Potent PPARα activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Kim, Young il ^a   Hirai, Shizuka ^a   Goto, Tsuyoshi ^a   Ohyane, Chie ^a   Takahashi, Haruya ^a   Tsugane, Taneaki ^b   Konishi, Chiaki ^c   Fujii, Takashi ^c   Inai, Shuji ^c   Iijima, Yoko ^d   Aoki, Koh ^d   Shibata, Daisuke ^d   Takahashi, Nobuyuki ^a   Kawada, Teruo ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Chiba Prefectural Agriculture and Forestry Research Center 1762   (Japan)

^c Nippon Del Monte Corporation   (Japan)

^d KAZUSA DNA RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

13 OXO 9,11 OCTADECADIENOIC ACID; ANTILIPEMIC AGENT; CONJUGATED LINOLEIC ACID; LUCIFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; 13-OXO-9,11-OCTADECADIENOIC ACID; LINOLENIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DYSLIPIDEMIA; ENZYME ACTIVITY; FATTY LIVER; GENE TARGETING; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TOMATO; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; CHEMISTRY; DIABETES MELLITUS; DRUG POTENTIATION; ISOLATION AND PURIFICATION; MOUSE MUTANT;

ANIMALS; DIABETES MELLITUS; FATTY LIVER; LINOLENIC ACIDS; LYCOPERSICON ESCULENTUM; MICE; MICE, OBESE; PPAR ALPHA; TRIGLYCERIDES;

EID: 84863011904     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031317     Document Type: Article

References (41)

