Thrombospondin-1 is an adipokine associated with obesity, adipose inflammation, and insulin resistance

Diabetes

Volumn 57, Issue 2, 2008, Pages 432-439

  Varma, Vijayalakshmi ^a   Yao Borengasser, Aiwei ^a   Bodies, Angela M ^a   Rasouli, Neda ^a   Phanavanh, Bounleut ^a   Nolen, Greg T ^a   Kern, Emily M ^a   Nagarajan, Radhakrishnan ^a   Spencer III, Horace J ^a   Lee, Mi Jeong ^b   Fried, Susan K ^b   McGehee Jr , Robert E ^a,c   Peterson, Charlotte A ^d   Kern, Philip A ^a,e  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

^e CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD68 ANTIGEN; MESSENGER RNA; METFORMIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PIOGLITAZONE; PLASMINOGEN ACTIVATOR INHIBITOR 1; THROMBOSPONDIN 1;

ADIPOCYTE; ADIPOSE TISSUE; ADULT; AGED; ARTICLE; BODY MASS; CELL CULTURE; COCULTURE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMPAIRED GLUCOSE TOLERANCE; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; SUBCUTANEOUS FAT; CELL LINE; CULTURE TECHNIQUE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; PATHOPHYSIOLOGY; PHYSIOLOGY; REFERENCE VALUE; STEM CELL;

ADIPOCYTES; ADIPOSE TISSUE; CELL CULTURE TECHNIQUES; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INSULIN RESISTANCE; MACROPHAGES; OBESITY; REFERENCE VALUES; RNA, MESSENGER; STEM CELLS; THROMBOSPONDIN 1;

EID: 40749150741     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db07-0840     Document Type: Article

References (48)

1. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830, 2003
2. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr: Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808, 2003
3. Wellen KE, Hotamisligil GS: Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 112:1785-1788, 2003
4. Vidal H: Gene expression in visceral and subcutaneous adipose tissues. Ann Med 33:547-555, 2001
5. Ramis JM, Franssen-van Hal NL, Kramer E, Llado I, Bouillaud F, Palou A, Keijer J: Carboxypeptidase E and thrombospondin-1 are differently expressed in subcutaneous and visceral fat of obese subjects. Cell Mol Life Sci 59:1960-1971, 2002
6. Hida K, Wada J, Zhang H, Hiragushi K, Tsuchiyama Y, Shikata K, Makino H: Identification of genes specifically expressed in the accumulated visceral adipose tissue of OLETF rats. J Lipid Res 41:1615-1622, 2000
7. Voros G, Maquoi E, Demeulemeester D, Clerx N, Collen D, Lijnen HR: Modulation of angiogenesis during adipose tissue development in murine models of obesity. Endocrinology 146:4545-4554, 2005
8. Bayraktar M, Dundar S, Kirazli S, Teletar F: Platelet factor 4, beta-thromboglobulin and thrombospondin levels in type I diabetes mellitus patients. J Int Med Res 22:90-94, 1994
9. Tschoepe D, Rauch U, Schwippert B: Platelet-leukocyte-cross-talk in diabetes mellitus. Horm Metab Res 29:631-635, 1997
10. Olson BA, Day JR, Laping NJ: Age-related expression of renal throm-bospondin 1 mRNA in F344 rats: resemblance to diabetes-induced expression in obese Zucker rats. Pharmacology 58:200-208, 1999
11. Poczatek MH, Hugo C, Darley-Usmar V, Murphy-Ullrich JE: Glucose stimulation of transforming growth factor-beta bioactivity in mesangial cells is mediated by thrombospondin-1. Am J Pathol 157:1353-1363, 2000
12. McLaren KM: Immunohistochemical localisation of thrombospondin in human megakaryocytes and platelets. J Clin Pathol 36:197-199, 1983
13. Mosher DF, Doyle MJ, Jaffe EA: Synthesis and secretion of throm-bospondin by cultured human endothelial cells. J Cell Biol 93:343-348, 1982
14. Jaffe EA, Ruggiero JT, Leung LK, Doyle MJ, McKeown-Longo PJ, Mosher DF: Cultured human fibroblasts synthesize and secrete thrombospondin and incorporate it into extracellular matrix. Proc Natl Acad SciUSA 80:998-1002, 1983
15. Jaffe EA, Ruggiero JT, Falcone DJ: Monocytes and macrophages synthesize and secrete thrombospondin. Blood 65:79-84, 1985
16. Okuno M, Arimoto E, Nishizuka M, Nishihara T, Imagawa M: Isolation of up- or down-regulated genes in PPARgamma-expressing NIH-3T3 cells during differentiation into adipocytes. FEBS Lett 519:108-112, 2002
17. Bornstein P: Thrombospondins as matricellular modulators of cell function. J Clin Invest 107:929-934, 2001
18. Esemuede N, Lee T, Pierre-Paul D, Sumpio BE, Gahtan V: The role of thrombospondin-1 in human disease. J Surg Res 122:135-142, 2004
19. Murphy-Ullrich JE, Poczatek M: Activation of latent TGF-beta by throm-bospondin-1: mechanisms and physiology. Cytokine Growth Factor Rev 11:59-69, 2000
20. Crawford SE, Stellmach V, Murphy-Ullrich JE, Ribeiro SM, Lawler J, Hynes RO, Boivin GP, Bouck N: Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell 93:1159-1170, 1998
21. Alessi MC, Peiretti F, Morange P, Henry M, Nalbone G, Juhan-Vague I: Production of plasminogen activator inhibitor 1 by human adipose tissue: possible link between visceral fat accumulation and vascular disease. Diabetes 46:860-867, 1997
22. Lundgren CH, Brown SL, Nordt TK, Sobel BE, Fujii S: Elaboration of type-1 plasminogen activator inhibitor from adipocytes: a potential pathogenetic link between obesity and cardiovascular disease. Circulation 93:106-110, 1996
23. Alessi MC, Bastelica D, Morange P, Berthet B, Leduc I, Verdier M, Geel O, Juhan-Vague I: Plasminogen activator inhibitor 1, transforming growth factor-β1, and BMI are closely associated in human adipose tissue during morbid obesity. Diabetes 49:1374-1380, 2000
24. Samad F, Yamamoto K, Pandey M, Loskutoff DJ: Elevated expression of transforming growth factor-beta in adipose tissue from obese mice. Mol Med 3:37-48, 1997
25. Mertens I, Verrijken A, Michiels JJ, Van der PM, Ruige JB, Van Gaal LF: Among inflammation and coagulation markers, PAI-1 is a true component of the metabolic syndrome. Int J Obes (Lond) 30:1308-1314, 2006
