Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3

Diabetologia

Volumn 56, Issue 4, 2013, Pages 886-892

  Lallukka, S ^a,b   Sevastianova, K ^a,b   Perttila J ^a   Hakkarainen, A ^c   Orho Melander, M ^d   Lundbom, N ^c   Olkkonen, V M ^a   Yki Jarvinen H ^a,b  

^a MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adipose tissue; Inflammation; NAFLD; PNPLA3 genotype

Indexed keywords

ADIPONECTIN; CD68 ANTIGEN; FATTY ACID; GLUCOSE; INSULIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1;

ADIPOQ GENE; ADIPOSE TISSUE; ADULT; ARTICLE; BIOPSY; BODY COMPOSITION; BODY MASS; CD68 GENE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIET RESTRICTION; DOWN REGULATION; FATTY ACID BLOOD LEVEL; FEMALE; GENE; GENE EXPRESSION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN TISSUE; INFLAMMATION; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MCP 1 GENE; NONALCOHOLIC FATTY LIVER; OBESITY; PNPLA3 GENE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TWIST1 GENE; UPREGULATION;

ADIPONECTIN; ADIPOSE TISSUE; ADULT; BODY COMPOSITION; FATTY LIVER; FEMALE; GENE EXPRESSION REGULATION; GENETIC VARIATION; GENOTYPE; HUMANS; LIPASE; LIVER; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MUTATION, MISSENSE; OBESITY;

EID: 84876469227     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-2829-9     Document Type: Article

References (41)

1. Cohen JC, Horton JD, Hobbs HH (2011) Human fatty liver disease: old questions and new insights. Science 332:1519-1523
2. Younossi ZM, Stepanova M, Afendy M et al (2011) Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008. Clin Gastroenterol Hepatol 9:524-530.e1, quiz e60
3. Kotronen A, Westerbacka J, Bergholm R, Pietilainen KH, Yki-Jarvinen H (2007) Liver fat in the metabolic syndrome. J Clin Endocrinol Metab 92:3490-3497
4. Kotronen A, Yki-Jarvinen H (2008) Fatty liver: a novel component of the metabolic syndrome. Arterioscler Thromb Vasc Biol 28:27-38
5. Romeo S, Kozlitina J, Xing C et al (2008) Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 40:1461-1465
6. He S, McPhaul C, Li JZ et al (2010) A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J Biol Chem 285:6706-6715
7. Kumari M, Schoiswohl G, Chitraju C et al (2012) Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab 15:691-702
8. Sookoian S, Pirola CJ (2011) Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology 53:1883-1894
9. Xu H, Barnes GT, Yang Q et al (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830
10. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808
11. Kolak M, Westerbacka J, Velagapudi VR et al (2007) Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity. Diabetes 56:1960-1968
12. Makkonen J, Westerbacka J, Kolak M et al (2007) Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity. Int J Obes (Lond) 31:1617-1625
13. Yamauchi T, Kamon J, Waki H et al (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941-946
14. Pietilainen KH, Kannisto K, Korsheninnikova E et al (2006) Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue: a study in monozygotic twins. J Clin Endocrinol Metab 91:2776-2781
15. Pettersson AT, Mejhert N, Jernas M et al (2011) Twist1 in human white adipose tissue and obesity. J Clin Endocrinol Metab 96:133-141
16. Zeyda M, Stulnig TM (2009) Obesity, inflammation, and insulin resistance: a mini-review. Gerontology 55:379-386
17. Turer AT, Scherer PE (2012) Adiponectin: mechanistic insights and clinical implications. Diabetologia 55:2319-2326
18. Kotronen A, Peltonen M, Hakkarainen A et al (2009) Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology 137:865-872
19. Kotronen A, Vehkavaara S, Seppala-Lindroos A, Bergholm R, Yki-Jarvinen H (2007) Effect of liver fat on insulin clearance. Am J Physiol Endocrinol Metab 293:E1709-E1715
20. Thomsen C, Becker U, Winkler K, Christoffersen P, Jensen M, Henriksen O (1994) Quantification of liver fat using magnetic resonance spectroscopy. Magn Reson Imaging 12:487-495
21. Szczepaniak LS, Nurenberg P, Leonard D et al (2005) Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 288:E462-E468
22. Yki-Jarvinen H, Nikkila EA, Kubo K, Foley JE (1986) Assay of glucose transport in human fat cells obtained by needle biopsy. Diabetologia 29:287-290
23. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45
24. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
25. Kanda H, Tateya S, Tamori Y et al (2006) MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116:1494-1505
26. Weisberg SP, Hunter D, Huber R et al (2006) CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116:115-124
27. Christiansen T, Richelsen B, Bruun JM (2005) Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. Int J Obes (Lond) 29:146-150
28. Westerbacka J, Corner A, Kolak M et al (2008) Insulin regulation of MCP-1 in human adipose tissue of obese and lean women. Am J Physiol Endocrinol Metab 294:E841-E845
29. Sell H, Eckel J (2007) Monocyte chemotactic protein-1 and its role in insulin resistance. Curr Opin Lipidol 18:258-262
30. Sosic D, Richardson JA, Yu K, Ornitz DM, Olson EN (2003) Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell 112:169-180
31. Pettersson AT, Laurencikiene J, Mejhert N et al (2010) A possible inflammatory role of twist1 in human white adipocytes. Diabetes 59:564-571
32. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K (2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116:1784-1792
33. Ohashi K, Parker JL, Ouchi N et al (2010) Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem 285:6153-6160
34. Ohashi K, Ouchi N, Matsuzawa Y (2012) Anti-inflammatory and anti-atherogenic properties of adiponectin. Biochimie 94:2137-2142
35. Fukushima J, Kamada Y, Matsumoto H et al (2009) Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization. Hepatol Res 39:724-738
36. Kim JY, van de Wall E, Laplante M et al (2007) Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 117:2621-2637
37. Westerbacka J, Corner A, Kannisto K et al (2006) Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects. Diabetologia 49:132-140
38. Kotronen A, Juurinen L, Tiikkainen M, Vehkavaara S, Yki-Jarvinen H (2008) Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. Gastroenterology 135:122-130
39. Sevastianova K, Santos A, Kotronen A et al (2012) Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. Am J Clin Nutr 96:727-734
40. Kotronen A, Johansson LE, Johansson LM et al (2009) A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetologia 52:1056-1060
41. Li JZ, Huang Y, Karaman R et al (2012) Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis. J Clin Invest 122:4130-4144