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Volumn 43, Issue 1, 2014, Pages 75-102

Mechanisms of glucocorticoid-induced insulin resistance: Focus on adipose tissue function and lipid metabolism

Author keywords

Adipose tissue; Cushing syndrome; Glucocorticoids; Insulin resistance; Lipids; Lipolysis

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; ADIPONECTIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROCORTISONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCOUPLING PROTEIN 1;

EID: 84896849509     PISSN: 08898529     EISSN: 15584410     Source Type: Journal    
DOI: 10.1016/j.ecl.2013.10.005     Document Type: Review
Times cited : (286)

References (215)
  • 1
    • 77957026223 scopus 로고    scopus 로고
    • MRI assessment of lean and adipose tissue distribution in female patients with Cushing's disease
    • Geer E.B., Shen W., Gallagher D., et al. MRI assessment of lean and adipose tissue distribution in female patients with Cushing's disease. Clin Endocrinol (Oxf) 2010, 73(4):469-475.
    • (2010) Clin Endocrinol (Oxf) , vol.73 , Issue.4 , pp. 469-475
    • Geer, E.B.1    Shen, W.2    Gallagher, D.3
  • 2
    • 84860744640 scopus 로고    scopus 로고
    • Body composition and cardiovascular risk markers after remission of Cushing's disease: a prospective study using whole-body MRI
    • Geer E.B., Shen W., Strohmayer E., et al. Body composition and cardiovascular risk markers after remission of Cushing's disease: a prospective study using whole-body MRI. JClin Endocrinol Metab 2012, 97(5):1702-1711.
    • (2012) JClin Endocrinol Metab , vol.97 , Issue.5 , pp. 1702-1711
    • Geer, E.B.1    Shen, W.2    Strohmayer, E.3
  • 3
    • 0033953665 scopus 로고    scopus 로고
    • Use of oral corticosteroids in the United Kingdom
    • van Staa T.P., Leufkens H.G., Abenhaim L., et al. Use of oral corticosteroids in the United Kingdom. QJM 2000, 93(2):105-111.
    • (2000) QJM , vol.93 , Issue.2 , pp. 105-111
    • van Staa, T.P.1    Leufkens, H.G.2    Abenhaim, L.3
  • 4
    • 2942650969 scopus 로고    scopus 로고
    • Adipose tissue as an endocrine organ
    • Kershaw E.E., Flier J.S. Adipose tissue as an endocrine organ. JClin Endocrinol Metab 2004, 89(6):2548-2556.
    • (2004) JClin Endocrinol Metab , vol.89 , Issue.6 , pp. 2548-2556
    • Kershaw, E.E.1    Flier, J.S.2
  • 5
    • 33747114039 scopus 로고    scopus 로고
    • Preventing cardiovascular disease and diabetes: a call to action from the American Diabetes Association and the American Heart Association
    • Eckel R.H., Kahn R., Robertson R.M., et al. Preventing cardiovascular disease and diabetes: a call to action from the American Diabetes Association and the American Heart Association. Circulation 2006, 113(25):2943-2946.
    • (2006) Circulation , vol.113 , Issue.25 , pp. 2943-2946
    • Eckel, R.H.1    Kahn, R.2    Robertson, R.M.3
  • 6
    • 0037469255 scopus 로고    scopus 로고
    • C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women
    • Ridker P.M., Buring J.E., Cook N.R., et al. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation 2003, 107(3):391-397.
    • (2003) Circulation , vol.107 , Issue.3 , pp. 391-397
    • Ridker, P.M.1    Buring, J.E.2    Cook, N.R.3
  • 7
    • 0346962890 scopus 로고    scopus 로고
    • The metabolic syndrome and risk of major coronary events in the Scandinavian Simvastatin Survival Study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS)
    • Girman C.J., Rhodes T., Mercuri M., et al. The metabolic syndrome and risk of major coronary events in the Scandinavian Simvastatin Survival Study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS). Am J Cardiol 2004, 93(2):136-141.
    • (2004) Am J Cardiol , vol.93 , Issue.2 , pp. 136-141
    • Girman, C.J.1    Rhodes, T.2    Mercuri, M.3
  • 8
    • 0346962893 scopus 로고    scopus 로고
    • Effect of increasing metabolic syndrome score on atherosclerotic risk profile and coronary artery disease angiographic severity
    • Solymoss B.C., Bourassa M.G., Campeau L., et al. Effect of increasing metabolic syndrome score on atherosclerotic risk profile and coronary artery disease angiographic severity. Am J Cardiol 2004, 93(2):159-164.
    • (2004) Am J Cardiol , vol.93 , Issue.2 , pp. 159-164
    • Solymoss, B.C.1    Bourassa, M.G.2    Campeau, L.3
  • 9
    • 0028339489 scopus 로고
    • Morbidity and mortality in Cushing's disease: an epidemiological approach
    • Etxabe J., Vazquez J.A. Morbidity and mortality in Cushing's disease: an epidemiological approach. Clin Endocrinol (Oxf) 1994, 40(4):479-484.
    • (1994) Clin Endocrinol (Oxf) , vol.40 , Issue.4 , pp. 479-484
    • Etxabe, J.1    Vazquez, J.A.2
  • 10
    • 0023109747 scopus 로고
    • Glucocorticoids and insulin promote the differentiation of human adipocyte precursor cells into fat cells
    • Hauner H., Schmid P., Pfeiffer E.F. Glucocorticoids and insulin promote the differentiation of human adipocyte precursor cells into fat cells. JClin Endocrinol Metab 1987, 64(4):832-835.
    • (1987) JClin Endocrinol Metab , vol.64 , Issue.4 , pp. 832-835
    • Hauner, H.1    Schmid, P.2    Pfeiffer, E.F.3
  • 11
    • 78651357560 scopus 로고    scopus 로고
    • Adipogenic and lipolytic effects of chronic glucocorticoid exposure
    • Campbell J.E., Peckett A.J., D'Souza A.M., et al. Adipogenic and lipolytic effects of chronic glucocorticoid exposure. Am J Physiol Cell Physiol 2011, 300(1):C198-C209.
    • (2011) Am J Physiol Cell Physiol , vol.300 , Issue.1
    • Campbell, J.E.1    Peckett, A.J.2    D'Souza, A.M.3
  • 12
    • 0028037616 scopus 로고
    • Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes
    • Slavin B.G., Ong J.M., Kern P.A. Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes. JLipid Res 1994, 35(9):1535-1541.
    • (1994) JLipid Res , vol.35 , Issue.9 , pp. 1535-1541
    • Slavin, B.G.1    Ong, J.M.2    Kern, P.A.3
  • 13
    • 0031762378 scopus 로고    scopus 로고
    • Effects of physiological hypercortisolemia on the regulation of lipolysis in subcutaneous adipose tissue
    • Samra J.S., Clark M.L., Humphreys S.M., et al. Effects of physiological hypercortisolemia on the regulation of lipolysis in subcutaneous adipose tissue. JClin Endocrinol Metab 1998, 83(2):626-631.
    • (1998) JClin Endocrinol Metab , vol.83 , Issue.2 , pp. 626-631
    • Samra, J.S.1    Clark, M.L.2    Humphreys, S.M.3
  • 14
    • 1442276278 scopus 로고    scopus 로고
    • Additive effects of cortisol and growth hormone on regional and systemic lipolysis in humans
    • Djurhuus C.B., Gravholt C.H., Nielsen S., et al. Additive effects of cortisol and growth hormone on regional and systemic lipolysis in humans. Am J Physiol Endocrinol Metab 2004, 286(3):E488-E494.
    • (2004) Am J Physiol Endocrinol Metab , vol.286 , Issue.3
    • Djurhuus, C.B.1    Gravholt, C.H.2    Nielsen, S.3
  • 15
    • 84868330463 scopus 로고    scopus 로고
    • Glucocorticoids antagonize tumor necrosis factor-alpha-stimulated lipolysis and resistance to the antilipolytic effect of insulin in human adipocytes
    • Lee M.J., Fried S.K. Glucocorticoids antagonize tumor necrosis factor-alpha-stimulated lipolysis and resistance to the antilipolytic effect of insulin in human adipocytes. Am J Physiol Endocrinol Metab 2012, 303(9):E1126-E1133.
    • (2012) Am J Physiol Endocrinol Metab , vol.303 , Issue.9
    • Lee, M.J.1    Fried, S.K.2
  • 16
    • 8744297386 scopus 로고    scopus 로고
    • Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis
    • Villena J.A., Roy S., Sarkadi-Nagy E., et al. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. JBiol Chem 2004, 279(45):47066-47075.
    • (2004) JBiol Chem , vol.279 , Issue.45 , pp. 47066-47075
    • Villena, J.A.1    Roy, S.2    Sarkadi-Nagy, E.3
  • 17
    • 3442895916 scopus 로고    scopus 로고
    • Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes
    • Gao Z., Zhang X., Zuberi A., et al. Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. Mol Endocrinol 2004, 18(8):2024-2034.
    • (2004) Mol Endocrinol , vol.18 , Issue.8 , pp. 2024-2034
    • Gao, Z.1    Zhang, X.2    Zuberi, A.3
  • 18
    • 44449135106 scopus 로고    scopus 로고
    • Depot-specific regulation of the conversion of cortisone to cortisol in human adipose tissue
    • Lee M.J., Fried S.K., Mundt S.S., et al. Depot-specific regulation of the conversion of cortisone to cortisol in human adipose tissue. Obesity (Silver Spring) 2008, 16(6):1178-1185.
    • (2008) Obesity (Silver Spring) , vol.16 , Issue.6 , pp. 1178-1185
    • Lee, M.J.1    Fried, S.K.2    Mundt, S.S.3
  • 19
    • 0024271697 scopus 로고
    • Muscle and adipose tissue morphology and metabolism in Cushing's syndrome
    • Rebuffe-Scrive M., Krotkiewski M., Elfverson J., et al. Muscle and adipose tissue morphology and metabolism in Cushing's syndrome. JClin Endocrinol Metab 1988, 67(6):1122-1128.
    • (1988) JClin Endocrinol Metab , vol.67 , Issue.6 , pp. 1122-1128
    • Rebuffe-Scrive, M.1    Krotkiewski, M.2    Elfverson, J.3
  • 20
    • 33747879402 scopus 로고    scopus 로고
    • Increased lipolysis of subcutaneous abdominal adipose tissue and altered noradrenergic activity in patients with Cushing's syndrome: an in-vivo microdialysis study
    • Krsek M., Rosicka M., Nedvidkova J., et al. Increased lipolysis of subcutaneous abdominal adipose tissue and altered noradrenergic activity in patients with Cushing's syndrome: an in-vivo microdialysis study. Physiol Res 2006, 55(4):421-428.
    • (2006) Physiol Res , vol.55 , Issue.4 , pp. 421-428
    • Krsek, M.1    Rosicka, M.2    Nedvidkova, J.3
  • 21
    • 0036079637 scopus 로고    scopus 로고
    • Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity
    • Diraison F., Dusserre E., Vidal H., et al. Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity. Am J Physiol Endocrinol Metab 2002, 282(1):E46-E51.
    • (2002) Am J Physiol Endocrinol Metab , vol.282 , Issue.1
    • Diraison, F.1    Dusserre, E.2    Vidal, H.3
  • 22
    • 64149103134 scopus 로고    scopus 로고
    • Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans
    • Roberts R., Hodson L., Dennis A.L., et al. Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans. Diabetologia 2009, 52(5):882-890.
    • (2009) Diabetologia , vol.52 , Issue.5 , pp. 882-890
    • Roberts, R.1    Hodson, L.2    Dennis, A.L.3
  • 23
    • 76949108087 scopus 로고    scopus 로고
    • Inverse relation between FASN expression in human adipose tissue and the insulin resistance level
    • Mayas M.D., Ortega F.J., Macias-Gonzalez M., et al. Inverse relation between FASN expression in human adipose tissue and the insulin resistance level. Nutr Metab (Lond) 2010, 7:3.
    • (2010) Nutr Metab (Lond) , vol.7 , pp. 3
    • Mayas, M.D.1    Ortega, F.J.2    Macias-Gonzalez, M.3
  • 24
    • 84874600898 scopus 로고    scopus 로고
    • De novo lipogenesis in human fat and liver is linked to ChREBP-beta and metabolic health
    • Eissing L., Scherer T., Todter K., et al. De novo lipogenesis in human fat and liver is linked to ChREBP-beta and metabolic health. Nat Commun 2013, 4:1528.
    • (2013) Nat Commun , vol.4 , pp. 1528
    • Eissing, L.1    Scherer, T.2    Todter, K.3
  • 25
    • 80054113921 scopus 로고    scopus 로고
    • Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue
    • Gathercole L.L., Morgan S.A., Bujalska I.J., et al. Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue. PLoS One 2011, 6(10):e26223.
