The promise and obstacle of p53 as a cancer therapeutic agent

Current Molecular Medicine

Volumn 2, Issue 4, 2002, Pages 329-345

  Willis, A C ^a   Chen, X ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Cancer therapy; Gene therapy; p53

Indexed keywords

1 ETHYL 2 [[3 ETHYL 5 (3 METHYLBENZOTHIAZOLIN 2 YLIDENE) 4 OXOTHIAZOLIDIN 2 YLIDENE]METHYL]PYRIDINIUM CHLORIDE; 4 (3 DIMETHYLAMINOPROPYLAMINO) 2 (4 METHOXYSTYRYL)QUINAZOLINE; ANTINEOPLASTIC AGENT; CARBOXYL GROUP; CD40 LIGAND; CHAPERONE; CISPLATIN; CRE RECOMBINASE; DACTINOMYCIN; EPSTEIN BARR VIRUS ANTIGEN; FLUOROURACIL; GANCICLOVIR; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; IRINOTECAN; LEPTOMYCIN B; LIPOSOME; MUTANT PROTEIN; P53 BINDING PROTEIN DERIVATIVE; PACLITAXEL; PRIMA 1; PROTEIN CTS; PROTEIN MDM2; PROTEIN P53; PROTEIN P63; PROTEIN P73; RIBOZYME; THYMIDINE KINASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS PROTEIN;

ANEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL DEATH; CELL PROLIFERATION; DRUG ACTIVATION; DRUG DESIGN; DRUG DISTRIBUTION; DRUG TARGETING; FEVER; FLU LIKE SYNDROME; GENE FUNCTION; GENE MUTATION; GENE REPLACEMENT THERAPY; GENE STRUCTURE; GENETIC TRANSFECTION; HEAD AND NECK CANCER; HEART ARRHYTHMIA; HUMAN; MITOSIS INHIBITION; MOUSE; NAUSEA; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN TARGETING; RESPIRATORY DISTRESS; REVIEW; SOLID; SOLID TUMOR; TUMOR SUPPRESSOR GENE; VIRAL GENE DELIVERY SYSTEM; WILD TYPE;

GENE THERAPY; GENES, P53; GENETIC VECTORS; HUMANS; MODELS, BIOLOGICAL; MODELS, GENETIC; MUTATION; NEOPLASMS;

HUMAN HERPESVIRUS 4;

EID: 0036625964     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/1566524023362474     Document Type: Review

References (156)

1. Hollstein, M., Rice, K., Greenblatt, M.S., Soussi, T., Fuchs, R., Sorlie, T., Hovig, E., Smith-Sorensen, B., Montesano, R. and Harris, C.C. (1994) Nucleic Acids Res., 22, 3551-5.
2. Nelson, W.G. and Kastan, M.B. (1994) Mol. Cell Biol., 14,1815-23.
3. Graeber, T.G., Osmanian, C., Jacks, T., Housman, D.E., Koch, C.J., Lowe, S.W. and Giaccia, A.J. (1996) Nature, 379, 88-91.
4. Lowe, S.W. and Ruley, H. E. (1993) Genes Dev., 7, 535-45.
5. Almog, N. and Rotter, V. (1997) Biochim. Biophys. Acta, 1333, F1-27.
6. Tanaka, H., Arakawa, H., Yamaguchi, T., Shiraishi, K., Fukuda, S., Matsui, K., Takei, Y. and Nakamura, Y.(2000) Nature, 404, 42-9.
7. el-Deiry, W.S. (1998) Semin. Cancer Biol., 8, 345-57.
8. Zhu, K., Wang, J., Zhu, J., Jiang, J., Shou, J. and Chen, X. (1999) Oncogene., 18, 7740-7.
9. Levine, A.J. (1997) Cell, 88, 323-31.
10. Vogelstein, B., Lane, D. and Levine, A.J. (2000) Nature, 408, 307-10.
11. Ko, L.J. and Prives, C. (1996) Genes. Dev., 10, 1054-72.
12. el-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, W.E., Kinzler, K.W. and Vogelstein. B.(1993) Cell, 75, 817-25.
