메뉴 건너뛰기




Volumn 36, Issue 2, 2012, Pages 146-155

Ursodeoxycholic acid with vitamin E in patients with nonalcoholic steatohepatitis: Long-term results

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; URSODEOXYCHOLIC ACID;

EID: 84858622244     PISSN: 22107401     EISSN: 2210741X     Source Type: Journal    
DOI: 10.1016/j.clinre.2011.10.011     Document Type: Article
Times cited : (53)

References (45)
  • 1
    • 0037382786 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    • Marchesini G., Bugianesi E., Forlani G., et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003, 37:917-923.
    • (2003) Hepatology , vol.37 , pp. 917-923
    • Marchesini, G.1    Bugianesi, E.2    Forlani, G.3
  • 2
    • 0025260531 scopus 로고
    • Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors
    • Wanless I.R., Lentz J.S. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 1990, 12:1106-1110.
    • (1990) Hepatology , vol.12 , pp. 1106-1110
    • Wanless, I.R.1    Lentz, J.S.2
  • 3
    • 0038805259 scopus 로고    scopus 로고
    • The prevalence and etiology of elevated aminotransferase levels in the United States
    • Clark J.M., Brancati F.L., Diehl A.M. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 2003, 98:960-967.
    • (2003) Am J Gastroenterol , vol.98 , pp. 960-967
    • Clark, J.M.1    Brancati, F.L.2    Diehl, A.M.3
  • 4
    • 0037299949 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: what is it, and why is it important in the Asia-Pacific region?
    • Farrell G.C. Nonalcoholic steatohepatitis: what is it, and why is it important in the Asia-Pacific region?. J Gastroenterol Hepatol 2003, 18:124-138.
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 124-138
    • Farrell, G.C.1
  • 5
    • 4344628555 scopus 로고    scopus 로고
    • The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease
    • McCullough A.J. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis 2004, 8:521-533.
    • (2004) Clin Liver Dis , vol.8 , pp. 521-533
    • McCullough, A.J.1
  • 6
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years
    • Powell E.E., Cooksley W.G., Hanson R., et al. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 1990, 11:74-80.
    • (1990) Hepatology , vol.11 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3
  • 7
    • 20444473800 scopus 로고    scopus 로고
    • Mechanisms of disease: pathogenesis of nonalcoholic fatty liver disease
    • Sanyal A.J. Mechanisms of disease: pathogenesis of nonalcoholic fatty liver disease. Nat Clin Pract Gastroenterol Hepatol 2005, 2:46-53.
    • (2005) Nat Clin Pract Gastroenterol Hepatol , vol.2 , pp. 46-53
    • Sanyal, A.J.1
  • 8
    • 33748150370 scopus 로고    scopus 로고
    • Pathophysiology of nonalcoholic steatohepatitis
    • McCullough A.J. Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol 2006, 40(3 Suppl 1):S17-S29.
    • (2006) J Clin Gastroenterol , vol.40 , Issue.3 SUPPL. 1
    • McCullough, A.J.1
  • 9
    • 0035431018 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
    • Marchesini G., Brizi M., Bianchi G., et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001, 50:1844-1850.
    • (2001) Diabetes , vol.50 , pp. 1844-1850
    • Marchesini, G.1    Brizi, M.2    Bianchi, G.3
  • 10
    • 0034831067 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis
    • Reid A.E. Nonalcoholic steatohepatitis. Gastroenterology 2001, 121:710-723.
    • (2001) Gastroenterology , vol.121 , pp. 710-723
    • Reid, A.E.1
  • 11
    • 0035078484 scopus 로고    scopus 로고
    • Etiopathogenesis of nonalcoholic steatohepatitis
    • Chitturi S., Farrell G.C. Etiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis 2001, 21:27-41.
    • (2001) Semin Liver Dis , vol.21 , pp. 27-41
    • Chitturi, S.1    Farrell, G.C.2
  • 12
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
    • Sanyal A.J., Campbell-Sargent C., Mirshahi F., et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001, 120:1183-1192.
