-
1
-
-
0030952289
-
Mechanisms of angiogenesis
-
Risau W. Mechanisms of angiogenesis. Nature 386 (1997) 671-674
-
(1997)
Nature
, vol.386
, pp. 671-674
-
-
Risau, W.1
-
2
-
-
0036782278
-
VEGF and the quest for tumour angiogenesis factors
-
Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat. Rev., Cancer 2 (2002) 795-803
-
(2002)
Nat. Rev., Cancer
, vol.2
, pp. 795-803
-
-
Ferrara, N.1
-
3
-
-
17444374974
-
Angiogenesis: a curse or cure?
-
Gupta K., and Zhang J. Angiogenesis: a curse or cure?. Postgrad. Med. J. 81 (2005) 236-242
-
(2005)
Postgrad. Med. J.
, vol.81
, pp. 236-242
-
-
Gupta, K.1
Zhang, J.2
-
4
-
-
0037699954
-
The biology of VEGF and its receptors
-
Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat. Med. 9 (2003) 669-676
-
(2003)
Nat. Med.
, vol.9
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
LeCouter, J.3
-
5
-
-
0026395163
-
The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA
-
Houck K.A., Ferrara N., Winer J., et al. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol. Endocrinol. 5 (1991) 1806-1814
-
(1991)
Mol. Endocrinol.
, vol.5
, pp. 1806-1814
-
-
Houck, K.A.1
Ferrara, N.2
Winer, J.3
-
6
-
-
12544258730
-
Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1
-
Suto K., Yamazaki Y., Morita T., et al. Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1. J. Biol. Chem. 280 (2005) 2126-2131
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 2126-2131
-
-
Suto, K.1
Yamazaki, Y.2
Morita, T.3
-
7
-
-
0021111648
-
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
-
Senger D.R., Galli S.J., Dvorak A.M., et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219 (1983) 983-985
-
(1983)
Science
, vol.219
, pp. 983-985
-
-
Senger, D.R.1
Galli, S.J.2
Dvorak, A.M.3
-
8
-
-
14644415949
-
Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma
-
Rini B.I., and Small E.J. Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. J. Clin. Oncol. 23 (2005) 1028-1043
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 1028-1043
-
-
Rini, B.I.1
Small, E.J.2
-
9
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
Leung D.W., Cachianes G., Kuang W.J., et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246 (1989) 1306-1309
-
(1989)
Science
, vol.246
, pp. 1306-1309
-
-
Leung, D.W.1
Cachianes, G.2
Kuang, W.J.3
-
10
-
-
0025999033
-
The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
-
Tischer E., Mitchell R., Hartman T., Silva M., et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem. 266 (1991) 11947-11954
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 11947-11954
-
-
Tischer, E.1
Mitchell, R.2
Hartman, T.3
Silva, M.4
-
12
-
-
19944431085
-
Clinical significance of the expression of isoform 165 vascular endothelial growth factor mRNA in noncancerous liver remnants of patients with hepatocellular carcinoma
-
Sheen I.S., Jeng K.S., Shih S.C., et al. Clinical significance of the expression of isoform 165 vascular endothelial growth factor mRNA in noncancerous liver remnants of patients with hepatocellular carcinoma. World J. Gastroenterol. 11 (2005) 187-192
-
(2005)
World J. Gastroenterol.
, vol.11
, pp. 187-192
-
-
Sheen, I.S.1
Jeng, K.S.2
Shih, S.C.3
-
13
-
-
22344439308
-
Cell binding isoforms of vascular endothelial growth factor-A (VEGF189) contribute to blood flow-distant metastasis of pulmonary adenocarcinoma
-
Nishi M., Abe Y., Tomii Y., et al. Cell binding isoforms of vascular endothelial growth factor-A (VEGF189) contribute to blood flow-distant metastasis of pulmonary adenocarcinoma. Int. J. Oncol. 26 (2005) 1517-1524
-
(2005)
Int. J. Oncol.
, vol.26
, pp. 1517-1524
-
-
Nishi, M.1
Abe, Y.2
Tomii, Y.3
-
14
-
-
0036842215
-
Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
-
Dvorak H.F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J. Clin. Oncol. 20 (2002) 4368-4380
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 4368-4380
-
-
Dvorak, H.F.1
-
16
-
-
0030806273
-
Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
-
Benjamin L.E., and Keshet E. Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 8761-8766
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 8761-8766
-
-
Benjamin, L.E.1
Keshet, E.2
-
17
-
-
0032557564
-
Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells
-
Gerber H.P., Dixit V., and Ferrara N. Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J. Biol. Chem. 273 (1998) 13313-13316
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13313-13316
-
-
Gerber, H.P.1
Dixit, V.2
Ferrara, N.3
-
18
-
-
0031943236
-
VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
-
Hood J.D., Meininger C.J., Ziche M., and Granger H.J. VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells. Am. J. Physiol. 274 (1998) H1054-H1058
-
(1998)
Am. J. Physiol.
, vol.274
-
-
Hood, J.D.1
Meininger, C.J.2
Ziche, M.3
Granger, H.J.4
-
19
-
-
4644234505
-
VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection
-
Storkebaum E., Lambrechts D., and Carmeliet P. VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. BioEssays 26 (2004) 943-954
-
(2004)
BioEssays
, vol.26
, pp. 943-954
-
-
Storkebaum, E.1
Lambrechts, D.2
Carmeliet, P.3
-
20
-
-
4143136640
-
Vascular endothelial growth factor: basic science and clinical progress
-
Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev. 25 (2004) 581-611
-
(2004)
Endocr. Rev.