13. Wang, X.W., Zhan, Q., Coursen, J.D., Khan, M.A., Kontny, H.U., Yu, L., Hollander, M.C., O'Connor, P.M., Fornace, A.J. Jr. and Harris, C.C. (1999) Proc. Natl. Acad. Sci. U.S.A., 96, 3706-11.
14. Hermeking, H., Lengauer, C., Polyak, K., He, T.C., Zhang, L., Thiagalingam, S., Kinzler, K.W. and Vogelstein, B. (1997) Mol. Cell, 1, 3-11.
15. Zhu, J. and Chen, X. (2000) Mol. Cell. Biol., 20, 5602-18.
16. Zhan, Q., Antinore, M.J., Wang, X.W., Carrier, F., Smith, M.L., Harris, C.C. and Fornace, A.J. Jr. (1999) Oncogene, 18, 2892-900.
17. Chan, T.A., Hermeking, H., Lengauer, C., Kinzler, K.W. and Vogelstein, B. (1999) Nature, 401, 616-20.
18. Kerr, J.F., Winterford, C.M. and Harmon, B.V. (1994) Cancer, 73, 2013-26.
19. Owen-Schaub, L.B., Zhang, W., Cusack, J.C., Angelo, L.S., Santee, S.M., Fujiwara, T., Roth, J.A., Deisseroth, A.B., Zhang, W.W. and Kruzel, E. (1995) Mol. Cell. Biol., 15, 3032-40.
20. Wu, G.S., Burns, T.F., McDonald, E.R. III., Jiang, W., Meng, R., Krantz, I.D., Kao, G., Gan, D.D., Zhou, J.Y., Muschel, R., Hamilton, S.R., Spinner, N.B., Markowitz, S., Wu, G. and El-Deiry, W.S. (1997) Nat. Genet, 17, 141-3.
21. Dohn, M., Jiang, J. and Chen, X. (2001) Oncogene, 20, 6503-15.
22. Strasser, A., O'Connor, L. and Dixit, V.M. (2000) Annu. Rev. Biochem., 69, 217-45.
23. Burns, T.F. and El-Deiry, W.S. (1999) J. Cell Physiol., 181, 231-9.
24. Lowe, S.W. and Lin, A.W. (2000) Carcinogenesis, 21, 485-95.
25. Miyashita, T. and Reed, J.C. (1995) Cell, 80, 293-9.
26. Robles, A.I., Bemmels, N.A., Foraker, A.B. and Harris, C.C. (2001) Cancer Res., 61, 6660-4.
27. Nakano, K. and Vousden, K.H. (2001) Mol. Cell, 7, 683-94.
28. Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T. and Tanaka, N. (2000) Science, 288, 1053-8.
29. Budihardjo, I., Oliver, H., Lutter, M., Luo, X. and Wang, X. (1999) Annu. Rev. Cell Dev. Biol., 15, 269-90.
30. Earnshaw, W.C., Martins, L.M. and Kaufmann, S.H. (1999) Annu. Rev. Biochem., 68, 383-424.
31. Momand, J., Zambetti, G.P., Olson, D.C., George, D. and Levine, A.J. (1992) Cell, 69, 1237-45.
32. Oliner, J.D., Pietenpol, J.A., Thiagalingam, S., Gyuris, J., Kinzler, K.W. and Vogelstein, B. (1993) Nature, 362, 857-60.