    • (2001) Gastroenterology , vol.120 , pp. 1183-1192
    • Sanyal, A.J.1    Campbell-Sargent, C.2    Mirshahi, F.3
  • 13
    • 77952529040 scopus 로고    scopus 로고
    • A position statement on NAFLD/NASH based on the EASL 2009 special conference
    • Ratziu V., Bellentani S., Cortez-Pinto H., et al. A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol 2010, 53:372-384.
    • (2010) J Hepatol , vol.53 , pp. 372-384
    • Ratziu, V.1    Bellentani, S.2    Cortez-Pinto, H.3
  • 14
    • 84933047295 scopus 로고    scopus 로고
    • Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study
    • Laurin J., Lindor K.D., Crippin J.S., et al. Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study. Hepatology 1996, 23:1464-1467.
    • (1996) Hepatology , vol.23 , pp. 1464-1467
    • Laurin, J.1    Lindor, K.D.2    Crippin, J.S.3
  • 15
    • 1542515099 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial
    • Lindor K.D., Kowdley K.V., Heathcote E.J., et al. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial. Hepatology 2004, 39:770-778.
    • (2004) Hepatology , vol.39 , pp. 770-778
    • Lindor, K.D.1    Kowdley, K.V.2    Heathcote, E.J.3
  • 16
    • 77951874018 scopus 로고    scopus 로고
    • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    • Sanyal A.J., Chalasani N., Kowdley K.V., et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010, 362:1675-1685.
    • (2010) N Engl J Med , vol.362 , pp. 1675-1685
    • Sanyal, A.J.1    Chalasani, N.2    Kowdley, K.V.3
  • 17
    • 33845336554 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin E in nonalcoholic steatohepatitis
    • Dufour J.F., Oneta C.M., Gonvers J.J., et al. Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin E in nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 2006, 4:1537-1543.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 1537-1543
    • Dufour, J.F.1    Oneta, C.M.2    Gonvers, J.J.3
  • 18
    • 70350043699 scopus 로고    scopus 로고
    • Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis
    • Balmer M.L., Siegrist K., Zimmermann A., et al. Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis. Liver Int 2009, 29:1184-1188.
    • (2009) Liver Int , vol.29 , pp. 1184-1188
    • Balmer, M.L.1    Siegrist, K.2    Zimmermann, A.3
  • 19
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner D.E., Brunt E.M., Van Natta M., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005, 41:1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 20
    • 0033200054 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
    • Brunt E.M., Janney C.G., Di Bisceglie A.M., et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999, 94:2467-2474.
    • (1999) Am J Gastroenterol , vol.94 , pp. 2467-2474
    • Brunt, E.M.1    Janney, C.G.2    Di Bisceglie, A.M.3
  • 21
    • 0025186310 scopus 로고
    • Effect of weight reduction on hepatic abnormalities in overweight patients
    • Palmer M., Schaffner F. Effect of weight reduction on hepatic abnormalities in overweight patients. Gastroenterology 1990, 99:1408-1413.
    • (1990) Gastroenterology , vol.99 , pp. 1408-1413
    • Palmer, M.1    Schaffner, F.2
  • 22
    • 27744490794 scopus 로고    scopus 로고
    • Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease
    • Suzuki A., Lindor K., St Saver J., et al. Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease. J Hepatol 2005, 43:1060-1066.
    • (2005) J Hepatol , vol.43 , pp. 1060-1066
    • Suzuki, A.1    Lindor, K.2    St Saver, J.3
  • 23
    • 33646483917 scopus 로고    scopus 로고
    • A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease
    • Zelber-Sagi S., Kessler A., Brazowsky E., et al. A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2006, 4:639-644.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 639-644
    • Zelber-Sagi, S.1    Kessler, A.2    Brazowsky, E.3
  • 24
    • 34547423962 scopus 로고    scopus 로고
    • Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats
    • Gary-Bobo M., Elachouri G., Gallas J.F., et al. Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats. Hepatology 2007, 46:122-129.
    • (2007) Hepatology , vol.46 , pp. 122-129
    • Gary-Bobo, M.1    Elachouri, G.2    Gallas, J.F.3
  • 25
    • 2542546652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss
    • Dixon J.B., Bhathal P.S., Hughes N.R., et al. Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss. Hepatology 2004, 39:1647-1654.