    • (2011) PLoS One , vol.6 , Issue.10
    • Gathercole, L.L.1    Morgan, S.A.2    Bujalska, I.J.3
  • 26
    • 40549135297 scopus 로고    scopus 로고
    • Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
    • Postic C., Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. JClin Invest 2008, 118(3):829-838.
    • (2008) JClin Invest , vol.118 , Issue.3 , pp. 829-838
    • Postic, C.1    Girard, J.2
  • 27
    • 35948969798 scopus 로고    scopus 로고
    • Glucocorticoid modulation of insulin signaling in human subcutaneous adipose tissue
    • Gathercole L.L., Bujalska I.J., Stewart P.M., et al. Glucocorticoid modulation of insulin signaling in human subcutaneous adipose tissue. JClin Endocrinol Metab 2007, 92(11):4332-4339.
    • (2007) JClin Endocrinol Metab , vol.92 , Issue.11 , pp. 4332-4339
    • Gathercole, L.L.1    Bujalska, I.J.2    Stewart, P.M.3
  • 28
    • 73549120403 scopus 로고    scopus 로고
    • Insulin sensitization of human preadipocytes through glucocorticoid hormone induction of forkhead transcription factors
    • Tomlinson J.J., Boudreau A., Wu D., et al. Insulin sensitization of human preadipocytes through glucocorticoid hormone induction of forkhead transcription factors. Mol Endocrinol 2010, 24(1):104-113.
    • (2010) Mol Endocrinol , vol.24 , Issue.1 , pp. 104-113
    • Tomlinson, J.J.1    Boudreau, A.2    Wu, D.3
  • 29
    • 84884211422 scopus 로고    scopus 로고
    • Short- and long-term glucocorticoid treatment enhances insulin signalling in human subcutaneous adipose tissue
    • Gathercole L.L., Morgan S.A., Bujalska I.J., et al. Short- and long-term glucocorticoid treatment enhances insulin signalling in human subcutaneous adipose tissue. Nutr Diabetes 2011, 1:e3.
    • (2011) Nutr Diabetes , vol.1
    • Gathercole, L.L.1    Morgan, S.A.2    Bujalska, I.J.3
  • 30
    • 84876263472 scopus 로고    scopus 로고
    • Glucocorticoids fail to cause insulin resistance in human subcutaneous adipose tissue invivo
    • Hazlehurst J.M., Gathercole L.L., Nasiri M., et al. Glucocorticoids fail to cause insulin resistance in human subcutaneous adipose tissue invivo. JClin Endocrinol Metab 2013, 98(4):1631-1640.
    • (2013) JClin Endocrinol Metab , vol.98 , Issue.4 , pp. 1631-1640
    • Hazlehurst, J.M.1    Gathercole, L.L.2    Nasiri, M.3
  • 31
    • 0036204548 scopus 로고    scopus 로고
    • Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes
    • Buren J., Liu H.X., Jensen J., et al. Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes. Eur J Endocrinol 2002, 146(3):419-429.
    • (2002) Eur J Endocrinol , vol.146 , Issue.3 , pp. 419-429
    • Buren, J.1    Liu, H.X.2    Jensen, J.3
  • 32
    • 2942675015 scopus 로고    scopus 로고
    • Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes
    • Lundgren M., Buren J., Ruge T., et al. Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes. JClin Endocrinol Metab 2004, 89(6):2989-2997.
    • (2004) JClin Endocrinol Metab , vol.89 , Issue.6 , pp. 2989-2997
    • Lundgren, M.1    Buren, J.2    Ruge, T.3
  • 33
    • 0033820515 scopus 로고    scopus 로고
    • Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction
    • Sakoda H., Ogihara T., Anai M., et al. Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction. Diabetes 2000, 49(10):1700-1708.
    • (2000) Diabetes , vol.49 , Issue.10 , pp. 1700-1708
    • Sakoda, H.1    Ogihara, T.2    Anai, M.3
  • 34
    • 0015432606 scopus 로고
    • Tissue effects of glucocorticoids
    • Baxter J.D., Forsham P.H. Tissue effects of glucocorticoids. Am J Med 1972, 53(5):573-589.
    • (1972) Am J Med , vol.53 , Issue.5 , pp. 573-589
    • Baxter, J.D.1    Forsham, P.H.2
  • 35
    • 3042803327 scopus 로고
    • Central obesity and coronary heart disease in men
    • Donahue R.P., Abbott R.D. Central obesity and coronary heart disease in men. Lancet 1987, 2(8569):1215.
    • (1987) Lancet , vol.2 , Issue.8569 , pp. 1215
    • Donahue, R.P.1    Abbott, R.D.2
  • 36
    • 44849093847 scopus 로고    scopus 로고
    • Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk
    • Despres J.P., Lemieux I., Bergeron J., et al. Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol 2008, 28(6):1039-1049.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.6 , pp. 1039-1049
    • Despres, J.P.1    Lemieux, I.2    Bergeron, J.3
  • 37
    • 0032554512 scopus 로고    scopus 로고
    • Impairment of health and quality of life in people with large waist circumference
    • Lean M.E., Han T.S., Seidell J.C. Impairment of health and quality of life in people with large waist circumference. Lancet 1998, 351(9106):853-856.
    • (1998) Lancet , vol.351 , Issue.9106 , pp. 853-856
    • Lean, M.E.1    Han, T.S.2    Seidell, J.C.3
  • 38
    • 0027966932 scopus 로고
    • Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men
    • Chan J.M., Rimm E.B., Colditz G.A., et al. Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care 1994, 17(9):961-969.
    • (1994) Diabetes Care , vol.17 , Issue.9 , pp. 961-969
    • Chan, J.M.1    Rimm, E.B.2    Colditz, G.A.3
  • 39
    • 0029874313 scopus 로고    scopus 로고
    • Abdominal fat and insulin resistance in normal and overweight women: direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM
    • Carey D.G., Jenkins A.B., Campbell L.V., et al. Abdominal fat and insulin resistance in normal and overweight women: direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Diabetes 1996, 45(5):633-638.
    • (1996) Diabetes , vol.45 , Issue.5 , pp. 633-638
    • Carey, D.G.1    Jenkins, A.B.2    Campbell, L.V.3
  • 40
    • 0028091785 scopus 로고
    • Regional adiposity and morbidity
    • Kissebah A.H., Krakower G.R. Regional adiposity and morbidity. Physiol Rev 1994, 74(4):761-811.
    • (1994) Physiol Rev , vol.74 , Issue.4 , pp. 761-811
    • Kissebah, A.H.1    Krakower, G.R.2
  • 41
    • 77955578871 scopus 로고    scopus 로고
    • Distribution of abdominal adipose tissue as a predictor of hepatic steatosis assessed by MRI
    • Ducluzeau P.H., Manchec-Poilblanc P., Roullier V., et al. Distribution of abdominal adipose tissue as a predictor of hepatic steatosis assessed by MRI. Clin Radiol 2010, 65(9):695-700.
    • (2010) Clin Radiol , vol.65 , Issue.9 , pp. 695-700
    • Ducluzeau, P.H.1    Manchec-Poilblanc, P.2    Roullier, V.3
  • 42
    • 69949093791 scopus 로고    scopus 로고
    • Persistent body fat mass and inflammatory marker increases after long-term cure of Cushing's syndrome
    • Barahona M.J., Sucunza N., Resmini E., et al. Persistent body fat mass and inflammatory marker increases after long-term cure of Cushing's syndrome. JClin Endocrinol Metab 2009, 94(9):3365-3371.
    • (2009) JClin Endocrinol Metab , vol.94 , Issue.9 , pp. 3365-3371
    • Barahona, M.J.1    Sucunza, N.2    Resmini, E.3
  • 43
    • 0024489441 scopus 로고
    • Body fat distribution measured with CT: correlations in healthy subjects, patients with anorexia nervosa, and patients with Cushing syndrome
    • Mayo-Smith W., Hayes C.W., Biller B.M., et al. Body fat distribution measured with CT: correlations in healthy subjects, patients with anorexia nervosa, and patients with Cushing syndrome. Radiology 1989, 170(2):515-518.
    • (1989) Radiology , vol.170 , Issue.2 , pp. 515-518
    • Mayo-Smith, W.1    Hayes, C.W.2    Biller, B.M.3
  • 44
    • 0035176348 scopus 로고    scopus 로고
    • Body composition and metabolic features in women with adrenal incidentaloma or Cushing's syndrome
    • Garrapa G.G., Pantanetti P., Arnaldi G., et al. Body composition and metabolic features in women with adrenal incidentaloma or Cushing's syndrome. JClin Endocrinol Metab 2001, 86(11):5301-5306.
    • (2001) JClin Endocrinol Metab , vol.86 , Issue.11 , pp. 5301-5306
    • Garrapa, G.G.1    Pantanetti, P.2    Arnaldi, G.3
  • 45
    • 0033918295 scopus 로고    scopus 로고
    • Leptin levels in relation to body composition and insulin concentration in patients with endogenous Cushing's syndrome compared to controls matched for body mass index
    • Schafroth U., Godang K., Ueland T., et al. Leptin levels in relation to body composition and insulin concentration in patients with endogenous Cushing's syndrome compared to controls matched for body mass index. JEndocrinol Invest 2000, 23(6):349-355.
    • (2000) JEndocrinol Invest , vol.23 , Issue.6 , pp. 349-355
    • Schafroth, U.1    Godang, K.2    Ueland, T.3
  • 46
    • 0029114151 scopus 로고
    • Estimation of body fat and lean tissue distribution by dual energy X-ray absorptiometry and abdominal body fat evaluation by computed tomography in Cushing's disease
    • Wajchenberg B.L., Bosco A., Marone M.M., et al. Estimation of body fat and lean tissue distribution by dual energy X-ray absorptiometry and abdominal body fat evaluation by computed tomography in Cushing's disease. JClin Endocrinol Metab 1995, 80(9):2791-2794.
    • (1995) JClin Endocrinol Metab , vol.80 , Issue.9 , pp. 2791-2794
    • Wajchenberg, B.L.1    Bosco, A.2    Marone, M.M.3
  • 47
    • 33644911468 scopus 로고    scopus 로고
    • Characterization of the metabolic phenotypes of Cushing's syndrome and growth hormone deficiency: a study of body composition and energy metabolism
    • Burt M.G., Gibney J., Ho K.K. Characterization of the metabolic phenotypes of Cushing's syndrome and growth hormone deficiency: a study of body composition and energy metabolism. Clin Endocrinol (Oxf) 2006, 64(4):436-443.
    • (2006) Clin Endocrinol (Oxf) , vol.64 , Issue.4 , pp. 436-443
    • Burt, M.G.1    Gibney, J.2    Ho, K.K.3
  • 48
    • 34247601590 scopus 로고    scopus 로고
    • Protein metabolism in glucocorticoid excess: study in Cushing's syndrome and the effect of treatment
    • Burt M.G., Gibney J., Ho K.K. Protein metabolism in glucocorticoid excess: study in Cushing's syndrome and the effect of treatment. Am J Physiol Endocrinol Metab 2007, 292(5):E1426-E1432.
    • (2007) Am J Physiol Endocrinol Metab , vol.292 , Issue.5
    • Burt, M.G.1    Gibney, J.2    Ho, K.K.3
  • 49
    • 0347359032 scopus 로고    scopus 로고
    • Computed tomography assessment of fat distribution in male and female patients with Cushing's syndrome
    • Rockall A.G., Sohaib S.A., Evans D., et al. Computed tomography assessment of fat distribution in male and female patients with Cushing's syndrome. Eur J Endocrinol 2003, 149(6):561-567.
    • (2003) Eur J Endocrinol , vol.149 , Issue.6 , pp. 561-567
    • Rockall, A.G.1    Sohaib, S.A.2    Evans, D.3
  • 50
    • 0033343114 scopus 로고    scopus 로고
    • Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure
    • Calao A., Pivonello R., Spiezia S., et al. Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure. JClin Endocrinol Metab 1999, 84:2664-2672.
    • (1999) JClin Endocrinol Metab , vol.84 , pp. 2664-2672
    • Calao, A.1    Pivonello, R.2    Spiezia, S.3
  • 51
    • 0038305844 scopus 로고    scopus 로고
    • Cardiovascular risk factors and common carotid artery caliber and stiffness in patients with Cushing's disease during active disease and 1 year after disease remission
    • Faggiano A., Pivonello R., Spiezia S., et al. Cardiovascular risk factors and common carotid artery caliber and stiffness in patients with Cushing's disease during active disease and 1 year after disease remission. JClin Endocrinol Metab 2003, 88:2527-2533.