33. Tao, W. and Levine, A.J. (1999) Proc. Natl. Acad. Sci. U.S.A., 96, 3077-80.
34. Freedman, D.A. and Levine, A.J. (1998) Mol. Cell Biol., 18, 7288-93.
35. Haupt, Y., Maya, R., Kazaz, A. and Oren, M. (1997) Nature, 387, 296-9.
36. Kubbutat, M.H., Jones, S.N. and Vousden, K.H. (1997) Nature, 387, 299-303.
37. Tao, W. and Levine, A.J. (1999) Proc. Natl. Acad. Sci. U. S.A., 96, 6937-41.
38. Hupp, T.R., Sparks, A. and Lane, D.P. (1995) Cell, 83, 237-45.
39. Anderson, M.E., Woelker, B., Reed, M., Wang, P. and Tegtmeyer, P. (1997) Mol. Cell. Biol., 17, 6255-64.
40. Bayle, J.H., Elenbaas, B. and Levine, A.J. (1995) Proc. Natl. Acad. Sci. U.S.A., 92, 5729-33.
41. Hupp, T.R. and Lane, D.P. (1994) Cold Spring Harb. Symp. Quant Biol., 59, 195-206.
42. Hupp, T.R., Meek, D.W., Midgley, C.A. and Lane, D.P. (1992) Cell, 71, 875-86.
43. Hupp, T.R., Meek, D.W., Midgley, C.A. and Lane, D.P. (1993) Nucleic Acids. Res., 21, 3167-74.
44. zur Hausen, H. (1996) Biochim. Biophys. Acta, 1288, F55-78.
45. Scheffner, M., Huibregtse, J.M., Vierstra, R.D. and Howley, P.M. (1993) Cell, 76, 495-505.
46. Cho, Y., Gorina, S., Jeffrey, P.D. and Pavletich, N.P. (1994) Science, 265, 346-55.
47. Milner, J. and Medcalf, E.A. (1991) Cell, 65, 765-74.
48. Pietenpol, J.A., Tokino, T., Thiagalingam, S., El-Deiry, W.S., Kinzler, K.W. and Vogelstein, B. (1994) Proc. Natl. Acad. Sci. U.S.A., 91, 1998-2002.
49. Levine, A.J., Momand, J. and Finlay, C.A. (1991) Nature, 351, 453-6.
50. Hussain, S.P. and Harris, C.C. (1998) Cancer Res., 58, 4023-37.
51. Frazier, M.W., He, X., Wang, J., Gu, Z., Cleveland, J.L. and Zambetti, G.P. (1998) Mol. Cell. Biol., 18, 3735-43.
52. Dittmer, D., Pati, S., Zambetti, G., Chu, S., Teresky, A.K., Moore, M., Finlay, C. and Levine, A.J. (1993) Nat. Genet, 4, 42-6.
53. Hsiao, M., Low, J., Dorn, E., Ku, D., Pattengale, P., Yeargin, J. and Haas, M. (1994) Am. J. Pathol., 145, 702-14.
54. Chene, P. (1998) J. Mol. Biol., 281, 205-9.
55. Brachmann, R.K., Vidal, M. and Boeke, J.D. (1996) Proc. Natl. Acad. Sci. U.S.A., 93, 4091-5.
56. Kirn, D., Martuza, R.L. and Zwiebel, J. (2001) Nat. Med, 7, 781-7.
57. Robbins, P.D. and Ghivizzani, S.C. (1998) Pharmacol. Ther, 80, 35-47.
58. McCormick, F. (2001) Nature Reviews Cancer, 1, 130-41.
59. Wills, K.N., Atencio, I.A., Avanzini, J.B., Neuteboom, S., Phelan, A., Philopena, J., Sutjipto, S., Vaillancourt, M.T., Wen, S.F., Ralston, R.O. and Johnson, D.E. (2001) J. Virol., 75, 8733-41.
60. Douglas, J.T., Rogers, B.E., Rosenfeld, M.E., Michael, S.I., Feng, M. and Curiel, D.T. (1996) Nat. Biotechnol, 14, 1574-8.
61. Chene, P. (2001) Current Medicinal Chemistry, 1, 151-161.
62. Cai, D.W., Mukhopadhyay, T., Liu, Y., Fujiwara, T. and Roth, JA. (1993) Hum. Gene Ther, 4, 617-24.
63. Fujiwara, T., Cai, D.W., Georges, R.N., Mukhopadhyay, T., Grimm, E.A. and Roth, J.A. (1994) J. Natl. Cancer Inst, 86, 1458-62.