    • (2004) Hepatology , vol.39 , pp. 1647-1654
    • Dixon, J.B.1    Bhathal, P.S.2    Hughes, N.R.3
  • 26
    • 33644870833 scopus 로고    scopus 로고
    • Gastrointestinal surgery for obesity: a question of life and death and expertise
    • Klein S. Gastrointestinal surgery for obesity: a question of life and death and expertise. Gastroenterology 2006, 130:630.
    • (2006) Gastroenterology , vol.130 , pp. 630
    • Klein, S.1
  • 27
    • 33645536593 scopus 로고    scopus 로고
    • Treatment of nonalcoholic fatty liver disease
    • Adams L.A., Angulo P. Treatment of nonalcoholic fatty liver disease. Postgrad Med J 2006, 82:315-322.
    • (2006) Postgrad Med J , vol.82 , pp. 315-322
    • Adams, L.A.1    Angulo, P.2
  • 28
    • 1642296465 scopus 로고    scopus 로고
    • Metformin in the treatment of patients with nonalcoholic steatohepatitis
    • Uygun A., Kadayifci A., Isik A.T., et al. Metformin in the treatment of patients with nonalcoholic steatohepatitis. Aliment Pharmacol Ther 2004, 19:537-544.
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 537-544
    • Uygun, A.1    Kadayifci, A.2    Isik, A.T.3
  • 29
    • 0141532275 scopus 로고    scopus 로고
    • Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone
    • Neuschwander-Tetri B.A., Brunt E.M., Wehmeier K.R., et al. Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. Hepatology 2003, 38:1008-1017.
    • (2003) Hepatology , vol.38 , pp. 1008-1017
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3
  • 30
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R., Harrison S.A., Brown K., et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006, 355:2297-2307.
    • (2006) N Engl J Med , vol.355 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3
  • 31
    • 46349088361 scopus 로고    scopus 로고
    • Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty liver improvement with rosiglitazone therapy (FLIRT) trial
    • Ratziu V., Giral P., Jacqueminet S., et al. Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty liver improvement with rosiglitazone therapy (FLIRT) trial. Gastroenterology 2008, 135:100-110.
    • (2008) Gastroenterology , vol.135 , pp. 100-110
    • Ratziu, V.1    Giral, P.2    Jacqueminet, S.3
  • 32
    • 0033025969 scopus 로고    scopus 로고
    • Comparison of serum concentrations of alpha-tocopherol and beta-carotene in a cross-sectional sample of obese and nonobese children (NHANES III). National health and nutrition examination survey
    • Strauss R.S. Comparison of serum concentrations of alpha-tocopherol and beta-carotene in a cross-sectional sample of obese and nonobese children (NHANES III). National health and nutrition examination survey. J Pediatr 1999, 134:160-165.
    • (1999) J Pediatr , vol.134 , pp. 160-165
    • Strauss, R.S.1
  • 33
    • 19144365586 scopus 로고    scopus 로고
    • A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease
    • Bugianesi E., Gentilcore E., Manini R., et al. A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am J Gastroenterol 2005, 100:1082-1090.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1082-1090
    • Bugianesi, E.1    Gentilcore, E.2    Manini, R.3
  • 34
    • 0034799895 scopus 로고    scopus 로고
    • Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with nonalcoholic steatohepatitis: a pilot study
    • Hasegawa T., Yoneda M., Nakamura K., et al. Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with nonalcoholic steatohepatitis: a pilot study. Aliment Pharmacol Ther 2001, 15:1667-1672.
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1667-1672
    • Hasegawa, T.1    Yoneda, M.2    Nakamura, K.3
  • 35
    • 0042265627 scopus 로고    scopus 로고
    • Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E
    • Kugelmas M., Hill D.B., Vivian B., et al. Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E. Hepatology 2003, 38:413-419.
    • (2003) Hepatology , vol.38 , pp. 413-419
    • Kugelmas, M.1    Hill, D.B.2    Vivian, B.3
  • 36
    • 38049109883 scopus 로고    scopus 로고
    • Ursodeoxycholic acid: mechanism of action and novel clinical applications
    • Ikegami T., Matsuzaki Y. Ursodeoxycholic acid: mechanism of action and novel clinical applications. Hepatol Res 2008, 38:123-131.