, vol.25
, pp. 581-611
-
-
Ferrara, N.1
-
21
-
-
0027171960
-
Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis
-
Jakeman L.B., Armanini M., Phillips H.S., and Ferrara N. Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis. Endocrinology 133 (1993) 848-859
-
(1993)
Endocrinology
, vol.133
, pp. 848-859
-
-
Jakeman, L.B.1
Armanini, M.2
Phillips, H.S.3
Ferrara, N.4
-
22
-
-
0027241752
-
Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis
-
Shweiki D., Itin A., Neufeld G., et al. Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis. J. Clin. Invest. 91 (1993) 2235-2243
-
(1993)
J. Clin. Invest.
, vol.91
, pp. 2235-2243
-
-
Shweiki, D.1
Itin, A.2
Neufeld, G.3
-
23
-
-
0343920277
-
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
-
Carmeliet P., Ferreira V., Breier G., et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380 (1996) 435-439
-
(1996)
Nature
, vol.380
, pp. 435-439
-
-
Carmeliet, P.1
Ferreira, V.2
Breier, G.3
-
24
-
-
0026756163
-
Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing
-
Brown L.F., Yeo K.T., Berse B., et al. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J. Exp. Med. 176 (1992) 1375-1379
-
(1992)
J. Exp. Med.
, vol.176
, pp. 1375-1379
-
-
Brown, L.F.1
Yeo, K.T.2
Berse, B.3
-
25
-
-
0038644624
-
Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis
-
Xia Y.P., Li B., Hylton D., et al. Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. Blood 102 (2003) 161-168
-
(2003)
Blood
, vol.102
, pp. 161-168
-
-
Xia, Y.P.1
Li, B.2
Hylton, D.3
-
26
-
-
0032560844
-
VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development
-
Larcher F., Murillas R., Bolontrade M., et al. VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development. Oncogene 17 (1998) 303-311
-
(1998)
Oncogene
, vol.17
, pp. 303-311
-
-
Larcher, F.1
Murillas, R.2
Bolontrade, M.3
-
27
-
-
2442636729
-
Loss of vascular endothelial growth factor A activity in murine epidermal keratinocytes delays wound healing and inhibits tumor formation
-
Rossiter H., Barresi C., Pammer J., et al. Loss of vascular endothelial growth factor A activity in murine epidermal keratinocytes delays wound healing and inhibits tumor formation. Cancer Res. 64 (2004) 3508-3516
-
(2004)
Cancer Res.
, vol.64
, pp. 3508-3516
-
-
Rossiter, H.1
Barresi, C.2
Pammer, J.3
-
28
-
-
0036985699
-
Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications
-
Ferrara N. Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin. Oncol. 29 (2002) 10-14
-
(2002)
Semin. Oncol.
, vol.29
, pp. 10-14
-
-
Ferrara, N.1
-
29
-
-
19144366076
-
Cloning and characterization of a novel human gene related to vascular endothelial growth factor
-
Grimmond S., Lagercrantz J., Drinkwater C., et al. Cloning and characterization of a novel human gene related to vascular endothelial growth factor. Genome Res. 6 (1996) 124-131
-
(1996)
Genome Res.
, vol.6
, pp. 124-131
-
-
Grimmond, S.1
Lagercrantz, J.2
Drinkwater, C.3
-
30
-
-
9044222479
-
Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively
-
Paavonen K., Horelli-Kuitunen N., Chilov D., et al. Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively. Circulation 93 (1996) 1079-1082
-
(1996)
Circulation
, vol.93
, pp. 1079-1082
-
-
Paavonen, K.1
Horelli-Kuitunen, N.2
Chilov, D.3
-
31
-
-
0031566171
-
Analysis of the promoter region of the human VEGF-related factor gene
-
Silins G., Grimmond S., Egerton M., et al. Analysis of the promoter region of the human VEGF-related factor gene. Biochem. Biophys. Res. Commun. 230 (1997) 413-418
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.230
, pp. 413-418
-
-
Silins, G.1
Grimmond, S.2
Egerton, M.3
-
32
-
-
2642641324
-
Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C
-
Ristimaki A., Narko K., Enholm B., et al. Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C. J. Biol. Chem. 273 (1998) 8413-8418
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 8413-8418
-
-
Ristimaki, A.1
Narko, K.2
Enholm, B.3
-
33
-
-
0033113716
-
Cold-induced mRNA expression of angiogenic factors in rat brown adipose tissue
-
Asano A., Kimura K., and Saito M. Cold-induced mRNA expression of angiogenic factors in rat brown adipose tissue. J. Vet. Med. Sci. 61 (1999) 403-409
-
(1999)
J. Vet. Med. Sci.
, vol.61
, pp. 403-409
-
-
Asano, A.1
Kimura, K.2
Saito, M.3
-
34
-
-
27744516670
-
The biology of vascular endothelial growth factor-B (VEGF-B)
-
Nash A.D., Baca M., Wright C., et al. The biology of vascular endothelial growth factor-B (VEGF-B). Pulm. Pharmacol. Ther. 19 (2006) 61-69
-
(2006)
Pulm. Pharmacol. Ther.
, vol.19
, pp. 61-69
-
-
Nash, A.D.1
Baca, M.2
Wright, C.3
-
35
-
-
0036400056
-
Human vascular endothelial growth factor B: characterization of recombinant isoforms and generation of neutralizing monoclonal antibodies
-
Scotney P.D., MacKenzie A., Maccarone P., et al. Human vascular endothelial growth factor B: characterization of recombinant isoforms and generation of neutralizing monoclonal antibodies. Clin. Exp. Pharmacol. Physiol. 29 (2002) 1024-1029
-
(2002)
Clin. Exp. Pharmacol. Physiol.
, vol.29
, pp. 1024-1029
-
-
Scotney, P.D.1
MacKenzie, A.2
Maccarone, P.3
-
36
-
-
1642297115
-
The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1
-
Christinger H.W., Fuh G., de Vos A.M., and Wiesmann C. The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1. J. Biol. Chem. 279 (2004) 10382-10388
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 10382-10388
-
-
Christinger, H.W.1
Fuh, G.2
de Vos, A.M.3
Wiesmann, C.4
-
37
-
-
0030782410
-
Crystal structure at 1.7 Å resolution of VEGF in complex with domain 2 of the Flt-1 receptor
-
Wiesmann C., Fuh G., Christinger H.W., et al. Crystal structure at 1.7 Å resolution of VEGF in complex with domain 2 of the Flt-1 receptor. Cell 91 (1997) 695-704
-
(1997)
Cell
, vol.91
, pp. 695-704
-
-
Wiesmann, C.1
Fuh, G.2
Christinger, H.W.3
-
38
-
-
9244227572
-
Vascular endothelial growth factor B, a novel growth factor for endothelial cells
-
Olofsson B., Pajusola K., Kaipainen A., et al. Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 2576-2581
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 2576-2581
-
-
Olofsson, B.1
Pajusola, K.2
Kaipainen, A.3
-
39
-
-
0029782928
-
Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform
-
Olofsson B., Pajusola K., von Euler G., et al. Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. J. Biol. Chem. 271 (1996) 19310-19317
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 19310-19317
-
-
Olofsson, B.1
Pajusola, K.2
von Euler, G.3
-
40
-
-
8544249876
-
Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia
-
Enholm B., Paavonen K., Ristimaki A., et al. Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia. Oncogene 14 (1997) 2475-2483
-
(1997)
Oncogene
, vol.14
, pp. 2475-2483
-
-
Enholm, B.1
Paavonen, K.2
Ristimaki, A.3
-
41
-
-
18844471324
-
Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors
-
Salven P., Lymboussaki A., Heikkila P., et al. Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors. Am. J. Pathol. 153 (1998) 103-108
-
(1998)
Am. J. Pathol.