1. Reilly MP, Rader DJ, (2003) The Metabolic Syndrome: more than the sum of its parts? Circulation 108: 1546-1551.
2. Miranda PJ, DeFronzo RA, Califf RM, Guyton JR, (2005) Metabolic syndrome: definition, pathophysiology, and mechanism. Am Heart J 149: 33-45.
3. Kahn BB, Flier JS, (2000) Obesity and insulin resistance. J Clin Invest 106: 473-481.
4. Ginsberg HN, (2000) Insulin resistance and cardiovascular disease. J Clin Invest 106: 453-458.
5. Escher P, Wahli W, (2000) Peroxisome proliferator-activated receptors: insights into multiple celluar function. Mutat Res 448: 121-138.
6. Desvergne B, Wahli W, (1999) Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20: 649-688.
7. Chinetti G, Fruchart JC, Staels B, (2000) Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res 49: 497-505.
8. Duval C, Chinetti G, Trottein F, Fruchart JC, Staeles B, (2002) The role of PPARs in atherosclerosis. Trends Mol Med 8: 422-430.
9. Goldenberg I, Benderly M, Goldbourt U, (2008) Update on the use of fibrates: focus on bezafibrate. Vasc Health Risk Manag 4: 131-141.
10. Tugwood JD, Issemann I, Anderson RG, Bundell KR, McPheat WL, et al. (1992) The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO J 11: 433-439.
11. Roepstorff C, Halberg N, Hillig T, Saha AK, Ruderman NB, et al. (2005) Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. Am J Physiol Endocrinol Metab 288: E133-E142.
12. Mandard S, Müllar M, Kersten S, (2004) Peroxisome proliferator-activated receptors alpha target genes. Cell Mol Life Sci 61: 393-416.
13. Kim S, Shin H-J, Kim SY, Kim JH, Lee YS, et al. (2004) Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARα. Mol Cell Endocrinol 220: 51-58.
14. Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ, et al. (1996) The PPARalpha-leukotriene B4 pathway to inflammation control. Nature 384: 39-43.
15. Hostetler HA, Peterscu AD, Kier AB, Schroeder F, (2005) Peroxisome proliferator activated receptor α interacts with high affinity and is conformationally responsive to endogenous ligands. J Biol Chem 280: 18667-18682.
16. Silvia YMC, John PVH, Steven GB, Lisa AL, Martha AB, (1999) Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα. J Lipid Res 40: 1426-1433.
17. Gudbrandsen OA, Rodríguez E, Wergedahl H, Mørk S, Reseland JE, et al. (2009) Trans-10, cis-12-conjugated linoleic acid reduces the hepatic triacylglycerol content and the leptin mRNA level in adipose tissue in obese Zucker fa/fa rats. Br J Nutr 102: 803-815.
18. Kim YI, Hirai S, Takahashi H, Goto T, Ohyane C, et al. (2011) 9-oxo-10(E),12(E)- octadecadienoic acid derived from tomato is a potent peroxisome proliferator-activated receptor α agonist to decrease triglyceride accumulation in mouse primary hepatocytes. Mol Nutr Food Res 55: 585-593.
19. Takahashi H, Kim YI, Hirai S, Goto T, Ohyane C, et al. (2011) Comparative and stability analyses of 9- and 13-oxo-ODAs in various species of tomato. Biosci Biotechnol Biochem In press.
20. Takahashi N, Kawada T, Goto T, Yamamoto T, Taimatsu A, et al. (2002) Dual action of isoprenols from herbal medicines on both PPARγ and PPARα in 3T3-L1 adipocytes and HepG2 hepatocytes. FEBS Lett 514: 315-322.
21. Takahashi N, Kawada T, Goto T, Kim CS, Taimatsu A, et al. (2003) Abietic acid activates peroxisome proliferator-activated receptor-γ (PPARγ) in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism. FEBS Lett 550: 190-194.
22. Suto J, Matsuura S, Imamura K, Yamanaka H, Sekikawa K, (1998) Genetic analysis of non-insulin-dependent diabetes mellitus in KK and KK-Ay mice. Eur J Endocrinol 139: 654-661.
23. Uemura T, Hirai S, Mizoguchi N, Goto T, Lee JY, et al. (2010) Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues. Mol Nutr Food Res 54: 1596-1608.
24. Bligh EG, Dyer WJ, (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911-917.
25. Goto T, Takahashi N, Kato S, Egawa K, Ebisu S, et al. (2005) Phytol directly activates peroxisome proliferator-activated receptor α (PPARα) and regulates gene expression involved in lipid metabolism in PPARα-expressing HepG2 hepatocytes. Biochem Biophys Res Commun 337: 440-445.
26. Vellosillo T, Martínez M, López MA, Vicente J, Cascón T, et al. (2007) Oxylipin produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade. Plant Cell 19: 831-846.
27. Xu HE, Stanley TB, Montana VG, Lambert MH, Shearer BG, et al. (2002) Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα. Nature 415: 813-817.
28. Park MK, Lee HJ, Hong SH, Choi SS, Yoo YH, et al. (2007) The increase in hepatic uncoupling by fenofibrate contributes to a decrease in adipose tissue in obese rats. J Korean Med Sci 22: 235-241.
29. Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8: 731-737.
30. Rakhshandehroo M, Hooiveld G, Müller M, Kersten S, (2009) Comparative analysis of gene regulation by the transcription factor PPARα between mouse and human. PLoS One 4: e6796.
31. Schoonjans K, Steals B, Auwerx J, (1996) Role of peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37: 907-925.
32. Kahn SA, Vanden HJP, (2003) Role of nuclear receptors in the regulation of gene expression by dietary fatty acids (review). J Nutr Biochem 14: 554-567.
33. Priore P, Giudetti AM, Natali F, Gnoni GV, Geelen MJ, (2007) Metabolism and short-term metabolic effects of conjugated linoleic acids in rat hepatocytes. Biochem Biophys Acta 10: 1299-1307.
34. Kersten S, Seydoux J, Peters JM, Gonzalez FJ, (1999) Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 103: 1489-1498.
35. Lefebvre P, Chinetti G, Fruchart JC, Staels B, (2006) Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. J Clin Invest 116: 571-580.
36. Tsuchida A, Yamauchi T, Takekawa S, Hada Y, Ito Y, et al. (2005) Peroxisome proliferator- activated receptor (PPAR) alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination. Diabetes 54: 3358-3370.
37. Hiuge A, Tenenbaum A, Maeda N, Benderly M, (2007) Effects of peroxisome proliferator- activated receptor ligands, bezafibrate and fenofibrate, on adiponectin level. Arterioscler Thromb Vasc Biol 27: 635-641.
38. Tsuchida A, Yamauchi T, Takekawa S, Hada Y, Ito Y, et al. (2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116: 1784-1792.
39. Shen YC, Chen SL, Wang CK, (2007) Contribution of tomato phenolics to antioxidation and down-regulation of blood lipids. J Agric Food Chem 55: 6475-6481.
40. Ibrahim HS, Ahmed LA, El-din MM, (2008) The functional role of some tomato products on lipid profile and liver function in adult rats. J Med Food 11: 551-559.
41. Aizawa K, Matsumoto T, Inakuma T, Ishijima T, Nakai Y, et al. (2009) Administration of tomato and paprika beverages modifies hepatic glucose and lipid metabolism in mice: a DNA microarray analysis. J Agric Food Chem 57: 10964-10971.