64. Roth, J.A., Nguyen, D., Lawrence, D.D., Kemp, B.L., Carrasco, C.H., Ferson, D.Z., Hong, W.K., Komaki, R., Lee, J.J., Nesbitt, J.C., Pisters, K.M., Putnam, J.B., Schea, R., Shin, D.M., Walsh, G.L., Dolormente, M.M., Han, C.I., Martin, F.D., Yen, N., Xu, K., Stephens, L.C., McDonnell, T.J., Mukhopadhyay, T. and Cai, D. (1996) Nat. Med., 2, 985-91.
65. Blackwell, J.L., Li, H., Gomez-Navarro, J., Dmitriev, I., Krasnykh, V., Richter, C.A., Shaw, D.R., Alvarez, R.D., Curiel, D.T. and Strong, T.V. (2000) Hum. Gene Ther., 11, 1657-69.
66. Wada, Y., Gotoh, A., Shirakawa, T., Hamada, K. and Kamidono, S. (2001) Mol, Urol., 5, 47-52.
67. Shimada, H., Shimizu, T., Ochiai, T., Liu, T.L., Sashiyama, H., Nakamura, A., Matsubara, H., Gunji, Y. Kobayashi, S., Tagawa, M., Sakiyama, S. and Hiwasa, T. (2001) Surg. Today, 31, 597-604.
68. Hickman, J.A. (1996) Eur. J. Cancer, 32A, 921-6.
69. Lowe, S.W., Ruley, H.E., Jacks, T. and Housman, D.E. (1993) Cell, 74, 957-67.
70. Cowen, D., Salem, N., Ashoori, F., Meyn, R., Meistrich, M.L., Roth, J.A. and Pollack, A. (2000) Clin. Cancer Res., 6, 4402-8.
71. Miyake, H., Hara, I., Hera, S., Arakawa, S. and Kamidono, S. (2000) Urology, 56, 332-6.
72. Inoue, A., Narumi, K., Matsubara, N., Sugawara, S., Saijo, Y., Satoh, K. and Nukiwa, T. (2000) Cancer Lett, 167, 105-12.
73. Nishizaki, M., Meyn, R.E., Levy, L.B., Atkinson, E.N., White, R.A., Roth, J.A. and Ji, L. (2001) Clin. Cancer Res., 7, 2887-97.
74. Swisher, S.G., Roth, J.A., Nemunaitis, J., Lawrence, D.D., Kemp, B.L., Carrasco, C.H., Connors, D.G., El-Naggar, A.K., Fossella, F., Glisson, B.S., Hong, W.K., Khuri, F.R., Kurie, J.M, Lee, J.J., Lee, J.S., Mack, M., Merritt, J.A., Nguyen, D.M., Nesbitt, J.C., Perez-Soler, R., Pisters, K.M., Putnam, J.B. Jr., Richli, W.R., Savin, M., Schrump, D.S., Shin, D.M., Shulkin, A., Walsh, G. L., Wait, J., Weill, D. and Waugh, K.A. (1999) J. Natl. Cancer Inst., 91, 763-71.
75. Clayman, G.L., Frank, D.K., Bruso, P.A. and Goepfert, H. (1999) Clin. Cancer Res., 5, 1715-22.
76. Nemunaitis, J., Swisher, S.G., Timmons, T., Connors, D., Mack, M., Doerksen, L., Weill, D., Wait, J., Lawrence, D.D., Kemp, B.L., Fossella, F., Glisson, B.S., Hong, W.K., Khuri, F.R., Kurie, J.M., Lee, J.J., Lee, J.S., Nguyen, D.M., Nesbitt, J.C., Perez-Soler, R., Pisters, K.M., Putnam, J.B., Richli, W.R., Shin, D.M., Walsh, G.L., Merritt, J. and Roth, J. (2000) J. Clin. Oncol., 18, 609-22.
77. Swisher, S., Roth, J.A., Komaki, R., Hicks, M., Ro, J., Dreiling, L., Yver, A.B., Stevens, C., Putnam, J.B., Smythe, W.R., Vaporciyan, A.A. and Walsh, G.L. (2000) Proc. Am. Soc. Clin. Oncol., 19, 461a, (abstract #1807).
78. Kaghad, M., Bonnet, H., Yang, A., Creancier, L., Biscan, J.C., Valent, A., Minty, A., Chalon, P., Lelias, J.M., Dumont, X., Ferrara, P., McKeon, F. and Caput, D. (1997) Cell, 90, 809-19.
79. Osada, M., Ohba, M., Kawahara, C., Ishioka, C., Kanamaru, R., Katoh, I., Ikawa, Y., Nimura, Y., Nakagawara, A., Obinata, M. and lkawa, S.(1998) Nat. Med., 4, 839-43.
80. Yang, A., Kaghad, M., Wang, Y., Gillett, E., Fleming, M.D., Dotsch, V., Andrews, N.C., Caput, D. and McKeon, F. (1998) Mol. Cell, 2, 305-16.
81. Jost, C.A., Marin, M.C. and Kaelin, W.G. Jr. (1997) Nature, 389, 191-4.
82. Dohn, M., Zhang, S. and Chen, X. (2001) Oncogene, 20, 3193-205.
83. Han, S., Semba, S., Abe, T., Makino, N., Furukawa, T., Fukushige, S., Takahashi, H., Sakurada, A., Sato, M., Shiiba, K., Matsuno, S., Nimura, Y., Nakagawara, A. and Horii, A. (1999) Eur. J. Surg. Oncol., 25, 194-8.
84. Gomez-Manzano, C., Fueyo, J., Kyritsis, A.P., Steck, P.A., Roth, J.A., McDonnell, T.J., Steck, K.D., Levin, V.A. and Yung, W.K. (1996) Cancer Res., 56,694-9.
85. Shinoura, N., Muramatsu, Y., Asai, A., Han, S., Horii, A., Kirino, T. and Hamada, H. (2000) Cancer Lett., 160, 67-73.
86. Sasaki, Y., Morimoto, I., Ishida, S., Yamashita, T., Imai, K. and Tokino, T. (2001) Gene. Ther., 8, 1401-8.
87. Mack, C.A., Song, W.R., Carpenter, H., Wickham, T.J., Kovesdi, I., Harvey, B.G., Magovern, C.J., Isom, O.W., Rosengart, T., Falck-Pedersen, E., Hackett, N.R., Crystal, R.G., and Mastrangeli, A. (1997) Hum. Gene Ther., 8, 99-109.
88. Zhang, W.W., Fang, X., Mazur, W., French, B.A., Georges, R.N. and Roth, J.A. (1994) Cancer Gene. Ther., 1, 5-13.
89. Zhang, W.W., Alemany, R. , Wang, J., Koch, P.E., Ordonez, N.G. and Roth, J.A. (1995) Hum. Gene. Ther, 6, 155-64.
90. Weitman, S.D., Lark, R.H., Coney, L.R., Fort, D.W., Frasca, V., Zurawski, V.R. Jr. and Kamen, B.A. (1992) Cancer Res., 52, 3396-401.
91. Jakubczak, J.L., Rollence, M.L., Stewart, D.A., Jafari, J.D., Von Seggern, D.J., Nemerow, G.R., Stevenson, S.C. and Hallenbeck, P.L. (2001) J. Virol., 75, 2972-81.
92. Rodriguez, R., Schuur, E.R., Lim, H.Y., Henderson, G.A., Simons, J.W. and Henderson, D.R. (1997) Cancer Res., 57, 2559-63.
93. Hallenbeck, P.L., Chang, Y.N., Hay, C., Golightly, D., Stewart, D., Lin, J., Phipps, S. and Chiang, Y.L. (1999) Hum.. Gene. Ther., 10, 1721-33.
94. Felgner, P.L., Tsai, Y.J., Sukhu, L., Wheeler, C.J., Manthorpe, M., Marshall, J. and Cheng, S. H. (1995) Ann. N. Y. Aced. Sci., 772, 126-39.
95. Lewis, J.G., Lin, K.Y., Kothavale, A., Flanagan, W.M., Matteucci, M.D., DePrince, R.B., Mook, R.A. Jr., Hendren, R.W. and Wagner. R.W.(1996) Proc. Natl. Aced. Sci. U.S.A., 93, 3176-81.
96. Namoto, M., Yonemitsu, Y., Nakagawa, K., Hashimoto, S., Kaneda, Y., Nawata, H. and Sueishi, K. (1998) Int. J. Oncol., 12, 777-84.
