Nitric oxide neurotoxicity in neurodegenerative diseases

Frontiers in Bioscience

Volumn 9, Issue , 2004, Pages 763-776

  Boje, Kathleen M K ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Acquired Immune Deficiency Syndrome (AIDS) Dementia Complex; Alzheimer's Disease; Amyotrophic Lateral Sclerosis; Blood Brain Barrier; HIV Associated Dementia; Huntington's Disease; Neurodegenerative Diseases; Neuroinflammation; Nitric Oxide

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE NITROGEN SPECIES; NEUROPROTECTIVE AGENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; BIOCHEMISTRY; BLOOD BRAIN BARRIER; BLOOD CEREBROSPINAL FLUID BARRIER; DEGENERATIVE DISEASE; EXCITOTOXICITY; HUMAN; HUNTINGTON CHOREA; INFLAMMATION; METABOLISM; MOLECULAR DYNAMICS; MULTIPLE SCLEROSIS; NEUROINFLAMMATION; NEUROPROTECTION; NEUROTOXICITY; PARKINSON DISEASE; PATHOPHYSIOLOGY; REVIEW; SYNTHESIS; ANIMAL; TOXICITY AND INTOXICATION;

ANIMALS; HUMANS; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; NITRIC OXIDE; REACTIVE NITROGEN SPECIES;

EID: 2542427512     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/1268     Document Type: Review

References (164)

1. Grisham, M. B., D. Jourdheuil & D. A. Wink: Nitric oxide I. Physiological chemistry of nitric oxide and its metabolites: implications in inflammation. Am J Physiol 276, G315-G321 (1999)
2. Koppenol, W. H.: The basic chemistry of nitrogen monoxide and peroxynitrite. Free Radical Biol Med 25, 385-391 (1998)
3. Kelm, M.: Nitric oxide metabolism and breakdown. Biochim Biophys Acta 1411, 273-289 (1999)
4. Liaudet, L., F. G. Soriano & C. Szabo: Biology of nitric oxide signaling. Critical Care Medicine 28, N37-52 (2000)
5. Blake, D. J. & S. Kroger: The neurobiology of duchenne muscular dystrophy: learning lessons from muscle? Trends in Neurosci 23(3), 92-99 (2000)
6. Bredt, D. S.: Endogenous nitric oxide synthesis: biological functions and pathophysiology. Free Radical Research 31(6), 577-596 (1999)
7. McCann, S. M., C. Mastronardi, A. Walczewska, S. Karanth, V. Rettori & W. H. Yu: The role of nitric oxide in reproduction. Brazilian J Med Bio Res 32(11), 1367-1379 (1999)
8. Noris, M. & G. Remuzzi: Physiology and pathophysiology of nitric oxide in chronic renal disease. Proceed Asso Am Physicians 111(6), 602-610 (1999)
9. Boger, R. H.: Nitric oxide and the mediation of the hemodynamic effects of growth hormone in humans. J Endocrinol Invest 22, 75-81 (1999)
10. Gerlach, M., D. Blum-Degen, J. Lan & P. Riederer: Nitric oxide in the pathogenesis of Parkinson's disease. Adv Neurol 80, 239-245 (1999)
11. Bigatello, L. M.: Nitric oxide: modulation of the pulmonary circulation. Minerva Anestesiologica 66(5), 307-313 (2000)
12. Matheson, P. J., M. A. Wilson & R. N. Garrison: Regulation of intestinal blood flow. J Surg Res 93(1), 182-196 (2000)
13. Ignarro, L. J.: Nitric oxide: a unique endogenous signaling molecule in vascular biology. Bioscience Reports 19(2), 51-71 (1999)
14. Contestabile, A.: Roles of NMDA receptor activity and nitric oxide production in brain development. Brain Res Rev 32(2-3), 476-509 (2000)
15. Agerman, K., B. Canlon, M. Duan & P. Ernfors: Neurotrophins, NMDA receptors, and nitric oxide in development and protection of the auditory system. Ann New York Acad Sci 884, 131-142 (1999)
16. Ischiropoulos, H. & J. S. Beckman: Oxidative stress and nitration in neurodegeneration: cause, effect, or association? J Clin Invest 111(2), 163-169 (2003)
17. Moncada, S., A. Higgs & R. Furchgott: International Union of Pharmacology Nomenclature in Nitric Oxide Research. Pharmacol Rev 49(2), 137-142 (1997)
18. Law, A., S. Gauthier & R. Quirion: Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type. Brain Res Rev 35(1), 73-96 (2001)
19. Boje, K. M. K.: Neurotoxic mechanisms of nitric oxide. In: Neuroinflammation: Mechanisms and Management, Ed. Wood, P. L. Humana Press: Towota, New Jersey. 2, 117-136 (2003)
20. Wink, D. & J. B. Mitchell: Chemical biology of nitric oxide: Insights into regulatory, cytotoxic and cytoprotective mechanisms of nitric oxide. Free Radical Biol Med 25, 434-456 (1998)
21. Dawson, T. M., M. Sasaki, M. Gonzalez-Zulueta & V. L. Dawson: Regulation of neuronal nitric oxide synthase and identification of novel nitric oxide signaling pathways. Prog Brain Res 118, 3-11 (1998)
22. Dawson, V. L. & T. Dawson: Nitric oxide in neurodegeneration. Prog Brain Res 118, 215-229 (1998)
23. Hemeka, M. T., D. L. Feinstein, E. Galea, M. Gleichmann, U. Wullner & T. Klockgether: Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell deathe by inhibition of inducible nitric oxide synthase. J Neuroimmunol 100, 156-168 (1999)
24. Murphy, S.: Production of nitric oxide by glial cells: Regulation and potential roles in the CNS. Glia 29, 1-14 (2000)
25. Boje, K. M. & P. K. Arora: Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res 587(2), 250-256 (1992)
26. Chao, C. C., S. Hu, T. W. Molitor, E. G. Shaskan & P. K. Peterson: Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol 149(8), 2736-2741 (1992)
27. Galea, E., D. L. Feinstein & D. J. Reis: Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures. Proc Nat Acad Sci USA 89(22), 10945-10949 (1992)
28. Wiesinger, H.: Arginine metabolism and the synthesis of nitric oxide in the nervous system. Prog Neurobiol 64(4), 365-391 (2001)
29. Lam, A. G., T. Koppal, K. T. Akama, L. Guo, J. M. Craft, B. Samy, J. P. Schavocky, D. M. Watterson & L. J. Van Eldik: Mechanism of glial activation by S100B: involvement of the transcription factor NFkappaB. Neurobiol Aging 22(5), 765-772 (2001)
30. Pou, S., L. Keaton, W. Surichamorn & G. M. Rosen: Mechanism of superoxide generation by neuronal nitric-oxide synthase. J Biol Chem 274(14), 9573-9580 (1999)
31. Squadrito, G. L. & W. A. Pryor: Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide. Free Radical Biol Med 25, 392-403 (1998)
32. Torreilles, F., S. Salman-Tabcheh, M.-C. Guerin & J. Torreilles: Neurodegenerative disorders: the role of peroxynitrite. Brain Res Rev 30, 153-163 (1999)
33. Crow, J. P. & J. S. Beckman The role of peroxynitrite in nitric oxide-mediated toxicity. Current Topics Microbiol Immunol 196, 57-73 (1995)
34. Lipton, S. A., Y.-B. Choi, Z.-H. Pan, S.-Z. Lei, H.-S. V. Chen, N. J. Sucher, J. Loscalzo, D. J. Singel & J. S. Stamler: A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364, 626-632 (1993)
35. Calabrese, V., T. E. Bates & A. M. Stella: NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochem Res 25(9-10), 1315-1341 (2000)
36. Dawson, V. L., H. P. Brahmbhatt, J. A. Mong & T. M. Dawson: Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronalglial cortical cultures. Neuropharmacology 33(11), 1425-1430 (1994)
37. Merrill, J. E., L. J. Ignarro, M. P. Sherman, J. Melinek & T. E. Lane: Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J Immunol 151(4), 2132-2141 (1993)
38. Boje, K. M. K.: Inhibition of nitric oxide synthase partially attenuates alterations in the blood-cerebrospinal fluid barrier during experimental meningitis in the rat. Eur J Pharmacol 272(2-3), 297-300 (1995)
39. Boje, K. M. K.: Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis. Brain Res 720, 75-83 (1996)