, vol.153
, pp. 103-108
-
-
Salven, P.1
Lymboussaki, A.2
Heikkila, P.3
-
42
-
-
18844473540
-
Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia
-
Bellomo D., Headrick J.P., Silins G.U., et al. Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Circ. Res. 86 (2000) E29-E35
-
(2000)
Circ. Res.
, vol.86
-
-
Bellomo, D.1
Headrick, J.P.2
Silins, G.U.3
-
43
-
-
0141788312
-
Vegfb gene knockout mice display reduced pathology and synovial angiogenesis in both antigen-induced and collagen-induced models of arthritis
-
Mould A.W., Tonks I.D., Cahill M.M., et al. Vegfb gene knockout mice display reduced pathology and synovial angiogenesis in both antigen-induced and collagen-induced models of arthritis. Arthritis Rheum. 48 (2003) 2660-2669
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 2660-2669
-
-
Mould, A.W.1
Tonks, I.D.2
Cahill, M.M.3
-
44
-
-
0034644557
-
Selective downregulation of VEGF-A(165), VEGF-R(1), and decreased capillary density in patients with dilative but not ischemic cardiomyopathy
-
Abraham D., Hofbauer R., Schafer R., et al. Selective downregulation of VEGF-A(165), VEGF-R(1), and decreased capillary density in patients with dilative but not ischemic cardiomyopathy. Circ. Res. 87 (2000) 644-647
-
(2000)
Circ. Res.
, vol.87
, pp. 644-647
-
-
Abraham, D.1
Hofbauer, R.2
Schafer, R.3
-
45
-
-
0042490796
-
Vascular endothelial growth factor-B promotes in vivo angiogenesis
-
Silvestre J.S., Tamarat R., Ebrahimian T.G., et al. Vascular endothelial growth factor-B promotes in vivo angiogenesis. Circ. Res. 93 (2003) 114-123
-
(2003)
Circ. Res.
, vol.93
, pp. 114-123
-
-
Silvestre, J.S.1
Tamarat, R.2
Ebrahimian, T.G.3
-
46
-
-
0038037949
-
Expression analysis of vascular endothelial growth factors and their relationships to lymph node metastasis in human colorectal cancer
-
Kawakami M., Furuhata T., Kimura Y., et al. Expression analysis of vascular endothelial growth factors and their relationships to lymph node metastasis in human colorectal cancer. J. Exp. Clin. Cancer Res. 22 (2003) 229-237
-
(2003)
J. Exp. Clin. Cancer Res.
, vol.22
, pp. 229-237
-
-
Kawakami, M.1
Furuhata, T.2
Kimura, Y.3
-
47
-
-
0031011529
-
Proteolytic processing regulates receptor specificity and activity of VEGF-C
-
Joukov V., Sorsa T., Kumar V., et al. Proteolytic processing regulates receptor specificity and activity of VEGF-C. EMBO J. 16 (1997) 3898-3911
-
(1997)
EMBO J.
, vol.16
, pp. 3898-3911
-
-
Joukov, V.1
Sorsa, T.2
Kumar, V.3
-
48
-
-
0038481179
-
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis
-
Siegfried G., Basak A., Cromlish J.A., et al. The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis. J. Clin. Invest. 111 (2003) 1723-1732
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 1723-1732
-
-
Siegfried, G.1
Basak, A.2
Cromlish, J.A.3
-
49
-
-
2942668041
-
Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation
-
Saharinen P., Tammela T., Karkkainen M.J., and Alitalo K. Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol. 25 (2004) 387-395
-
(2004)
Trends Immunol.
, vol.25
, pp. 387-395
-
-
Saharinen, P.1
Tammela, T.2
Karkkainen, M.J.3
Alitalo, K.4
-
50
-
-
9144236286
-
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
-
Karkkainen M.J., Haiko P., Sainio K., et al. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat. Immunol. 5 (2004) 74-80
-
(2004)
Nat. Immunol.
, vol.5
, pp. 74-80
-
-
Karkkainen, M.J.1
Haiko, P.2
Sainio, K.3
-
51
-
-
0030453355
-
VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development
-
Kukk E., Lymboussaki A., Taira S., et al. VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. Development 122 (1996) 3829-3837
-
(1996)
Development
, vol.122
, pp. 3829-3837
-
-
Kukk, E.1
Lymboussaki, A.2
Taira, S.3
-
52
-
-
0036733564
-
Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis
-
Schoppmann S.F., Birner P., Stockl J., et al. Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am. J. Pathol. 161 (2002) 947-956
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 947-956
-
-
Schoppmann, S.F.1
Birner, P.2
Stockl, J.3
-
53
-
-
0034842967
-
Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma
-
Skobe M., Hamberg L.M., Hawighorst T., et al. Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma. Am. J. Pathol. 59 (2001) 893-903
-
(2001)
Am. J. Pathol.
, vol.59
, pp. 893-903
-
-
Skobe, M.1
Hamberg, L.M.2
Hawighorst, T.3
-
54
-
-
0033607817
-
Vascular endothelial growth factor (VEGF) and VEGF-C show overlapping binding sites in embryonic endothelia and distinct sites in differentiated adult endothelia
-
Lymboussaki A., Olofsson B., Eriksson U., and Alitalo K. Vascular endothelial growth factor (VEGF) and VEGF-C show overlapping binding sites in embryonic endothelia and distinct sites in differentiated adult endothelia. Circ. Res. 85 (1999) 992-999
-
(1999)
Circ. Res.
, vol.85
, pp. 992-999
-
-
Lymboussaki, A.1
Olofsson, B.2
Eriksson, U.3
Alitalo, K.4
-
55
-
-
0030973506
-
Hyperplasia of lymphatic vessels in VEGF-C transgenic mice
-
Jeltsch M., Kaipainen A., Joukov V., et al. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science 276 (1997) 1423-1425
-
(1997)
Science
, vol.276
, pp. 1423-1425
-
-
Jeltsch, M.1
Kaipainen, A.2
Joukov, V.3
-
56
-
-
0036310244
-
Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes
-
Saaristo A., Veikkola T., Enholm B., et al. Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes. FASEB J. 16 (2002) 1041-1049
-
(2002)
FASEB J.