97. Pollock, R., Lang, A., Ge, T., Sun, D., Tan, M. and Yu, D. (1998) Clin. Cancer Res., 4, 1985-94.
98. Xu, L., Pirollo, K.F. and Chang, E.H. (1997) Hum. Gene. Ther, 8, 467-75.
99. Zou, Y., Zong, G., Ling, Y.H., Hao, M.M., Lozano, G., Hong, W.K. and Perez-Soler, R. (1998) J. Natl. Cancer Inst, 90, 1130-7.
100. Zou, Y., Zong, G., Ling, Y.H. and Perez-Soler, R. (2000) Cancer Gene Ther., 7, 683-96.
101. Keer, H.N., Kozlowski, J.M., Tsai, Y.C., Lee, C., McEwan, R.N. and Grayhack, J.T. (1990) J. Urol., 143, 381-5.
102. Inoue, T., Cavanaugh, P.G., Steck, P.A., Brunner, N. and Nicolson, G.L.(1993) J. Cell Physiol., 156, 212-7.
103. Xu, L., Pirollo, K.F., Tang, W.H., Rait, A. and Chang, E.H. (1999) Hum. Gene Ther, 10, 2941-52.
104. Xu, L., Tang, W.H., Huang, C.C., Alexander, W., Xiang, L.M., Pirollo, K.F., Rait, A. and Chang, E.H. (2001) Mol. Med., 7, 723-34.
105. Xu, L., Pirollo, K.F. and Chang, E.H. (2001) J. Control Release, 74, 115-28.
106. Barker, D.D. and Berk, A.J. (1987) Virology, 156, 107-21.
107. Bischoff, J.R., Kirn, D.H., Williams, A., Heise, C., Horn, S. , Muna, M., Ng, L., Nye, J.A., Sampson-Johannes, A., Fattaey, A. and McCormick, F. (1996) Science, 274, 373-6.
108. You, L., Yang, C.T. and Jablons, D.M. (2000) Cancer Res., 60, 1009-13.
109. Vollmer, C.M., Ribas, A., Butterfield, L.H., Dissette, V.B., Andrews, K.J., Eilber, F.C. Montejo, L.D. Chen, A.Y., Hu, B., Glaspy, J.A., McBride, W. H. and Economou, J.S. (1999) Cancer Res., 59, 4369-74.
110. Turnell, A.S., Grand, R.J. and Gallimor e, P.H. (1999) J. Virol., 73, 2074-83.
111. Rothmann, T., Hengstermann, A., Whitaker, N.J., Scheffner, M. and zur Hausen, H. (1998) J. Virol., 72, 9470-8.
112. Hall, A.R., Dix, B.R., O'Carroll, S.J. and Braithwaite, A.W. (1998) Nat. Med., 4, 1068-72.
113. Goodrum, F.D. and Ornelles, D.A. (1998) J. Virol., 72, 9479-90.
114. Nemunaitis, J., Ganly, I., Khuri, F., Arseneau, J., Kuhn, J., McCarty, T., Landers, S., Maples, P., Romel, L., Randlev, B., Reid, T., Kaye, S. and Kim, D. (2000) Cancer Res., 60, 6359-66.
115. Goodrum, F.D. and Ornelles, D.A. (1997) J. Virol., 71, 548-61.
116. Ganly, I., Kirn, D., Eckhardt, G., Rodriguez, G.I., Soutar, D.S., Otto, R., Robertson, A.G., Park, O., Gulley, M.L., Heise, C., Von Hoff, D.D., Kaye, S.B. and Eckhardt, S.G. (2000) Clin. Cancer Res., 6, 798-806.
117. Nemunaitis, J., Khuri, F., Ganly, I., Arseneau, J., Posner, M., Vokes, E., Kuhn, J., McCarty, T., Landers, S., Blackburn, A., Romel, L., Randlev, B., Kaye, S. and Kirn, D. (2001) J. Clin. Oncol., 19, 289-98.
