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Volumn 51, Issue 8, 2007, Pages 1397-1403

Adipose tissue expression of 11β-hydroxysteroid dehydrogenase type 1 in Cushing's syndrome and in obesity

Author keywords

11 hydroxysteroid dehydrogenase type 1; Adipose tissue; Cortisol; Cortisone; Cushing's syndrome; Metabolic syndrome; Obesity

Indexed keywords


EID: 38649088252     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/s0004-27302007000800027     Document Type: Review
Times cited : (22)

References (51)
  • 1
    • 0017711792 scopus 로고
    • Evidence for an unidentified steroid in a child with apparent mineralocorticoid hypertension
    • New MI, Levine LS, Biglieri EG, Pareira J, Ulick S. Evidence for an unidentified steroid in a child with apparent mineralocorticoid hypertension. J Clin Endocrinol Metab 1977;44:924-33.
    • (1977) J Clin Endocrinol Metab , vol.44 , pp. 924-933
    • New, M.I.1    Levine, L.S.2    Biglieri, E.G.3    Pareira, J.4    Ulick, S.5
  • 2
    • 0018598286 scopus 로고
    • A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol
    • Ulick S, Levine LS, Gunczler P, Zanconato G, Ramires LC, Raul W, et al. A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol. J Clin Endocrinol Metab 1979;49:757-64.
    • (1979) J Clin Endocrinol Metab , vol.49 , pp. 757-764
    • Ulick, S.1    Levine, L.S.2    Gunczler, P.3    Zanconato, G.4    Ramires, L.C.5    Raul, W.6
  • 3
    • 0023792158 scopus 로고
    • Purification and characterization of the 11β-dehydrogenase component of the rat liver 11β-hydroxysteroid dehydrogenase complex
    • Lakshmi V, Monder C. Purification and characterization of the 11β-dehydrogenase component of the rat liver 11β-hydroxysteroid dehydrogenase complex. Endocrinology 1988;123:2390-8.
    • (1988) Endocrinology , vol.123 , pp. 2390-2398
    • Lakshmi, V.1    Monder, C.2
  • 4
    • 0027331415 scopus 로고
    • Regulation of 11β-hydroxysteroid dehydrogenase by sex steroids in vivo: Further evidence for the existence of a second dehydrogenase in rat kidney
    • Low SC, Assaad SN, Rajan V, Chapman KE, Edwards CR, Seckl JR. Regulation of 11β-hydroxysteroid dehydrogenase by sex steroids in vivo: further evidence for the existence of a second dehydrogenase in rat kidney. J Endocrinol 1993;139:27-35.
    • (1993) J Endocrinol , vol.139 , pp. 27-35
    • Low, S.C.1    Assaad, S.N.2    Rajan, V.3    Chapman, K.E.4    Edwards, C.R.5    Seckl, J.R.6
  • 5
    • 7444240354 scopus 로고    scopus 로고
    • 11β-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: From metabolism to memory
    • Seckl JR, Walker BR. 11β-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory. Trends Endocrinol Metab 2004;15:418-24.
    • (2004) Trends Endocrinol Metab , vol.15 , pp. 418-424
    • Seckl, J.R.1    Walker, B.R.2
  • 6
    • 0030936556 scopus 로고    scopus 로고
    • Does central obesity reflect "Cushing's disease of the omentum"?
    • Bujalska IJ, Kumar S, Stewart PM. Does central obesity reflect "Cushing's disease of the omentum"? Lancet 1997;349:1210-3.
    • (1997) Lancet , vol.349 , pp. 1210-1213
    • Bujalska, I.J.1    Kumar, S.2    Stewart, P.M.3
  • 7
    • 0036959901 scopus 로고    scopus 로고
    • A switch in the dehydrogenase to reductase activity of 11β-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells
    • Bujalska IJ, Kumar S, Hewison M, Stewart PM. A switch in the dehydrogenase to reductase activity of 11β-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells. J Clin Endocrinol Metab 2002;87:1205-10.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1205-1210
    • Bujalska, I.J.1    Kumar, S.2    Hewison, M.3    Stewart, P.M.4
  • 8
    • 85047693986 scopus 로고    scopus 로고
    • Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice
    • Masuzaki H, Yamamoto H, Kenyon CJ, Elmquist JK, Morton NM, Paterson JM, et al. Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest 2003;112:83-90.