, vol.16
, pp. 1041-1049
-
-
Saaristo, A.1
Veikkola, T.2
Enholm, B.3
-
57
-
-
0035970622
-
Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin
-
Enholm B., Karpanen T., Jeltsch M., et al. Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin. Circ. Res. 88 (2001) 623-629
-
(2001)
Circ. Res.
, vol.88
, pp. 623-629
-
-
Enholm, B.1
Karpanen, T.2
Jeltsch, M.3
-
58
-
-
0030851721
-
Genomic organization of human and mouse genes for vascular endothelial growth factor C
-
Chilov D., Kukk E., Taira S., et al. Genomic organization of human and mouse genes for vascular endothelial growth factor C. J. Biol. Chem. 272 (1997) 25176-25183
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 25176-25183
-
-
Chilov, D.1
Kukk, E.2
Taira, S.3
-
60
-
-
17744390184
-
Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
-
Mandriota S.J., Jussila L., Jeltsch M., et al. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J. 20 (2001) 672-682
-
(2001)
EMBO J.
, vol.20
, pp. 672-682
-
-
Mandriota, S.J.1
Jussila, L.2
Jeltsch, M.3
-
61
-
-
33644834225
-
Overexpression of cyclooxygenase-2 in gastric cancer correlates with the high abundance of vascular endothelial growth factor-C and lymphatic metastasis
-
Liu J., Yu H.G., Yu J.P., et al. Overexpression of cyclooxygenase-2 in gastric cancer correlates with the high abundance of vascular endothelial growth factor-C and lymphatic metastasis. Med. Oncol. 22 (2005) 389-398
-
(2005)
Med. Oncol.
, vol.22
, pp. 389-398
-
-
Liu, J.1
Yu, H.G.2
Yu, J.P.3
-
62
-
-
23844550392
-
High lymphatic vessel density correlates with overexpression of VEGF-C in gastric cancer
-
Hachisuka T., Narikiyo M., Yamada Y., et al. High lymphatic vessel density correlates with overexpression of VEGF-C in gastric cancer. Oncol. Rep. 13 (2005) 733-737
-
(2005)
Oncol. Rep.
, vol.13
, pp. 733-737
-
-
Hachisuka, T.1
Narikiyo, M.2
Yamada, Y.3
-
63
-
-
4143145525
-
Clinical implication of expression of vascular endothelial growth factor-C in metastatic lymph nodes of uterine cervical cancers
-
Fujimoto J., Toyoki H., Sato E., et al. Clinical implication of expression of vascular endothelial growth factor-C in metastatic lymph nodes of uterine cervical cancers. Br. J. Cancer 91 (2004) 466-469
-
(2004)
Br. J. Cancer
, vol.91
, pp. 466-469
-
-
Fujimoto, J.1
Toyoki, H.2
Sato, E.3
-
64
-
-
1242269816
-
Role of lymphangiogenic factors in tumor metastasis
-
He Y., Karpanen T., and Alitalo K. Role of lymphangiogenic factors in tumor metastasis. Biochim. Biophys. Acta 1654 (2004) 3-12
-
(2004)
Biochim. Biophys. Acta
, vol.1654
, pp. 3-12
-
-
He, Y.1
Karpanen, T.2
Alitalo, K.3
-
65
-
-
0033591045
-
Restricted expression pattern of vegf-d in the adult and fetal mouse: high expression in the embryonic lung
-
Farnebo F., Piehl F., and Lagercrantz J. Restricted expression pattern of vegf-d in the adult and fetal mouse: high expression in the embryonic lung. Biochem. Biophys. Res. Commun. 257 (1999) 891-894
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.257
, pp. 891-894
-
-
Farnebo, F.1
Piehl, F.2
Lagercrantz, J.3
-
66
-
-
31544456384
-
Vascular endothelial growth factor-D is a survival factor for human breast carcinoma cells
-
Akahane M., Akahane T., Matheny S.L., et al. Vascular endothelial growth factor-D is a survival factor for human breast carcinoma cells. Int. J. Cancer 118 (2006) 841-849
-
(2006)
Int. J. Cancer
, vol.118
, pp. 841-849
-
-
Akahane, M.1
Akahane, T.2
Matheny, S.L.3
-
67
-
-
5044240149
-
Vascular endothelial growth factor receptor-3 in hypoxia-induced vascular development
-
Nilsson I., Rolny C., Wu Y., et al. Vascular endothelial growth factor receptor-3 in hypoxia-induced vascular development. FASEB J. 18 (2004) 1507-1515
-
(2004)
FASEB J.
, vol.18
, pp. 1507-1515
-
-
Nilsson, I.1
Rolny, C.2
Wu, Y.3
-
68
-
-
0037714018
-
VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses
-
Rissanen T.T., Markkanen J.E., Gruchala M., et al. VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses. Circ. Res. 92 (2003) 1098-1106
-
(2003)
Circ. Res.
, vol.92
, pp. 1098-1106
-
-
Rissanen, T.T.1
Markkanen, J.E.2
Gruchala, M.3
-
69
-
-
0037097816
-
Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo
-
Byzova T.V., Goldman C.K., Jankau J., et al. Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo. Blood 99 (2002) 4434-4442
-
(2002)
Blood
, vol.99
, pp. 4434-4442
-
-
Byzova, T.V.1
Goldman, C.K.2
Jankau, J.3
-
70
-
-
0035126049
-
VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
-
Stacker S.A., Caesar C., Baldwin M.E., et al. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat. Med. 7 (2001) 186-191
-
(2001)
Nat. Med.
, vol.7
, pp. 186-191
-
-
Stacker, S.A.1
Caesar, C.2
Baldwin, M.E.3
-
71
-
-
0035150839
-
Localization of vascular endothelial growth factor-D in malignant melanoma suggests a role in tumour angiogenesis
-
Achen M.G., Williams R.A., Minekus M.P., et al. Localization of vascular endothelial growth factor-D in malignant melanoma suggests a role in tumour angiogenesis. J. Pathol. 193 (2001) 147-154
-
(2001)
J. Pathol.
, vol.193
, pp. 147-154
-
-
Achen, M.G.1
Williams, R.A.2
Minekus, M.P.3
-
72
-
-
24344509918
-
Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer
-
Von Marschall Z., Scholz A., Stacker S.A., et al. Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer. Int. J. Oncol. 27 (2005) 669-679
-
(2005)
Int. J. Oncol.