    • (2003) JClin Endocrinol Metab , vol.88 , pp. 2527-2533
    • Faggiano, A.1    Pivonello, R.2    Spiezia, S.3
  • 52
    • 18044398761 scopus 로고    scopus 로고
    • The metabolic syndrome and cardiovascular risk in Cushing's syndrome
    • viii
    • Pivonello R., Faggiano A., Lombardi G., et al. The metabolic syndrome and cardiovascular risk in Cushing's syndrome. Endocrinol Metab Clin North Am 2005, 34(2):327-339. viii.
    • (2005) Endocrinol Metab Clin North Am , vol.34 , Issue.2 , pp. 327-339
    • Pivonello, R.1    Faggiano, A.2    Lombardi, G.3
  • 53
    • 84874849998 scopus 로고    scopus 로고
    • Predictors of mortality and long-term outcomes in treated Cushing's disease: a study of 346 patients
    • Lambert J.K., Goldberg L., Fayngold S., et al. Predictors of mortality and long-term outcomes in treated Cushing's disease: a study of 346 patients. JClin Endocrinol Metab 2013, 98(3):1022-1030.
    • (2013) JClin Endocrinol Metab , vol.98 , Issue.3 , pp. 1022-1030
    • Lambert, J.K.1    Goldberg, L.2    Fayngold, S.3
  • 54
    • 0035824440 scopus 로고    scopus 로고
    • Atransgenic model of visceral obesity and the metabolic syndrome
    • Masuzaki H., Paterson J., Shinyama H., et al. Atransgenic model of visceral obesity and the metabolic syndrome. Science 2001, 294(5549):2166-2170.
    • (2001) Science , vol.294 , Issue.5549 , pp. 2166-2170
    • Masuzaki, H.1    Paterson, J.2    Shinyama, H.3
  • 55
    • 69949092969 scopus 로고    scopus 로고
    • Omental adipose tissue type 1 11 beta-hydroxysteroid dehydrogenase oxoreductase activity, body fat distribution, and metabolic alterations in women
    • Veilleux A., Rheaume C., Daris M., et al. Omental adipose tissue type 1 11 beta-hydroxysteroid dehydrogenase oxoreductase activity, body fat distribution, and metabolic alterations in women. JClin Endocrinol Metab 2009, 94(9):3550-3557.
    • (2009) JClin Endocrinol Metab , vol.94 , Issue.9 , pp. 3550-3557
    • Veilleux, A.1    Rheaume, C.2    Daris, M.3
  • 56
    • 40749150741 scopus 로고    scopus 로고
    • Thrombospondin-1 is an adipokine associated with obesity, adipose inflammation, and insulin resistance
    • Varma V., Yao-Borengasser A., Bodles A.M., et al. Thrombospondin-1 is an adipokine associated with obesity, adipose inflammation, and insulin resistance. Diabetes 2008, 57(2):432-439.
    • (2008) Diabetes , vol.57 , Issue.2 , pp. 432-439
    • Varma, V.1    Yao-Borengasser, A.2    Bodles, A.M.3
  • 57
    • 78649652068 scopus 로고    scopus 로고
    • Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation
    • Spencer M., Yao-Borengasser A., Unal R., et al. Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation. Am J Physiol Endocrinol Metab 2010, 299(6):E1016-E1027.
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , Issue.6
    • Spencer, M.1    Yao-Borengasser, A.2    Unal, R.3
  • 59
    • 83155187250 scopus 로고    scopus 로고
    • Adipose tissue extracellular matrix and vascular abnormalities in obesity and insulin resistance
    • Spencer M., Unal R., Zhu B., et al. Adipose tissue extracellular matrix and vascular abnormalities in obesity and insulin resistance. JClin Endocrinol Metab 2011, 96(12):E1990-E1998.
    • (2011) JClin Endocrinol Metab , vol.96 , Issue.12
    • Spencer, M.1    Unal, R.2    Zhu, B.3
  • 60
  • 61
    • 8544258847 scopus 로고    scopus 로고
    • Glucocorticoid regulation of leptin synthesis and secretion in humans: elevated plasma leptin levels in Cushing's syndrome
    • Masuzaki H., Ogawa Y., Hosoda K., et al. Glucocorticoid regulation of leptin synthesis and secretion in humans: elevated plasma leptin levels in Cushing's syndrome. JClin Endocrinol Metab 1997, 82(8):2542-2547.
    • (1997) JClin Endocrinol Metab , vol.82 , Issue.8 , pp. 2542-2547
    • Masuzaki, H.1    Ogawa, Y.2    Hosoda, K.3
  • 62
    • 0030453726 scopus 로고    scopus 로고
    • Difference in leptin mRNA levels between omental and subcutaneous abdominal adipose tissue from obese humans
    • Hube F., Lietz U., Igel M., et al. Difference in leptin mRNA levels between omental and subcutaneous abdominal adipose tissue from obese humans. Horm Metab Res 1996, 28(12):690-693.
    • (1996) Horm Metab Res , vol.28 , Issue.12 , pp. 690-693
    • Hube, F.1    Lietz, U.2    Igel, M.3
  • 63
    • 33747061905 scopus 로고    scopus 로고
    • Comparison of serum high-molecular weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin
    • Aso Y., Yamamoto R., Wakabayashi S., et al. Comparison of serum high-molecular weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin. Diabetes 2006, 55(7):1954-1960.
    • (2006) Diabetes , vol.55 , Issue.7 , pp. 1954-1960
    • Aso, Y.1    Yamamoto, R.2    Wakabayashi, S.3
  • 64
    • 51049123168 scopus 로고    scopus 로고
    • Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women
    • Heidemann C., Sun Q., van Dam R.M., et al. Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women. Ann Intern Med 2008, 149(5):307-316.
    • (2008) Ann Intern Med , vol.149 , Issue.5 , pp. 307-316
    • Heidemann, C.1    Sun, Q.2    van Dam, R.M.3
  • 65
    • 0036290813 scopus 로고    scopus 로고
    • Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes
    • Fasshauer M., Klein J., Neumann S., et al. Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2002, 290(3):1084-1089.
    • (2002) Biochem Biophys Res Commun , vol.290 , Issue.3 , pp. 1084-1089
    • Fasshauer, M.1    Klein, J.2    Neumann, S.3
  • 66
    • 77955654730 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptor system in the rat adrenal gland: ontogenetic and physiologic regulation, and its involvement in regulating adrenocortical growth and steroidogenesis
    • Paschke L., Zemleduch T., Rucinski M., et al. Adiponectin and adiponectin receptor system in the rat adrenal gland: ontogenetic and physiologic regulation, and its involvement in regulating adrenocortical growth and steroidogenesis. Peptides 2010, 31(9):1715-1724.
    • (2010) Peptides , vol.31 , Issue.9 , pp. 1715-1724
    • Paschke, L.1    Zemleduch, T.2    Rucinski, M.3
  • 67
    • 0348048487 scopus 로고    scopus 로고
    • Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue
    • Bruun J.M., Lihn A.S., Madan A.K., et al. Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue. Am J Physiol Endocrinol Metab 2004, 286(1):E8-E13.
    • (2004) Am J Physiol Endocrinol Metab , vol.286 , Issue.1
    • Bruun, J.M.1    Lihn, A.S.2    Madan, A.K.3
  • 68
    • 0031762908 scopus 로고    scopus 로고
    • Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid
    • Fried S.K., Bunkin D.A., Greenberg A.S. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. JClin Endocrinol Metab 1998, 83(3):847-850.
    • (1998) JClin Endocrinol Metab , vol.83 , Issue.3 , pp. 847-850
    • Fried, S.K.1    Bunkin, D.A.2    Greenberg, A.S.3
  • 69
    • 33845592201 scopus 로고    scopus 로고
    • Adipose tissue-derived factors: impact on health and disease
    • Trujillo M.E., Scherer P.E. Adipose tissue-derived factors: impact on health and disease. Endocr Rev 2006, 27(7):762-778.
    • (2006) Endocr Rev , vol.27 , Issue.7 , pp. 762-778
    • Trujillo, M.E.1    Scherer, P.E.2
  • 70
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg S.P., McCann D., Desai M., et al. Obesity is associated with macrophage accumulation in adipose tissue. JClin Invest 2003, 112(12):1796-1808.
    • (2003) JClin Invest , vol.112 , Issue.12 , pp. 1796-1808
    • Weisberg, S.P.1    McCann, D.2    Desai, M.3
  • 71
    • 84863628857 scopus 로고    scopus 로고
    • BVT.2733, a selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice
    • Wang L., Liu J., Zhang A., et al. BVT.2733, a selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice. PLoS One 2012, 7(7):e40056.
    • (2012) PLoS One , vol.7 , Issue.7
    • Wang, L.1    Liu, J.2    Zhang, A.3
  • 72
    • 50049097319 scopus 로고    scopus 로고
    • Developmental biology: neither fat nor flesh
    • Cannon B., Nedergaard J. Developmental biology: neither fat nor flesh. Nature 2008, 454(7207):947-948.
    • (2008) Nature , vol.454 , Issue.7207 , pp. 947-948
    • Cannon, B.1    Nedergaard, J.2
  • 73
    • 33847768085 scopus 로고    scopus 로고
    • Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice
    • Almind K., Manieri M., Sivitz W.I., et al. Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci USA 2007, 104(7):2366-2371.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.7 , pp. 2366-2371
    • Almind, K.1    Manieri, M.2    Sivitz, W.I.3
  • 74
    • 64749111074 scopus 로고    scopus 로고
    • Role of Jhdm2a in regulating metabolic gene expression and obesity resistance
    • Tateishi K., Okada Y., Kallin E.M., et al. Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature 2009, 458(7239):757-761.
    • (2009) Nature , vol.458 , Issue.7239 , pp. 757-761
    • Tateishi, K.1    Okada, Y.2    Kallin, E.M.3
  • 75
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • Cypess A.M., Lehman S., Williams G., et al. Identification and importance of brown adipose tissue in adult humans. NEngl J Med 2009, 360(15):1509-1517.
    • (2009) NEngl J Med , vol.360 , Issue.15 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3
  • 77
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • Virtanen K.A., Lidell M.E., Orava J., et al. Functional brown adipose tissue in healthy adults. NEngl J Med 2009, 360(15):1518-1525.
    • (2009) NEngl J Med , vol.360 , Issue.15 , pp. 1518-1525
    • Virtanen, K.A.1    Lidell, M.E.2    Orava, J.3
  • 78
    • 84873335794 scopus 로고    scopus 로고
    • Essential roles of 11beta-HSD1 in regulating brown adipocyte function
    • Liu J., Kong X., Wang L., et al. Essential roles of 11beta-HSD1 in regulating brown adipocyte function. JMol Endocrinol 2013, 50(1):103-113.
    • (2013) JMol Endocrinol , vol.50 , Issue.1 , pp. 103-113
    • Liu, J.1    Kong, X.2    Wang, L.3
  • 79
    • 70350540686 scopus 로고    scopus 로고
    • 11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle
    • Morgan S.A., Sherlock M., Gathercole L.L., et al. 11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle. Diabetes 2009, 58(11):2506-2515.
    • (2009) Diabetes , vol.58 , Issue.11 , pp. 2506-2515
    • Morgan, S.A.1    Sherlock, M.2    Gathercole, L.L.3
  • 80
    • 57949086076 scopus 로고    scopus 로고
    • Fat in liver/muscle correlates more strongly with insulin sensitivity in rats than abdominal fat
    • Lim S., Son K.R., Song I.C., et al. Fat in liver/muscle correlates more strongly with insulin sensitivity in rats than abdominal fat. Obesity (Silver Spring) 2009, 17(1):188-195.
    • (2009) Obesity (Silver Spring) , vol.17 , Issue.1 , pp. 188-195
    • Lim, S.1    Son, K.R.2    Song, I.C.3
  • 81
    • 0036097562 scopus 로고    scopus 로고
    • Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion
    • Greco A.V., Mingrone G., Giancaterini A., et al. Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion. Diabetes 2002, 51(1):144-151.
    • (2002) Diabetes , vol.51 , Issue.1 , pp. 144-151
    • Greco, A.V.1    Mingrone, G.2    Giancaterini, A.3
  • 82
    • 0032960890 scopus 로고    scopus 로고
    • Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects
    • Jacob S., Machann J., Rett K., et al. Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 1999, 48(5):1113-1119.
    • (1999) Diabetes , vol.48 , Issue.5 , pp. 1113-1119
    • Jacob, S.1    Machann, J.2    Rett, K.3
  • 83
    • 0013173349 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy study of soleus muscle in non-obese healthy and Type 2 diabetic Asian Northern Indian males: high intramyocellular lipid content correlates with excess body fat and abdominal obesity
    • Misra A., Sinha S., Kumar M., et al. Proton magnetic resonance spectroscopy study of soleus muscle in non-obese healthy and Type 2 diabetic Asian Northern Indian males: high intramyocellular lipid content correlates with excess body fat and abdominal obesity. Diabet Med 2003, 20(5):361-367.
