A key role for the endothelium in NOD1 mediated vascular inflammation: Comparison to TLR4 responses

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Gatheral, Timothy ^a   Reed, Daniel M ^a   Moreno, Laura ^a,b   Gough, Peter J ^c   Votta, Bart J ^c   Sehon, Clark A ^c   Rickard, David J ^c   Bertin, John ^c   Lim, Eric ^a,d   Nicholson, Andrew G ^a,d   Mitchell, Jane A ^a,e  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b SCHOOL OF MEDICINE   (Spain)

^c GLAXOSMITHKLINE   (United States)

^d ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^e Institute of Cardiovascular Medicine and Science (ICMS)   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN RIP2; PROTEIN SERINE THREONINE KINASE; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOSENSOR; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INTRACELLULAR SIGNALING; MALE; NONHUMAN; PHARMACOLOGICAL STIMULATION; PROTEIN FUNCTION; VASCULAR SMOOTH MUSCLE; VASCULITIS;

ANIMALS; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GRAM-NEGATIVE BACTERIA; HUMANS; MALE; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; NOD1 SIGNALING ADAPTOR PROTEIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDOGLYCAN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASE 2; TOLL-LIKE RECEPTOR 4; VASCULITIS;

NEGIBACTERIA; POSIBACTERIA;

EID: 84864772374     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042386     Document Type: Article

References (36)

1. Martin G, Brunkhorst FM, Janes JM, Reinhart K, Sundin DP, et al. (2009) The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes. Crit Care 13: R103.
2. Patel GP, Balk RA, (2011) Systemic Steroids in Severe Sepsis and Septic Shock. Am J Respir Crit Care Med.
3. Marti-Carvajal AJ, Sola I, Lathyris D, Cardona AF, (2011) Human recombinant activated protein C for severe sepsis. Cochrane Database Syst Rev. pp. CD004388.
4. Mitka M, (2011) Drug for severe sepsis is withdrawn from market, fails to reduce mortality. JAMA 306: 2439-2440.
5. Mitchell JA, Ryffel B, Quesniaux VF, Cartwright N, Paul-Clark M, (2007) Role of pattern-recognition receptors in cardiovascular health and disease. Biochem Soc Trans 35: 1449-1452.
6. Mitchell JA, Paul-Clark MJ, Clarke GW, McMaster SK, Cartwright N, (2007) Critical role of toll-like receptors and nucleotide oligomerisation domain in the regulation of health and disease. J Endocrinol 193: 323-330.
7. Netea MG, van der Meer JW, (2011) Immunodeficiency and genetic defects of pattern-recognition receptors. N Engl J Med 364: 60-70.
8. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, et al. (1999) Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162: 3749-3752.
9. McDonald C, Inohara N, Nunez G, (2005) Peptidoglycan signaling in innate immunity and inflammatory disease. J Biol Chem 280: 20177-20180.
10. Szabo C, Mitchell JA, Thiemermann C, Vane JR, (1993) Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol 108: 786-792.
11. Bishop-Bailey D, Larkin SW, Warner TD, Chen G, Mitchell JA, (1997) Characterization of the induction of nitric oxide synthase and cyclo-oxygenase in rat aorta in organ culture. Br J Pharmacol 121: 125-133.
12. Myhre AE, Aasen AO, Thiemermann C, Wang JE, (2006) Peptidoglycan-an endotoxin in its own right? Shock 25: 227-235.
13. Cartwright N, Murch O, McMaster SK, Paul-Clark MJ, van Heel DA, et al. (2007) Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo. Am J Respir Crit Care Med 175: 595-603.
14. Moreno L, McMaster SK, Gatheral T, Bailey LK, Harrington LS, et al. (2010) Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages. Br J Pharmacol 160: 1997-2007.
15. Lee J, Tattoli I, Wojtal KA, Vavricka SR, Philpott DJ, et al. (2009) pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem 284: 23818-23829.
16. Jimenez R, Belcher E, Sriskandan S, Lucas R, McMaster S, et al. (2005) Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle. Proc Natl Acad Sci U S A 102: 4637-4642.
17. Pavlidis P, Noble WS, (2003) Matrix2png: a utility for visualizing matrix data. Bioinformatics 19: 295-296.
18. Ding GJ, Fischer PA, Boltz RC, Schmidt JA, Colaianne JJ, et al. (1998) Characterization and quantitation of NF-kappaB nuclear translocation induced by interleukin-1 and tumor necrosis factor-alpha. Development and use of a high capacity fluorescence cytometric system. J Biol Chem 273: 28897-28905.
19. Jourdan KB, Mitchell JA, Evans TW, (1997) Release of isoprostanes by human pulmonary artery in organ culture: a cyclo-oxygenase and nitric oxide dependent pathway. Biochem Biophys Res Commun 233: 668-672.
20. Maniatis NA, Orfanos SE, (2008) The endothelium in acute lung injury/acute respiratory distress syndrome. Current Opinion in Critical Care 14: 22-30.
21. Orfanos SE, Mavrommati I, Korovesi I, Roussos C, (2004) Pulmonary endothelium in acute lung injury: from basic science to the critically ill. Intensive Care Med 30: 1702-1714.
22. Cartwright N, McMaster SK, Sorrentino R, Paul-Clark M, Sriskandan S, et al. (2007) Elucidation of toll-like receptor and adapter protein signaling in vascular dysfunction induced by gram-positive Staphylococcus aureus or gram-negative Escherichia coli. Shock 27: 40-47.
23. Opitz B, Forster S, Hocke AC, Maass M, Schmeck B, et al. (2005) Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circ Res 96: 319-326.
24. Opitz B, Puschel A, Beermann W, Hocke AC, Forster S, et al. (2006) Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells. J Immunol 176: 484-490.
25. Nishio H, Kanno S, Onoyama S, Ikeda K, Tanaka T, et al. (2011) Nod1 Ligands Induce Site-Specific Vascular Inflammation. Arterioscler Thromb Vasc Biol.
26. Kanayama A, Seth RB, Sun L, Ea CK, Hong M, et al. (2004) TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell 15: 535-548.
27. Yamamoto M, Takeda K, Akira S, (2004) TIR domain-containing adaptors define the specificity of TLR signaling. Mol Immunol 40: 861-868.
28. Hasegawa M, Fujimoto Y, Lucas PC, Nakano H, Fukase K, et al. (2008) A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J 27: 373-383.
29. Strober W, Murray PJ, Kitani A, Watanabe T, (2006) Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol 6: 9-20.
30. Liu SF, Malik AB, (2006) NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 290: L622-L645.
31. Magalhaes JG, Lee J, Geddes K, Rubino S, Philpott DJ, et al. (2011) Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands. Eur J Immunol 41: 1445-1455.
32. Park JH, Kim YG, McDonald C, Kanneganti TD, Hasegawa M, et al. (2007) RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J Immunol 178: 2380-2386.
33. van Heel DA, Ghosh S, Butler M, Hunt K, Foxwell BM, et al. (2005) Synergistic enhancement of Toll-like receptor responses by NOD1 activation. Eur J Immunol 35: 2471-2476.
34. Fritz JH, Girardin SE, Fitting C, Werts C, Mengin-Lecreulx D, et al. (2005) Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol 35: 2459-2470.
35. Barochia A, Solomon S, Cui X, Natanson C, Eichacker PQ, (2011) Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies. Expert Opin Drug Metab Toxicol 7: 479-494.
36. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, et al. (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345: 1368-1377.