, vol.27
, pp. 669-679
-
-
Von Marschall, Z.1
Scholz, A.2
Stacker, S.A.3
-
73
-
-
19944390993
-
Clinical significance of VEGF-A, -C and -D expression in esophageal malignancies
-
Kleespies A., Bruns C.J., and Jauch K.W. Clinical significance of VEGF-A, -C and -D expression in esophageal malignancies. Onkologie 28 (2005) 281-288
-
(2005)
Onkologie
, vol.28
, pp. 281-288
-
-
Kleespies, A.1
Bruns, C.J.2
Jauch, K.W.3
-
74
-
-
3843135260
-
Enhancement of pleural dissemination and lymph node metastasis of intrathoracic lung cancer cells by vascular endothelial growth factors (VEGFs)
-
Ishii H., Yazawa T., Sato H., et al. Enhancement of pleural dissemination and lymph node metastasis of intrathoracic lung cancer cells by vascular endothelial growth factors (VEGFs). Lung Cancer 45 (2004) 325-337
-
(2004)
Lung Cancer
, vol.45
, pp. 325-337
-
-
Ishii, H.1
Yazawa, T.2
Sato, H.3
-
75
-
-
0027979253
-
Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus
-
Lyttle D.J., Fraser K.M., Fleming S.B., et al. Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus. J. Virol. 68 (1994) 84-92
-
(1994)
J. Virol.
, vol.68
, pp. 84-92
-
-
Lyttle, D.J.1
Fraser, K.M.2
Fleming, S.B.3
-
76
-
-
0032553299
-
A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain
-
Ogawa S., Oku A., Sawano A., et al. A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain. J. Biol. Chem. 273 (1998) 31273-31282
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 31273-31282
-
-
Ogawa, S.1
Oku, A.2
Sawano, A.3
-
77
-
-
0033556287
-
A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases
-
Meyer M., Clauss M., Lepple-Wienhues A., et al. A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases. EMBO J. 18 (1999) 363-374
-
(1999)
EMBO J.
, vol.18
, pp. 363-374
-
-
Meyer, M.1
Clauss, M.2
Lepple-Wienhues, A.3
-
78
-
-
13044287362
-
Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1
-
Wise L.M., Veikkola T., Mercer A.A., et al. Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 3071-3076
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 3071-3076
-
-
Wise, L.M.1
Veikkola, T.2
Mercer, A.A.3
-
79
-
-
0037631338
-
NZ-7, is essential for the activation of VEGFR-2 signaling
-
NZ-7, is essential for the activation of VEGFR-2 signaling. J. Biol. Chem. 278 (2003) 13453-13461
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13453-13461
-
-
Kiba, A.1
Yabana, N.2
Shibuya, M.3
-
80
-
-
0032890336
-
Structure, expression and receptor-binding properties of placenta growth factor (PlGF)
-
Claesson-Welsh L. (Ed), Springer-Verlag, Berlin
-
Persico M.G., Vincenti V., and DiPalma T. Structure, expression and receptor-binding properties of placenta growth factor (PlGF). In: Claesson-Welsh L. (Ed). Vascular Growth Factors and Angiogenesis (1999), Springer-Verlag, Berlin 31-40
-
(1999)
Vascular Growth Factors and Angiogenesis
, pp. 31-40
-
-
Persico, M.G.1
Vincenti, V.2
DiPalma, T.3
-
81
-
-
0037703184
-
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
-
Autiero M., Waltenberger J., Communi D., et al. Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat. Med. 9 (2003) 936-943
-
(2003)
Nat. Med.
, vol.9
, pp. 936-943
-
-
Autiero, M.1
Waltenberger, J.2
Communi, D.3
-
82
-
-
0028134936
-
Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
-
Park J.E., Chen H.H., Winer J., et al. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. Biol. Chem. 269 (1994) 25646-25654
-
(1994)
Biol. Chem.
, vol.269
, pp. 25646-25654
-
-
Park, J.E.1
Chen, H.H.2
Winer, J.3
-
83
-
-
0038692867
-
VEGF-A(164/165) and PlGF: roles in angiogenesis and arteriogenesis
-
Nagy J.A., Dvorak A.M., and Dvorak H.F. VEGF-A(164/165) and PlGF: roles in angiogenesis and arteriogenesis. Trends Cardiovasc. Med. 13 (2003) 169-175
-
(2003)
Trends Cardiovasc. Med.
, vol.13
, pp. 169-175
-
-
Nagy, J.A.1
Dvorak, A.M.2
Dvorak, H.F.3
-
84
-
-
19244379078
-
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
-
Carmeliet P., Moons L., Luttun A., et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med. 7 (2001) 575-583
-
(2001)
Nat. Med.
, vol.7
, pp. 575-583
-
-
Carmeliet, P.1
Moons, L.2
Luttun, A.3
-
85
-
-
0037096168
-
Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability
-
Odorisio T., Schietroma C., Zaccaria M.L., et al. Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability. J. Cell Sci. 115 (2002) 2559-2567
-
(2002)
J. Cell Sci.
, vol.115
, pp. 2559-2567
-
-
Odorisio, T.1
Schietroma, C.2
Zaccaria, M.L.3
-
86
-
-
0037438583
-
A critical role of placental growth factor in the induction of inflammation and edema formation
-
Oura H., Bertoncini J., Velasco P., et al. A critical role of placental growth factor in the induction of inflammation and edema formation. Blood 101 (2003) 560-567
-
(2003)
Blood
, vol.101
, pp. 560-567
-
-
Oura, H.1
Bertoncini, J.2
Velasco, P.3
-
87
-
-
17644379417
-
Placenta growth factor expression is correlated with survival of patients with colorectal cancer
-
Wei S.C., Tsao P.N., Yu S.C., et al. Placenta growth factor expression is correlated with survival of patients with colorectal cancer. Gut 54 (2005) 666-672
-
(2005)
Gut
, vol.54
, pp. 666-672
-
-
Wei, S.C.1
Tsao, P.N.2
Yu, S.C.3
-
88
-
-
24744450546
-
Placenta growth factor stimulates the growth of Philadelphia chromosome positive acute lymphoblastic leukemia cells by both autocrine and paracrine pathways
-
Ikai T., Miwa H., Shikami M., et al. Placenta growth factor stimulates the growth of Philadelphia chromosome positive acute lymphoblastic leukemia cells by both autocrine and paracrine pathways. Eur. J. Haematol. 75 (2005) 273-279
-
(2005)
Eur. J. Haematol.
