W, Parsons JT. Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase. J Cell Biol 1997;139: 529-39.
47. Shi Q, Hjelmeland AB, Keir ST, et al. A novel low- molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth. Mol Carcinog 2007; 46:488-96.
48. Hatakeyama S,Tomioka D, Kawahara E, et al. Anticancer activity of NVP-TAE226, a potent dual FAK/IGF-IR kinase inhibitor, against pancreatic cancer. J Clin Oncol 2006;18S:13162.
49. Kawahara E, Ohmori O, Nonomura K, et al. NVP- TAE226, a potent dual FAK/IGF-IR kinase inhibitor, prevents breast cancer metastasis in vivo. J Clin Oncol 2006;18S:13163.
50. Nam S, Kim D, Cheng JQ, et al. Action of the Src family kinase inhibitor, dasatinib (BMS-354835), on human prostate cancer cells. Cancer Res 2005;65: 9185-9.