118. Schrijvers, D., Johnson, J., Jiminez, U., Gore, M., Kosmidis, P., Szpirglas, H., Robbins, K., Oliveira, J., Lewensohn, R., Schuller, J., Riviere, A., Arvay, C., Langecker, P., Jacob, H., Cvitkovic, E. and Vokes, E. (1998) J. Clin. Oncol., 16, 1054-9.
119. Clayman, G.L., el-Naggar, A.K., Lippman, S.M., Henderson, Y.C., Frederick, M., Merritt, J.A., Zumstein, L.A., Timmons, T.M., Liu, T.J., Ginsberg, L., Roth, J.A., Hong, W.K., Bruso, P. and Goepfert, H. (1998) J. Clin. Oncol., 16, 2221-32.
120. Khuri, F.R., Nemunaitis, J., Ganly, I., Arseneau, J., Tannock, I.F., Romel, L., Gore, M., Ironside, J., MacDougall, R.H., Heise, C., Randlev, B., Gillenwater, A.M., Bruso, P., Kaye, S.B., Hong, W.K. and Kirn, D.H. (2000) Nat. Med, 6, 879-85.
121. Heise, C.C., Williams, A.M., Xue, S., Propst, M. and Kirn, D.H. (1999) Cancer Res., 59, 2623-8.
122. Raj, K., Ogston, P. and Beard., P. (2001) Nature, 412, 914-7.
123. Andreu, T., Ebensperger, C., Westphal, E.M., Klenner, T., Stewart, A.F., Westhof, A., Muller, P., Knaus, R. and von Melchner, H. (2001) Cancer Res., 61, 6925-30.
124. Russ, A.P., Friedel, C., Grez, M. and von Melchner, H. (1996) J. Virol., 70, 4927-32.
125. Friedler, A., Hansson, L.O., Veprintsev, D.B., Freund, S.M., Rippin, T.M., Nikolova, P.V., Proctor, M.R., Rudiger, S. and Fersht, A.R. (2002) Proc. Natl. Acad. Sci. U.S.A., 99, 937-942.
126. Foster, B.A., Coffey, H.A., Morin, M.J. and Rastinejad, F. (1999) Science, 286, 2507-10.
127. Bykov, V.J., Issaeva, N., Shilov, A., Hultcrantz, M., Pugacheva, E., Chumakov, P., Bergman, J., Wiman, K.G. and Selivanova, G. (2002) Nat. Med., 8, 282-8.
128. Abarzua, P., LoSardo, J.E., Gubler, M.L., Spathis, R., Lu, Y.A, Felix, A. and Neri, A. (1996) Oncogene, 13, 2477-82.
129. Selivanova, G., Iotsova, V., Okan, I., Fritsche, M., Strom, M., Groner, B., Grafstrom, R.C. and Wiman, K.G. (1997) Nat. Med., 3, 632-8.
130. Kim, A.L., Raffo, A.J., Brandt-Rauf, P.W., Pincus, M.R., Monaco, R., Abarzua, P. and Fine, R.L. (1999) J. Biol. Chem., 274, 34924-31.
131. Selivanova, G., Ryabchenko, L., Jansson, E., Iotsova, V. and Wiman, K.G. (1999) Mol. Cell Biol., 19, 3395-402.
132. Tortora, G., Caputo, R., Damiano, V., Bianco, R., Chen, J., Agrawal, S., Bianco, A.R. and Ciardiello, F. (2000) Int. J. Cancer, 88, 804-9.
133. Wang, H., Nan, L., Yu, D., Agrawal, S. and Zhang, R. (2001) Clin. Cancer Res., 7, 3613-24.
134. Chen, L., Agrawal, S., Zhou, W., Zhang, R. and Chen, J. (1998) Proc. Natl, Acad. Sci. U.S.A., 95, 195-200.
135. Garcia-Echeverria, C., Chene, P., Blommers, M.J. and Furet, P. (2000) J. Med. Chem., 43, 3205-8.
136. Lozano, G. and Liu, G. (1998) Semin. Cancer Biol., 8, 337-44.
137. Conseiller, E., Debussche, L., Landais, D., Venot, C., Maratrat, M., Sierra, V., Tocque, B. and Bracco, L. (1998) J. Clin. Invest., 101, 120-7.