, vol.75
, pp. 273-279
-
-
Ikai, T.1
Miwa, H.2
Shikami, M.3
-
89
-
-
16844366948
-
Vascular endothelial growth factor: a therapeutic target for tumors of the Ewing's sarcoma family
-
Dalal S., Berry A.M., Cullinane C.J., et al. Vascular endothelial growth factor: a therapeutic target for tumors of the Ewing's sarcoma family. Clin. Cancer Res. 11 (2005) 2364-2378
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 2364-2378
-
-
Dalal, S.1
Berry, A.M.2
Cullinane, C.J.3
-
90
-
-
20544458863
-
Identification of the heparin-binding region of snake venom vascular endothelial growth factor (VEGF-F) and its blocking of VEGF-A165
-
Yamazaki Y., Tokunaga Y., Takani K., et al. Identification of the heparin-binding region of snake venom vascular endothelial growth factor (VEGF-F) and its blocking of VEGF-A165. Biochemistry 44 (2005) 8858-8864
-
(2005)
Biochemistry
, vol.44
, pp. 8858-8864
-
-
Yamazaki, Y.1
Tokunaga, Y.2
Takani, K.3
-
91
-
-
0025259592
-
Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family
-
Shibuya M., Yamaguchi S., Yamane A., et al. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 5 (1990) 519-524
-
(1990)
Oncogene
, vol.5
, pp. 519-524
-
-
Shibuya, M.1
Yamaguchi, S.2
Yamane, A.3
-
92
-
-
0027424647
-
Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth
-
Peters K.G., De Vries C., and Williams L.T. Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 8915-8919
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 8915-8919
-
-
Peters, K.G.1
De Vries, C.2
Williams, L.T.3
-
93
-
-
0029021660
-
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
-
Fong G.H., Rossant J., Gertsenstein M., and Breitman M.L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376 (1995) 66-70
-
(1995)
Nature
, vol.376
, pp. 66-70
-
-
Fong, G.H.1
Rossant, J.2
Gertsenstein, M.3
Breitman, M.L.4
-
94
-
-
0035895711
-
Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family
-
Zachary I., and Gliki G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc. Res. 49 (2001) 568-581
-
(2001)
Cardiovasc. Res.
, vol.49
, pp. 568-581
-
-
Zachary, I.1
Gliki, G.2
-
95
-
-
0030751493
-
Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia
-
Gerber H.P., Condorelli F., Park J., and Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J. Biol. Chem. 272 (1997) 23659-23667
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 23659-23667
-
-
Gerber, H.P.1
Condorelli, F.2
Park, J.3
Ferrara, N.4
-
96
-
-
0029867554
-
Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
-
Barleon B., Sozzani S., Zhou D., et al. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87 (1996) 3336-3343
-
(1996)
Blood
, vol.87
, pp. 3336-3343
-
-
Barleon, B.1
Sozzani, S.2
Zhou, D.3
-
97
-
-
0029929716
-
The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis
-
Clauss M., Weich H., Breier G., et al. The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J. Biol. Chem. 271 (1996) 17629-17634
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 17629-17634
-
-
Clauss, M.1
Weich, H.2
Breier, G.3
-
98
-
-
0035160312
-
Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
-
Lyden D., Hattori K., Dias S., et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat. Med. 7 (2001) 1194-1201
-
(2001)
Nat. Med.
, vol.7
, pp. 1194-1201
-
-
Lyden, D.1
Hattori, K.2
Dias, S.3
-
99
-
-
0036862208
-
Modulation of human NK cell lines by vascular endothelial growth factor and receptor VEGFR-1 (FLT-1)
-
Chen W.S., Kitson R.P., and Goldfarb R.H. Modulation of human NK cell lines by vascular endothelial growth factor and receptor VEGFR-1 (FLT-1). In Vivo 16 (2002) 439-445
-
(2002)
In Vivo
, vol.16
, pp. 439-445
-
-
Chen, W.S.1
Kitson, R.P.2
Goldfarb, R.H.3
-
100
-
-
0037423321
-
Angiogenesis-independent endothelial protection of liver: role of VEGFR-1
-
LeCouter J., Moritz D.R., Li B., et al. Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science 299 (2003) 890-893
-
(2003)
Science
, vol.299
, pp. 890-893
-
-
LeCouter, J.1
Moritz, D.R.2
Li, B.3
-
101
-
-
0043156081
-
Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor
-
Selvaraj S.K., Giri R.K., Perelman N., et al. Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor. Blood 102 (2003) 1515-1524
-
(2003)
Blood
, vol.102
, pp. 1515-1524
-
-
Selvaraj, S.K.1
Giri, R.K.2
Perelman, N.3
-
102
-
-
0036344496
-
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
-
Hattori K., Heissig B., Wu Y., et al. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat. Med. 8 (2002) 841-849
-
(2002)
Nat. Med.
, vol.8
, pp. 841-849
-
-
Hattori, K.1
Heissig, B.2
Wu, Y.3
-
103
-
-
0036344495
-
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
-
Luttun A., Tjwa M., Moons L., et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. 8 (2002) 831-840
-
(2002)
Nat. Med.
, vol.8
, pp. 831-840
-
-
Luttun, A.1
Tjwa, M.2
Moons, L.3
-
104
-
-
0037423858
-
VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocyte-mediated mechanism
-
Pipp F., Heil M., Issbrucker K., et al. VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocyte-mediated mechanism. Circ. Res. 92 (2003) 378-385
-
(2003)
Circ. Res.
, vol.92
, pp. 378-385
-
-
Pipp, F.1
Heil, M.2
Issbrucker, K.3
-
105
-
-
0027421333
-
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
-
Kendall R.L., and Thomas K.A. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 10705-10709
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 10705-10709
-
-
Kendall, R.L.1
Thomas, K.A.2
-
106
-
-
0037389767
-
Levels of soluble vascular endothelial growth factor (VEGF) receptor 1 in astrocytic tumors and its relation to malignancy, vascularity, and VEGF-A
-
Lamszus K., Ulbricht U., Matschke J., et al. Levels of soluble vascular endothelial growth factor (VEGF) receptor 1 in astrocytic tumors and its relation to malignancy, vascularity, and VEGF-A. Clin. Cancer Res. 9 (2003) 1399-1405
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1399-1405
-
-
Lamszus, K.1
Ulbricht, U.2
Matschke, J.3
-
107
-
-
0036497957
-
Significance of vascular endothelial growth factor (VEGF)/soluble VEGF receptor-1 relationship in breast cancer
-
Toi M., Bando H., Ogawa T., et al. Significance of vascular endothelial growth factor (VEGF)/soluble VEGF receptor-1 relationship in breast cancer. Int. J. Cancer 98 (2002) 14-18
-
(2002)
Int. J. Cancer
, vol.98
, pp. 14-18
-
-
Toi, M.1
Bando, H.2
Ogawa, T.3
-
108
-
-
0025739016
-
Identification of a new endothelial cell growth factor receptor tyrosine kinase
-
Terman B.I., Carrion M.E., Kovacs E., et al. Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6 (1991) 1677-1683
-
(1991)
Oncogene
, vol.6
, pp. 1677-1683
-
-
Terman, B.I.1
Carrion, M.E.2
Kovacs, E.3
-
109
-
-
0025998533
-
A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit
-
Matthews W., Jordan C.T., Gavin M., et al. A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 9026-9030
-
(1991)
Proc. Natl. Acad. Sci. U. S. A.