40. Borgerding, R. A. & S. Murphy: Expression of inducible nitric oxide synthase in cerebral endothelial cells is regulated by cytokine-activated astrocytes. J Neurochem 65(3), 1342-1347 (1995)
41. Boje, K. M. K. & S. S. Lakhman: Nitric oxide redox species exert differential permeability effects on the blood-brain barrier. J Pharmacol Exp Ther 293, 545-550 (2000)
42. Heales, J. R., J. P. Bolanos, V. C. Stewart, P. S. Brookes, J. M. Land & J. B. Clark: Nitric oxide, mitochondria and neurological disease. Biochim Biophys Acta 1410, 215-228 (1999)
43. Dawson, T. M., D. S. Bredt, M. Fotuhi, P. M. Hwang & S. H. Snyder: Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc Nat Acad Sci USA 88(17), 7797-7801 (1991)
44. Gonzalez-Zulueta, M., L. M. Ensz, G. Mukhina, R. M. Lebovitz, R. M. Zwacka, J. F. Engelhardt, L. W. Oberley, V. L. Dawson & T. M. Dawson: Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide - mediated neurotoxicity. J Neurosci 18, 2040-2055 (1998)
45. Mohanakumar, K. P., B. Thomas, S. M. Sharma, D. Muralikrishnan, R. Chowdhury & C. C. Chiueh: Nitric oxide: an antioxidant and neuroprotector. Ann NY Acad Sci 962, 389-401 (2002)
46. Chiueh, C. C.: Neuroprotective properties of nitric oxide. Ann NY Acad Sci 890, 301-311 (1999)
47. Kim, Y.-M., C. A. Bombeck & T. R. Billiar: Nitric oxide as a bifunctional regulator of apoptosis. Circ Res 84, 253-256 (1999)
48. Hogg, N. & B. Kalyanaraman: Nitric oxide and lipid peroxidation. Biochim Biophys Acta 1411, 378-384 (1999)
49. Hensley, K., T. Tabatabaie, C. A. Stewart, Q. Pye & R. A. Floyd: Nitric oxide and derived species as toxic agents in stroke, AIDS dementia, and chronic neurodegenrative disorders. Chem Res Toxicol 10, 527-532 (1997)
50. Beckman, J. S., J. Chen, J. P. Crow & Y. Z. Ye: Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration. Prog Brain Res 103, 371-380 (1994)
51. Schmidt, H. H. H. W., H. Hofmann, U. Schindler, Z. S. Shutenko, D. D. Cunningham & M. Feelish: No NO• from NO synthase. Proc Natl Acad Sci USA 93, 14492-14497 (1996)
52. Rusche, K. M., M. M. Spiering & M. A. Marletta: Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase. Biochemistry 37, 15503-15512 (1998)
53. Arnelle, D. R. & J. S. Stamler: NO+, NO, and NO-donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation. Arch Biochem Biophys 318(2), 279-285 (1995)
54. Murphy, M. E. & H. Sies: Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase. Proc Natl Acad Sci USA 88, 10860-10864 (1991)
55. Chazotte-Aubert, L., S. Oikawa, I. Gilibert, F. Bianchini, S. Kawanishi & H. Ohshima: Cytotoxicity and site-specific DNA damage induced by nitroxyl anion (NO(-)) in the presence of hydrogen peroxide. Implications for various pathophysiological conditions. J Biol Chem 274, 20909-20915 (1999)
56. Patel, R. P., J. McAndrew, H. Sellak, C. R. White, H. Ho, B. A. Freeman & V. M. Darley-Usmar: Biological aspects of reactive nitrogen species. Biochim Biophys Acta 1411, 385-400 (1999)
57. Leist, M. & P. Nicotera: Apoptosis, excitotoxicity and neuropathology. Exp Cell Res 239, 183-201 (1998)
58. Wink, D. A., K. S. Kasprzak, C. M. Maragos, R. K. Elespuru, M. Misra, T. M. Dunams, T. A. Cebula, W. H. Koch, A. W. Andrews, J. S. Allen & et al.: DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science 254(5034), 1001-1003 (1991)
59. Derojaswalker, T., S. Tamir, H. Ji, J. S. Wishnok & S. R. Tannenbaum: Nitric oxide induces oxidative damage in addition to deamination in macrophage DNA. Chem Res Toxicol 8, 473-477 (1995)
60. Graziewicz, M., D. A. Wink & F. Laval: Nitric oxide inhibits DNA ligase activity: potential mechanisms for NO-mediated DNA damage. Carcinogenesis 17, 2501-2505 (1996)
