Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia induced by lipopolysaccharide

International Immunopharmacology

Volumn 10, Issue 3, 2010, Pages 331-338

  Zhang, Lijia ^a   Wu, Chunfu ^a   Zhao, Siqi ^a   Yuan, Dan ^a   Lian, Guoning ^a   Wang, Xiaoxiao ^a   Wang, Lihui ^a   Yang, Jingyu ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Demethoxycurcumin; Mitogen activated protein kinase; N9 microglia cells; Nuclear factor B; Pro inflammatory mediators; Reactive oxygen species

Indexed keywords

CURCUMIN; DEMETHOXYCURCUMIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; GENETIC TRANSCRIPTION; IN VITRO STUDY; INHIBITION KINETICS; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIPHENYL COMPOUNDS; BLOTTING, WESTERN; CELL SURVIVAL; CURCUMIN; DOWN-REGULATION; INFLAMMATION; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MICE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; PICRATES; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 76849092518     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.12.004     Document Type: Article

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