The protective role of hydrogen-rich saline in experimental liver injury in mice

Journal of Hepatology

Volumn 54, Issue 3, 2011, Pages 471-480

  Sun, Hanyong ^a   Chen, Lei ^a   Zhou, Weiping ^a   Hu, Liang ^a   Li, Liang ^a   Tu, Qianqian ^a   Chang, Yanxin ^a   Liu, Qu ^a   Sun, Xuejun ^a   Wu, Mengchao ^a   Wang, Hongyang ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Acute hepatic failure; Apoptosis; Hepatic cirrhosis; Hepatocyte proliferation; Hydrogen rich saline; Inflammation; JNK; Reactive oxygen species

Indexed keywords

ANTIOXIDANT; CARBON TETRACHLORIDE; CASPASE 3; CYTOKINE; HYDROGEN; HYDROGEN RICH SALINE; LIVER PROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; SODIUM CHLORIDE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; KIDNEY; LIVER CELL; LIVER CIRRHOSIS; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; HYDROGEN; INJECTIONS, INTRAPERITONEAL; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KIDNEY; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; LIVER FAILURE, ACUTE; MALE; MICE; MICE, INBRED C57BL; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SODIUM CHLORIDE;

EID: 79951670028     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.08.011     Document Type: Article

References (36)