    • (2003) J Clin Invest , vol.112 , pp. 83-90
    • Masuzaki, H.1    Yamamoto, H.2    Kenyon, C.J.3    Elmquist, J.K.4    Morton, N.M.5    Paterson, J.M.6
  • 9
    • 12144291638 scopus 로고    scopus 로고
    • Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11β-hydroxysteroid dehydrogenase type 1 deficient mice
    • Morton NM, Paterson JM, Masuzaki H, Holmes MC, Staels B, Fievet C, et al. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11β-hydroxysteroid dehydrogenase type 1 deficient mice. Diabetes 2004;53:931-8.
    • (2004) Diabetes , vol.53 , pp. 931-938
    • Morton, N.M.1    Paterson, J.M.2    Masuzaki, H.3    Holmes, M.C.4    Staels, B.5    Fievet, C.6
  • 10
    • 0000156413 scopus 로고
    • The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism)
    • Cushing H. The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). Bull Johns Hopkins Hosp 1932;50:137-95.
    • (1932) Bull Johns Hopkins Hosp , vol.50 , pp. 137-195
    • Cushing, H.1
  • 11
    • 0141739647 scopus 로고    scopus 로고
    • Tissue-specific Cushing's syndrome, 11β-hydroxysteroid dehydrogenase and the redefinition of corticosteroid hormone action
    • Stewart PM. Tissue-specific Cushing's syndrome, 11β-hydroxysteroid dehydrogenase and the redefinition of corticosteroid hormone action. Eur J Endocrinol 2003;149:163-8.
    • (2003) Eur J Endocrinol , vol.149 , pp. 163-168
    • Stewart, P.M.1
  • 12
    • 0041487561 scopus 로고    scopus 로고
    • The adrenal cortex
    • Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, Foster DW, Wilson JD, 10th ed. Philadelphia: Saunders
    • th ed. Philadelphia: Saunders, 2003. pp. 491-539.
    • (2003) Williams textbook of endocrinology , pp. 491-539
    • Stewart, P.M.1
  • 13
    • 0028027675 scopus 로고
    • Changes in body composition and adipose tissue distribution after treatment of women with Cushing's syndrome
    • Lönn L, Kvist H, Ernest I, Sjöström L. Changes in body composition and adipose tissue distribution after treatment of women with Cushing's syndrome. Metabolism 1994;43:1517-22.
    • (1994) Metabolism , vol.43 , pp. 1517-1522
    • Lönn, L.1    Kvist, H.2    Ernest, I.3    Sjöström, L.4
  • 15
    • 34248148124 scopus 로고    scopus 로고
    • Extra-adrenal regeneration of glucorticoids by 11β-hydroxysteroid dehydrogenase type 1: Physiological regulator and pharmacological target for energy petitioning
    • Walker BR. Extra-adrenal regeneration of glucorticoids by 11β-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy petitioning. Proc Nutr Soc 2007;66:1-8.
    • (2007) Proc Nutr Soc , vol.66 , pp. 1-8
    • Walker, B.R.1
  • 16
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven GM. Role of insulin resistance in human disease. Diabetes 1988;37:1595-607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 17
    • 0030144120 scopus 로고    scopus 로고
    • Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: A dose response study
    • Ljung T, Andersson B, Bengtson BA, Bjorntorp P, Marin P. Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: a dose response study. Obes Res 1996;4:277-82.
