Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation

Antioxidants and Redox Signaling

Volumn 4, Issue 3, 2002, Pages 491-499

  Kasahara, Tadashi ^a   Koguchi, Emiko ^a   Funakoshi, Megumi ^a   Aizu yokota, Eriko ^a   Sonoda, Yoshiko ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; CYTOCHROME C; ETOPOSIDE; FOCAL ADHESION KINASE; HYDROGEN PEROXIDE; AKT1 PROTEIN, HUMAN; BID PROTEIN, HUMAN; CARRIER PROTEIN; CASPASE; DNA FRAGMENT; FOCAL ADHESION KINASE 1; IMMUNOSUPPRESSIVE ACID PROTEIN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BID; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; PTK2 PROTEIN, HUMAN; SERINE; TUMOR PROTEIN; TYROSINE;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CELL SURVIVAL; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; ANIMAL; BIOLOGICAL MODEL; DNA DAMAGE; GAMMA RADIATION; GENETICS; HUMAN; METABOLISM; TIME;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CASPASES; CELL SURVIVAL; CYTOCHROME C GROUP; DNA DAMAGE; DNA FRAGMENTATION; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GAMMA RAYS; HL-60 CELLS; HUMANS; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; TIME FACTORS; TYROSINE;

EID: 0036019938     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/15230860260196290     Document Type: Article

References (48)

1. Bcl-2 protects from oxidative damage and apoptotic cell death without interfering with activation of NF-kappa B by TNF
2. Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3
3. Removal of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: Protection with antioxidants and glutamate receptor antagonists
4. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
5. Focal adhesions, contractility, and signaling
6. Regulation of cell death protease caspase-9 by phosphorylation
7. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
8. Ex vivo induction of apoptosis in lymphocytes is mediated by oxidative stress: Role for lymphocyte loss in HIV infection
9. CREB is a regulatory target for the protein kinase Akt/PKB
10. Control of adhesion-dependent cell survival by focal adhesion kinase
11. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
12. Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation
13. Inhibition of pp125FAK in cultured fibroblasts results in apoptosis
14. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
15. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis
16. Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: Possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state
17. Reactive oxygen species are downstream mediators of p53-dependent apoptosis
18. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
19. Tumor necrosis factor alpha induces BID cleavage and bypasses antiapoptotic signals in prostate cancer LNCaP cells
20. Ionizing radiation-induced, mitochondria dependent generation of reactive oxygen/nitrogen
21. Caspase-mediated cleavage of focal adhesion kinase pp125FAK and disassembly of focal adhesions in human endothelial cell apoptosis
22. Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin
23. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
24. Oxidative stress in exposed to low level of ionizing radiation
25. Protease activation during apoptosis: Death by a thousand cuts?
26. Apoptosis by death factor
27. Caspases: Killer proteases
28. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
29. Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2
30. NF-kappaB activation by tumor necrosis factor requires the Akt serine-threonine kinase
31. A model for p53-induced apoptosis
32. Fasmediated apoptosis in neuroblastoma requires mitochondrial activation and is inhibited by FLICE inhibitor protein and bcl-2
33. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
34. Mammalian thioredoxin is a direct inhibitor of apoptosis signal regulating kinase (ASK) 1
35. Signaling through the focal adhesion kinase
36. Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP
37. A suppressive role of p125FAK protein tyrosine kinase in hydrogen peroxide-induced apoptosis of T98G cells
38. Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60
39. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase
40. Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell
41. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
42. Induction of human endothelial cell apoptosis requires both heat shock and oxidative stress responses
43. Manganese superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor
44. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
45. Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells
46. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease
47. BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
48. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked