Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation

Journal of Neurochemistry

Volumn 120, Issue 2, 2012, Pages 292-301

  Choi, Sang Ho ^a   Aid, Saba ^a   Kim, Hyung Wook ^a   Jackson, Sharon H ^b   Bosetti, Francesca ^a,c  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

alternative activation; Alzheimer's disease; microglia; NADPH oxidase; neuroinflammation

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; APOCYNIN; CD11B ANTIGEN; CD40 LIGAND; CHEMOKINE RECEPTOR CCR2; GLUTATHIONE PEROXIDASE 1; GLYCOPROTEIN GP 91; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR ALPHA; LIPOPOLYSACCHARIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ENCEPHALITIS; ENZYME INHIBITION; GENE DELETION; HIPPOCAMPUS; HISTOPATHOLOGY; LYMPHOCYTIC INFILTRATION; MALE; MICROGLIA; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION;

ACETOPHENONES; AGED; ALZHEIMER DISEASE; ANIMALS; ANTIGENS, CD11B; DNA HELICASES; ENCEPHALITIS; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FRONTAL LOBE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INJECTIONS, INTRAVENTRICULAR; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; NADPH OXIDASE; POSTMORTEM CHANGES; RECEPTORS, IMMUNOLOGIC; RNA, MESSENGER;

MUS;

EID: 84155164228     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07572.x     Document Type: Article

References (33)

1. Aliev G., Obrenovich M. E., Reddy V. P., Shenk J. C., Moreira P. I., Nunomura A., Zhu X., Smith M. A., and, Perry G., (2008) Antioxidant therapy in Alzheimer's disease: theory and practice. Mini Rev. Med. Chem. 8, 1395-1406.
2. Babior B. M., (1999) NADPH oxidase: an update. Blood 93, 1464-1476. (Pubitemid 29102471)
3. Block M. L., (2008) NADPH oxidase as a therapeutic target in Alzheimer's disease. BMC Neurosci., 9 (Suppl. 2), S8.
4. Bruce-Keller A. J., Gupta S., Parrino T. E., Knight A. G., Ebenezer P. J., Weidner A. M., LeVine H., III, Keller J. N., and, Markesbery W. R., (2010) NOX activity is increased in mild cognitive impairment. Antioxid. Redox Signal. 12, 1371-1382.
5. Choi S. H., and, Bosetti F., (2009) Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. Aging (Albany NY) 1, 234-244.
6. Choi S. H., Langenbach R., and, Bosetti F., (2008) Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide- induced inflammatory response and brain injury. FASEB J. 22, 1491-1501. (Pubitemid 351656789)
7. Choi S. H., Aid S., Choi U., and, Bosetti F., (2010) Cyclooxygenases-1 and -2 differentially modulate leukocyte recruitment into the inflamed brain. Pharmacogenomics J. 10, 448-457.
8. Colton C. A., (2009) Heterogeneity of microglial activation in the innate immune response in the brain. J. Neuroimmune Pharmacol. 4, 399-418.
9. Colton C. A., Mott R. T., Sharpe H., Xu Q., Van Nostrand W. E., and, Vitek M. P., (2006) Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD. J. Neuroinflammation 3, 27.
10. Harrison P. J., Heath P. R., Eastwood S. L., Burnet P. W., McDonald B., and, Pearson R. C., (1995) The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins. Neurosci. Lett. 200, 151-154.
11. Jackman K. A., Miller A. A., De Silva T. M., Crack P. J., Drummond G. R., and, Sobey C. G., (2009) Reduction of cerebral infarct volume by apocynin requires pretreatment and is absent in Nox2-deficient mice. Br. J. Pharmacol. 156, 680-688.
12. Jackson S. H., Gallin J. I., and, Holland S. M., (1995) The p47phox mouse knock-out model of chronic granulomatous disease. J. Exp. Med. 182, 751-758.
13. Jimenez S., Baglietto-Vargas D., and, Caballero C., et al. (2008) Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic. J. Neurosci. 28, 11650-11661.
14. Kraal G., van der Laan L. J., Elomaa O., and, Tryggvason K., (2000) The macrophage receptor MARCO. Microbes Infect. 2, 313-316. (Pubitemid 30167665)
15. Lynch M. A., (2009) The multifaceted profile of activated microglia. Mol. Neurobiol. 40, 139-156.
16. Mander P. K., Jekabsone A., and, Brown G. C., (2006) Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase. J. Immunol. 176, 1046-1052. (Pubitemid 43099705)
17. Martinez F. O., Sica A., Mantovani A., and, Locati M., (2008) Macrophage activation and polarization. Front. Biosci. 13, 453-461. (Pubitemid 351599757)
18. McGeer P. L., and, McGeer E. G., (2008) Glial reactions in Parkinson's disease. Mov. Disord. 23, 474-483.
19. McGeer P. L., Itagaki S., Tago H., and, McGeer E. G., (1987) Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR. Neurosci. Lett. 79, 195-200. (Pubitemid 17144469)
20. Neumann H., Kotter M. R., and, Franklin R. J., (2009) Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132, 288-295.
21. Nimmerjahn A., Kirchhoff F., and, Helmchen F., (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-1318. (Pubitemid 40746128)
22. Park L., Zhou P., and, Pitstick R., et al. (2008) Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proc. Natl. Acad. Sci. U S A 105, 1347-1352. (Pubitemid 351397056)
23. Pawate S., Shen Q., Fan F., and, Bhat N. R., (2004) Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma. J. Neurosci. Res. 77, 540-551. (Pubitemid 39007006)
24. Qin L., Liu Y., Cooper C., Liu B., Wilson B., and, Hong J. S., (2002) Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species. J. Neurochem. 83, 973-983. (Pubitemid 35316048)
25. Qin L., Liu Y., Wang T., Wei S. J., Block M. L., Wilson B., Liu B., and, Hong J. S., (2004) NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J. Biol. Chem. 279, 1415-1421. (Pubitemid 38082669)
26. Reisberg B., Prichep L., and, Mosconi L., et al. (2008) The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's disease. Alzheimers Dement. 4, S98-S108.
27. Shaftel S. S., Griffin W. S., and, O'Banion M. K., (2008) The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. J. Neuroinflammation 5, 7.
28. Shimohama S., Tanino H., and, Kawakami N., et al. (2000) Activation of NADPH oxidase in Alzheimer's disease brains. Biochem. Biophys. Res. Commun. 273, 5-9. (Pubitemid 30426853)
29. Streit W. J., (2010) Microglial activation and neuroinflammation in Alzheimer's disease: a critical examination of recent history. Front. Aging Neurosci. 2, 22.
30. Sugama S., Yang L., Cho B. P., DeGiorgio L. A., Lorenzl S., Albers D. S., Beal M. F., Volpe B. T., and, Joh T. H., (2003) Age-related microglial activation in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice. Brain Res. 964, 288-294. (Pubitemid 36165153)
31. Wang Q., Tompkins K. D., Simonyi A., Korthuis R. J., Sun A. Y., and, Sun G. Y., (2006) Apocynin protects against global cerebral ischemia-reperfusion- induced oxidative stress and injury in the gerbil hippocampus. Brain Res. 1090, 182-189. (Pubitemid 43817927)
32. Wilkinson B. L., and, Landreth G. E., (2006) The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease. J. Neuroinflammation 3, 30.
33. Wyss-Coray T., (2006) Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat. Med. 12, 1005-1015. (Pubitemid 44353380)