Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells

Journal of Biological Chemistry

Volumn 277, Issue 41, 2002, Pages 38978-38987

  Golubovskaya, Vita ^a   Beviglia, Lucia ^b   Xu, Li Hui ^b   Shelton Earp III, H ^a   Craven, Rolf ^a   Cance, William ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DEGRADATION; ENZYME INHIBITION; TUMORS;

APOPTOSIS;

BIOCHEMISTRY;

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CASPASE 3; CASPASE 8; EPIDERMAL GROWTH FACTOR RECEPTOR; FOCAL ADHESION KINASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN KINASE B; RECEPTOR;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME MECHANISM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADENOVIRIDAE; APOPTOSIS; BREAST NEOPLASMS; CASPASE 3; CASPASES; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; FEMALE; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENES, REPORTER; HUMANS; IMMUNOHISTOCHEMISTRY; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0037064030     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205002200     Document Type: Article

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