    • (2003) Diabet Med , vol.20 , Issue.5 , pp. 361-367
    • Misra, A.1    Sinha, S.2    Kumar, M.3
  • 84
    • 0032764784 scopus 로고    scopus 로고
    • 13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
    • 13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 1999, 48(8):1600-1606.
    • (1999) Diabetes , vol.48 , Issue.8 , pp. 1600-1606
    • Perseghin, G.1    Scifo, P.2    De Cobelli, F.3
  • 85
    • 33845542745 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction
    • Morino K., Petersen K.F., Shulman G.I. Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes 2006, 55(Suppl 2):S9-S15.
    • (2006) Diabetes , vol.55 , Issue.SUPPL. 2
    • Morino, K.1    Petersen, K.F.2    Shulman, G.I.3
  • 86
    • 84879285103 scopus 로고    scopus 로고
    • Regulation of lipid metabolism by glucocorticoids and 11beta-HSD1 in skeletal muscle
    • Morgan S.A., Gathercole L.L., Simonet C., et al. Regulation of lipid metabolism by glucocorticoids and 11beta-HSD1 in skeletal muscle. Endocrinology 2013, 154(7):2374-2384.
    • (2013) Endocrinology , vol.154 , Issue.7 , pp. 2374-2384
    • Morgan, S.A.1    Gathercole, L.L.2    Simonet, C.3
  • 87
    • 0034107084 scopus 로고    scopus 로고
    • Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus
    • Goodpaster B.H., Thaete F.L., Kelley D.E. Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. Am J Clin Nutr 2000, 71(4):885-892.
    • (2000) Am J Clin Nutr , vol.71 , Issue.4 , pp. 885-892
    • Goodpaster, B.H.1    Thaete, F.L.2    Kelley, D.E.3
  • 88
    • 70349326750 scopus 로고    scopus 로고
    • Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
    • Fabbrini E., Magkos F., Mohammed B.S., et al. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci USA 2009, 106(36):15430-15435.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.36 , pp. 15430-15435
    • Fabbrini, E.1    Magkos, F.2    Mohammed, B.S.3
  • 89
    • 0020630564 scopus 로고
    • The effects of glucocorticoids on insulin-stimulated lipogenesis in primary cultures of rat hepatocytes
    • Amatruda J.M., Danahy S.A., Chang C.L. The effects of glucocorticoids on insulin-stimulated lipogenesis in primary cultures of rat hepatocytes. Biochem J 1983, 212(1):135-141.
    • (1983) Biochem J , vol.212 , Issue.1 , pp. 135-141
    • Amatruda, J.M.1    Danahy, S.A.2    Chang, C.L.3
  • 90
    • 77953631114 scopus 로고    scopus 로고
    • Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription
    • Zhao L.F., Iwasaki Y., Zhe W., et al. Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription. Endocr J 2010, 57(4):317-324.
    • (2010) Endocr J , vol.57 , Issue.4 , pp. 317-324
    • Zhao, L.F.1    Iwasaki, Y.2    Zhe, W.3
  • 91
    • 1642545652 scopus 로고    scopus 로고
    • Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone
    • Dolinsky V.W., Douglas D.N., Lehner R., et al. Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone. Biochem J 2004, 378(Pt 3):967-974.
    • (2004) Biochem J , vol.378 , Issue.PART 3 , pp. 967-974
    • Dolinsky, V.W.1    Douglas, D.N.2    Lehner, R.3
  • 92
    • 0037216466 scopus 로고    scopus 로고
    • Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets
    • Schwarz J.M., Linfoot P., Dare D., et al. Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets. Am J Clin Nutr 2003, 77(1):43-50.
    • (2003) Am J Clin Nutr , vol.77 , Issue.1 , pp. 43-50
    • Schwarz, J.M.1    Linfoot, P.2    Dare, D.3
  • 93
    • 50049104872 scopus 로고    scopus 로고
    • The glucocorticoid receptor controls hepatic dyslipidemia through Hes1
    • Lemke U., Krones-Herzig A., Berriel Diaz M., et al. The glucocorticoid receptor controls hepatic dyslipidemia through Hes1. Cell Metab 2008, 8(3):212-223.
    • (2008) Cell Metab , vol.8 , Issue.3 , pp. 212-223
    • Lemke, U.1    Krones-Herzig, A.2    Berriel Diaz, M.3
  • 94
    • 10844271391 scopus 로고    scopus 로고
    • Relationship of nonalcoholic hepatic steatosis to overnight low-dose dexamethasone suppression test in obese individuals
    • Zoppini G., Targher G., Venturi C., et al. Relationship of nonalcoholic hepatic steatosis to overnight low-dose dexamethasone suppression test in obese individuals. Clin Endocrinol (Oxf) 2004, 61(6):711-715.
    • (2004) Clin Endocrinol (Oxf) , vol.61 , Issue.6 , pp. 711-715
    • Zoppini, G.1    Targher, G.2    Venturi, C.3
  • 95
    • 84857403547 scopus 로고    scopus 로고
    • Aswitch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease
    • Ahmed A., Rabbitt E., Brady T., et al. Aswitch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease. PLoS One 2012, 7(2):e29531.
    • (2012) PLoS One , vol.7 , Issue.2
    • Ahmed, A.1    Rabbitt, E.2    Brady, T.3
  • 96
    • 10744221420 scopus 로고    scopus 로고
    • Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver
    • Westerbacka J., Yki-Jarvinen H., Vehkavaara S., et al. Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver. JClin Endocrinol Metab 2003, 88(10):4924-4931.
    • (2003) JClin Endocrinol Metab , vol.88 , Issue.10 , pp. 4924-4931
    • Westerbacka, J.1    Yki-Jarvinen, H.2    Vehkavaara, S.3
  • 97
    • 24044436526 scopus 로고    scopus 로고
    • Relationship of non-alcoholic hepatic steatosis to cortisol secretion in diet-controlled Type 2 diabetic patients
    • Targher G., Bertolini L., Zoppini G., et al. Relationship of non-alcoholic hepatic steatosis to cortisol secretion in diet-controlled Type 2 diabetic patients. Diabet Med 2005, 22(9):1146-1150.
    • (2005) Diabet Med , vol.22 , Issue.9 , pp. 1146-1150
    • Targher, G.1    Bertolini, L.2    Zoppini, G.3
  • 98
    • 0346728586 scopus 로고    scopus 로고
    • Hepatic steatosis in Cushing's syndrome: a radiological assessment using computed tomography
    • Rockall A.G., Sohaib S.A., Evans D., et al. Hepatic steatosis in Cushing's syndrome: a radiological assessment using computed tomography. Eur J Endocrinol 2003, 149(6):543-548.
    • (2003) Eur J Endocrinol , vol.149 , Issue.6 , pp. 543-548
    • Rockall, A.G.1    Sohaib, S.A.2    Evans, D.3
  • 99
    • 0036117963 scopus 로고    scopus 로고
    • Acute severe steatohepatitis related to prednisolone therapy
    • Dourakis S.P., Sevastianos V.A., Kaliopi P. Acute severe steatohepatitis related to prednisolone therapy. Am J Gastroenterol 2002, 97(4):1074-1075.
    • (2002) Am J Gastroenterol , vol.97 , Issue.4 , pp. 1074-1075
    • Dourakis, S.P.1    Sevastianos, V.A.2    Kaliopi, P.3
  • 100
    • 0032747485 scopus 로고    scopus 로고
    • Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosus
    • Nanki T., Koike R., Miyasaka N. Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosus. Am J Gastroenterol 1999, 94(11):3379.
    • (1999) Am J Gastroenterol , vol.94 , Issue.11 , pp. 3379
    • Nanki, T.1    Koike, R.2    Miyasaka, N.3
  • 101
    • 24644523307 scopus 로고    scopus 로고
    • Glucocorticoid use and serum lipid levels in US adults: the Third National Health and Nutrition Examination Survey
    • Choi H.K., Seeger J.D. Glucocorticoid use and serum lipid levels in US adults: the Third National Health and Nutrition Examination Survey. Arthritis Rheum 2005, 53(4):528-535.
    • (2005) Arthritis Rheum , vol.53 , Issue.4 , pp. 528-535
    • Choi, H.K.1    Seeger, J.D.2
  • 102
    • 84864329629 scopus 로고    scopus 로고
    • Low-dose dexamethasone administration for 3 weeks favorably affects plasma HDL concentration and composition but does not affect very low-density lipoprotein kinetics
    • Wang X., Magkos F., Patterson B.W., et al. Low-dose dexamethasone administration for 3 weeks favorably affects plasma HDL concentration and composition but does not affect very low-density lipoprotein kinetics. Eur J Endocrinol 2012, 167(2):217-223.
    • (2012) Eur J Endocrinol , vol.167 , Issue.2 , pp. 217-223
    • Wang, X.1    Magkos, F.2    Patterson, B.W.3
  • 103
    • 33749578271 scopus 로고    scopus 로고
    • The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients
    • Filipsson H., Monson J.P., Koltowska-Haggstrom M., et al. The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients. JClin Endocrinol Metab 2006, 91(10):3954-3961.
    • (2006) JClin Endocrinol Metab , vol.91 , Issue.10 , pp. 3954-3961
    • Filipsson, H.1    Monson, J.P.2    Koltowska-Haggstrom, M.3
  • 104
    • 0029839797 scopus 로고    scopus 로고
    • ACTH lowers serum lipids in steroid-treated hyperlipemic patients with kidney disease
    • Berg A.L., Nilsson-Ehle P. ACTH lowers serum lipids in steroid-treated hyperlipemic patients with kidney disease. Kidney Int 1996, 50(2):538-542.
    • (1996) Kidney Int , vol.50 , Issue.2 , pp. 538-542
    • Berg, A.L.1    Nilsson-Ehle, P.2
  • 105
    • 0026028085 scopus 로고
    • ACTH 1-24 decreases hepatic lipase activities and low density lipoprotein concentrations in healthy men
    • Berg A.L., Hansson P., Nilsson-Ehle P. ACTH 1-24 decreases hepatic lipase activities and low density lipoprotein concentrations in healthy men. JIntern Med 1991, 229(2):201-203.
    • (1991) JIntern Med , vol.229 , Issue.2 , pp. 201-203
    • Berg, A.L.1    Hansson, P.2    Nilsson-Ehle, P.3
  • 106
    • 0028058083 scopus 로고
    • Direct effects of corticotropin on plasma lipoprotein metabolism in man-studies invivo and invitro
    • Berg A.L., Nilsson-Ehle P. Direct effects of corticotropin on plasma lipoprotein metabolism in man-studies invivo and invitro. Metabolism 1994, 43(1):90-97.
    • (1994) Metabolism , vol.43 , Issue.1 , pp. 90-97
    • Berg, A.L.1    Nilsson-Ehle, P.2
  • 107
    • 9144250366 scopus 로고    scopus 로고
    • Diagnosis and complications of Cushing's syndrome: a consensus statement
    • Arnaldi G., Angeli A., Atkinson A.B., et al. Diagnosis and complications of Cushing's syndrome: a consensus statement. JClin Endocrinol Metab 2003, 88(12):5593-5602.
    • (2003) JClin Endocrinol Metab , vol.88 , Issue.12 , pp. 5593-5602
    • Arnaldi, G.1    Angeli, A.2    Atkinson, A.B.3
  • 108
    • 79961239249 scopus 로고    scopus 로고
    • Metabolic and cardiovascular outcomes in patients with Cushing's syndrome of different aetiologies during active disease and 1 year after remission
    • Giordano R., Picu A., Marinazzo E., et al. Metabolic and cardiovascular outcomes in patients with Cushing's syndrome of different aetiologies during active disease and 1 year after remission. Clin Endocrinol 2011, 75(3):354-360.
    • (2011) Clin Endocrinol , vol.75 , Issue.3 , pp. 354-360
    • Giordano, R.1    Picu, A.2    Marinazzo, E.3
  • 109
    • 10844237159 scopus 로고    scopus 로고
    • High cardiovascular risk in patients with Cushing's syndrome according to 1999 WHO/ISH guidelines
    • Mancini T., Kola B., Mantero F., et al. High cardiovascular risk in patients with Cushing's syndrome according to 1999 WHO/ISH guidelines. Clin Endocrinol (Oxf) 2004, 61(6):768-777.
    • (2004) Clin Endocrinol (Oxf) , vol.61 , Issue.6 , pp. 768-777
    • Mancini, T.1    Kola, B.2    Mantero, F.3
  • 110
    • 0025088301 scopus 로고
    • 11 beta-hydroxysteroid dehydrogenase bioactivity and messenger RNA expression in rat forebrain: localization in hypothalamus, hippocampus, and cortex
    • Moisan M.P., Seckl J.R., Edwards C.R. 11 beta-hydroxysteroid dehydrogenase bioactivity and messenger RNA expression in rat forebrain: localization in hypothalamus, hippocampus, and cortex. Endocrinology 1990, 127(3):1450-1455.