, vol.88
, pp. 9026-9030
-
-
Matthews, W.1
Jordan, C.T.2
Gavin, M.3
-
110
-
-
0027466849
-
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
-
Millauer B., Wizigmann-Voos S., Schnurch H., et al. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72 (1993) 835-846
-
(1993)
Cell
, vol.72
, pp. 835-846
-
-
Millauer, B.1
Wizigmann-Voos, S.2
Schnurch, H.3
-
111
-
-
0031008750
-
The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts
-
Takahashi T., and Shibuya M. The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts. Oncogene 14 (1997) 2079-2089
-
(1997)
Oncogene
, vol.14
, pp. 2079-2089
-
-
Takahashi, T.1
Shibuya, M.2
-
113
-
-
0035355472
-
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
-
Takahashi T., Yamaguchi S., Chida K., and Shibuya M. A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. EMBO J. 20 (2001) 2768-2778
-
(2001)
EMBO J.
, vol.20
, pp. 2768-2778
-
-
Takahashi, T.1
Yamaguchi, S.2
Chida, K.3
Shibuya, M.4
-
114
-
-
0033451902
-
Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors
-
Partanen T.A., Alitalo K., and Miettinen M. Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors. Cancer 86 (1999) 2406-2412
-
(1999)
Cancer
, vol.86
, pp. 2406-2412
-
-
Partanen, T.A.1
Alitalo, K.2
Miettinen, M.3
-
115
-
-
1842830358
-
Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels
-
Baffert F., Thurston G., Rochon-Duck M., et al. Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels. Circ. Res. 94 (2004) 984-992
-
(2004)
Circ. Res.
, vol.94
, pp. 984-992
-
-
Baffert, F.1
Thurston, G.2
Rochon-Duck, M.3
-
116
-
-
1842293350
-
Flk-1 expression defines a population of early embryonic hematopoietic precursors
-
Kabrun N., Buhring H.J., Choi K., et al. Flk-1 expression defines a population of early embryonic hematopoietic precursors. Development 124 (1997) 2039-2048
-
(1997)
Development
, vol.124
, pp. 2039-2048
-
-
Kabrun, N.1
Buhring, H.J.2
Choi, K.3
-
117
-
-
0035793623
-
Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants
-
Gille H., Kowalski J., Li B., et al. Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants. J. Biol. Chem. 276 (2001) 3222-3230
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 3222-3230
-
-
Gille, H.1
Kowalski, J.2
Li, B.3
-
118
-
-
0032515047
-
Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
-
Gerber H.P., McMurtrey A., Kowalski J., et al. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem. 273 (1998) 30336-30343
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 30336-30343
-
-
Gerber, H.P.1
McMurtrey, A.2
Kowalski, J.3
-
119
-
-
13944260479
-
Angiogenesis inhibition by vascular endothelial growth factor receptor-2 blockade reduces stromal matrix metalloproteinase expression, normalizes stromal tissue, and reverts epithelial tumor phenotype in surface heterotransplants
-
Vosseler S., Mirancea N., Bohlen P., et al. Angiogenesis inhibition by vascular endothelial growth factor receptor-2 blockade reduces stromal matrix metalloproteinase expression, normalizes stromal tissue, and reverts epithelial tumor phenotype in surface heterotransplants. Cancer Res. 65 (2005) 1294-1305
-
(2005)
Cancer Res.
, vol.65
, pp. 1294-1305
-
-
Vosseler, S.1
Mirancea, N.2
Bohlen, P.3
-
120
-
-
22144495334
-
Angiogenesis and radiation response modulation after vascular endothelial growth factor receptor-2 (VEGFR2) blockade
-
Li J., Huang S., Armstrong E.A., et al. Angiogenesis and radiation response modulation after vascular endothelial growth factor receptor-2 (VEGFR2) blockade. Int. J. Radiat. Oncol. Biol. Phys. 62 (2005) 1477-1485
-
(2005)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.62
, pp. 1477-1485
-
-
Li, J.1
Huang, S.2
Armstrong, E.A.3
-
121
-
-
0028091775
-
Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors
-
Pajusola K., Aprelikova O., Pelicci G., et al. Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors. Oncogene 9 (1994) 3545-3555
-
(1994)
Oncogene
, vol.9
, pp. 3545-3555
-
-
Pajusola, K.1
Aprelikova, O.2
Pelicci, G.3
-
122
-
-
0034946248
-
Alternative splicing of the human VEGFGR-3/FLT4 gene as a consequence of an integrated human endogenous retrovirus
-
Hughes D.C. Alternative splicing of the human VEGFGR-3/FLT4 gene as a consequence of an integrated human endogenous retrovirus. J. Mol. Evol. 53 (2001) 77-79
-
(2001)
J. Mol. Evol.
, vol.53
, pp. 77-79
-
-
Hughes, D.C.1
-
123
-
-
0242443253
-
Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function
-
Veikkola T., Lohela M., Ikenberg K., et al. Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function. FASEB J. 17 (2003) 2006-2013
-
(2003)
FASEB J.
, vol.17
, pp. 2006-2013
-
-
Veikkola, T.1
Lohela, M.2
Ikenberg, K.3
-
124
-
-
0034041161
-
Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
-
Karkkainen M.J., Ferrell R.E., Lawrence E.C., et al. Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema. Nat. Genet. 25 (2000) 153-159
-
(2000)
Nat. Genet.
, vol.25
, pp. 153-159
-
-
Karkkainen, M.J.1
Ferrell, R.E.2
Lawrence, E.C.3
-
126
-
-
4043049430
-
Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
-
Chen L., Hamrah P., Cursiefen C., et al. Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity. Nat. Med. 10 (2004) 813-815
-
(2004)
Nat. Med.
