Ginseng derivative ocotillol enhances neuronal activity through increased glutamate release: A possible mechanism underlying increased spontaneous locomotor activity of mice

Neuroscience

Volumn 195, Issue , 2011, Pages 1-8

  Wang, Z J ^a   Sun, L ^a   Peng, W ^b   Ma, S ^b   Zhu, C ^b   Fu, F ^b   Heinbockel, T ^a  

^a HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b YANTAI UNIVERSITY   (China)

Author keywords

Brain slice; Excitatory postsynaptic currents; Ginsenosides; Glutamate receptors; Locomotor activity; Ocotillol

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR; GINSENOSIDE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; KAINIC ACID RECEPTOR; OCOTILLOL; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; EXCITATORY POSTSYNAPTIC POTENTIAL; GLUTAMATE RELEASE; GLUTAMATERGIC TRANSMISSION; IN VIVO STUDY; LOCOMOTION; MEMBRANE DEPOLARIZATION; MITRAL CELL; MOUSE; NERVE CELL EXCITABILITY; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; OLFACTORY BULB; PATCH CLAMP; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION;

ACTION POTENTIALS; ANIMALS; EXCITATORY POSTSYNAPTIC POTENTIALS; GINSENOSIDES; GLUTAMIC ACID; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; NEURONS; NEUROPROTECTIVE AGENTS; OLFACTORY BULB; ORGAN CULTURE TECHNIQUES; PANAX; PATCH-CLAMP TECHNIQUES;

EID: 80053566875     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.08.002     Document Type: Article

References (34)