61. Kwon, N. S., D. J. Stuehr & C. Nathan: Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J Exp Med 174, 761-768 (1991)
62. Zhang, J., V. L. Dawson, T. M. Dawson & S. H. Snyder: Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 263(5147), 687-689 (1994)
63. Beal, M. F.: Mitochondria, NO and neurodegeneration. Biochem Soc Symp 66, 43-54 (1999)
64. Murphy, M. P.: Nitric oxide and cell death. Biochim Biophys Acta 1411, 401-414 (1999)
65. Brown, G. C.: Nitric oxide and mitochondrial respiration. Biochim Biophys Acta 1411, 351-369 (1999)
66. Dimmeler, S., F. Lottspeich & B. Brune: Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem 267(24), 16771-16774 (1992)
67. Gaston, B.: Nitric oxide and thiol groups. Biochim Biophys Acta 1411, 323-333 (1999)
68. Brolliet, M.-C.: S-Nitrosylation of proteins. Cell Mol Life Sci 55, 1036-1042 (1999)
69. Dawson, V. L., T. M. Dawson, E. D. London, D. S. Bredt & S. H. Snyder: Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Nat Acad Sci USA 88, 6368-6371 (1991)
70. Aizenman, E., J. C. Brimecombe, W. K. Potthoff & P. A. Rosenberg: Why is the role of nitric oxide in NMDA receptor function and dysfunction so controversial? Prog Brain Res 118, 53-71 (1998)
71. Lipton, S. A., P. V. Rayudu, Y. B. Choi, N. J. Sucher & H. S. Chen: Redox modulation of the NMDA receptor by NO-related species. Prog Brain Res 118, 73-82 (1998)
72. Kim, W. K., Y. B. Choi, P. V. Rayudu, Das. P, W. Asaad, D. R. Arnelle, J. S. Stamler & S. A. Lipton: Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO-. Neuron 24, 461-469 (1999)
73. Schubert, P., T. Ogata, C. Marchini & S. Ferroni: Glia-related pathomechanisms in Alzheimer's disease: a therapeutic target? Mechanisms of Ageing & Development 123(1), 47-57 (2001)
74. Gras, G., F. Chretien, A. V. Vallat-Decouvelaere, G. Le Pavec, F. Porcheray, C. Bossuet, C. Leone, P. Mialocq, N. Dereuddre-Bosquet, P. Clayette, R. Le Grand, C. Creminon, D. Dormont, A. C. Rimaniol & F. Gray: Regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in HIV infection? Brain Pathology 13(2), 211-222 (2003)
75. Teismann, P., K. Tieu, O. Cohen, D. K. Choi, C. Wu du, D. Marks, M. Vila, V. Jackson-Lewis & S. Przedborski: Pathogenic role of glial cells in Parkinson's disease. Movement Disorders 18(2), 121-129 (2003)
76. Knott, C., G. Stern & G. P. Wilkin: Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2. Mol Cell Neurosci 16(6), 724-739 (2000)
77. Wood, P. L.: Microglia: Roles of microglia in chronic neurodegenerative diseases. In: Neuroinflammation: Mechanisms and Management, Ed. Wood, P. L. Humana Press: Towota, New Jersey. 2, 117-136 (2003)
78. de Vries, H. E., J. Kuiper, A. G. de Boer, T. J. C. Van Berkel & D. D. Breimer: The blood-brain barrier in neuroinflammatory diseases. Pharmacol Rev 49, 143-156 (1997)
79. Boje, K. M., D. Jaworowicz, Jr. & J. J. Raybon: Neuroinflammatory role of prostaglandins during experimental meningitis: evidence suggestive of an in vivo relationship between nitric oxide and prostaglandins. J Pharmacol Exp Ther 304(1), 319-325 (2003)
80. Teismann, P., K. Tieu, D. K. Choi, D. C. Wu, A. Naini, S. Hunot, M. Vila, V. Jackson-Lewis & S. Przedborski: Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. Proc Nat Acad Sci USA 100(9), 5473-5478 (2003)
81. Anderson, I., C. Adinolfi, S. Doctrow, K. Huffman, K. A. Joy, B. Malfroy, P. Soden, H. T. Rupniak & J. C. Barnes: Oxidative signalling and inflammatory pathways in Alzheimer's disease. Biochemical Society Symposia (67), 141-149 (2001)
82. Corasaniti, M. T., D. Rotiroti, G. Nappi & G. Bagetta: Neurobiological mediators of neuronal apoptosis in experimental neuroAIDS. Toxicol Lett 139(2-3), 199-206 (2003)
