Acute glucocorticoid deficiency is associated with plasma elevations of interleukin-6: Does the latter participate in the symptomatology of the steroid withdrawal syndrome and adrenal insufficiency?

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 6, 1996, Pages 2303-2306

  Papanicolaou, Dimitris A ^a   Tsigos, Constantine ^a   Oldfield, Edward H ^a   Chrousos, George P ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DEXAMETHASONE; HYDROCORTISONE; INTERLEUKIN 1; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANOREXIA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CUSHING SYNDROME; FATIGUE; FEMALE; FEVER; HUMAN; HYPERCORTISOLISM; INFLUENZA; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; SOMNOLENCE; TRANSSPHENOIDAL SURGERY;

EID: 0029931263     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.81.6.8964868     Document Type: Article

References (25)

1. Chrousos GP. 1995 The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Mod. 332:1351-1362.
2. Lyson K, McCann SM. 1991 The effect of interleukin-6 on pituitary hormone release in vivo and in vitro. Neuroendocrinology. 54:262-266.
3. Perlstein RS, Whitnall MH, Abrams JS, Mougey EH, Neta R. 1993 Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharicie in vivo. Endocrinology. 132:446-952.
4. Mastorakos G, Chrousos GP, Weber JS. 1993 Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. J Clin Endocrinol Metab. 77:1690-1694.
5. Barber AE, Coyle SM, Marano MA, et al. 1943 Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man. J Immunol. 150:1999-2006.
6. Breuninger LM, Dempsey WL, Uhl J, Murasco DM. 1993 Hydrocortisone regulation of interleukin-6 protein production by a purified population of human peripheral blood monocytes. Clin Immunol Immunopathol. 69:205-214.
7. Lee SW, Tsou AP, Chan H, et al. 1988 Glucocorticoids selectively inhibit the transcription of the interleukin 1β gene and decrease the stability of interleukin 1β mRNA. Proc Natl Acad Sci USA. 85:1204-1208.
8. Oldfield EH, Doppman JL, Nieman LK, et al. 1991 Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing's syndrome. N Engl J Med. 325:897-905.
9. Watabe T, Tanaka K, Kumagae M, et al. 1987 Hormonal responses to insulin-induced hypoglycemia in man. J Clin Endocrinol Metab. 65:1187-1191.
10. Chrousos GP, Schulte HM, Oldfield EH, et al. 1984 The corticotropin releasing factor stimulation test: an aid in the differential diagnosis of Cushing's syndrome. N Engl J Med. 310:622-626.
11. Kao M, Voina S, Nichols A, Horton R. 1975 Parallel radioimmunoassay for plasma Cortisol and 11-deoxycortisol. Clin Chem. 21:1644-1647.
12. Sakamoto K, Arakawa H, Ishiko T, et al. 1994 Elevation of circulating interleukin 6 after surgery: factors influencing the serum level. Cytokine. 6:181-186.
13. Cruickshank AM, Fraser WD, Burns JG, Van Damme J, Shenkin A. 1990 Response of serum interleukin-6 in patients undergoing elective surgery of varying severity. Clin Sci. 79:161-165.
14. Parry-Billings Mark, Baigrie RJ, Lamont PM, Morris PJ, Newsholme EA. 1942 Effects of major and minor surgery on plasma glutamine and cytokine levels. Arch Surg. 127:1237-1240.
15. Doherty GM, Jensen JC, Buresh CM, Norton JA. 1992 Hormonal regulation of inflammatory cell cytokine transcript and bioactivity production in response to endotoxin. Cytokine. 4:55-62.
16. Rock CS, Coyle SM, Keogh CV, et al. 1992 Influence of hypercortisolemia on the acute-phase protein response to endotoxin in humans. Surgery. 112:467-474.
17. Høgevold HE, Kierulf P, Øvstebo R, Reikerås O. 1942 Acute phase reactants and interleukin 6 after total hip replacement; effects of high dose corticosteroids. Eur J Surg. 158:339-345.
18. Papanicolaou DA, Petrides J, Tsigos C, et al. Physical stress stimulates the secretion of interleukin-6 (IL-6) in humans [Abstract]. Proc of the 77th Annual Meet of The Endocrine Soc. 1995;639.
19. Van Gool J, Van Vugt H, Helle M, Aarden LA. 1990 The relation among stress, adrenalin, interleukin 6 and acute phase proteins in the rat. Clin Immunol Immunopathol. 57:200-210.
20. Saruta T, Suzuki H, Handa M, Igarashi Y, Kondo K, Senba S. 1986 Multiple factors contribute to the pathogenesis of hypertension in Cushing's syndrome. J Clin Endocrinol Metab. 62:275-279.
21. Mastorakos G, Weber JS, Magiakou MA, Gunn H, Chrousos GP. 1994 Hypothalamic-pituitary-adrenal axis activation and stimulation of systemic vasopressin secretion by recombinant interleukin-6 in humans: potential implications for the syndrome of inappropriate vasopressin secretion. J Clin Endocrinol Metab. 79:934-938.
22. Rothwell NJ. 1993 Cytokines and thermogenesis. Int J Obesity. 17(Suppl 3): S98-S101.
23. Tsigos C, Papanicolaou DA, Defensor R, Mitsiadis CS, Yanovski SZ, Chrousos GP. Dose-response relationships between single subcutaneous injections of interleukin-6 and thermogenesis/hypothalamic-pituitary-adrenal (HPA) axis activity in human volunteers [Abstract]. Proc of the 77th Annual Meet of The Endocrine Soc. 1995;640.
24. Amatruda TT, Hurst MM, D'Esopo ND. 1965 Certain endocrine and metabolic facets of the steroid withdrawal syndrome. J Clin Endocrinol Metab. 25:1207-1217.
25. Orth N, Kovacs WJ, DeBold CR. 1992 The adrenal cortex. In: Wilson JD, Foster DW, eds. Williams' textbook of endocrinology. 8th ed. Philadelphia: Saunders; 489-619.