Abdominal fat and insulin resistance in normal and overweight women: Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM

Diabetes

Volumn 45, Issue 5, 1996, Pages 633-638

  Carey, David G ^a   Jenkins, Arthur B ^a   Campbell, Lesley V ^a   Freund, Judith ^a   Chisholm, Donald J ^a  

^a ST VINCENT S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; LIPID;

ADULT; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; CALORIMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; DIET; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GLUCOSE METABOLISM; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID OXIDATION; LUNG GAS EXCHANGE; MEASUREMENT; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; RISK FACTOR;

EID: 0029874313     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.5.633     Document Type: Article

References (43)

1. Reaven GM: The role of insulin resistance and hyperinsulinemia in coronary heart disease. Metabolism 41:16-19, 1992
2. Bengtsson C, Bjorkelund C, Lapidus L, Lissner L: Associations of serum lipid concentrations and obesity with mortality in women: 20 year follow up of participants in prospective population study Gothenberg, Sweden. Br Med J 307:1385-1388, 1993
3. Bjorntorp P: Metabolic implications of body fat distribution. Diabetes Care 14:1132-1143, 1991
4. Haffner S, Stern M, Hazuda H, Pugh J, Patterson J: Do upper-body and centralized adiposity measure different aspects of regional body fat distribution? Diabetes 36:43-51, 1987
5. Stern M, Haffner S: Body fat distribution and hyperinsulinemia as risk factors for diabetes and cardiovascular disease. Arteriosclerosis 6:123-130, 1986
6. Peiris A, Sothmann M, Hoffmann R, Hennes M, Lee M, Wilson C, Gustafson A, Kissebah A: Adiposity, fat distribution and cardiovascular risk. Ann Int Med 110:867-872, 1989
7. Park KS, Rhee B, Lee K-U, Kim S, Lee H, Koh C, Min H: Intra-abdominal fat is associated with decreased insulin sensitivity in healthy young men. Metabolism 40:600-603, 1991
8. Banerji M, Chaiken RL, Gordon D, Kral JG, Lebovitz HE: Does intraabdominal adipose tissue in black men determine whether NIDDM is insulin-resistant or insulin sensitive? Diabetes 44:141-146, 1995
9. Bonora E, DelPrato S, Bonadonna R, Gulli G, Solini A, Shank M, Ghiatas A, Lancaster J, Kilcoyne K, Alyassin A, DeFronzo R: Total body fat content and fat topography are associated differently with in vivo glucose metabolism in nonobese and obese nondiabetic women. Diabetes 41: 1151-1159, 1992
10. Pouliot M, Despres J, Nadeau A, Moorjani S, Prud'homme D, Lupien P, Tremblay A, Bouchard C: Visceral obesity in men, associations with glucose tolerance, plasma insulin, and lipoprotein levels. Diabetes 41: 826-834, 1992
11. Peiris AN, Mueller RA, Smith GA, Struve MF, Kissebah AH: Splanchnic insulin metabolism in obesity. J Clin Invest 78:1648-1657, 1986
12. Despres J-P: Abdominal obesity as an important component of insulin-resistance syndrome. Nutrition 9:452-459, 1993
13. Pedersen S, Borglum J, Schmitz O, Bak J, Sorensen N, Richelsen B: Abdominal obesity is associated with insulin resistance and reduced glycogen synthetase activity in skeletal muscle. Metabolism 42:998-1005, 1993
14. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward K, Beard JC, Palmer JP, Porte D Jr: Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function. Diabetes 42:1662-1673, 1993
15. Barakat HA, Mooney N, O'Brian K, Long S, Khazani PG, Pories W, Caro JF: Coronary artery disease risk factors in morbidly obese women with normal glucose tolerance. Diabetes Care 16:144-149, 1993
16. Eriksson J, Franssila-Kallunki A, Ekstrand A, Saloranta C, Widén E, Schalin C, Groop L: Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 321:337-343, 1989
17. Durnin JV, Womersley J: Body fat assessed from total body density and its estimation from skinfold thickness measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 32:77-97, 1974
18. Schmidt LE, Cox MS, Buzzard M, Cleary PA Reproducibility of a comprehensive diet history in the diabetes control and complications trial. J Am Diet Assoc 94:1392-1397, 1994
19. Ross R, Shaw K, Martel Y, De Guise J, Avruch L: Adipose tissue distribution measured by magnetic resonance imaging in obese women. Am J Clin Nutr 57:470-475, 1993