    • (1990) Endocrinology , vol.127 , Issue.3 , pp. 1450-1455
    • Moisan, M.P.1    Seckl, J.R.2    Edwards, C.R.3
  • 111
    • 0025870302 scopus 로고
    • Regional distribution of 11 beta-hydroxysteroid dehydrogenase in rat brain
    • Lakshmi V., Sakai R.R., McEwen B.S., et al. Regional distribution of 11 beta-hydroxysteroid dehydrogenase in rat brain. Endocrinology 1991, 128(4):1741-1748.
    • (1991) Endocrinology , vol.128 , Issue.4 , pp. 1741-1748
    • Lakshmi, V.1    Sakai, R.R.2    McEwen, B.S.3
  • 112
    • 0027177088 scopus 로고
    • The 11 beta-hydroxysteroid dehydrogenase inhibitor glycyrrhetinic acid affects corticosteroid feedback regulation of hypothalamic corticotrophin-releasing peptides in rats
    • Seckl J.R., Dow R.C., Low S.C., et al. The 11 beta-hydroxysteroid dehydrogenase inhibitor glycyrrhetinic acid affects corticosteroid feedback regulation of hypothalamic corticotrophin-releasing peptides in rats. JEndocrinol 1993, 136(3):471-477.
    • (1993) JEndocrinol , vol.136 , Issue.3 , pp. 471-477
    • Seckl, J.R.1    Dow, R.C.2    Low, S.C.3
  • 113
    • 84875824479 scopus 로고    scopus 로고
    • Expression of 11beta-hydroxysteroid dehydrogenase type 1 in the human hypothalamus
    • Bisschop P.H., Dekker M.J., Osterthun W., et al. Expression of 11beta-hydroxysteroid dehydrogenase type 1 in the human hypothalamus. JNeuroendocrinol 2013, 25(5):425-432.
    • (2013) JNeuroendocrinol , vol.25 , Issue.5 , pp. 425-432
    • Bisschop, P.H.1    Dekker, M.J.2    Osterthun, W.3
  • 114
    • 0033014744 scopus 로고    scopus 로고
    • Induction of obesity and hyperleptinemia by central glucocorticoid infusion in the rat
    • Zakrzewska K.E., Cusin I., Stricker-Krongrad A., et al. Induction of obesity and hyperleptinemia by central glucocorticoid infusion in the rat. Diabetes 1999, 48(2):365-370.
    • (1999) Diabetes , vol.48 , Issue.2 , pp. 365-370
    • Zakrzewska, K.E.1    Cusin, I.2    Stricker-Krongrad, A.3
  • 115
    • 12444257790 scopus 로고    scopus 로고
    • Role of glucocorticoids in the physiopathology of excessive fat deposition and insulin resistance
    • Asensio C., Muzzin P., Rohner-Jeanrenaud F. Role of glucocorticoids in the physiopathology of excessive fat deposition and insulin resistance. Int J Obes Relat Metab Disord 2004, 28(Suppl 4):S45-S52.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , Issue.SUPPL. 4
    • Asensio, C.1    Muzzin, P.2    Rohner-Jeanrenaud, F.3
  • 116
    • 0035408764 scopus 로고    scopus 로고
    • Intracerebroventricular glucocorticoid infusion in normal rats: induction of parasympathetic-mediated obesity and insulin resistance
    • Cusin I., Rouru J., Rohner-Jeanrenaud F. Intracerebroventricular glucocorticoid infusion in normal rats: induction of parasympathetic-mediated obesity and insulin resistance. Obes Res 2001, 9(7):401-406.
    • (2001) Obes Res , vol.9 , Issue.7 , pp. 401-406
    • Cusin, I.1    Rouru, J.2    Rohner-Jeanrenaud, F.3
  • 117
    • 84863032246 scopus 로고    scopus 로고
    • Glucocorticoid signaling in the arcuate nucleus modulates hepatic insulin sensitivity
    • Yi C.X., Foppen E., Abplanalp W., et al. Glucocorticoid signaling in the arcuate nucleus modulates hepatic insulin sensitivity. Diabetes 2012, 61(2):339-345.
    • (2012) Diabetes , vol.61 , Issue.2 , pp. 339-345
    • Yi, C.X.1    Foppen, E.2    Abplanalp, W.3
  • 118
    • 34447116241 scopus 로고    scopus 로고
    • Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome
    • Kuo L.E., Kitlinska J.B., Tilan J.U., et al. Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat Med 2007, 13(7):803-811.
    • (2007) Nat Med , vol.13 , Issue.7 , pp. 803-811
    • Kuo, L.E.1    Kitlinska, J.B.2    Tilan, J.U.3
  • 119
    • 57349092160 scopus 로고    scopus 로고
    • Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome
    • Kola B., Christ-Crain M., Lolli F., et al. Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome. JClin Endocrinol Metab 2008, 93(12):4969-4973.
    • (2008) JClin Endocrinol Metab , vol.93 , Issue.12 , pp. 4969-4973
    • Kola, B.1    Christ-Crain, M.2    Lolli, F.3
  • 120
    • 33745654517 scopus 로고    scopus 로고
    • Expanding role of AMPK in endocrinology
    • Kola B., Boscaro M., Rutter G.A., et al. Expanding role of AMPK in endocrinology. Trends Endocrinol Metab 2006, 17(5):205-215.
    • (2006) Trends Endocrinol Metab , vol.17 , Issue.5 , pp. 205-215
    • Kola, B.1    Boscaro, M.2    Rutter, G.A.3
  • 121
    • 78650964142 scopus 로고    scopus 로고
    • Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans
    • Gauthier M.S., O'Brien E.L., Bigornia S., et al. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun 2011, 404(1):382-387.
    • (2011) Biochem Biophys Res Commun , vol.404 , Issue.1 , pp. 382-387
    • Gauthier, M.S.1    O'Brien, E.L.2    Bigornia, S.3
  • 122
    • 44949151646 scopus 로고    scopus 로고
    • AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: a novel mechanism in Cushing's syndrome
    • Christ-Crain M., Kola B., Lolli F., et al. AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: a novel mechanism in Cushing's syndrome. FASEB J 2008, 22(6):1672-1683.
    • (2008) FASEB J , vol.22 , Issue.6 , pp. 1672-1683
    • Christ-Crain, M.1    Kola, B.2    Lolli, F.3
  • 123
    • 70449699754 scopus 로고    scopus 로고
    • Cannabinoids for clinicians: the rise and fall of the cannabinoid antagonists
    • Butler H., Korbonits M. Cannabinoids for clinicians: the rise and fall of the cannabinoid antagonists. Eur J Endocrinol 2009, 161(5):655-662.
    • (2009) Eur J Endocrinol , vol.161 , Issue.5 , pp. 655-662
    • Butler, H.1    Korbonits, M.2
  • 124
    • 85047690626 scopus 로고    scopus 로고
    • The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
    • Cota D., Marsicano G., Tschop M., et al. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. JClin Invest 2003, 112(3):423-431.
    • (2003) JClin Invest , vol.112 , Issue.3 , pp. 423-431
    • Cota, D.1    Marsicano, G.2    Tschop, M.3
  • 125
    • 0038755185 scopus 로고    scopus 로고
    • Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism
    • Di S., Malcher-Lopes R., Halmos K.C., et al. Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism. JNeurosci 2003, 23(12):4850-4857.
    • (2003) JNeurosci , vol.23 , Issue.12 , pp. 4850-4857
    • Di, S.1    Malcher-Lopes, R.2    Halmos, K.C.3
  • 126
    • 24944499667 scopus 로고    scopus 로고
    • Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and gamma-aminobutyric acid inputs to hypothalamic magnocellular neurons
    • Di S., Malcher-Lopes R., Marcheselli V.L., et al. Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and gamma-aminobutyric acid inputs to hypothalamic magnocellular neurons. Endocrinology 2005, 146(10):4292-4301.
    • (2005) Endocrinology , vol.146 , Issue.10 , pp. 4292-4301
    • Di, S.1    Malcher-Lopes, R.2    Marcheselli, V.L.3
  • 127
    • 84884169835 scopus 로고    scopus 로고
    • CB1 receptor mediates the effects of glucocorticoids on AMPK activity in the hypothalamus
    • Scerif M., Fuzesi T., Thomas J.D., et al. CB1 receptor mediates the effects of glucocorticoids on AMPK activity in the hypothalamus. JEndocrinol 2013, 219(1):79-88.
    • (2013) JEndocrinol , vol.219 , Issue.1 , pp. 79-88
    • Scerif, M.1    Fuzesi, T.2    Thomas, J.D.3
  • 128
    • 67649419169 scopus 로고    scopus 로고
    • The dysregulation of the endocannabinoid system in diabesity-a tricky problem
    • Scherer T., Buettner C. The dysregulation of the endocannabinoid system in diabesity-a tricky problem. JMol Med (Berl) 2009, 87(7):663-668.
    • (2009) JMol Med (Berl) , vol.87 , Issue.7 , pp. 663-668
    • Scherer, T.1    Buettner, C.2
  • 129
    • 4043077286 scopus 로고    scopus 로고
    • 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response
    • Tomlinson J.W., Walker E.A., Bujalska I.J., et al. 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr Rev 2004, 25(5):831-866.
    • (2004) Endocr Rev , vol.25 , Issue.5 , pp. 831-866
    • Tomlinson, J.W.1    Walker, E.A.2    Bujalska, I.J.3
  • 130
    • 0035051205 scopus 로고    scopus 로고
    • Tissue-specific dysregulation of cortisol metabolism in human obesity
    • Rask E., Olsson T., Soderberg S., et al. Tissue-specific dysregulation of cortisol metabolism in human obesity. JClin Endocrinol Metab 2001, 86(3):1418-1421.
    • (2001) JClin Endocrinol Metab , vol.86 , Issue.3 , pp. 1418-1421
    • Rask, E.1    Olsson, T.2    Soderberg, S.3
  • 131
    • 1842552244 scopus 로고    scopus 로고
    • Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss
    • Engeli S., Bohnke J., Feldpausch M., et al. Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss. Obes Res 2004, 12(1):9-17.
    • (2004) Obes Res , vol.12 , Issue.1 , pp. 9-17
    • Engeli, S.1    Bohnke, J.2    Feldpausch, M.3
  • 132
    • 34548621405 scopus 로고    scopus 로고
    • 11Beta-HSD type 1 expression in human adipose tissue: impact of gender, obesity, and fat localization
    • Paulsen S.K., Pedersen S.B., Fisker S., et al. 11Beta-HSD type 1 expression in human adipose tissue: impact of gender, obesity, and fat localization. Obesity (Silver Spring) 2007, 15(8):1954-1960.
    • (2007) Obesity (Silver Spring) , vol.15 , Issue.8 , pp. 1954-1960
    • Paulsen, S.K.1    Pedersen, S.B.2    Fisker, S.3
  • 133
    • 68549139946 scopus 로고    scopus 로고
    • Clinical review: the pathogenetic role of cortisol in the metabolic syndrome: a hypothesis
    • Anagnostis P., Athyros V.G., Tziomalos K., et al. Clinical review: the pathogenetic role of cortisol in the metabolic syndrome: a hypothesis. JClin Endocrinol Metab 2009, 94(8):2692-2701.
    • (2009) JClin Endocrinol Metab , vol.94 , Issue.8 , pp. 2692-2701
    • Anagnostis, P.1    Athyros, V.G.2    Tziomalos, K.3
  • 134
    • 0030936556 scopus 로고    scopus 로고
    • Does central obesity reflect "Cushing's disease of the omentum"?
    • Bujalska I.J., Kumar S., Stewart P.M. Does central obesity reflect "Cushing's disease of the omentum"?. Lancet 1997, 349(9060):1210-1213.
    • (1997) Lancet , vol.349 , Issue.9060 , pp. 1210-1213
    • Bujalska, I.J.1    Kumar, S.2    Stewart, P.M.3
  • 135
    • 63249083541 scopus 로고    scopus 로고
    • Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans
    • Stimson R.H., Andersson J., Andrew R., et al. Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans. Diabetes 2009, 58(1):46-53.
    • (2009) Diabetes , vol.58 , Issue.1 , pp. 46-53
    • Stimson, R.H.1    Andersson, J.2    Andrew, R.3
  • 136
    • 43049122505 scopus 로고    scopus 로고
    • 11beta-hydroxysteroid dehydrogenase type 1 and obesity
    • Morton N.M., Seckl J.R. 11beta-hydroxysteroid dehydrogenase type 1 and obesity. Front Horm Res 2008, 36:146-164.