    • (1996) Obes Res , vol.4 , pp. 277-282
    • Ljung, T.1    Andersson, B.2    Bengtson, B.A.3    Bjorntorp, P.4    Marin, P.5
  • 19
    • 18244405083 scopus 로고    scopus 로고
    • Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: A dose-response study
    • Pasquali R, Ambrosi B, Armanini D, Cavagnine F, Uberti ED, Del Rio G, et al. Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: a dose-response study. J Clin Endocrinol Metab 2002;87:166-75.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 166-175
    • Pasquali, R.1    Ambrosi, B.2    Armanini, D.3    Cavagnine, F.4    Uberti, E.D.5    Del Rio, G.6
  • 20
    • 0034304053 scopus 로고    scopus 로고
    • The activity of the hypothalamic-pituitary-adrenal-axis and the sympathetic nervous system in relation to waist-hip circumference in men
    • Ljung T, Holm G, Friberg P, Bjorn A, Bengtsson B-A, Svensson J, et al. The activity of the hypothalamic-pituitary-adrenal-axis and the sympathetic nervous system in relation to waist-hip circumference in men. Obes Res 2000;8:487-95.
    • (2000) Obes Res , vol.8 , pp. 487-495
    • Ljung, T.1    Holm, G.2    Friberg, P.3    Bjorn, A.4    Bengtsson, B.-A.5    Svensson, J.6
  • 22
    • 0842291475 scopus 로고    scopus 로고
    • Association of 24h-cortisol production rates, cortisol binding globulin, and plasma free cortisol levels with body composition, leptin levels, and aging in adult men women
    • Purnell JQ, Brandon DD, Isabelle LM, Loriaux DL, Samuels MH. Association of 24h-cortisol production rates, cortisol binding globulin, and plasma free cortisol levels with body composition, leptin levels, and aging in adult men women. J Clin Endocrinol Metab 2004;89:281-7.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 281-287
    • Purnell, J.Q.1    Brandon, D.D.2    Isabelle, L.M.3    Loriaux, D.L.4    Samuels, M.H.5
  • 25
    • 2342510149 scopus 로고    scopus 로고
    • Metabolic syndrome without obesity: Hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice
    • Paterson JM, Morton NM, Fievet C, Kenyon CJ, Holmes MC, Staels B, et al. Metabolic syndrome without obesity: hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice. Proc Nat Acad Sci USA 2004; 101:7088-93.
    • (2004) Proc Nat Acad Sci USA , vol.101 , pp. 7088-7093
    • Paterson, J.M.1    Morton, N.M.2    Fievet, C.3    Kenyon, C.J.4    Holmes, M.C.5    Staels, B.6
  • 26
    • 2542481820 scopus 로고    scopus 로고
    • Down-regulation of adipose tissue 11β-hydroxysteroid dehydrogenase type 1 by high fat feeding in mice: A potential adaptive mechanism counteracting metabolic disease
    • Morton NM, Ramage L, Seckl JR. Down-regulation of adipose tissue 11β-hydroxysteroid dehydrogenase type 1 by high fat feeding in mice: a potential adaptive mechanism counteracting metabolic disease. Endocrinology 2004;145:2707-12.
    • (2004) Endocrinology , vol.145 , pp. 2707-2712
    • Morton, N.M.1    Ramage, L.2    Seckl, J.R.3
  • 27
    • 0036432995 scopus 로고    scopus 로고
    • Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreased blood glucose concentrations in hyperglycaemic mice
    • Alberts P, Engblom L, Eddling N, Forsgren M, Klingstron G, Larsson C, et al. Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreased blood glucose concentrations in hyperglycaemic mice. Diabetologia 2002;45:1528-32.
    • (2002) Diabetologia , vol.45 , pp. 1528-1532
    • Alberts, P.1    Engblom, L.2    Eddling, N.3    Forsgren, M.4    Klingstron, G.5    Larsson, C.6
  • 28
    • 23944493717 scopus 로고    scopus 로고
    • 11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
    • Hermanowski-Vosatka A, Blakovec JM, Cheng K, Chen HY, Hernandez, Koo GC, et al. 11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. J Exp Med 2005;202:517-27.