, vol.10
, pp. 813-815
-
-
Chen, L.1
Hamrah, P.2
Cursiefen, C.3
-
127
-
-
0033846016
-
Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing
-
Paavonen K., Puolakkainen P., Jussila L., et al. Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am. J. Pathol. 156 (2000) 1499-1504
-
(2000)
Am. J. Pathol.
, vol.156
, pp. 1499-1504
-
-
Paavonen, K.1
Puolakkainen, P.2
Jussila, L.3
-
128
-
-
25444485785
-
Expression of vascular endothelial growth factor C (VEGF-C) and VEGF receptor-3 in human prostate cancer is associated with regional lymph node metastasis
-
Jennbacken K., Vallbo C., Wang W., and Damber J.E. Expression of vascular endothelial growth factor C (VEGF-C) and VEGF receptor-3 in human prostate cancer is associated with regional lymph node metastasis. Prostate 65 (2005) 110-116
-
(2005)
Prostate
, vol.65
, pp. 110-116
-
-
Jennbacken, K.1
Vallbo, C.2
Wang, W.3
Damber, J.E.4
-
129
-
-
0032933883
-
VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer
-
Valtola R., Salven P., Heikkila P., et al. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer. Am. J. Pathol. 154 (1999) 1381-1390
-
(1999)
Am. J. Pathol.
, vol.154
, pp. 1381-1390
-
-
Valtola, R.1
Salven, P.2
Heikkila, P.3
-
130
-
-
21144437844
-
Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
-
He Y., Rajantie I., Pajusola K., et al. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res. 65 (2005) 4739-4746
-
(2005)
Cancer Res.
, vol.65
, pp. 4739-4746
-
-
He, Y.1
Rajantie, I.2
Pajusola, K.3
-
131
-
-
0034531849
-
Neuropilin is a mediator of angiogenesis
-
Miao H.Q., and Klagsbrun M. Neuropilin is a mediator of angiogenesis. Cancer Metastasis Rev. 19 (2000) 29-37
-
(2000)
Cancer Metastasis Rev.
, vol.19
, pp. 29-37
-
-
Miao, H.Q.1
Klagsbrun, M.2
-
132
-
-
0034282885
-
The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1
-
Fuh G., Garcia K.C., and de Vos A.M. The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1. J. Biol. Chem. 275 (2000) 26690-26695
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 26690-26695
-
-
Fuh, G.1
Garcia, K.C.2
de Vos, A.M.3
-
133
-
-
0036942108
-
Neuropilins as Semaphorin receptors: in vivo functions in neuronal cell migration and axon guidance
-
Bagri A., and Tessier-Lavigne M. Neuropilins as Semaphorin receptors: in vivo functions in neuronal cell migration and axon guidance. Adv. Exp. Med. Biol. 515 (2002) 13-31
-
(2002)
Adv. Exp. Med. Biol.
, vol.515
, pp. 13-31
-
-
Bagri, A.1
Tessier-Lavigne, M.2
-
134
-
-
0029562097
-
Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs
-
Kitsukawa T., Shimono A., Kawakami A., et al. Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs. Development 121 (1995) 4309-4318
-
(1995)
Development
, vol.121
, pp. 4309-4318
-
-
Kitsukawa, T.1
Shimono, A.2
Kawakami, A.3
-
135
-
-
0032549799
-
Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
-
Soker S., Takashima S., Miao H.Q., et al. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92 (1998) 735-745
-
(1998)
Cell
, vol.92
, pp. 735-745
-
-
Soker, S.1
Takashima, S.2
Miao, H.Q.3
-
136
-
-
0345411635
-
Neuropilin-1 is expressed on bone marrow stromal cells: a novel interaction with hematopoietic cells?
-
Tordjman R., Ortega N., Coulombel L., et al. Neuropilin-1 is expressed on bone marrow stromal cells: a novel interaction with hematopoietic cells?. Blood 94 (1999) 2301-2309
-
(1999)
Blood
, vol.94
, pp. 2301-2309
-
-
Tordjman, R.1
Ortega, N.2
Coulombel, L.3
-
138
-
-
33344474679
-
Neuropilins in neoplasms: expression, regulation, and function
-
Bielenberg D.R., Pettaway C.A., Takashima S., et al. Neuropilins in neoplasms: expression, regulation, and function. Exp. Cell Res. 312 (2006) 584-593
-
(2006)
Exp. Cell Res.
, vol.312
, pp. 584-593
-
-
Bielenberg, D.R.1
Pettaway, C.A.2
Takashima, S.3
-
139
-
-
0000767476
-
Angiogenesis
-
Sporn M.B., and Roberts A.B. (Eds), Springer-Verlag, New York
-
Klagsbrun M., and Folkman J. Angiogenesis. In: Sporn M.B., and Roberts A.B. (Eds). Peptide Growth Factors and their Receptors (1991), Springer-Verlag, New York 549-586
-
(1991)
Peptide Growth Factors and their Receptors
, pp. 549-586
-
-
Klagsbrun, M.1
Folkman, J.2
-
140
-
-
0034756449
-
Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins
-
Herzog Y., Kalcheim C., Kahane N., et al. Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins. Mech. Dev. 109 (2001) 115-119
-
(2001)
Mech. Dev.
, vol.109
, pp. 115-119
-
-
Herzog, Y.1
Kalcheim, C.2
Kahane, N.3
-
141
-
-
0036803751
-
Abnormal lymphatic vessel development in neuropilin 2 mutant mice
-
Yuan L., Moyon D., Pardanaud L., et al. Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development 129 (2002) 4797-4806
-
(2002)
Development
, vol.129
, pp. 4797-4806
-
-
Yuan, L.1
Moyon, D.2
Pardanaud, L.3
-
142
-
-
0032707249
-
A requirement for neuropilin-1 in embryonic vessel formation
-
Kawasaki T., Kitsukawa T., Bekku Y., et al. A requirement for neuropilin-1 in embryonic vessel formation. Development 126 (1999) 4895-4902
-
(1999)
Development
, vol.126
, pp. 4895-4902
-
-
Kawasaki, T.1
Kitsukawa, T.2
Bekku, Y.3
-
143
-
-
0034646262
-
Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: in vivo expression and antitumor activity
-
Gagnon M.L., Bielenberg D.R., Gechtman Z., et al. Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: in vivo expression and antitumor activity. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 2573-2578
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 2573-2578
-
-
Gagnon, M.L.1
Bielenberg, D.R.2
Gechtman, Z.3
|