    • (2008) Front Horm Res , vol.36 , pp. 146-164
    • Morton, N.M.1    Seckl, J.R.2
  • 137
    • 43849098723 scopus 로고    scopus 로고
    • Anovel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis
    • Bujalska I.J., Gathercole L.L., Tomlinson J.W., et al. Anovel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis. JEndocrinol 2008, 197(2):297-307.
    • (2008) JEndocrinol , vol.197 , Issue.2 , pp. 297-307
    • Bujalska, I.J.1    Gathercole, L.L.2    Tomlinson, J.W.3
  • 138
    • 0031283178 scopus 로고    scopus 로고
    • 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress
    • Kotelevtsev Y., Holmes M.C., Burchell A., et al. 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci USA 1997, 94(26):14924-14929.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.26 , pp. 14924-14929
    • Kotelevtsev, Y.1    Holmes, M.C.2    Burchell, A.3
  • 139
    • 0035931269 scopus 로고    scopus 로고
    • Phenotypic analysis of mice bearing targeted deletions of 11beta-hydroxysteroid dehydrogenases 1 and 2 genes
    • Holmes M.C., Kotelevtsev Y., Mullins J.J., et al. Phenotypic analysis of mice bearing targeted deletions of 11beta-hydroxysteroid dehydrogenases 1 and 2 genes. Mol Cell Endocrinol 2001, 171(1-2):15-20.
    • (2001) Mol Cell Endocrinol , vol.171 , Issue.1-2 , pp. 15-20
    • Holmes, M.C.1    Kotelevtsev, Y.2    Mullins, J.J.3
  • 140
    • 0036432995 scopus 로고    scopus 로고
    • Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice
    • Alberts P., Engblom L., Edling N., et al. Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia 2002, 45(11):1528-1532.
    • (2002) Diabetologia , vol.45 , Issue.11 , pp. 1528-1532
    • Alberts, P.1    Engblom, L.2    Edling, N.3
  • 141
    • 12144291638 scopus 로고    scopus 로고
    • Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice
    • Morton N.M., Paterson J.M., Masuzaki H., et al. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes 2004, 53(4):931-938.
    • (2004) Diabetes , vol.53 , Issue.4 , pp. 931-938
    • Morton, N.M.1    Paterson, J.M.2    Masuzaki, H.3
  • 142
    • 0033305631 scopus 로고    scopus 로고
    • Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase
    • Bujalska I.J., Kumar S., Hewison M., et al. Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase. Endocrinology 1999, 140(7):3188-3196.
    • (1999) Endocrinology , vol.140 , Issue.7 , pp. 3188-3196
    • Bujalska, I.J.1    Kumar, S.2    Hewison, M.3
  • 143
    • 63249128191 scopus 로고    scopus 로고
    • Liver is the site of splanchnic cortisol production in obese nondiabetic humans
    • Basu R., Basu A., Grudzien M., et al. Liver is the site of splanchnic cortisol production in obese nondiabetic humans. Diabetes 2009, 58(1):39-45.
    • (2009) Diabetes , vol.58 , Issue.1 , pp. 39-45
    • Basu, R.1    Basu, A.2    Grudzien, M.3
  • 144
    • 84862748339 scopus 로고    scopus 로고
    • Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11beta-hydroxysteroid dehydrogenase type 1
    • Lavery G.G., Zielinska A.E., Gathercole L.L., et al. Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11beta-hydroxysteroid dehydrogenase type 1. Endocrinology 2012, 153(7):3236-3248.
    • (2012) Endocrinology , vol.153 , Issue.7 , pp. 3236-3248
    • Lavery, G.G.1    Zielinska, A.E.2    Gathercole, L.L.3
  • 145
    • 85047693986 scopus 로고    scopus 로고
    • Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice
    • Masuzaki H., Yamamoto H., Kenyon C.J., et al. Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. JClin Invest 2003, 112(1):83-90.
    • (2003) JClin Invest , vol.112 , Issue.1 , pp. 83-90
    • Masuzaki, H.1    Yamamoto, H.2    Kenyon, C.J.3
  • 146
    • 2342510149 scopus 로고    scopus 로고
    • Metabolic syndrome without obesity: hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice
    • Paterson J.M., Morton N.M., Fievet C., et al. Metabolic syndrome without obesity: hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice. Proc Natl Acad Sci USA 2004, 101(18):7088-7093.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.18 , pp. 7088-7093
    • Paterson, J.M.1    Morton, N.M.2    Fievet, C.3
  • 147
    • 33644679335 scopus 로고    scopus 로고
    • Apolygenic model of the metabolic syndrome with reduced circulating and intra-adipose glucocorticoid action
    • Morton N.M., Densmore V., Wamil M., et al. Apolygenic model of the metabolic syndrome with reduced circulating and intra-adipose glucocorticoid action. Diabetes 2005, 54(12):3371-3378.
    • (2005) Diabetes , vol.54 , Issue.12 , pp. 3371-3378
    • Morton, N.M.1    Densmore, V.2    Wamil, M.3
  • 148
    • 63249113536 scopus 로고    scopus 로고
    • Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?
    • Stewart P.M., Tomlinson J.W. Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?. Diabetes 2009, 58(1):14-15.
    • (2009) Diabetes , vol.58 , Issue.1 , pp. 14-15
    • Stewart, P.M.1    Tomlinson, J.W.2
  • 149
    • 84884693007 scopus 로고    scopus 로고
    • 11-Dehydrocorticosterone causes metabolic syndrome, which is prevented when 11beta-HSD1 is knocked out in livers of male mice
    • Harno E., Cottrell E.C., Keevil B.G., et al. 11-Dehydrocorticosterone causes metabolic syndrome, which is prevented when 11beta-HSD1 is knocked out in livers of male mice. Endocrinology 2013, 154(10):3599-3609.
    • (2013) Endocrinology , vol.154 , Issue.10 , pp. 3599-3609
    • Harno, E.1    Cottrell, E.C.2    Keevil, B.G.3
  • 150
    • 0036324073 scopus 로고    scopus 로고
    • Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity
    • Rask E., Walker B.R., Soderberg S., et al. Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity. JClin Endocrinol Metab 2002, 87(7):3330-3336.
    • (2002) JClin Endocrinol Metab , vol.87 , Issue.7 , pp. 3330-3336
    • Rask, E.1    Walker, B.R.2    Soderberg, S.3
  • 151
    • 33749064918 scopus 로고    scopus 로고
    • Adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing's syndrome
    • Mariniello B., Ronconi V., Rilli S., et al. Adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing's syndrome. Eur J Endocrinol 2006, 155(3):435-441.
    • (2006) Eur J Endocrinol , vol.155 , Issue.3 , pp. 435-441
    • Mariniello, B.1    Ronconi, V.2    Rilli, S.3
  • 152
    • 0036075081 scopus 로고    scopus 로고
    • Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study
    • Paulmyer-Lacroix O., Boullu S., Oliver C., et al. Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study. JClin Endocrinol Metab 2002, 87(6):2701-2705.
    • (2002) JClin Endocrinol Metab , vol.87 , Issue.6 , pp. 2701-2705
    • Paulmyer-Lacroix, O.1    Boullu, S.2    Oliver, C.3
  • 153
    • 2942683384 scopus 로고    scopus 로고
    • Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue
    • Tomlinson J.W., Moore J.S., Clark P.M., et al. Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue. JClin Endocrinol Metab 2004, 89(6):2711-2716.
    • (2004) JClin Endocrinol Metab , vol.89 , Issue.6 , pp. 2711-2716
    • Tomlinson, J.W.1    Moore, J.S.2    Clark, P.M.3
  • 154
    • 23044460294 scopus 로고    scopus 로고
    • Obesity and type 2 diabetes do not alter splanchnic cortisol production in humans
    • Basu R., Singh R.J., Basu A., et al. Obesity and type 2 diabetes do not alter splanchnic cortisol production in humans. JClin Endocrinol Metab 2005, 90(7):3919-3926.
    • (2005) JClin Endocrinol Metab , vol.90 , Issue.7 , pp. 3919-3926
    • Basu, R.1    Singh, R.J.2    Basu, A.3
  • 155
    • 0036882136 scopus 로고    scopus 로고
    • Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity
    • Tomlinson J.W., Sinha B., Bujalska I., et al. Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity. JClin Endocrinol Metab 2002, 87(12):5630-5635.
    • (2002) JClin Endocrinol Metab , vol.87 , Issue.12 , pp. 5630-5635
    • Tomlinson, J.W.1    Sinha, B.2    Bujalska, I.3
  • 156
    • 4544263736 scopus 로고    scopus 로고
    • 11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus
    • Valsamakis G., Anwar A., Tomlinson J.W., et al. 11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus. JClin Endocrinol Metab 2004, 89(9):4755-4761.
    • (2004) JClin Endocrinol Metab , vol.89 , Issue.9 , pp. 4755-4761
    • Valsamakis, G.1    Anwar, A.2    Tomlinson, J.W.3
  • 157
    • 0034099201 scopus 로고    scopus 로고
    • Lack of relationship between 11beta-hydroxysteroid dehydrogenase setpoint and insulin sensitivity in the basal state and after 24h of insulin infusion in healthy subjects and type 2 diabetic patients
    • Kerstens M.N., Riemens S.C., Sluiter W.J., et al. Lack of relationship between 11beta-hydroxysteroid dehydrogenase setpoint and insulin sensitivity in the basal state and after 24h of insulin infusion in healthy subjects and type 2 diabetic patients. Clin Endocrinol (Oxf) 2000, 52(4):403-411.
    • (2000) Clin Endocrinol (Oxf) , vol.52 , Issue.4 , pp. 403-411
    • Kerstens, M.N.1    Riemens, S.C.2    Sluiter, W.J.3
  • 158
    • 60849127882 scopus 로고    scopus 로고
    • Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss
    • Purnell J.Q., Kahn S.E., Samuels M.H., et al. Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss. Am J Physiol Endocrinol Metab 2009, 296(2):E351-E357.
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , Issue.2
    • Purnell, J.Q.1    Kahn, S.E.2    Samuels, M.H.3
  • 159
    • 36448973807 scopus 로고    scopus 로고
    • Type 2 diabetes and metabolic syndrome are associated with increased expression of 11beta-hydroxysteroid dehydrogenase 1 in obese subjects
    • Alberti L., Girola A., Gilardini L., et al. Type 2 diabetes and metabolic syndrome are associated with increased expression of 11beta-hydroxysteroid dehydrogenase 1 in obese subjects. Int J Obes (Lond) 2007, 31(12):1826-1831.
    • (2007) Int J Obes (Lond) , vol.31 , Issue.12 , pp. 1826-1831
    • Alberti, L.1    Girola, A.2    Gilardini, L.3
  • 160
    • 56949099309 scopus 로고    scopus 로고
    • Adipose tissue 11-beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase gene expressions are increased in patients with type 2 diabetes mellitus
    • Uckaya G., Karadurmus N., Kutlu O., et al. Adipose tissue 11-beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase gene expressions are increased in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 2008, 82(Suppl 2):S135-S140.
    • (2008) Diabetes Res Clin Pract , vol.82 , Issue.SUPPL. 2
    • Uckaya, G.1    Karadurmus, N.2    Kutlu, O.3
  • 161
    • 58149330675 scopus 로고    scopus 로고
    • Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity
    • Tomlinson J.W., Finney J., Gay C., et al. Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity. Diabetes 2008, 57(10):2652-2660.
    • (2008) Diabetes , vol.57 , Issue.10 , pp. 2652-2660
    • Tomlinson, J.W.1    Finney, J.2    Gay, C.3
  • 162
    • 0032990860 scopus 로고    scopus 로고
    • Cortisol metabolism in human obesity: impaired cortisone→cortisol conversion in subjects with central adiposity
    • Stewart P.M., Boulton A., Kumar S., et al. Cortisol metabolism in human obesity: impaired cortisone→cortisol conversion in subjects with central adiposity. JClin Endocrinol Metab 1999, 84(3):1022-1027.
    • (1999) JClin Endocrinol Metab , vol.84 , Issue.3 , pp. 1022-1027
    • Stewart, P.M.1    Boulton, A.2    Kumar, S.3
  • 163
    • 0037902924 scopus 로고    scopus 로고
    • Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians
    • Lindsay R.S., Wake D.J., Nair S., et al. Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. JClin Endocrinol Metab 2003, 88(6):2738-2744.
    • (2003) JClin Endocrinol Metab , vol.88 , Issue.6 , pp. 2738-2744
    • Lindsay, R.S.1    Wake, D.J.2    Nair, S.3
  • 164
    • 85047681877 scopus 로고    scopus 로고
    • Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines
    • Tomlinson J.W., Moore J., Cooper M.S., et al. Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. Endocrinology 2001, 142(5):1982-1989.
