Gastrodin inhibits expression of inducible no synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-Stimulated microglia via MAPK pathways

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Dai, Ji Nan ^a   Zong, Yi ^a   Zhong, Lian Mei ^a   Li, Yue Min ^a   Zhang, Wei ^a   Bian, Li Gong ^a   Ai, Qing Long ^a   Liu, Yi Dan ^b   Sun, Jun ^a   Lu, Di ^a  

^a KUNMING MEDICAL UNIVERSITY   (China)

^b Kunming Pharmaceutical Co   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 2; GASTRODIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; BENZYL ALCOHOL DERIVATIVE; CYTOKINE; GLUCOSIDE; I KAPPA B; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; IMMUNOFLUORESCENCE TEST; MICROGLIA; MOUSE; NERVE CELL CULTURE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; CELL CULTURE; CELL LINE; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

MURINAE;

ANIMALS; BENZYL ALCOHOLS; CELL LINE; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLOOXYGENASE 2; CYTOKINES; GLUCOSIDES; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79960170945     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021891     Document Type: Article

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