    • (2005) J Exp Med , vol.202 , pp. 517-527
    • Hermanowski-Vosatka, A.1    Blakovec, J.M.2    Cheng, K.3    Chen, H.Y.4    Koo, H.G.C.5
  • 29
    • 0036075081 scopus 로고    scopus 로고
    • Expression of the mRNA coding for 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: An in situ hybridization study
    • Paulmyer-Lacroix O, Boullu S, Oliver C, Alessi MC, Grino M. Expression of the mRNA coding for 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study. J Clin Endocrinol Metab 2001;87:2701-5.
    • (2001) J Clin Endocrinol Metab , vol.87 , pp. 2701-2705
    • Paulmyer-Lacroix, O.1    Boullu, S.2    Oliver, C.3    Alessi, M.C.4    Grino, M.5
  • 30
    • 0041381335 scopus 로고    scopus 로고
    • Local and systemic impact of transcriptional up-regulation of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity
    • Wake DJ, Rask E, Livingstone, Sodeberg S, Olsson T, Walker BR. Local and systemic impact of transcriptional up-regulation of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity. J Clin Endocrinol Metab 2003;88:3983-8.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3983-3988
    • Wake, D.J.1    Rask, E.2    Livingstone3    Sodeberg, S.4    Olsson, T.5    Walker, B.R.6
  • 31
    • 0037902924 scopus 로고    scopus 로고
    • Subcutaneous adipose 11β-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians
    • Lindsay RS, Wake JW, Saraswathy N, Bunt J, Livingstone DEW, Permana PA, et al. Subcutaneous adipose 11β-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. J Clin Endocrinol Metab 2003;88:2738-44.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2738-2744
    • Lindsay, R.S.1    Wake, J.W.2    Saraswathy, N.3    Bunt, J.4    Livingstone, D.E.W.5    Permana, P.A.6
  • 32
    • 1842552244 scopus 로고    scopus 로고
    • Regulation of 11β-HSD genes in human adipose tissue: Influence of central obesity and weight loss
    • Engeli S, Bohnke J, Feldpausch M, Gorzelniak K, Heintze U, Janke J, et al. Regulation of 11β-HSD genes in human adipose tissue: influence of central obesity and weight loss. Obes Res 2004;12:9-17.
    • (2004) Obes Res , vol.12 , pp. 9-17
    • Engeli, S.1    Bohnke, J.2    Feldpausch, M.3    Gorzelniak, K.4    Heintze, U.5    Janke, J.6
  • 33
    • 0036882136 scopus 로고    scopus 로고
    • Expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity
    • Tomlinson JW, Sinha B, Bujalska I, Hewison M, Stewart PM. Expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity. J Clin Endocrinol Metab 2002;87:5630-5.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 5630-5635
    • Tomlinson, J.W.1    Sinha, B.2    Bujalska, I.3    Hewison, M.4    Stewart, P.M.5
  • 34
    • 14644388141 scopus 로고    scopus 로고
    • Increased in vivo generation of cortisol in adipose tissue in human obesity and the effects of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone
    • Sandeep TC, Andrew R, Homer NZM, Andrews RC, Smith K, Walker BR. Increased in vivo generation of cortisol in adipose tissue in human obesity and the effects of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone. Diabetes 2005;54:872-9.
    • (2005) Diabetes , vol.54 , pp. 872-879
    • Sandeep, T.C.1    Andrew, R.2    Homer, N.Z.M.3    Andrews, R.C.4    Smith, K.5    Walker, B.R.6
  • 35
    • 85047681877 scopus 로고    scopus 로고
    • Regulation of the expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue-specific induction by cytokines
    • Tomlinson JW, Moore J, Cooper MS, Bujalska I, Shahmanesh M, Burt C, et al. Regulation of the expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue-specific induction by cytokines. Endocrinology 2001;142:1982-9.
