A novel anti-neuroinflammatory pyridylimidazole compound KR-31360

Biochemical Pharmacology

Volumn 79, Issue 4, 2010, Pages 596-609

  Ock, Jiyeon ^a   Kim, Sangseop ^a   Yi, Kyu Yang ^b   Kim, Nak Jung ^b   Han, Hyung Soo ^a   Cho, Je Yoel ^c   Suk, Kyoungho ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Kyungpook National University   (South Korea)

Author keywords

Microglia; Neurodegenerative disease; Neuroinflammation; Neuroprotection; Pyridylimidazole compound; TLR pathway

Indexed keywords

IMIDAZO[4,5 B]PYRIDINE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; KR 31022; KR 31036; KR 31080; KR 31103; KR 31179; KR 31360; KR 31361; KR 35046; KR 35047; KR 35048; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG SCREENING; EMBRYO; GENE EXPRESSION; IC 50; MALE; MICROARRAY ANALYSIS; MICROGLIA; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELLS, CULTURED; COCULTURE TECHNIQUES; DRUGS, INVESTIGATIONAL; IMIDAZOLES; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED C57BL; NEURODEGENERATIVE DISEASES; PYRIDINES; RATS;

EID: 71549121038     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.09.026     Document Type: Article

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