-
1
-
-
0026612521
-
FAK, a structurally distinctive protein-tyrosine kinase associated with focal adhesions
-
M. D. Schaller, C. A. Borgman, B. S. Cobb, R. R. Vines, A. B. Reynolds, J. T. Parsons, PP125FAK, a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc. Natl. Acad. Sci. U.S.A. 89, 5192-5196 (1992).
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 5192-5196
-
-
Schaller, M.D.1
Borgman, C.A.2
Cobb, B.S.3
Vines, R.R.4
Reynolds, A.B.5
Parsons, J.T.6
-
2
-
-
0034730632
-
The focal adhesion kinase suppresses transformationassociated, anchorage-independent apoptosis in human breast cancer cells
-
L. H. Xu, X. Yang, C. A. Bradham, D. A. Brenner, A. S. Baldwin, R. J. Craven, W. G. Cance, The focal adhesion kinase suppresses transformationassociated, anchorage-independent apoptosis in human breast cancer cells. J. Biol. Chem. 275, 30597-30604 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 30597-30604
-
-
Xu, L.H.1
Yang, X.2
Bradham, C.A.3
Brenner, D.A.4
Baldwin, A.S.5
Craven, R.J.6
Cance, W.G.7
-
3
-
-
42949160485
-
P53 regulates FAK expression in human tumor cells
-
V. M. Golubovskaya, R. Finch, F. Kweh, N. A. Massoll, M. Campbell-Thompson, M. R.Wallace, W. G. Cance, p53 regulates FAK expression in human tumor cells. Mol. Carcinog. 47, 373-382 (2008).
-
(2008)
Mol. Carcinog.
, vol.47
, pp. 373-382
-
-
Golubovskaya, V.M.1
Finch, R.2
Kweh, F.3
Massoll, N.A.4
Campbell-Thompson, M.5
Wallace, M.R.6
Cance, W.G.7
-
4
-
-
0027448821
-
Expression of focal adhesion kinase gene and invasive cancer
-
T. M.Weiner, E. T. Liu, R. J. Craven, W. G. Cance, Expression of focal adhesion kinase gene and invasive cancer. Lancet 342, 1024-1025 (1993).
-
(1993)
Lancet
, vol.342
, pp. 1024-1025
-
-
Weiner, T.M.1
Liu, E.T.2
Craven, R.J.3
Cance, W.G.4
-
5
-
-
0029690892
-
Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer
-
L. V. Owens, L. Xu, G. A. Dent, X. Yang, G. C. Sturge, R. J. Craven, W. G. Cance, Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer. Ann. Surg. Oncol. 3, 100-105 (1996).
-
(1996)
Ann. Surg. Oncol.
, vol.3
, pp. 100-105
-
-
Owens, L.V.1
Xu, L.2
Dent, G.A.3
Yang, X.4
Sturge, G.C.5
Craven, R.J.6
Cance, W.G.7
-
6
-
-
0029039421
-
Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors
-
L. V. Owens, L. Xu, R. J. Craven, G. A. Dent, T. M. Weiner, L. Kornberg, E. T. Liu, W. G. Cance, Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res. 55, 2752-2755 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 2752-2755
-
-
Owens, L.V.1
Xu, L.2
Craven, R.J.3
Dent, G.A.4
Weiner, T.M.5
Kornberg, L.6
Liu, E.T.7
Cance, W.G.8
-
7
-
-
9644275426
-
Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis
-
H. M. Lightfoot, A. Lark, C. A. Livasy, D. T. Moore, D. Cowan, L. Dressler, R. J. Craven, W. G. Cance, Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. Breast Cancer Res. Treat. 88, 109-116 (2004).
-
(2004)
Breast Cancer Res. Treat.