83. Greco, A., L. Minghetti, G. Sette, C. Fieschi & G. Levi: Cerebrospinal fluid isoprostane shows oxidative stress in patients with multiple sclerosis. Neurology 53(8), 1876-1879 (1999)
84. Almer, G., C. Guegan, P. Teismann, A. Naini, G. Rosoklija, A. P. Hays, C. Chen & S. Przedborski: Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. Ann Neurol 49(2), 176-185 (2001)
85. Noda, M., H. Nakanishi & N. Akaike: Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide. Neuroscience 92(4), 1465-1474 (1999)
86. Bezzi, P., G. Carmignoto, L. Pasti, S. Vesce, D. Rossi, B. L. Rizzini, T. Pozzan & A. Volterra: Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature 391(6664), 281-285 (1998)
87. Poser, C. M.: Notes on the pathogenesis of multiple sclerosis. Clin Neurosci 2(3-4), 258-265 (1994)
88. Stone, L. A., M. E. Smith, P. S. Albert, C. N. Bash, H. Maloni, J. A. Frank & H. F. McFarland: Blood-brain barrier disruption on contrast-enhanced MRI in patients with mild relapsing-remitting multiple sclerosis: relationship to course, gender, and age. Neurology 45(6), 1122-1126 (1995)
89. Power, C. & R. T. Johnson: HIV-1 associated dementia: clinical features and pathogenesis. Can J Neurol Sci 22(2), 92-100 (1995)
90. Zhang, J., H. Benveniste, B. Klitzman & C. A. Piantadosi: Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. Stroke 26(2), 298-304 (1995)
91. Stewart, D. J.: A critique of the role of the blood-brain barrier in the chemotherapy of human brain tumors. J Neuro Oncology 20(2), 121-139 (1994)
92. Tunkel, A. R. & W. M. Scheld: Pathogenesis and pathophysiology of bacterial meningitis. Annual Rev Med 44, 103-120 (1993)
93. Thiel, V. E. & K. L. Audus: Nitric oxide and blood-brain barrier integrity. Antioxidants and Redox Signaling 3(2), 273-279 (2001)
94. Lee, S. C., D. W. Dickson, W. Liu & C. F. Brosnan: Induction of nitric oxide synthase activity in human astrocytes by interleukin-1 beta and interferon-gamma. J Neuroimmunol 46(1-2), 19-24 (1993)
95. Lee, S. C., D. W. Dickson, C. F. Brosnan & A. Casadevall: Human astrocytes inhibit Cryptococcus neoformans growth by a nitric oxide-mediated mechanism. J Exp Med 180(1), 365-369 (1994)
96. Skaper, S. D., L. Facci & A. Leon: Inflammatory mediator stimulation of astrocytes and meningeal fibroblasts induces neuronal degeneration via the nitridergic pathway. J Neurochem 64(1), 266-276 (1995)
97. Kilbourn, R. G. & P. Belloni: Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin. J Nat Cancer Inst 82(9), 772-776 (1990)
98. Rosenkranz-Weis, P., W. C. Sessa, S. Milstien, S. Kaufman, C. A. Watson & J. S. Pober: Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity. J Clin Invest 93(5), 2236-2243 (1994)
99. Boje, K. M. K.: Cerebrovascular permeability changes during experimental meningitis in the rat. J Pharmacol Exp Ther 274(3), 1199-1203 (1995)
100. Korytko, P. J. & K. M. K. Boje: Pharmacological characterization of nitric oxide production in a rat model of meningitis. Neuropharmacol 35, 231-237 (1996)
101. 2 formation parallels blood-brain barrier disruption in an experimental rat model of bacterial meningitis. Brain Research Bull 46, 541-546 (1998)
102. Mayhan, W. G.: Nitric oxide donor-induced increase in permeability of the blood-brain barrier. Brain Res 866, 101-108 (2000)
103. Giovannoni, G., R. F. Miller, S. J. Heales, J. M. Land, M. J. Harrison & E. J. Thompson: Elevated cerebrospinal fluid and serum nitrate and nitrite levels in patients with central nervous system complications of HIV-1 infection: a correlation with blood-brain-barrier dysfunction. J Neurol Sci 156(1), 53-58 (1998)