20. Svendsen OL, Hassager C, Bergmann I, Christiansen C: Measurement of abdominal and intra-abdominal fat in postmenopausal women by dual energy x-ray absorptiometry and anthropometry: comparison with computerized tomography. Int J Obes 17:45-51, 1993
21. Jensen MD, Kanaley JA, Reed JE, Sheedy PF: Measurement of abdominal and visceral fat with computed tomography and dual energy X-ray absorptiometry. Am J Clin Nutr 61:274-278, 1995
22. Borkman M, Storlien LH, Pan DA, Jenkins AB, Chisholm DJ, Campbell LV: The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. N Engl J Med 328:238-244, 1993
23. Ho KKY, Jenkins AB, Furler SM, Borkman M, Chisholm DJ: Impact of octreotide, a long-acting somatostatin analogue, on glucose tolerance and insulin sensitivity in acromegaly. Clin Endocrinol 36:271-279, 1992
24. Vaag A, Henriksen J, Beck-Nielsen H. Decreased insulin activation of glycogen synthase in skeletal muscles in young non-obese first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest 89:782-788, 1992
25. Borkman M, Campbell LV, Chisholm DJ, Storlien LH: Comparison of the effects on insulin sensitivity of high-carbohydrate and high-fat diets in normal subjects. J Clin Endocrinol Metab 72:432-437, 1991
26. Seidell J, Oosterlee A, Thijssen M, Burema J, Deurenberg P, Hautvast J, Rijus J: Assessment of intra-abdominal fat with computer tomography: effects of degree of obesity, sex and age Eur J Clin Nutr 42:805-815, 1987
27. Evans D, Murray R, Kissebah A: Relationship between skeletal muscle insulin resistance, insulin mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography. J Clin Invest 74:1515-1525, 1984
28. Beck-Nielsen H, Vaag A, Damsbo P, Handberg A, Hother-Nielsen O, Henriksen JE, Thye-Ronn P: Insulin resistance in skeletal muscles in patients with NIDDM. Diabetes Care 15:418-429, 1992
29. Despres J, Nadeau A, Trembley A, Ferland M, Moorjani S, Lupien P, Theriault G, Pinault S, Bouchard C. Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women. Diabetes 38:304-309, 1989
30. Kohort W, Kirwan J, Staten M, Bourey R, King D, Holloszy J: Insulin resistance in aging is related to abdominal obesity. Diabetes 42 273-281, 1993
31. Despres J, Moorjani S, Ferland M, Trembley A, Lupien P, Nadeau A, Pinault S, Theriault G, Bouchard C: Adipose tissue distribution and plasma lipoprotein levels in obese women: importance of intra- abdominal fat. Arteriosclerosis 9:203-210, 1989
32. Hollenbeck C, Reaven GM: Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. J Clin Endocrinol Metab 64:1169-1173, 1987
33. Lancaster JL, Ghiatas AA, Alyassin A, Kilcoyne RF, Bonora E, DeFronzo RA: Measurement of abdominal fat with T1-weighted MR images. J MRI 1:363-369, 1991
34. Storlien LH, Kraegen EW, Chisholm DJ, Ford GL, Bruce DG, Pascoe WS: Fish oil prevents insulin resistance induced by high-fat feeding in rats. Science 237:885-888, 1987
35. Kraegen EW, Clark PW, Jenkins AB, Daley EA, Chisholm DJ, Storlien LH: Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 40:1397-1403, 1991
36. Belzung F, Racolt T, Groscolas R: Fish oil n-3 fatty acids selectively limit the hypertrophy of abdominal fat deposits in growing rats fed high-fat diets. Am J Physiol 264:R1111-R1118, 1993
37. Bouchard C, Tremblay A, Despres J-P, Nadeau A, Lupien P, Theriault G, Dussault J, Moorjani S, Pinault S, Fournier G: The response to long term overfeeding in identical twins N Engl J Med 322:1477-1482, 1990
38. Ryu J, Craven T, Macarthur R, Hinson W, Bond M, Hagaman A, Crouse J: Relationship of intraabdominal fat as measured by magnetic resonance imaging to postprandial lipemia in middle-aged subjects. Am J Clin Nutr 60:586-591, 1994
39. Roust LR, Jensen MD: Post prandial free fatty acid kinetics are abnormal in upper body obesity. Diabetes 42:1567-1573, 1993
40. Boden G, Jadali F, White J, Liang Y, Mozzoli M, Chen X, Coleman E, Smith C. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 88:960-966, 1991
41. Dagenais GR, Tancredi RG, Zierler KL: Free fatty acid oxidation by forearm muscle at rest, and evidence for an intramuscular lipid pool in the human forearm J Clin Invest 58:421-431, 1976
42. Falholt K, Jensen I, Lindkaer Jensen S, Mortensen H, Volund A, Heding L, Noerskov Petersen P, Falholt W: Carbohydrate and lipid metabolism of skeletal muscle in type 2 diabetic patients. Diabetic Med 5:27-31, 1988
43. Storlien LH, Jenkins AB, Chisholm DJ, Pascoe WS, Khouri S, Kraegen EW: Influence of dietary fat composition on development of insulin resistance in rats. Diabetes 40:280-289, 1991