, vol.88
, pp. 109-116
-
-
Lightfoot, H.M.1
Lark, A.2
Livasy, C.A.3
Moore, D.T.4
Cowan, D.5
Dressler, L.6
Craven, R.J.7
Cance, W.G.8
-
8
-
-
0037237066
-
Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: Immunohistochemistry and real-time PCR analyses
-
A. L. Lark, C. A. Livasy, B. Calvo, L. Caskey, D. T. Moore, X. Yang, W. G. Cance, Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: Immunohistochemistry and real-time PCR analyses. Clin. Cancer Res. 9, 215-222 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 215-222
-
-
Lark, A.L.1
Livasy, C.A.2
Calvo, B.3
Caskey, L.4
Moore, D.T.5
Yang, X.6
Cance, W.G.7
-
9
-
-
0034044795
-
Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: Correlation with preinvasive and invasive phenotypes
-
W. G. Cance, J. E. Harris, M. V. Iacocca, E. Roche, X. Yang, J. Chang, S. Simkins, L. Xu, Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: Correlation with preinvasive and invasive phenotypes. Clin. Cancer Res. 6, 2417-2423 (2000).
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2417-2423
-
-
Cance, W.G.1
Harris, J.E.2
Iacocca, M.V.3
Roche, E.4
Yang, X.5
Chang, J.6
Simkins, S.7
Xu, L.8
-
10
-
-
21644466387
-
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53*
-
V. M. Golubovskaya, R. Finch, W. G. Cance, Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53*. J. Biol. Chem. 280, 25008-25021 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 25008-25021
-
-
Golubovskaya, V.M.1
Finch, R.2
Cance, W.G.3
-
11
-
-
34548085454
-
Focal adhesion kinase and p53 signaling in cancer cells
-
V. M. Golubovskaya, W. G. Cance, Focal adhesion kinase and p53 signaling in cancer cells. Int. Rev. Cytol. 263, 103-153 (2007).
-
(2007)
Int. Rev. Cytol.
, vol.263
, pp. 103-153
-
-
Golubovskaya, V.M.1
Cance, W.G.2
-
12
-
-
38149070791
-
Nuclear FAK promotes cell proliferation and survival through FERMenhanced p53 degradation
-
S. T. Lim, X. L. Chen, Y. Lim, D. A. Hanson, T. T. Vo, K. Howerton, N. Larocque, S. J. Fisher, D. D. Schlaepfer, D. Ilic, Nuclear FAK promotes cell proliferation and survival through FERMenhanced p53 degradation. Mol. Cell 29, 9-22 (2008).
-
(2008)
Mol. Cell
, vol.29
, pp. 9-22
-
-
Lim, S.T.1
Chen, X.L.2
Lim, Y.3
Hanson, D.A.4
Vo, T.T.5
Howerton, K.6
Larocque, N.7
Fisher, S.J.8
Schlaepfer, D.D.9
Ilic, D.10
-
13
-
-
2442583529
-
Cloning and characterization of the promoter region of human focal adhesion kinase gene: Nuclear factor ?B and p53 binding sites
-
V. Golubovskaya, A. Kaur, W. G. Cance, Cloning and characterization of the promoter region of human focal adhesion kinase gene: Nuclear factor ?B and p53 binding sites. Biochim. Biophys. Acta 1678, 111-125 (2004).
-
(2004)
Biochim. Biophys. Acta
, vol.1678
, pp. 111-125
-
-
Golubovskaya, V.1
Kaur, A.2
Cance, W.G.3
-
14
-
-
84890067907
-
FAK overexpression and p53 mutations positively correlate in a populationbased series of breast cancer tumors
-
V. Golubovskaya, K. Conway-Dorsey, D. Moore, R. Millikan, W. G. Cance, FAK overexpression and p53 mutations positively correlate in a populationbased series of breast cancer tumors. American Association for Cancer Research Proceedings Supplement, late-breaking abstract LB-155, 49, 44 (2008).