104. Strelow, L. I., D. Janigro & J. A. Nelson: The blood-brain barrier and AIDS. Advances in Virus Research 56, 355-388 (2001)
105. Mollace, V., H. S. Nottet, P. Clayette, M. C. Turco, C. Muscoli, D. Salvemini & C. F. Perno: Oxidative stress and neuroAIDS: triggers, modulators and novel antioxidants. Trends Neurosci 24(7), 411-416 (2001)
106. Kaul, M., G. A. Garden & S. A. Lipton: Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410(6831), 988-994 (2001)
107. van de Bovenkamp, M., H. S. Nottet & C. F. Pereira: Interactions of human immunodeficiency virus-1 proteins with neurons: possible role in the development of human immunodeficiency virus-1-associated dementia. European J Clin Invest 32(8), 619-627 (2002)
108. Nath, A.: Human immunodeficiency virus (HIV) proteins in neuropathogenesis of HIV dementia. J Infect Dis 186(Suppl 2), S193-198 (2002)
109. Adamson, D. C., K. L. Kopnisky, T. M. Dawson & V. L. Dawson: Mechanisms and structural determinants of HIV-1 coat protein, gp41-induced neurotoxicity. J Neurosci 19(1), 64-71 (1999)
110. Hori, K., P. R. Burd, K. Furuke, J. Kutza, K. A. Weih & K. A. Clouse: Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide (NO) production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome. Blood 93(6), 1843-1850 (1999)
111. Adamson, D. C., J. C. McArthur, T. M. Dawson & V. L. Dawson: Rate and severity of HIV-associated dementia (HAD): correlations with Gp41 and iNOS. Mol Med 5(2), 98-109 (1999)
112. Rostasy, K., L. Monti, C. Yiannoutsos, M. Kneissl, J. Bell, T. L. Kemper, J. C. Hedreen & B. A. Navia: Human immunodeficiency virus infection, inducible nitric oxide synthase expression, and microglial activation: pathogenetic relationship to the acquired immunodeficiency syndrome dementia complex. Ann Neurol 46(2), 207-216 (1999)
113. Vincent, V. A., C. J. De Groot, P. J. Lucassen, P. Portegies, D. Troost, F. J. Tilders & A. M. Van Dam: Nitric oxide synthase expression and apoptotic cell death in brains of AIDS and AIDS dementia patients. Aids 13(3), 317-326 (1999)
114. Boven, L. A., L. Gomes, C. Hery, F. Gray, J. Verhoef, P. Portegies, M. Tardieu & H. S. Nottet: Increased peroxynitrite activity in AIDS dementia complex: implications for the neuropathogenesis of HIV-1 infection. J Immunol 162(7), 4319-4327 (1999)
115. Torre, D., A. Pugliese & F. Speranza: Role of nitric oxide in HIV-1 infection: friend or foe? The Lancet Infectious Diseases 2(5), 273-280 (2002)
116. Adamson, D. C., B. Wildemann, M. Sasaki, J. D. Glass, J. C. McArthur, V. I. Christov, T. M. Dawson & V. L. Dawson: Immunologic NO synthase: Elevation in severe AIDS dementia and induction by HIV-1 gp41. Science 274, 1917-1921 (1996)
117. Beckman, J. S.: Peroxynitrite versus hydroxyl radical: the role of nitric oxide in superoxide-dependent cerebral injury. Ann New York Acad Sci 738, 69-75 (1994)
118. Beckman, J. S., M. Carson, C. D. Smith & W. H. Koppenol: ALS, SOD and peroxynitrite. Nature 364(6438), 584 (1993)
119. Estevez, A. G., J. P. Crow, J. B. Sampson, C. Reiter, Y. Zhuang, G. J. Richardson, M. M. Tarpey, L. Barbeito & J. S. Beckman: Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science 286(5449), 2498-2500 (1999)
120. Almer, G., S. Vukosavic, N. Romero & S. Przedborski: Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem 72(6), 2415-2425 (1999)
121. Sasaki, S., N. Shibata, T. Komori & M. Iwata: iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis. Neurosci Lett 291(1), 44-48 (2000)
122. Beal, M. F., R. J. Ferrante, S. E. Browne, R. T. Matthews, N. W. Kowall & R. H. Brown, Jr.: Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann Neurol 42(4), 644-654 (1997)
