Pseudoginsenoside-F11 (PF11) exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways

Neuropharmacology

Volumn 79, Issue , 2014, Pages 642-656

  Wang, Xiaoxiao ^a   Wang, Chunming ^a   Wang, Jiming ^b   Zhao, Siqi ^a,c   Zhang, Kuo ^a   Wang, Jingmin ^a   Zhang, Wei ^a   Wu, Chunfu ^a   Yang, Jingyu ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c INSTITUTE OF BIOPHYSICS   (China)

Author keywords

Akt; MAPKs; Microglia; NF B; PF11; TLR4

Indexed keywords

CYCLOOXYGENASE 2; CYTOKINE; GINSENOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; NITRITE; OXIDOREDUCTASE; PROSTAGLANDIN E2; PROTEIN KINASE B; PSEUDOGINSENOSIDE; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; MAP KINASE KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; NEUROPROTECTIVE AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PSEUDOGINSENOSIDE F11; TLR4 PROTEIN, HUMAN; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN CELL CULTURE; BRAIN CORTEX; CELL ACTIVATION; CELL DEATH; CELL TRANSPORT; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DPPH RADICAL SCAVENGING ASSAY; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; INTRAHIPPOCAMPAL DRUG ADMINISTRATION; MALE; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANIMAL; BRAIN; C57BL MOUSE; CELL CULTURE; CELL LINE; DRUG EFFECTS; HUMAN; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; TOXICITY; TUMOR CELL LINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRAIN; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; GINSENOSIDES; HUMANS; LIPOPOLYSACCHARIDES; MALE; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; TOLL-LIKE RECEPTOR 4;

EID: 84896734847     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.01.022     Document Type: Article

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