-
(2008)
American Association for Cancer Research Proceedings Supplement, Late-breaking Abstract LB-155
, vol.49
, pp. 44
-
-
Golubovskaya, V.1
Conway-Dorsey, K.2
Moore, D.3
Millikan, R.4
Cance, W.G.5
-
15
-
-
2942531163
-
Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein
-
E. Kurenova, L. H. Xu, X. Yang, A. S. Baldwin Jr., R. J. Craven, S. K. Hanks, Z.-g. Liu, W. G. Cance, Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Mol. Cell. Biol. 24, 4361-4371 (2004).
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 4361-4371
-
-
Kurenova, E.1
Xu, L.H.2
Yang, X.3
Baldwin Jr., A.S.4
Craven, R.J.5
Hanks, S.K.6
Liu, Z.-G.7
Cance, W.G.8
-
16
-
-
0029054725
-
RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
-
B. Z. Stanger, P. Leder, T. H. Lee, E. Kim, B. Seed, RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81, 513-523 (1995).
-
(1995)
Cell
, vol.81
, pp. 513-523
-
-
Stanger, B.Z.1
Leder, P.2
Lee, T.H.3
Kim, E.4
Seed, B.5
-
17
-
-
0032033132
-
The death domain kinase RIP mediates the TNF-induced NF-?B signal
-
M. A. Kelliher, S. Grimm, Y. Ishida, F. Kuo, B. Z. Stanger, P. Leder, The death domain kinase RIP mediates the TNF-induced NF-?B signal. Immunity 8, 297-303 (1998).
-
(1998)
Immunity
, vol.8
, pp. 297-303
-
-
Kelliher, M.A.1
Grimm, S.2
Ishida, Y.3
Kuo, F.4
Stanger, B.Z.5
Leder, P.6
-
18
-
-
84890064231
-
-
personal communication
-
S. Frisch, personal communication.
-
-
-
Frisch, S.1
-
19
-
-
0033772308
-
FAK integrates growth factor and integrin signals to promote cell migration
-
D. J. Sieg, C. R. Hauck, D. Ilic, C. K. Klingbeil, E. Schaefer, C. H. Damsky, D. D. Schlaepfer, FAK integrates growth factor and integrin signals to promote cell migration. Nat. Cell Biol. 2, 249-256 (2000).
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 249-256
-
-
Sieg, D.J.1
Hauck, C.R.2
Ilic, D.3
Klingbeil, C.K.4
Schaefer, E.5
Damsky, C.H.6
Schlaepfer, D.D.7
-
20
-
-
0037064030
-
Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells
-
V. Golubovskaya, L. Beviglia, L. H. Xu, H. S. Earp III, R. Craven, W. Cance, Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. J. Biol. Chem. 277, 38978-38987 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 38978-38987
-
-
Golubovskaya, V.1
Beviglia, L.2
Xu, L.H.3
Earp III, H.S.4
Craven, R.5
Cance, W.6
-
21
-
-
33745468872
-
Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion
-
S. Y. Chen, H. C. Chen, Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion. Mol. Cell. Biol. 26, 5155-5167 (2006).
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 5155-5167
-
-
Chen, S.Y.1
Chen, H.C.2
-
22
-
-
32944475609
-
Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells
-
C. A. Garces, E. V. Kurenova, V. M. Golubovskaya, W. G. Cance, Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells. Cancer Res. 66, 1446-1454 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 1446-1454
-
-
Garces, C.A.1
Kurenova, E.V.2
Golubovskaya, V.M.3
Cance, W.G.4
-
23
-
-
0038005805
-
Focal adhesion kinase Nterminus in breast carcinoma cells induces rounding, detachment and apoptosis
-
L. Beviglia, V. Golubovskaya, L. Xu, X. Yang, R. J. Craven, W. G. Cance, Focal adhesion kinase Nterminus in breast carcinoma cells induces rounding, detachment and apoptosis. Biochem. J. 373, 201-210 (2003).
-
(2003)
Biochem. J.