123. Taskiran, D., A. Sagduyu, N. Yuceyar, F. Z. Kutay & S. Pogun: Increased cerebrospinal fluid and serum nitrite and nitrate levels in amyotrophic lateral sclerosis. Int J Neurosci 101(1-4), 65-72 (2000)
124. Tohgi, H., T. Abe, K. Yamazaki, T. Murata, E. Ishizaki & C. Isobe: Increase in oxidized NO products and reduction in oxidized glutathione in cerebrospinal fluid from patients with sporadic form of amyotrophic lateral sclerosis. Neurosci Lett 260(3), 204-206 (1999)
125. Allen, S., P. R. Heath, J. Kirby, S. B. Wharton, M. R. Cookson, F. M. Menzies, R. E. Banks & P. J. Shaw: Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways. J Biol Chem 278(8), 6371-6383 (2003)
126. Whitehouse, P. J.: Genesis of Alzheimer's disease. Neurology 48(5 Suppl 7), S2-7 (1997)
127. Drouet, B., M. Pincon-Raymond, J. Chambaz & T. Pillot: Molecular basis of Alzheimer's disease. Cell & Mol Life Sciences 57(5), 705-715 (2000)
128. Hardy, J. & D. J. Selkoe: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297(5580), 353-356 (2002)
129. Tohgi, H., T. Abe, K. Yamazaki, T. Murata, E. Ishizaki & C. Isobe: Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease. Neurosci Lett 269(1), 52-54 (1999)
130. Hensley, K., M. L. Maidt, Z. Yu, H. Sang, W. R. Markesbery & R. A. Floyd: Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation. J Neurosci 18(20), 8126-8132 (1998)
131. Williamson, K. S., S. P. Gabbita, S. Mou, M. West, Q. N. Pye, W. R. Markesbery, R. V. Cooney, P. Grammas, U. Reimann-Philipp, R. A. Floyd & K. Hensley: The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain. Nitric Oxide 6(2), 221-227 (2002)
132. Kowall, N. W.: Beta amyloid neurotoxicity and neuronal degeneration in Alzheimer's disease. Neurobiol Aging 15(2), 257-258 (1994)
133. Cotman, C. W. & A. J. Anderson: A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol Neurobiol 10(1), 19-45 (1995)
134. Colton, C. A., C. M. Brown, M. Czapiga & M. P. Vitek: Apolipoprotein-E allele-specific regulation of nitric oxide production. Ann NY Acad Sci 962, 212-225 (2002)
135. Katsuse, O., E. Iseki & K. Kosaka: Immunohistochemical study of the expression of cytokines and nitric oxide synthases in brains of patients with dementia with Lewy bodies. Neuropathology 23(1), 9-15 (2003)
136. Deckel, A. W.: Nitric oxide and nitric oxide synthase in Huntington's disease. J Neurosci Res 64(2), 99-107 (2001)
137. Nucifora, F. C., Jr., M. Sasaki, M. F. Peters, H. Huang, J. K. Cooper, M. Yamada, H. Takahashi, S. Tsuji, J. Troncoso, V. L. Dawson, T. M. Dawson & C. A. Ross: Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science 291(5512), 2423-2428 (2001)
138. Steffan, J. S., L. Bodai, J. Pallos, M. Poelman, A. McCampbell, B. L. Apostol, A. Kazantsev, E. Schmidt, Y. Z. Zhu, M. Greenwald, R. Kurokawa, D. E. Housman, G. R. Jackson, J. L. Marsh & L. M. Thompson: Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 413(6857), 739-743 (2001)
139. Perez-Severiano, F., B. Escalante, P. Vergara, C. Rios & J. Segovia: Age-dependent changes in nitric oxide synthase activity and protein expression in striata of mice transgenic for the Huntington's disease mutation. Brain Res 951(1), 36-42 (2002)
140. Parkinson, J. F., B. Mitrovic & J. E. Merril: The role of nitric oxide in multiple sclerosis. J Mol Med 75, 174-186 (1997)
141. Cross, A. H., P. T. Manning, R. M. Keeling, R. E. Schmidt & T. P. Misko: Peroxynitrite formation within the central nervous system in active multiple sclerosis. J Neuroimmunol 88(1-2), 45-56 (1998)
