Weight loss increases 11β-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 6, 2004, Pages 2711-2716

  Tomlinson, Jeremy W ^a   Moore, Jasbir S ^a   Clark, Penny M S ^b   Holder, Geoff ^b   Shakespeare, Lynette ^b   Stewart, Paul M ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CHOLESTEROL; CORTISONE; HYDROCORTISONE; MESSENGER RNA;

ADIPOCYTE; ADIPOSE TISSUE BLOOD FLOW; BODY COMPOSITION; BODY MASS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONFERENCE PAPER; FEMALE; HORMONE ACTION; HORMONE BLOOD LEVEL; HORMONE INHIBITION; HORMONE METABOLISM; HUMAN; INSULIN SENSITIVITY; LOW CALORY DIET; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; STATISTICAL ANALYSIS; SYSTOLIC BLOOD PRESSURE; TISSUE CULTURE; WEIGHT REDUCTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADIPOCYTES; ADIPOSE TISSUE; ADRENAL CORTEX HORMONES; ADULT; BLOOD PRESSURE; BODY COMPOSITION; CELL DIVISION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; OBESITY; STEM CELLS; WEIGHT LOSS;

EID: 2942683384     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-031376     Document Type: Conference Paper

References (42)

1. Fraser R, Ingram MC, Anderson NH, Morrison C, Davies E, Connell JM 1999 Cortisol effects on body mass, blood pressure, and cholesterol in the general population. Hypertension 33:1364-1368
2. Dunkleman SS, Fairhurst B, Plager J, Waterhouse C 1964 Cortisol metabolism in obesity. J Clin Endocrinol Metab 24:832-841
3. Marin P, Darin N, Amemiya T, Andersson B, Jern S, Bjorntorp P 1992 Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism 41:882-886
4. Bujalska IJ, Kumar S, Hewison M, Stewart PM 1999 Differentiation of adipose stromal cells: the roles of glucocorticoids and 11β-hydroxysteroid dehydrogenase. Endocrinology 140:3188-3196
5. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS 2001 A transgenic model of visceral obesity and the metabolic syndrome. Science 294:2166-2170
6. Rask E, Walker BR, Soderberg S, Livingstone DE, Eliasson M, Johnson O, Andrew R, Olsson T 2002 Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11β-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab 87:3330-3336
7. Stewart PM, Boulton A, Kumar S, Clark PM, Shackleton CH 1999 Cortisol metabolism in human obesity: impaired cortisone→»cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 84:1022-1027
8. Rask E, Olsson T, Soderberg S, Andrew R, Livingstone DE, Johnson O, Walker BR 2001 Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab 86:1418-1421
9. Palermo M, Shackleton CH, Mantero F, Stewart PM 1996 Urinary free cortisone and the assessment of 11β-hydroxysteroid dehydrogenase activity in man. Clin Endocrinol (Oxf) 45:605-611
10. Csabi GY, Juricskay S, Molnar D 2000 Urinary cortisol to cortisone metabolites in hypertensive obese children. J Endocrinol Invest 23:435-439
11. Reynolds RM, Walker BR, Syddall HE, Andrew R, Wood PJ, Whorwood CB, Phillips DI 2001 Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors. J Clin Endocrinol Metab 86:245-250
12. Andrew R, Gale CR, Walker BR, Seckl JR, Martyn CN 2002 Glucocorticoid metabolism and the metabolic syndrome: associations in an elderly cohort. Exp Clin Endocrinol Diabetes 110:284-290
13. Andrew R, Phillips DI, Walker BR 1998 Obesity and gender influence cortisol secretion and metabolism in man. J Clin Endocrinol Metab 83:1806-1809
14. Tiosano D, Eisentein I, Militianu D, Chrousos GP, Hochberg Z 2003 11β-Hydroxysteroid dehydrogenase activity in hypothalamic obesity. J Clin Endocrinol Metab 88:379-384
15. Casassus P, Fontbonne A, Thibult N, Ducimetiere P, Richard JL, Claude JR, Warnet J M, Rosselin G, Eschwege E 1992 Upper-body fat distribution: a hyperinsulinemia-independent predictor of coronary heart disease mortality. The Paris Prospective Study. Arterioscler Thromb 12:1387-1392
16. Paulmyer-Lacroix O, Boullu S, Oliver C, Alessi MC, Grino M 2002 Expression of the mRNA coding for 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study. J Clin Endocrinol Metab 87:2701-2705
17. Tomlinson JW, Sinha B, Bujalska I, Hewison M, Stewart PM 2002 Expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity. J Clin Endocrinol Metab 87:5630-5635
18. Deleted in proof.
19. Zhang HH, Kumar S, Barnett AH, Eggo MC 2000 Ceiling culture of mature human adipocytes: use in studies of adipocyte functions. J Endocrinol 164:119-128
20. Bujalska IJ, Kumar S, Stewart PM 1997 Does central obesity reflect "Cushing's disease of the omentum?" Lancet 349:1210-1213