, vol.373
, pp. 201-210
-
-
Beviglia, L.1
Golubovskaya, V.2
Xu, L.3
Yang, X.4
Craven, R.J.5
Cance, W.G.6
-
24
-
-
0035392952
-
Loss of focal adhesion kinase (FAK): Inhibits epidermal growth factor receptor-dependent migration and induces aggregation of nh(2)-terminal FAK in the nuclei of apoptotic glioblastoma cells
-
G. Jones, J. Machado Jr., A. Merlo, Loss of focal adhesion kinase (FAK) inhibits epidermal growth factor receptor-dependent migration and induces aggregation of nh(2)-terminal FAK in the nuclei of apoptotic glioblastoma cells. Cancer Res. 61, 4978-4981 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 4978-4981
-
-
Jones, G.1
Machado Jr., J.2
Merlo, A.3
-
25
-
-
0347356250
-
Nuclear import of N-terminal FAK by activation of the FcεRI receptor in RBL-2H3 cells
-
G. Jones, G. Stewart, Nuclear import of N-terminal FAK by activation of the FcεRI receptor in RBL-2H3 cells. Biochem. Biophys. Res. Commun. 314, 39-45 (2004).
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.314
, pp. 39-45
-
-
Jones, G.1
Stewart, G.2
-
26
-
-
0034610067
-
Nuclear localization and apoptotic regulation of an amino-terminal domain focal adhesion kinase fragment in endothelial cells
-
M. Lobo, I. Zachary, Nuclear localization and apoptotic regulation of an amino-terminal domain focal adhesion kinase fragment in endothelial cells. Biochem. Biophys. Res. Commun. 276, 1068-1074 (2000).
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.276
, pp. 1068-1074
-
-
Lobo, M.1
Zachary, I.2
-
27
-
-
0346220294
-
PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation
-
G. Kadare, M. Toutant, E. Formstecher, J. C. Corvol, M. Carnaud, M. C. Boutterin, J. A. Girault, PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation. J. Biol. Chem. 278, 47434-47440 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 47434-47440
-
-
Kadare, G.1
Toutant, M.2
Formstecher, E.3
Corvol, J.C.4
Carnaud, M.5
Boutterin, M.C.6
Girault, J.A.7
-
28
-
-
4644250606
-
Cytoplasmic p53: Bax and forward
-
J. E. Chipuk, D. R. Green, Cytoplasmic p53: Bax and Forward. Cell Cycle 3, 429-431 (2004).
-
(2004)
Cell Cycle
, vol.3
, pp. 429-431
-
-
Chipuk, J.E.1
Green, D.R.2
-
29
-
-
0842278331
-
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
-
J. E. Chipuk, T. Kuwana, L. Bouchier-Hayes, N. M. Droin, D. D. Newmeyer, M. Schuler, D. R. Green, Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303, 1010-1014 (2004).
-
(2004)
Science
, vol.303
, pp. 1010-1014
-
-
Chipuk, J.E.1
Kuwana, T.2
Bouchier-Hayes, L.3
Droin, N.M.4
Newmeyer, D.D.5
Schuler, M.6
Green, D.R.7
-
30
-
-
41649107660
-
The 7 amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in interaction with FAK and is critical for p53 functioning
-
V. Golubovskaya, R. Finch, M. Zheng, E. V. Kurenova, W. G. Cance, The 7 amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in interaction with FAK and is critical for p53 functioning. Biochem. J. 411, 151-160 (2008).
-
(2008)
Biochem. J.
, vol.411
, pp. 151-160
-
-
Golubovskaya, V.1
Finch, R.2
Zheng, M.3
Kurenova, E.V.4
Cance, W.G.5
-
31
-
-
48849112195
-
Focal adhesion kinase versus p53: Apoptosis or survival?
-
W. G. Cance, V. M. Golubovskaya, Focal adhesion kinase versus p53: Apoptosis or survival? Sci. Signal. 1, pe22 (2008).
-
(2008)
Sci. Signal
, vol.1
-
-
Cance, W.G.1
Golubovskaya, V.M.2
|