26. Bergman RN, Finegood DT, Ader M: Assessment of insulin sensitivity in vivo. Endocr Rev 6:45-86, 1985
27. Boston RC, Stefanovski D, Moate PJ, Sumner AE, Watanabe RM, Bergman RN: MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test. Diabetes Technol Ther 5:1003-1015, 2003
28. Halvorsen YD, Bond A, Sen A, Franklin DM, Lea-Currie YR, Sujkowski D, Ellis PN, Wilkison WO, Gimble JM: Thiazolidinediones and glucocorticoids synergistically induce differentiation of human adipose tissue stromal cells: biochemical, cellular, and molecular analysis. Metabolism 50:407-413, 2001
29. Di Gregorio GB, Yao-Borengasser A, Rasouli N, Varma V, Lu T, Miles LM, Ranganathan G, Peterson CA, McGehee RE, Kern PA: Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes 54:2305-2313, 2005
30. Wabitsch M, Brenner RE, Melzner I, Braun M, Moller P, Heinze E, Debatin KM, Hauner H: Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int J Obes Relat Metab Disord 25:8-15, 2001
31. Bodles AM, Varma V, Yao-Borengasser A, Phanavanh B, Peterson CA, McGehee RE Jr, Rasouli N, Wabitsch M, Kern PA: Pioglitazone induces apoptosis of macrophages in human adipose tissue. J Lipid Res 47:2080-2088, 2006
32. Bastelica D, Morange P, Berthet B, Borghi H, Lacroix O, Grino M, Juhan-Vague I, Alessi MC: Stromal cells are the main plasminogen activator inhibitor-1-producing cells in human fat: evidence of differences between visceral and subcutaneous deposits. Arterioscler Thromb Vasc Biol 22:173-178, 2002
33. Rasouli N, Raue U, Miles LM, Lu T, Di Gregorio GB, Elbein SC, Kern PA: Pioglitazone improves insulin sensitivity through reduction in muscle lipid and redistribution of lipid into adipose tissue. Am J Physiol Endocrinol Metab 288:E930-E934, 2005
34. Zirlik A, Leugers A, Lohrmann J, Ernst S, Sobel BE, Bode C, Nordt TK: Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones. Thromb Haemost 91:674-682, 2004
35. Nakagawa T, Li JH, Garcia G, Mu W, Piek E, Bottinger EP, Chen Y, Zhu HJ, Kang DH, Schreiner GF, Lan HY, Johnson RJ: TGF-beta induces proangio-genic and antiangiogenic factors via parallel but distinct Smad pathways. Kidney Int 66:605-613, 2004
36. Raman P, Krukovets I, Marinic TE, Bornstein P, Stenina OI: Glycosylation mediates upregulation of a potent antiangiogenic and proatherogenic protein, thrombospondin-1, by glucose in vascular smooth muscle cells. J Biol Chem 282:5704-5714, 2006
37. Stenina OI, Krukovets I, Wang K, Zhou Z, Forudi F, Penn MS, Topol EJ, Plow EF: Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker rat. Circulation 107:3209-3215, 2003
38. Bagavandoss P, Wilks JW: Specific inhibition of endothelial cell proliferation by thrombospondin. Biochem Biophys Res Commun 170:867-872, 1990
39. Boden G, Shulman GI: Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 32 (Suppl. 3):14-23, 2002
40. Rajala MW, Scherer PE: Minireview: the adipocyte: at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144:3765-3773, 2003
41. Greenberg AS, Obin MS: Obesity and the role of adipose tissue in inflammation and metabolism. Am, J Clin Nutr 83:461S-465S, 2006
42. Cancello R, Clement K: Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG 113:1141-1147, 2006
43. Kanaya AM, Wassel FC, Vittinghoff E, Harris TB, Park SW, Goodpaster BH, Tylavsky F, Cummings SR: Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1. Arch Intern Med 166:350-356, 2006
44. Cigolini M, Tonoli M, Borgato L, Frigotto L, Manzato F, Zeminian S, Cardinale C, Camin M, Chiaramonte E, De Sandre G, Lunardi C: Expression of plasminogen activator inhibitor-1 in human adipose tissue: a role for TNF-alpha? Atherosclerosis 143:81-90, 1999
45. Song CZ, Siok TE, Gelehrter TD: Smad4/DPC4 and Smad3 mediate transforming growth factor-beta (TGF-beta) signaling through direct binding to a novel TGF-beta-responsive element in the human plasminogen activator inhibitor-1 promoter. J Biol Chem 273:29287-29290, 1998
46. Sprengers ED, Kluft C: Plasminogen activator inhibitors. Blood 69:381-387, 1987
47. Cohen RN: Nuclear receptor corepressors and PPARgamma. Nucl Recept Signal 4:e003, 2006
48. Pascual G, Fong AL, Ogawa S, Gamliel A, Li AC, Perissi V, Rose DW, Willson TM, Rosenfeld MG, Glass CK: A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature 437:759-763, 2005