Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells

Cell Growth and Differentiation

Volumn 7, Issue 4, 1996, Pages 413-418

  Xu, Li Hui ^a   Owens, Lewis V ^a   Sturge, Glenn C ^a   Yang, Xihui ^a   Liu, Edison T ^a   Craven, Rolf J ^a   Cance, William G ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE;

APOPTOSIS; ARTICLE; CANCER; CANCER INVASION; CARCINOGENESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

APOPTOSIS; BASE SEQUENCE; BLOTTING, WESTERN; CELL ADHESION; CELL ADHESION MOLECULES; FLOW CYTOMETRY; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN-TYROSINE KINASES; TUMOR CELLS, CULTURED;

EID: 0029848157     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., and McGuire, W. L. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science (Washington DC), 235. 177-182, 1987.
2. Slamon, D. J., Godolphin, W., Jones, L. A., Holt, J. A., Wong, S. G., Keith, D. E., Levin, W. J., Stuart, S. G., Udove, J., Ullrich, A., and Press, M. F. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science (Washington DC), 244: 707-712, 1989.
3. c-src protein kinase activity in human colon carcinoma. Proc. Natl. Acad. Sci. USA, 84: 2251-2255, 1987.
4. c-src protein kinase is an early event in colonic carcinogenesis. Proc. Natl. Acad. Sci. USA, 87: 558-562, 1990.
5. c-src in progressive stages of human colorectal cancer. J. Clin Invest., 91: 53-60, 1993.
6. Muthuswamy, S. K , Siegel, P. M., Dankort, D. L., Webster, M. A., and Muller, W. J. Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity. Mol. Cell. Biol., 14: 735-743, 1994.
7. Pietrsa, R. J., Fendly, B. M., Chazin, V. R., Pegram, M. D , Howell, S. B , and Slamon, D. J. Antibody to Her-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells. Oncogene, 9: 1829-1838, 1994.
8. Weiner, T. M., Liu, E. T , Craven, R. J., and Cance, W. G. Expression of growth factor receptors, the focal adhesion kinase. and other tyrosine kinases in human soft tissue tumors Ann. Surg. Oncol., 1: 18-27, 1994.
9. Weiner, T. M., Liu, E. T., Craven, R. J., and Cance, W. G. Expression of focal adhesion kinase gene and invasive cancer Lancet, 342: 1024-1025, 1993
10. FAK) in invasive human tumors. Cancer Res., 55: 2752-2755, 1995.
11. src with two tyrosine-phosphorylated cellular proteins. Mol. Cell. Biol., 9: 3951-3958, 1989.
12. FAK. Mol. Cell. Biol., 14: 147-155, 1994.
13. FAK, a structurally distinctive protem-tyrosine kinase associated with focal adhesions. Proc. Natl. Acad. Sci. USA, 89: 5192-5196, 1992.
14. FAK, to cellular focal adhesions. J. Cell Biol , 123: 993-1005, 1993.
15. FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. J. Cell Biol., 119: 893-903, 1992.
16. 1 integrins. Proc. Natl. Acad. Sci USA, 88: 8392-8396, 1991.
17. Guan, J-L , and Shalloway, D. Regulation of focal adhesion-associated tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature (Lond.), 358: 690-692, 1992.
18. Hanks, S. K., Calalb, M. B., Harper, M. C., and Patel, S. K. Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc. Natl. Acad. Sci. USA, 89: 8487-8491, 1992.
19. Frisch, S M., and Francis, H. Disruption of epithelial cell-matrix interactions induces apoptosis J. Cell Biol., 124: 619-626, 1994.
20. FAK. DNA Cell Biol., 12: 823-830, 1993.
21. Augustine, K., Liu, E. T., and Sadler, T. W. Antisense attenuation of wnt-1 and wnt-3a expression in whole embryo culture reveals roles for these genes in craniofacial. spinal cord and cardiac morphogenesis. Dev. Genet., 14: 500-520, 1993.
22. Burgess, T. L., Fisher, E. F., Ross, S. L, Bready, J. V., Qian, Y-X., Bayewitch, L. A., Cohen, A. M., Herrera, C J., Hu, S. S-F., Kramer, T. B., Lott, F. D., Martin, F. H., Pierce, G. F., Simonet, L., and Farrell, C. L. The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism. Proc. Natl. Acad Sci. USA, 92: 4051-4055, 1995.
23. Hotz, M. A., Gong, J., Traganos, F., and Darzynkiewicz, Z. Flow cytometric detection of apoptosis: comparison of the assays of in situ DNA degradation and chromatin changes. Cytometry, 15: 237-244, 1994.
24. Huschtscha, L. I., Jeitner, T. M., Andersson, C. E., Bartier, W. A., and Tattersall, M. H N. Identification of apoptotic and necrotic human leukemic cells by flow cytometry. Exp. Cell. Res., 212: 161-165, 1994
25. Wyllie, A. H. glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature (Lond.), 284: 555-556, 1980.
26. Raff, M. C. Social controls on cell survival and cell death. Nature (Lond.), 356: 397-399, 1992.
27. Ruoslahti, E., and Reed, J. C. Anchorage dependence, integrins, and apoptosis. Cell, 77: 477-478, 1994.
28. Sambrook, J., Fritsch, E. F., and Maniatis, T. Western blotting In: N. Ford and C Nolan (eds.), Molecular Cloning: A Laboratory Manual, 2nd ed., pp. 18.60-18.75. Cold Spring Harbor, NY. Cold Spring Harbor Press, 1989.
29. Bissonnette, R., Echeverri, F., Mahboubi, A., and Green, D. R. Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature (Lond.), 359: 552-554, 1992.