138. Naumann, U., Kugler, S., Wolburg, H., Wick, W., Rascher, G., Schulz, J.B., Conseiller, E., Bahr, M. and Weller, M. (2001) Cancer Res., 61, 5833-42.
139. Levitskaya, J., Sharipo, A., Leonchiks, A., Ciechanover, A. and Masucci, M.G. (1997) Proc. Natl. Acad. Sci. U.S.A., 94, 12616-21.
140. Heessen, S., Leonchiks, A. Issaeva, N., Sharipo, A., Selivanova, G,, Masucci, M.G. and Dantuma, N.P. (2002) Proc. Natl. Acad. Sci. U.S.A., 99, 1532-7.
141. Chou, R.H. and Huang, H. (2002) J. Cell Biochem., 84, 615-24.
142. Hietanen, S., Lain, S., Krausz, E., Blattner, C. and Lane, D.P. (2000) Proc. Natl. Acad. Sci. U.S.A., 97, 8501-6.
143. Wadhwa, R., Takano, S., Robert, M., Yoshida, A., Nomura, H., Reddel, R.R., Mitsui, Y. and Kaul, S.C. (1998) J. Biol. Chem., 273, 29586-91.
144. Britten, C.D., Rowinsky, E.K., Baker, S.D., Weiss, G.R., Smith, L., Stephenson, J., Rothenberg, M., Smetzer, L., Cramer, J., Collins, W., Von Hoff, D.D. and Eckhardt, S.G. (2000) Clin. Cancer Res., 6, 42-9.
145. Wadhwa, R., Sugihara, T., Yoshida, A., Nomura, H., Reddel, R.R., Simpson, R., Maruta, H. and Kaul, S.C. (2000) Cancer Res., 60, 6818-21.
146. Watanabe, T. and Sullenger, B.A. (2000) Proc. Natl. Acad. Sci. U.S.A., 97, 8490-4.
147. Chen, H.L. and Carbone, D.P. (1997) Mol. Med. Today, 3, 160-7.
148. Vierboom, M.P., Nijman, H.W., Offringa, R., van der Voort, E.I., van Hall, T., van den Broek, L., Fleuren, G.J., Kenemans, P., Kast, W.M. and Melief, C.J. (1997) J. Exp. Med., 186, 695-704.
149. Ropke, M., Hald, J., Guldberg, P., Zeuthen, J., Norgaard, L., Fugger, L., Svejgaard, A., Van der Burg, S., Nijman, H.W., Melief, C.J. and Claesson, M.H. (1996) Proc. Natl. Acad. Sci. U.S.A., 93, 14704-7.
150. Nikitina, E.Y., Clark, J.I., Van Beynen, J., Chada, S., Virmani, A.K., Carbone, D.P. and Gabrilovich, D.I. (2001) Clin. Cancer Res., 7, 127-35.
151. Hoffmann, T.K., Nakano, K., Elder, E.M., Dworacki, G., Finkelstein, S.D., Appella, E., Whiteside, T.L. and DeLeo, A.B. (2000) J. Immunol., 165, 5938-44.
152. Gnjatic, S., Cai, Z., Viguier, M., Chouaib, S., Guillet, J.G. and Choppin, J. (1998) J. Immunol., 160, 328-33.
153. Lee, P.P., Yee, C., Savage, P.A., Fong, L., Brockstedt, D., Weber, J.S., Johnson, D., Swetter, S., Thompson, J., Greenberg, P.D., Roederer, M. and Davis, M.M. (1999) Nat. Med., 5, 677-85.
154. Lutzker, S.G. and Lattime, E.C. (2001) Clin. Cancer Res., 7, 2-4.
155. Wurtzen, P.A., Pedersen, L.O., Poulsen, H.S. and Claesson, M.H. (2001) Int. J. Cancer, 93, 855-61.
156. Komarov, P.G., Komarova, E.A., Kondratov, R.V., ChristovTselkov, K., Coon, J.S., Chernov, M.V. and Gudkov, A.V. (1999) Science, 285, 1733-7.