    • (2001) Endocrinology , vol.142 , Issue.5 , pp. 1982-1989
    • Tomlinson, J.W.1    Moore, J.2    Cooper, M.S.3
  • 165
    • 38649088252 scopus 로고    scopus 로고
    • Adipose tissue expression of 11beta-hydroxysteroid dehydrogenase type 1 in Cushing's syndrome and in obesity
    • Espindola-Antunes D., Kater C.E. Adipose tissue expression of 11beta-hydroxysteroid dehydrogenase type 1 in Cushing's syndrome and in obesity. Arq Bras Endocrinol Metabol 2007, 51(8):1397-1403.
    • (2007) Arq Bras Endocrinol Metabol , vol.51 , Issue.8 , pp. 1397-1403
    • Espindola-Antunes, D.1    Kater, C.E.2
  • 166
    • 0028839840 scopus 로고
    • Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation
    • Walker B.R., Connacher A.A., Lindsay R.M., et al. Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. JClin Endocrinol Metab 1995, 80(11):3155-3159.
    • (1995) JClin Endocrinol Metab , vol.80 , Issue.11 , pp. 3155-3159
    • Walker, B.R.1    Connacher, A.A.2    Lindsay, R.M.3
  • 167
    • 0037238379 scopus 로고    scopus 로고
    • Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes
    • Andrews R.C., Rooyackers O., Walker B.R. Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes. JClin Endocrinol Metab 2003, 88(1):285-291.
    • (2003) JClin Endocrinol Metab , vol.88 , Issue.1 , pp. 285-291
    • Andrews, R.C.1    Rooyackers, O.2    Walker, B.R.3
  • 168
    • 33947491197 scopus 로고    scopus 로고
    • Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity invivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis
    • Tomlinson J.W., Sherlock M., Hughes B., et al. Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity invivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis. JClin Endocrinol Metab 2007, 92(3):857-864.
    • (2007) JClin Endocrinol Metab , vol.92 , Issue.3 , pp. 857-864
    • Tomlinson, J.W.1    Sherlock, M.2    Hughes, B.3
  • 169
    • 0037194658 scopus 로고    scopus 로고
    • Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1
    • Barf T., Vallgarda J., Emond R., et al. Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1. JMed Chem 2002, 45(18):3813-3815.
    • (2002) JMed Chem , vol.45 , Issue.18 , pp. 3813-3815
    • Barf, T.1    Vallgarda, J.2    Emond, R.3
  • 170
    • 23944493717 scopus 로고    scopus 로고
    • 11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
    • Hermanowski-Vosatka A., Balkovec J.M., Cheng K., et al. 11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. JExp Med 2005, 202(4):517-527.
    • (2005) JExp Med , vol.202 , Issue.4 , pp. 517-527
    • Hermanowski-Vosatka, A.1    Balkovec, J.M.2    Cheng, K.3
  • 171
    • 41449104843 scopus 로고    scopus 로고
    • Inhibition of 11betaHSD1 with the S-phenylethylaminothiazolone BVT116429 increases adiponectin concentrations and improves glucose homeostasis in diabetic KKAy mice
    • Sundbom M., Kaiser C., Bjorkstrand E., et al. Inhibition of 11betaHSD1 with the S-phenylethylaminothiazolone BVT116429 increases adiponectin concentrations and improves glucose homeostasis in diabetic KKAy mice. BMC Pharmacol 2008, 8:3.
    • (2008) BMC Pharmacol , vol.8 , pp. 3
    • Sundbom, M.1    Kaiser, C.2    Bjorkstrand, E.3
  • 172
    • 34249775822 scopus 로고    scopus 로고
    • Depot-specific modulation of rat intraabdominal adipose tissue lipid metabolism by pharmacological inhibition of 11beta-hydroxysteroid dehydrogenase type 1
    • Berthiaume M., Laplante M., Festuccia W., et al. Depot-specific modulation of rat intraabdominal adipose tissue lipid metabolism by pharmacological inhibition of 11beta-hydroxysteroid dehydrogenase type 1. Endocrinology 2007, 148(5):2391-2397.
    • (2007) Endocrinology , vol.148 , Issue.5 , pp. 2391-2397
    • Berthiaume, M.1    Laplante, M.2    Festuccia, W.3
  • 173
    • 35148876079 scopus 로고    scopus 로고
    • 11beta-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues
    • Berthiaume M., Laplante M., Festuccia W.T., et al. 11beta-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues. Am J Physiol Endocrinol Metab 2007, 293(4):E1045-E1052.
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , Issue.4
    • Berthiaume, M.1    Laplante, M.2    Festuccia, W.T.3
  • 174
    • 67349178689 scopus 로고    scopus 로고
    • Additive action of 11beta-HSD1 inhibition and PPAR-gamma agonism on hepatic steatosis and triglyceridemia in diet-induced obese rats
    • Berthiaume M., Laplante M., Festuccia W.T., et al. Additive action of 11beta-HSD1 inhibition and PPAR-gamma agonism on hepatic steatosis and triglyceridemia in diet-induced obese rats. Int J Obes (Lond) 2009, 33(5):601-604.
    • (2009) Int J Obes (Lond) , vol.33 , Issue.5 , pp. 601-604
    • Berthiaume, M.1    Laplante, M.2    Festuccia, W.T.3
  • 175
    • 77950808186 scopus 로고    scopus 로고
    • Effect of 11 beta-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog
    • Edgerton D.S., Basu R., Ramnanan C.J., et al. Effect of 11 beta-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog. Am J Physiol Endocrinol Metab 2010, 298(5):E1019-E1026.
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , Issue.5
    • Edgerton, D.S.1    Basu, R.2    Ramnanan, C.J.3
  • 176
    • 77955630861 scopus 로고    scopus 로고
    • The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy
    • Rosenstock J., Banarer S., Fonseca V.A., et al. The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy. Diabetes Care 2010, 33(7):1516-1522.
    • (2010) Diabetes Care , vol.33 , Issue.7 , pp. 1516-1522
    • Rosenstock, J.1    Banarer, S.2    Fonseca, V.A.3
  • 177
    • 79955046317 scopus 로고    scopus 로고
    • Effects of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor, MK-0916, in patients with type 2 diabetes mellitus and metabolic syndrome
    • Feig P.U., Shah S., Hermanowski-Vosatka A., et al. Effects of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor, MK-0916, in patients with type 2 diabetes mellitus and metabolic syndrome. Diabetes Obes Metab 2011, 13(6):498-504.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.6 , pp. 498-504
    • Feig, P.U.1    Shah, S.2    Hermanowski-Vosatka, A.3
  • 178
    • 79955639922 scopus 로고    scopus 로고
    • Efficacy and safety of the selective 11beta-HSD-1 inhibitors MK-0736 and MK-0916 in overweight and obese patients with hypertension
    • Shah S., Hermanowski-Vosatka A., Gibson K., et al. Efficacy and safety of the selective 11beta-HSD-1 inhibitors MK-0736 and MK-0916 in overweight and obese patients with hypertension. JAm Soc Hypertens 2011, 5(3):166-176.
    • (2011) JAm Soc Hypertens , vol.5 , Issue.3 , pp. 166-176
    • Shah, S.1    Hermanowski-Vosatka, A.2    Gibson, K.3
  • 179
    • 84866303279 scopus 로고    scopus 로고
    • Biomarkers of hypothalamic-pituitary-adrenal axis activity in mice lacking 11beta-HSD1 and H6PDH
    • Abrahams L., Semjonous N.M., Guest P., et al. Biomarkers of hypothalamic-pituitary-adrenal axis activity in mice lacking 11beta-HSD1 and H6PDH. JEndocrinol 2012, 214(3):367-372.
    • (2012) JEndocrinol , vol.214 , Issue.3 , pp. 367-372
    • Abrahams, L.1    Semjonous, N.M.2    Guest, P.3
  • 180
    • 18244405083 scopus 로고    scopus 로고
    • Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: a dose-response study
    • Pasquali R., Ambrosi B., Armanini D., et al. Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: a dose-response study. JClin Endocrinol Metab 2002, 87(1):166-175.
    • (2002) JClin Endocrinol Metab , vol.87 , Issue.1 , pp. 166-175
    • Pasquali, R.1    Ambrosi, B.2    Armanini, D.3
  • 181
    • 65249109370 scopus 로고    scopus 로고
    • Combined receptor antagonist stimulation of the hypothalamic-pituitary-adrenal axis test identifies impaired negative feedback sensitivity to cortisol in obese men
    • Mattsson C., Reynolds R.M., Simonyte K., et al. Combined receptor antagonist stimulation of the hypothalamic-pituitary-adrenal axis test identifies impaired negative feedback sensitivity to cortisol in obese men. JClin Endocrinol Metab 2009, 94(4):1347-1352.
    • (2009) JClin Endocrinol Metab , vol.94 , Issue.4 , pp. 1347-1352
    • Mattsson, C.1    Reynolds, R.M.2    Simonyte, K.3
  • 182
    • 0034534234 scopus 로고    scopus 로고
    • Abnormalities of the hypothalamic-pituitary-adrenal axis in nondepressed women with abdominal obesity and relations with insulin resistance: evidence for a central and a peripheral alteration
    • Vicennati V., Pasquali R. Abnormalities of the hypothalamic-pituitary-adrenal axis in nondepressed women with abdominal obesity and relations with insulin resistance: evidence for a central and a peripheral alteration. JClin Endocrinol Metab 2000, 85(11):4093-4098.
    • (2000) JClin Endocrinol Metab , vol.85 , Issue.11 , pp. 4093-4098
    • Vicennati, V.1    Pasquali, R.2
  • 183
    • 0031715553 scopus 로고    scopus 로고
    • Effect of fat distribution on the pharmacokinetics of cortisol in obesity
    • Lottenberg S.A., Giannella-Neto D., Derendorf H., et al. Effect of fat distribution on the pharmacokinetics of cortisol in obesity. Int J Clin Pharmacol Ther 1998, 36(9):501-505.
    • (1998) Int J Clin Pharmacol Ther , vol.36 , Issue.9 , pp. 501-505
    • Lottenberg, S.A.1    Giannella-Neto, D.2    Derendorf, H.3
  • 184
    • 0030467287 scopus 로고    scopus 로고
    • Differential stimulation of cortisol and dehydroepiandrosterone levels by food in obese and normal subjects: relation to body fat distribution
    • Korbonits M., Trainer P.J., Nelson M.L., et al. Differential stimulation of cortisol and dehydroepiandrosterone levels by food in obese and normal subjects: relation to body fat distribution. Clin Endocrinol 1996, 45(6):699-706.
    • (1996) Clin Endocrinol , vol.45 , Issue.6 , pp. 699-706
    • Korbonits, M.1    Trainer, P.J.2    Nelson, M.L.3
  • 185
    • 0029881473 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-adrenal axis activity and its relationship to the autonomic nervous system in women with visceral and subcutaneous obesity: effects of the corticotropin-releasing factor/arginine-vasopressin test and of stress
    • Pasquali R., Anconetani B., Chattat R., et al. Hypothalamic-pituitary-adrenal axis activity and its relationship to the autonomic nervous system in women with visceral and subcutaneous obesity: effects of the corticotropin-releasing factor/arginine-vasopressin test and of stress. Metabolism 1996, 45(3):351-356.
    • (1996) Metabolism , vol.45 , Issue.3 , pp. 351-356
    • Pasquali, R.1    Anconetani, B.2    Chattat, R.3
  • 186
    • 0033018598 scopus 로고    scopus 로고
    • Cortisol effects on body mass, blood pressure, and cholesterol in the general population
    • Fraser R., Ingram M.C., Anderson N.H., et al. Cortisol effects on body mass, blood pressure, and cholesterol in the general population. Hypertension 1999, 33(6):1364-1368.
    • (1999) Hypertension , vol.33 , Issue.6 , pp. 1364-1368
    • Fraser, R.1    Ingram, M.C.2    Anderson, N.H.3
  • 187
    • 0026685047 scopus 로고
    • Cortisol secretion in relation to body fat distribution in obese premenopausal women
    • Marin P., Darin N., Amemiya T., et al. Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism 1992, 41(8):882-886.
    • (1992) Metabolism , vol.41 , Issue.8 , pp. 882-886
    • Marin, P.1    Darin, N.2    Amemiya, T.3
  • 188
    • 0031800688 scopus 로고    scopus 로고
    • Pulsatile secretion of ACTH and cortisol in premenopausal women: effect of obesity and body fat distribution
    • Pasquali R., Biscotti D., Spinucci G., et al. Pulsatile secretion of ACTH and cortisol in premenopausal women: effect of obesity and body fat distribution. Clin Endocrinol (Oxf) 1998, 48(5):603-612.