    • (2001) Endocrinology , vol.142 , pp. 1982-1989
    • Tomlinson, J.W.1    Moore, J.2    Cooper, M.S.3    Bujalska, I.4    Shahmanesh, M.5    Burt, C.6
  • 36
    • 0031784958 scopus 로고    scopus 로고
    • Obesity and gender influence cortisol secretion and metabolism in man
    • Andrew R, Philips DIW, Walker BR. Obesity and gender influence cortisol secretion and metabolism in man. J Clin Endocrinol Metab 1998;83:1806-9.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1806-1809
    • Andrew, R.1    Philips, D.I.W.2    Walker, B.R.3
  • 37
    • 0032990860 scopus 로고    scopus 로고
    • Cortisol metabolism in human obesity: Impaired cortisone-cortisol conversion in subjects with central adiposity
    • Stewart PM, Boulton A, Kumar S, Clark PMS, Shackleton CHL. Cortisol metabolism in human obesity: impaired cortisone-cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 1999;84:1022-7.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1022-1027
    • Stewart, P.M.1    Boulton, A.2    Kumar, S.3    Clark, P.M.S.4    Shackleton, C.H.L.5
  • 38
    • 7244232607 scopus 로고    scopus 로고
    • Interaction between an 11β-HSD1 gene variant and birth era modifies the risk of hypertension in Pima Indians
    • Franks PW, Knowler WC, Nair S, Koska J, Lee Y-H, Lindsay RS, et al. Interaction between an 11β-HSD1 gene variant and birth era modifies the risk of hypertension in Pima Indians. Hypertension 2004;44:681-8.
    • (2004) Hypertension , vol.44 , pp. 681-688
    • Franks, P.W.1    Knowler, W.C.2    Nair, S.3    Koska, J.4    Lee, Y.-H.5    Lindsay, R.S.6
  • 39
    • 3142661851 scopus 로고    scopus 로고
    • 11β-hydroxysteroid dehydrogenase type 1: Genetic polymorphisms are associated with type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle
    • Nair S, Lee YH, Lindsay RS, Walker BR, Tataranni PA, Bogardus C, et al. 11β-hydroxysteroid dehydrogenase type 1: Genetic polymorphisms are associated with type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle. Diabetologia 2004;47:1088-95.
    • (2004) Diabetologia , vol.47 , pp. 1088-1095
    • Nair, S.1    Lee, Y.H.2    Lindsay, R.S.3    Walker, B.R.4    Tataranni, P.A.5    Bogardus, C.6
  • 40
    • 18744413888 scopus 로고    scopus 로고
    • Association studies between microsatellite markers within the gene encoding for human 11β-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism
    • Draper N, Echwald SM, Lavery GG, Walker EA, Fraser R, Davies E, et al. Association studies between microsatellite markers within the gene encoding for human 11β-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism. J Clin Endocrinol Metab 2002;87:4984-90.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 4984-4990
    • Draper, N.1    Echwald, S.M.2    Lavery, G.G.3    Walker, E.A.4    Fraser, R.5    Davies, E.6
  • 41
    • 33749064918 scopus 로고    scopus 로고
    • Adipose tissue 11β-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing's syndrome
    • Mariniello B, Ronconi V, Rilli S, Bernante P, Boscoro M, Mantero F, et al. Adipose tissue 11β-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing's syndrome. Eur J Endocrinol 2006;155:435-41.
    • (2006) Eur J Endocrinol , vol.155 , pp. 435-441
    • Mariniello, B.1    Ronconi, V.2    Rilli, S.3    Bernante, P.4    Boscoro, M.5    Mantero, F.6
  • 42
    • 38649112555 scopus 로고    scopus 로고
    • Espíndola-Antunes D, Goto EM, Guimarães AO, Pesquero JB, Silva-Júnior JA, Kater CE. Quantitative mRNA expression of 11β-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor alpha in visceral adipose tissue of patients with Cushing's syndrome and obese and non-obese controls. Proc Endocr Soc Meeting 2007; [abstract].
    • Espíndola-Antunes D, Goto EM, Guimarães AO, Pesquero JB, Silva-Júnior JA, Kater CE. Quantitative mRNA expression of 11β-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor alpha in visceral adipose tissue of patients with Cushing's syndrome and obese and non-obese controls. Proc Endocr Soc Meeting 2007; [abstract].