    • (2008) Hepatol Res , vol.38 , pp. 123-131
    • Ikegami, T.1    Matsuzaki, Y.2
  • 37
    • 33748205007 scopus 로고    scopus 로고
    • Therapy of NAFLD: antioxidants and cytoprotective agents
    • Chang C.Y., Argo C.K., Al-Osaimi A.M., et al. Therapy of NAFLD: antioxidants and cytoprotective agents. J Clin Gastroenterol 2006, 40(Suppl 1):S51-S60.
    • (2006) J Clin Gastroenterol , vol.40 , Issue.SUPPL. 1
    • Chang, C.Y.1    Argo, C.K.2    Al-Osaimi, A.M.3
  • 38
    • 77955699301 scopus 로고    scopus 로고
    • High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial
    • Leuschner U.F., Lindenthal B., Herrmann G., et al. High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial. Hepatology 2010, 52:472-479.
    • (2010) Hepatology , vol.52 , pp. 472-479
    • Leuschner, U.F.1    Lindenthal, B.2    Herrmann, G.3
  • 39
    • 79954764140 scopus 로고    scopus 로고
    • A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis
    • Ratziu V., De Ledinghen V., Oberti F., et al. A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis. J Hepatol 2011, 54:1011-1019.
    • (2011) J Hepatol , vol.54 , pp. 1011-1019
    • Ratziu, V.1    De Ledinghen, V.2    Oberti, F.3
  • 40
    • 0033054812 scopus 로고    scopus 로고
    • Comparison of three doses of ursodeoxycholic acid in the treatment of primary biliary cirrhosis: a randomized trial
    • Angulo P., Dickson E.R., Therneau T.M., et al. Comparison of three doses of ursodeoxycholic acid in the treatment of primary biliary cirrhosis: a randomized trial. J Hepatol 1999, 30:830-835.
    • (1999) J Hepatol , vol.30 , pp. 830-835
    • Angulo, P.1    Dickson, E.R.2    Therneau, T.M.3
  • 41
    • 0034998596 scopus 로고    scopus 로고
    • High-dose ursodeoxycholic acid as a therapy for patients with primary sclerosing cholangitis
    • Harnois D.M., Angulo P., Jorgensen R.A., Larusso N.F., Lindor K.D. High-dose ursodeoxycholic acid as a therapy for patients with primary sclerosing cholangitis. Am J Gastroenterol 2001, 96:1558-1562.
    • (2001) Am J Gastroenterol , vol.96 , pp. 1558-1562
    • Harnois, D.M.1    Angulo, P.2    Jorgensen, R.A.3    Larusso, N.F.4    Lindor, K.D.5
  • 42
    • 40949086356 scopus 로고    scopus 로고
    • High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis is safe and effective
    • Cullen S.N., Rust C., Fleming K., Edwards C., Beuers U., Chapman R.W. High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis is safe and effective. J Hepatol 2008, 48:792-800.
    • (2008) J Hepatol , vol.48 , pp. 792-800
    • Cullen, S.N.1    Rust, C.2    Fleming, K.3    Edwards, C.4    Beuers, U.5    Chapman, R.W.6
  • 44
    • 20444443042 scopus 로고    scopus 로고
    • Sampling variability of liver biopsy in nonalcoholic fatty liver disease
    • Ratziu V., Charlotte F., Heurtier A., et al. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 2005, 128:1898-1906.
    • (2005) Gastroenterology , vol.128 , pp. 1898-1906
    • Ratziu, V.1    Charlotte, F.2    Heurtier, A.3
  • 45
    • 33750617920 scopus 로고    scopus 로고
    • Correlation of paired liver biopsies in morbidly obese patients with suspected nonalcoholic fatty liver disease
    • Merriman R.B., Ferrell L.D., Patti M.G., et al. Correlation of paired liver biopsies in morbidly obese patients with suspected nonalcoholic fatty liver disease. Hepatology 2006, 44:874-880.
    • (2006) Hepatology , vol.44 , pp. 874-880
    • Merriman, R.B.1    Ferrell, L.D.2    Patti, M.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.