    • (1998) Clin Endocrinol (Oxf) , vol.48 , Issue.5 , pp. 603-612
    • Pasquali, R.1    Biscotti, D.2    Spinucci, G.3
  • 189
    • 77949393613 scopus 로고    scopus 로고
    • Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence
    • Adam E.K., Doane L.D., Zinbarg R.E., et al. Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence. Psychoneuroendocrinology 2010, 35(6):921-931.
    • (2010) Psychoneuroendocrinology , vol.35 , Issue.6 , pp. 921-931
    • Adam, E.K.1    Doane, L.D.2    Zinbarg, R.E.3
  • 190
    • 77957819636 scopus 로고    scopus 로고
    • Cortisol is negatively associated with insulin sensitivity in overweight Latino youth
    • Adam T.C., Hasson R.E., Ventura E.E., et al. Cortisol is negatively associated with insulin sensitivity in overweight Latino youth. JClin Endocrinol Metab 2010, 95(10):4729-4735.
    • (2010) JClin Endocrinol Metab , vol.95 , Issue.10 , pp. 4729-4735
    • Adam, T.C.1    Hasson, R.E.2    Ventura, E.E.3
  • 191
    • 77954463370 scopus 로고    scopus 로고
    • Glucocorticoid receptor gene, low-grade inflammation, and heart failure: the Heart and Soul study
    • Otte C., Wust S., Zhao S., et al. Glucocorticoid receptor gene, low-grade inflammation, and heart failure: the Heart and Soul study. JClin Endocrinol Metab 2010, 95(6):2885-2891.
    • (2010) JClin Endocrinol Metab , vol.95 , Issue.6 , pp. 2885-2891
    • Otte, C.1    Wust, S.2    Zhao, S.3
  • 192
    • 70449353451 scopus 로고    scopus 로고
    • Clinical features associated with glucocorticoid receptor polymorphisms. An overview
    • Manenschijn L., van den Akker E.L., Lamberts S.W., et al. Clinical features associated with glucocorticoid receptor polymorphisms. An overview. Ann N Y Acad Sci 2009, 1179:179-198.
    • (2009) Ann N Y Acad Sci , vol.1179 , pp. 179-198
    • Manenschijn, L.1    van den Akker, E.L.2    Lamberts, S.W.3
  • 193
    • 84874851489 scopus 로고    scopus 로고
    • BclI glucocorticoid receptor polymorphism is associated with greater body fatness: the Hoorn and CODAM studies
    • Geelen C.C., van Greevenbroek M.M., van Rossum E.F., et al. BclI glucocorticoid receptor polymorphism is associated with greater body fatness: the Hoorn and CODAM studies. JClin Endocrinol Metab 2013, 98(3):E595-E599.
    • (2013) JClin Endocrinol Metab , vol.98 , Issue.3
    • Geelen, C.C.1    van Greevenbroek, M.M.2    van Rossum, E.F.3
  • 194
    • 0033798376 scopus 로고    scopus 로고
    • Stress and body shape: stress-induced cortisol secretion is consistently greater among women with central fat
    • Epel E.S., McEwen B., Seeman T., et al. Stress and body shape: stress-induced cortisol secretion is consistently greater among women with central fat. Psychosom Med 2000, 62(5):623-632.
    • (2000) Psychosom Med , vol.62 , Issue.5 , pp. 623-632
    • Epel, E.S.1    McEwen, B.2    Seeman, T.3
  • 195
    • 0033913091 scopus 로고    scopus 로고
    • Activity of the hypothalamic-pituitary-adrenal axis in different obesity phenotypes
    • Pasquali R., Vicennati V. Activity of the hypothalamic-pituitary-adrenal axis in different obesity phenotypes. Int J Obes Relat Metab Disord 2000, 24(Suppl 2):S47-S49.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , Issue.SUPPL. 2
    • Pasquali, R.1    Vicennati, V.2
  • 196
    • 84877716099 scopus 로고    scopus 로고
    • High long-term cortisol levels, measured in scalp hair, are associated with a history of cardiovascular disease
    • Manenschijn L., Schaap L., van Schoor N.M., et al. High long-term cortisol levels, measured in scalp hair, are associated with a history of cardiovascular disease. JClin Endocrinol Metab 2013, 98(5):2078-2083.
    • (2013) JClin Endocrinol Metab , vol.98 , Issue.5 , pp. 2078-2083
    • Manenschijn, L.1    Schaap, L.2    van Schoor, N.M.3
  • 197
  • 198
    • 0031737777 scopus 로고    scopus 로고
    • Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals
    • Huizenga N.A., Koper J.W., de Lange P., et al. Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals. JClin Endocrinol Metab 1998, 83(1):47-54.
    • (1998) JClin Endocrinol Metab , vol.83 , Issue.1 , pp. 47-54
    • Huizenga, N.A.1    Koper, J.W.2    de Lange, P.3
  • 199
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H., Barnes G.T., Yang Q., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. JClin Invest 2003, 112(12):1821-1830.
    • (2003) JClin Invest , vol.112 , Issue.12 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 200
    • 0032717064 scopus 로고    scopus 로고
    • Decreased expression and function of adipocyte hormone-sensitive lipase in subcutaneous fat cells of obese subjects
    • Large V., Reynisdottir S., Langin D., et al. Decreased expression and function of adipocyte hormone-sensitive lipase in subcutaneous fat cells of obese subjects. JLipid Res 1999, 40(11):2059-2066.
    • (1999) JLipid Res , vol.40 , Issue.11 , pp. 2059-2066
    • Large, V.1    Reynisdottir, S.2    Langin, D.3
  • 201
    • 37349006913 scopus 로고    scopus 로고
    • TNF-alpha and adipocyte biology
    • Cawthorn W.P., Sethi J.K. TNF-alpha and adipocyte biology. FEBS Lett 2008, 582(1):117-131.
    • (2008) FEBS Lett , vol.582 , Issue.1 , pp. 117-131
    • Cawthorn, W.P.1    Sethi, J.K.2
  • 202
    • 4243150843 scopus 로고    scopus 로고
    • The role of TNF-alpha in insulin resistance
    • Borst S.E. The role of TNF-alpha in insulin resistance. Endocrine 2004, 23(2-3):177-182.
    • (2004) Endocrine , vol.23 , Issue.2-3 , pp. 177-182
    • Borst, S.E.1
  • 203
    • 77957838795 scopus 로고    scopus 로고
    • Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
    • Kosteli A., Sugaru E., Haemmerle G., et al. Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. JClin Invest 2010, 120(10):3466-3479.
    • (2010) JClin Invest , vol.120 , Issue.10 , pp. 3466-3479
    • Kosteli, A.1    Sugaru, E.2    Haemmerle, G.3
  • 204
    • 67650224475 scopus 로고    scopus 로고
    • Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization
    • Capel F., Klimcakova E., Viguerie N., et al. Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization. Diabetes 2009, 58(7):1558-1567.
    • (2009) Diabetes , vol.58 , Issue.7 , pp. 1558-1567
    • Capel, F.1    Klimcakova, E.2    Viguerie, N.3
  • 205
    • 0023947267 scopus 로고
    • Glucocorticoids suppress the production of tumour necrosis factor by lipopolysaccharide-stimulated human monocytes
    • Waage A., Bakke O. Glucocorticoids suppress the production of tumour necrosis factor by lipopolysaccharide-stimulated human monocytes. Immunology 1988, 63(2):299-302.
    • (1988) Immunology , vol.63 , Issue.2 , pp. 299-302
    • Waage, A.1    Bakke, O.2
  • 206
    • 11144304196 scopus 로고    scopus 로고
    • Suppression of cytokine-induced expression of endothelin-1 by dexamethasone in human retinal pigment epithelial cells
    • Udono-Fujimori R., Totsune K., Murakami O., et al. Suppression of cytokine-induced expression of endothelin-1 by dexamethasone in human retinal pigment epithelial cells. JCardiovasc Pharmacol 2004, 44:S471-S473.
    • (2004) JCardiovasc Pharmacol , vol.44
    • Udono-Fujimori, R.1    Totsune, K.2    Murakami, O.3
  • 207
    • 12944250985 scopus 로고    scopus 로고
    • Interleukin-6 is inhibited by glucocorticoids and stimulates ACTH secretion and POMC expression in human corticotroph pituitary adenomas
    • Pereda M.P., Lohrer P., Kovalovsky D., et al. Interleukin-6 is inhibited by glucocorticoids and stimulates ACTH secretion and POMC expression in human corticotroph pituitary adenomas. Exp Clin Endocrinol Diabetes 2000, 108:202-207.
    • (2000) Exp Clin Endocrinol Diabetes , vol.108 , pp. 202-207
    • Pereda, M.P.1    Lohrer, P.2    Kovalovsky, D.3
  • 208
    • 0027196668 scopus 로고
    • Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man
    • Barber A.E., Coyle S.M., Marano M.A., et al. Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man. JImmunol 1993, 150(5):1999-2006.
    • (1993) JImmunol , vol.150 , Issue.5 , pp. 1999-2006
    • Barber, A.E.1    Coyle, S.M.2    Marano, M.A.3
  • 209
    • 0030854812 scopus 로고    scopus 로고
    • Exercise and circadian rhythm-induced variations in plasma cortisol differentially regulate interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor-alpha (TNF alpha) production in humans: high sensitivity of TNF alpha and resistance of IL-6
    • DeRijk R., Michelson D., Karp B., et al. Exercise and circadian rhythm-induced variations in plasma cortisol differentially regulate interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor-alpha (TNF alpha) production in humans: high sensitivity of TNF alpha and resistance of IL-6. JClin Endocrinol Metab 1997, 82(7):2182-2191.
    • (1997) JClin Endocrinol Metab , vol.82 , Issue.7 , pp. 2182-2191
    • DeRijk, R.1    Michelson, D.2    Karp, B.3
  • 210
    • 0344688183 scopus 로고    scopus 로고
    • Glucocorticoids and invasive fungal infections
    • Lionakis M.S., Kontoyiannis D.P. Glucocorticoids and invasive fungal infections. Lancet 2003, 362(9398):1828-1838.
    • (2003) Lancet , vol.362 , Issue.9398 , pp. 1828-1838
    • Lionakis, M.S.1    Kontoyiannis, D.P.2
  • 211
    • 0042330251 scopus 로고    scopus 로고
    • Minireview: the adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis
    • Rajala M.W., Scherer P.E. Minireview: the adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 2003, 144(9):3765-3773.
    • (2003) Endocrinology , vol.144 , Issue.9 , pp. 3765-3773
    • Rajala, M.W.1    Scherer, P.E.2
  • 212
    • 6944237757 scopus 로고    scopus 로고
    • Adipokines: inflammation and the pleiotropic role of white adipose tissue
    • Trayhurn P., Wood I.S. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004, 92(3):347-355.
    • (2004) Br J Nutr , vol.92 , Issue.3 , pp. 347-355
    • Trayhurn, P.1    Wood, I.S.2
  • 213
    • 0029931263 scopus 로고    scopus 로고
    • Acute glucocorticoid deficiency is associated with plasma elevations of interleukin-6: does the latter participate in the symptomatology of steroid withdrawal syndrome and adrenal insufficiency?
    • Papanicolaou D.A., Tsigos C., Oldfield E.H., et al. Acute glucocorticoid deficiency is associated with plasma elevations of interleukin-6: does the latter participate in the symptomatology of steroid withdrawal syndrome and adrenal insufficiency?. JClin Endocrinol Metab 1996, 81:2303-2306.
    • (1996) JClin Endocrinol Metab , vol.81 , pp. 2303-2306
    • Papanicolaou, D.A.1    Tsigos, C.2    Oldfield, E.H.3
  • 214
    • 33947270991 scopus 로고    scopus 로고
    • Increased insulin-stimulated endothelin-1 release is a distinct vascular phenotype distinguishing Cushing's disease from metabolic syndrome
    • Setola E., Losa M., Lanzi R., et al. Increased insulin-stimulated endothelin-1 release is a distinct vascular phenotype distinguishing Cushing's disease from metabolic syndrome. Clin Endocrinol 2007, 66:586-592.
    • (2007) Clin Endocrinol , vol.66 , pp. 586-592
    • Setola, E.1    Losa, M.2    Lanzi, R.3
  • 215
    • 0038360797 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist is associated with fat distribution in endogenous Cushing's syndrome: a longitudinal study
    • Ueland T., Kristo C., Godang K., et al. Interleukin-1 receptor antagonist is associated with fat distribution in endogenous Cushing's syndrome: a longitudinal study. JClin Endocrinol Metab 2003, 88:1492-1496.
    • (2003) JClin Endocrinol Metab , vol.88 , pp. 1492-1496
    • Ueland, T.1    Kristo, C.2    Godang, K.3


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