142. Giovannoni, G., S. J. Heales, N. C. Silver, J. O'Riordan, R. F. Miller, J. M. Land, J. B. Clark & E. J. Thompson: Raised serum nitrate and nitrite levels in patients with multiple sclerosis. J Neurol Sci 145(1), 77-81 (1997)
143. Svenningsson, A., A. S. Petersson, O. Andersen & G. K. Hansson: Nitric oxide metabolites in CSF of patients with MS are related to clinical disease course. Neurology 53(8), 1880-1882 (1999)
144. Brundin, L., E. Morcos, T. Olsson, N. P. Wiklund & M. Andersson: Increased intrathecal nitric oxide formation in multiple sclerosis; cerebrospinal fluid nitrite as activity marker. Eur J Neurol 6(5), 585-590 (1999)
145. Danilov, A. I., M. Andersson, N. Bavand, N. P. Wiklund, T. Olsson & L. Brundin: Nitric oxide metabolite determinations reveal continuous inflammation in multiple sclerosis. J Neuroimmunol 136(1-2), 112-118 (2003)
146. Drulovic, J., S. Mesaros, T. Samard ic, D. Maksimovic, N. Stojsavljevic, Z. Levic & M. M. Stojokvic: Raised cerebrospinal fluid nitrite and nitrate levels in patients with multiple sclerosis: no correlation with disease activity. Multiple Sclerosis 7(1), 19-22 (2001)
147. Zhang, Y., V. L. Dawson & T. M. Dawson: Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiol Dis 7, 240-250 (2000)
148. Hunot, S., N. Dugas, B. Faucheux, A. Hartmann, M. Tardieu, P. Debre, Y. Agid, B. Dugas & E. C. Hirsch: Fc epsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells. J Neurosci 19, 3440-3447 (1999)
149. Hunot, S., F. Boissiere, B. Faucheux, B. Brugg, A. Mouatt-Prigent, Y. Agid & E. C. Hirsch: Nitric oxide synthase and neuronal vulnerability in Parkinson's disease. Neurosci 72, 355-363 (1996)
150. Hunot, S. & E. C. Hirsch: Neuroinflammatory processes in Parkinson's disease. Ann Neurol 53(Suppl 3), S49-58; discussion S58-60 (2003)
151. Jenner, P.: Oxidative stress in Parkinson's disease. Ann Neurol 53(Suppl 3), S26-36; discussion S36-28 (2003)
152. Hantraye, P., E. Brouillet, R. Ferrante, S. Palfi, R. Dolan, Matthews, R. T, & M. F. Beal: Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat Med 2, 1017-1021 (1996)
153. Przedborski, S., V. Jackson-Lewis, R. Yokoyama, T. Shibata, V. L. Dawson & T. M. Dawson: Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proc Nat Acad Sci USA 93, 4565-4571 (1996)
154. Olanow, C. W. & W. G. Tatton: Etiology and pathogenesis of Parkinson's disease. Ann Rev Neurosci 22, 123-144 (1999)
155. Good, P. F., A. Hsu, P. Werner, D. P. Perl & C. W. Olanow: Protein nitration in Parkinson's disease. Neuropathol Exp Neurol 57, 338-342 (1998)
156. Qureshi, G. A., S. Baig, I. Bednar, P. Sodersten, G. Forsberg & A. Siden: Increased cerebrospinal fluid concentration of nitrite in Parkinson's disease. Neuroreport 6, 1642-1644 (1995)
157. Wolozin, B. & N. Golts: Iron and Parkinson's disease. Neuroscientist 8(1), 22-32 (2002)
158. Koshland, D. E., Jr.: The molecule of the year. Science 258(5090), 1861 (1992)
159. Snyder, S. H. & D. S. Bredt: Nitric oxide as a neuronal messenger. Trends in Pharmacol Sci 12(4), 125-128 (1991)
160. Bredt, D. S., P. M. Hwang & S. H. Snyder: Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347(6295), 768-770 (1990)
161. Bredt, D. S. & S. H. Snyder: Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA 86, 9030-9033 (1989)
162. Christopherson, K. S. & D. S. Bredt: Nitric oxide in excitable tissues: physiological roles and disease. J Clin Invest 100(10), 2424-2429 (1997)
163. Szabo, C.: Physiological and pathophysiological roles of nitric oxide in the central nervous system. Brain Res Bull 41(3), 131-141 (1996)
164. Vallance, P. & J. Leiper: Blocking NO synthesis: How, where and why? Nature Rev. Drug Discovery 1, 939-950 (2002)