  • 44
    • 4043077286 scopus 로고    scopus 로고
    • 11β-hydroxysteroid dehydrogenase type 1: A tissue specific regulator of glucocorticoid response
    • Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, et al. 11β-hydroxysteroid dehydrogenase type 1: a tissue specific regulator of glucocorticoid response. Endocr Rev 2004;25:831-66.
    • (2004) Endocr Rev , vol.25 , pp. 831-866
    • Tomlinson, J.W.1    Walker, E.A.2    Bujalska, I.J.3    Draper, N.4    Lavery, G.G.5    Cooper, M.S.6
  • 45
    • 34249845549 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor α and γ agonists in 11β-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men
    • Wake DJ, Stimson RH, Tam GD, Homer NZM, Andrew R, Carpe F, et al. Effects of peroxisome proliferator-activated receptor α and γ agonists in 11β-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men. J Clin Endocrinol Metab 2007;92:1848-56.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1848-1856
    • Wake, D.J.1    Stimson, R.H.2    Tam, G.D.3    Homer, N.Z.M.4    Andrew, R.5    Carpe, F.6
  • 46
    • 33644764205 scopus 로고    scopus 로고
    • Effect of nutrient ingestion on total-body and splanic cortisol production in humans
    • Basu R, Singh R, Basu A, Johson CM, Rizza RA. Effect of nutrient ingestion on total-body and splanic cortisol production in humans. Diabetes 2006;55:667-74.
    • (2006) Diabetes , vol.55 , pp. 667-674
    • Basu, R.1    Singh, R.2    Basu, A.3    Johson, C.M.4    Rizza, R.A.5
  • 47
    • 33751510948 scopus 로고    scopus 로고
    • Wake DJ, Homer NZD, Andrew R, Walker BR. Acute in vivo regulation of 11β-hydroxysteroid dehydrogenase type 1 by insulin and intralipid infusions in humans. J Clin Endocrinol Metab 2006;91:4682-8.
    • Wake DJ, Homer NZD, Andrew R, Walker BR. Acute in vivo regulation of 11β-hydroxysteroid dehydrogenase type 1 by insulin and intralipid infusions in humans. J Clin Endocrinol Metab 2006;91:4682-8.
  • 48
    • 0035111323 scopus 로고    scopus 로고
    • Intracellular regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase (11β-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary- adrenal axis: Analysis of 11β-HSD-1-deficient mice
    • Harris HJ, Kotelevtsev Y, Mullings JJ, Seckl JR, Holmes MC. Intracellular regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase (11β-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary- adrenal axis: analysis of 11β-HSD-1-deficient mice. Endocrinology 2001;142:114-20.
    • (2001) Endocrinology , vol.142 , pp. 114-120
    • Harris, H.J.1    Kotelevtsev, Y.2    Mullings, J.J.3    Seckl, J.R.4    Holmes, M.C.5
  • 49
    • 0942290504 scopus 로고    scopus 로고
    • 11β-hydroxysteroid dehydrogenase type 1 in obesity and type 2 diabetes
    • Stulnig TM, Waldhausl W. 11β-hydroxysteroid dehydrogenase type 1 in obesity and type 2 diabetes. Diabetologia 2004;47:1-11.
    • (2004) Diabetologia , vol.47 , pp. 1-11
    • Stulnig, T.M.1    Waldhausl, W.2
  • 50
    • 0028839840 scopus 로고
    • Carbenoxolone increases hepatic insulin sensitivity in man: A novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation
    • Walker BR, Connacher AA, Lindsay RM, Webb DJ, Edwards CRW. Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. J Clin Endocrinol Metab 1995;80:3155-9.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3155-3159
    • Walker, B.R.1    Connacher, A.A.2    Lindsay, R.M.3    Webb, D.J.4    Edwards, C.R.W.5
  • 51
    • 0037238379 scopus 로고    scopus 로고
    • Effects of the 11β- hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes
    • Andrews RC, Rooyackers O, Walker BR. Effects of the 11β- hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes. J Clin Endocrinol Metab 2003;88:285-91.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 285-291
    • Andrews, R.C.1    Rooyackers, O.2    Walker, B.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.