1. P.J. Ferret, R. Hammoud, M. Tulliez, A. Tran, H. Trébéden, and P. Jaffray Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse Hepatology 33 2001 1173 1180 (Pubitemid 32378217)
2. G. Aram, J.J. Potter, X. Liu, L. Wang, M.S. Torbenson, and E. Mezey Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration Hepatology 49 2009 911 919
3. T. Sakurai, G. He, A. Matsuzawa, G. Yu, S. Maeda, and G. Hardiman Hepatocyte necrosis induced by oxidative stress and il-1a release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis Cancer Cell 14 2008 156 165
4. D.J. Betteridge What is oxidative stress? Metabolism 49 2000 3 8 (Pubitemid 30091785)
5. W. Augustin, I. Wiswedel, H. Noack, T. Reinheckel, and O. Reichelt Role of endogenous and exogenous antioxidants in the defence against functional damage and lipid peroxidation in rat liver mitochondria Mol Cell Biochem 174 1997 199 205 (Pubitemid 27404191)
6. E. Sewerynek, D. Melchiorri, R.J. Reiter, G.G. Ortiz, and A. Lewinski Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin Eur J Pharmacol 293 1995 327 334 (Pubitemid 3006672)
7. I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, and K. Yamagata Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals Nat Med 13 2007 688 694 (Pubitemid 46889750)
8. Y. Sato, S. Kajiyama, A. Amano, Y. Kondo, T. Sasaki, and S. Handa Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice Biochem Biophys Res Commun 375 2008 346 350
9. N. Nakashima-Kamimura, T. Mori, I. Ohsawa, S. Asoh, and S. Ohta Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice Cancer Chemother Pharmacol 64 2009 753 761
10. A.M. James, H.M. Cocheme, and M.P. Murphy Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing Mech Ageing Dev 126 2006 982 986 (Pubitemid 41033179)
11. K. Fukuda, S. Asoh, M. Ishikawa, Y. Yamamoto, I. Ohsawa, and S. Ohta Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress Biochem Biophys Res Commun 361 2007 670 674 (Pubitemid 47238041)
12. K. Hayashida, M. Sano, I. Ohsawa, K. Shinmura, K. Tamaki, and K. Kimura Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury Biochem Biophys Res Commun 373 2008 30 35
13. B.M. Buchholz, D.J. Kaczorowski, R. Sugimoto, R. Yang, Y. Wang, and T.R. Billiar Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury Am J Transplant 8 2008 2015 2024
14. J.M. Cai, Z.M. Kang, K. Liu, W.W. Liu, R.P. Li, and J.H. Zhang Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model Brain Res 1256 2009 129 137
15. X. Zheng, Y. Mao, J. Cai, Y. Li, W. Liu, and P. Sun Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats Free Radic Res 43 2009 478 484
16. O. Park, W.I. Jeong, L. Wang, H. Wang, Z.X. Lian, and M.E. Gershwin Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride Hepatology 49 2009 1683 1694
17. C. Constandinou, N. Henderson, and J.P. Iredale Modeling liver fibrosis in rodents Methods Mol Med 117 2005 237 250
18. S. Maeda, H. Kamata, J.L. Luo, H. Leffert, and M. Karin IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis Cell 121 2005 977 990 (Pubitemid 40884391)
19. L. Chen, H.X. Yan, J. Chen, W. Yang, Q. Liu, and B. Zhai Negative regulation of c-Myc transcription by pancreas duodenum homeobox-1 Endocrinology 148 2007 2168 2180 (Pubitemid 46997053)
20. L. Chen, H.X. Yan, W. Yang, L. Hu, L.X. Yu, and Q. Liu The role of microRNA expression pattern in humanintrahepatic cholangiocarcinoma J Hepatology 50 2009 358 369
21. A.L. Leon, and M. Rojkind A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections J Histochem Cytochem 33 1985 737 743 (Pubitemid 15237739)
22. G. Tiegs, M. Wolter, and A. Wendel Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice Biochem Pharmacol 38 1989 627 631 (Pubitemid 19050102)
23. E.C. Veerman, K. Nazmi, W.V. Hof, J.G. Bolscher, A.L. Hertog, and A.A. Nieuw Reactive oxygen species play no role in the candidacidal activity of the salivary antimicrobial peptide histatin 5 Biochem J 381 2004 447 452 (Pubitemid 38969689)
24. E. Seki, S.D. Minicis, C.H. Osterreicher, J. Kluwe, Y.K. Osawa, and D.A. Brenner TLR4 enhances TGF-b signaling and hepatic fibrosis Nat Med 13 2007 1325 1332
25. W.E. Naugler, T. Sakurai, S. Kim, S. Maeda, K. Kim, and A.M. Elsharkawy Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production Science 317 2007 121 124 (Pubitemid 47056470)
26. H. Jaeschke Reactive oxygen and mechanisms of inflammatory liver injury J Gastroenterol Hepatol 15 2000 718 724 (Pubitemid 30615053)
27. R.F. Schwabe, and D.A. Brenner Mechanisms of liver injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways Am J Physiol Gastrointest Liver Physiol 290 2006 G583 G589
28. K. Setsukinai, Y. Urano, K. Kakinuma, H.J. Majima, and T. Nagano Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species J Biol Chem 278 2003 3170 3175 (Pubitemid 36801227)
29. S. Liu, M. Liu, and S. Peterson Hydroxyl radical formation is greater in striatal core than in penumbra in a rat model of ischemic stroke J Neurosci Res 71 2003 882 888 (Pubitemid 36293009)
30. L. Nanetti, R. Taffi, and A. Vignini Reactive oxygen species plasmatic levels in ischemic stroke Mol Cell Biochem 303 2007 19 25 (Pubitemid 47261297)
31. J.S. Cardinal, J. Zhan, and Y. Wang Oral hydrogen water prevents chronic allograft nephropathy in rats Kidney Int 77 2010 101 109
32. A.T. Williams, and R.F. Burk Carbon tetrachloride hepatotoxicity: an example of free radical-mediated injury Semin Liver Dis 10 1990 279 284
33. A. Pavanato, M.J. Tuñón, S. Sánchez-Campos, C.A. Marroni, S. Llesuy, and J. González-Gallego Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis Dig Dis Sci 48 2003 824 829 (Pubitemid 36390692)
34. J. Medina, and R.M. Otero Pathophysiological basis for antioxidant therapy in chronic liver disease Drugs 65 2005 2445 2461 (Pubitemid 41697314)
35. T. Sakurai, S. Maeda, L. Chang, and M. Karin Loss of hepatic NFkappaB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation Proc Natl Acad Sci 103 2006 10544 10551 (Pubitemid 44078014)
36. W.E. Naugler, T. Sakurai, S. Kim, Sunhwa. Kim, S. Maeda, and K.H. Kim Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production Science 317 2007 121 124 (Pubitemid 47056470)