21. McTernan CL, Draper N, Nicholson H, Chalder SM, Driver P, Hewison M, Kilby MD, Stewart PM 2001 Reduced placental 11β-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: an analysis of possible mechanisms. J Clin Endocrinol Metab 86:4979-4983
22. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
23. Yashkov YI, Vinnitsky LI, Poroykova MV, Vorobyova NT 2000 Some hormonal changes before and after vertical banded gastroplasty for severe obesity. Obes Surg 10:48-53
24. Yanovski JA, Yanovski SZ, Gold PW, Chrousos GP 1997 Differences in corticotropin-releasing hormone-stimulated adrenocorticotropin and cortisol before and after weight loss. J Clin Endocrinol Metab 82:1874-1878
25. Walker BR, Connacher AA, Lindsay RM, Webb DJ, Edwards CR 1995 Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. J Clin Endocrinol Metab 80:3155-3159
26. Andrews RC, Herlihy O, Livingstone DE, Andrew R, Walker BR 2002 Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance. J Clin Endocrinol Metab 87:5587-5593
27. Kotelevtsev Y, Holmes MC, Burchell A, Houston PM, Schmoll D, Jamieson P, Best R, Brown R, Edwards CR, Seckl JR, Mullins JJ 1997 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci USA 94:14924-14929
28. Liu Y, Nakagawa Y, Wang Y, Li R, Li X, Ohzeki T, Friedman TC 2003 Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice. Diabetes 52:1409-1416
29. Morton NM, Patterson JM, Masuzaki H, Holmes, MC, Staels B, Fievet C, Walker BR, Flier JS, Mullins JJ, Seckl JR 2003 Reduced intra-adipose glucocorticoid regeneration: a novel adaptive response to, and therapy for, the metabolic syndrome. Endocr Abstr 5:S23
30. Jamieson A, Wallace AM, Andrew R, Nunez BS, Walker BR, Fraser R, White PC, Connell JM 1999 Apparent cortisone reductase deficiency: a functional defect in 11β-hydroxysteroid dehydrogenase type 1. J Clin Endocrinol Metab 84:3570-3574
31. Laing I, Adams JE, Wood PJ, Taylor NF, Ray DW 2002 Cortisone reductase deficiency (11β-hydroxysteroid dehydrogenase type 1) deficiency presenting with features of late onset congenital adrenal hyperplasia. Endocr Abstr 3:P264
32. Biason-Lauber A, Suter SL, Shackleton CH, Zachmann M 2000 Apparent cortisone reductase deficiency: a rare cause of hyperandrogenemia and hypercortisolism. Horm Res 53:260-266
33. Nordenstrom A, Marcus C, Axelson M, Wedell A, Ritzen EM 1999 Failure of cortisone acetate treatment in congenital adrenal hyperplasia because of defective 11β-hydroxysteroid dehydrogenase reductase activity. J Clin Endocrinol Metab 84:1210-1213
34. Phillipov G, Palermo M, Shackleton CH 1996 Apparent cortisone reductase deficiency: a unique form of hypercortisolism. J Clin Endocrinol Metab 81: 3855-3860
35. Draper N, Walker EA, Bujalska IJ, Tomlinson JW, Chalder SM, Arlt W, Lavery GG, Bedendo O, Ray DW, Laing I, Malunowicz E, White PC, Hewison M, Mason PJ, Connell JM, Shackleton CH, Stewart PM 2003 Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. Nat Genet 34:434-439
36. Barf T, Vallgarda J, Emond R, Haggstrom C, Kurz G, Nygren A, Larwood V, Mosialou E, Axelsson K, Olsson R, Engblom L, Edling N, Ronquist-Nii Y, Ohman B, Alberts P, Abrahmsen L 2002 Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs: discovery of potent and selective inhibitors of the 11β-hydroxysteroid dehydrogenase type 1. J Med Chem 45:3813-3815
37. Fontbonne A, Thibult N, Eschwege E, Ducimetiere P 1992 Body fat distribution and coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes mellitus: the Paris Prospective Study, 15-year follow-up. Diabetologia 35:464-468
38. Montague CT, Prins JB, Sanders L, Zhang J, Sewter CP, Digby J, Byrne CD, O'Rahilly S 1998 Depot-related gene expression in human subcutaneous and omental adipocytes. Diabetes 47:1384-1391
39. Hauner H, Entenmann G 1991 Regional variation of adipose differentiation in cultured stromal-vascular cells from the abdominal and femoral adipose tissue of obese women. Int J Obes 15:121-126
40. Tomlinson JW, Moore J, Cooper MS, Bujalska I, Shahmanesh M, Burt C, Strain A, Hewison M, Stewart PM 2001 Regulation of expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. Endocrinology 142:1982-1989
41. Draper N, Echwald SM, Lavery GG, Walker EA, Fraser R, Davies E, Sorensen TI, Astrup A, Adamski J, Hewison M, Connell JM, Pedersen O, Stewart PM 2002 Association studies between microsatellite markers within the gene encoding human 11β-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism. J Clin Endocrinol Metab 87:4984-4990
42. Caramelli E, Strippoli P, Di Giacomi T, Tietz C, Carinci P, Pasquali R 2001 Lack of mutations of type 1 11β-hydroxysteroid dehydrogenase gene in patients with abdominal obesity. Endocr Res 27:47-61