1. Akao T., Kida H., Kanaoka M., Hattori M., Kobashi K. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharm Pharmacol 1998, 50:1155-1160.
2. Aroniadou-Anderjaska V., Ennis M., Shipley M.T. Current-source density analysis in the rat olfactory bulb: laminar distribution of kainate/AMPA and NMDA receptor-mediated currents. J Neurophysiol 1999, 81:15-28.
3. Aroniadou-Anderjaska V., Zhou F.M., Priest C.A., Ennis M., Shipley M.T. Tonic and synaptically evoked presynaptic inhibition of sensory input to the rat olfactory bulb via GABA(B) heteroreceptors. J Neurophysiol 2000, 84:1194-1203.
4. Bae E.A., Park S.Y., Kim D.H. Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull 2000, 23:1481-1485.
5. Chang Y., Wang S.J. Ginsenoside Rg1 and Rb1 enhance glutamate exocytosis from rat cortical nerve terminals by affecting vesicle mobilization through the activation of protein kinase C. Eur J Pharmacol 2008, 590:74-79.
6. Duan Y., Nicholson R.A. 20(S)-protopanaxadiol and the ginsenoside Rh2 inhibit Na+ channel-activated depolarization and Na+ channel-dependent amino acid neurotransmitter release in synaptic fractions isolated from mammalian brain. Comp Biochem Physiol C Toxicol Pharmacol 2008, 147:351-356.
7. Ennis M., Hamilton K.A., Hayar A. Neurochemistry of the main olfactory system. Handbook of neurochemistry and molecular neurobiology 2007, Vol. 20:137-204. Springer, Heidelberg, Sensory Neurochemistry (Johnson DA, Volume ed). 3rd edition. A. Lajtha (Ed.).
8. Ennis M., Zhou F.M., Ciombor K.J., Aroniadou-Anderjaska V., Hayar A., Borrelli E., Zimmer L.A., Shipley M.T. Dopamine D2 receptor-mediated presynaptic inhibition of olfactory nerve terminals. J Neurophysiol 2001, 86:2986-2997.
9. Hao Y., Yang J.Y., Wu C.F., Wu M.F. Pseudoginsenoside-F11 decreases morphine-induced behavioral sensitization and extracellular glutamate levels in the medial prefrontal cortex in mice. Pharmacol Biochem Behav 2007, 86:660-666.
10. Harkey M.R., Henderson G.L., Gershwin M.E., Stern J.S., Hackman R.M. Variability in commercial ginseng products: an analysis of 25 preparations. Am J Clin Nutr 2001, 73:1101-1106.
11. Hasegawa H., Sung J.H., Benno Y. Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins. Planta Med 1997, 63:436-440.
12. Heinbockel T., Heyward P., Conquet F., Ennis M. Regulation of main olfactory bulb mitral cell excitability by metabotropic glutamate receptor mGluR1. J Neurophysiol 2004, 92:3085-3096.
13. Heyward P., Ennis M., Keller A., Shipley M.T. Membrane bistability in olfactory bulb mitral cells. J Neurosci 2001, 21:5311-5320.
14. Jeong S.M., Lee J.H., Kim J.H., Lee B.H., Yoon I.S., Lee J.H., Kim D.H., Rhim H., Kim Y., Nah S.Y. Stereospecificity of ginsenoside Rg3 action on ion channels. Mol Cells 2004, 18(3):383-389.
15. Karikura M., Miyase T., Tanizawa H., Takino Y., Taniyama T., Hayashi T. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats. Chem Pharm Bull (Tokyo) 1990, 38:2859-2861.
16. Lee D.S., Kim Y.S., Ko C.N., Cho K.H., Bae H.S., Lee K.S., Kim J.J., Park E.K., Kim D.H. Fecal metabolic activities of herbal components to bioactive compounds. Arch Pharm Res 2002, 25:165-169.
17. Lee E., Kim S., Chung K.C., Choo M.K., Kim D.H., Nam G., Rhim H. 20(S)-ginsenoside Rh2, a newly identified active ingredient of ginseng, inhibits NMDA receptors in cultured rat hippocampal neurons. Eur J Pharmacol 2006, 536:69-77.
18. Li Z., Guo Y.Y., Wu C.F., Li X., Wang J.H. Protective effects of pseudoginsenoside-F11 on scopolamine-induced memory impairment in mice and rats. J Pharm Pharmacol 1999, 51:435-440.
19. Liu Y.L., Semjonous N.M., Murphy K.G., Ghatei M.A., Bloom S.R. The effects of pancreatic polypeptide on locomotor activity and food intake in mice. Int J Obes (Lond) 2008, 32:1712-1715.
20. Ma S.G., Jiang Y.T., Song S.J., Wang Z.H., Bai J., Xu S.X., Liu K. Alkaline-degradation products of ginsenosides from leaves and stems of Panax quinquefolium. Yao Xue Xue Bao 2005, 40:924-930.
21. Mook-Jung I., Hong H.S., Boo J.H., Lee K.H., Yun S.H., Cheong M.Y., Joo I., Huh K., Jung M.W. Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice. J Neurosci Res 2001, 63:509-515.
22. Peng L.L., Shen H.M., Jiang Z.L., Li X., Wang G.H., Zhang Y.F., Ke K.F. Inhibition of NMDA receptors underlies the neuroprotective effect of ginsenoside Rb3. Am J Chin Med 2009, 37:759-770.
23. Shepherd G.W., Chen W.R., Greer C.A. Olfactory bulb. The synaptic organization of the brain 2004, 165-216. Oxford, New York. G.M. Shepherd (Ed.).
24. Tawab M.A., Bahr U., Karas M., Wurglics M., Schubert-Zsilavecz M. Degradation of ginsenosides in humans after oral administration. Drug Metab Dispos 2003, 31:1065-1071.
25. Wang W., Zhao Y.Q., Rayburn E.R., Hill D.L., Wang H., Zhang R. In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother Pharmacol 2007, 59:589-601.
26. Wu C.F., Liu Y.L., Song M., Liu W., Wang J.H., Li X., Yang J.Y. Protective effects of pseudoginsenoside-F11 on methamphetamine-induced neurotoxicity in mice. Pharmacol Biochem Behav 2003, 76:103-109.
27. Xu Q.F., Fang X.L., Chen D.F. Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats. J Ethnopharmacol 2003, 84:187-192.
28. Yamaguchi Y., Higashi M., Kobayashi H. Effects of ginsenosides on impaired performance caused by scopolamine in rats. Eur J Pharmacol 1996, 312:149-151.
29. Yang S.J., Chen X., Zhang W.J., Zhong G.G., Sun C.W., Jiang Y. Effect of PQS-pseudoginsenoside-F11 on action potential of cultivated rat cardiac cells. Chin Pharmacol Bull 1994, 10(4):284-287.
30. Yuan C.S., Wang X., Wu J.A., Attele A.S., Xie J.T., Gu M. Effects of Panax quinquefolius L. on brainstem neuronal activities: comparison between Wisconsin-cultivated and Illinois-cultivated roots. Phytomedicine 2001, 8(3):178-183.
31. Zhang X., Ma X., Si B., Zhao Y. Simultaneous determination of five active hydrolysis ingredients from Panax quinquefolium L. by HPLC-ELSD. Biomed Chromatogr 2010, 25(6):646-651.
32. Zhang Y.F., Fan X.J., Li X., Peng L.L., Wang G.H., Ke K.F., Jiang Z.L. Ginsenoside Rg1 protects neurons from hypoxic-ischemic injury possibly by inhibiting Ca2+ influx through NMDA receptors and L-type voltage-dependent Ca2+ channels. Eur J Pharmacol 2008, 586:90-99.
33. Zhao H., Li Q., Pei X., Zhang Z., Yang R., Wang J., Li Y. Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus. Behav Brain Res 2009, 201:311-317.
34. Zhu S., Zou K., Cai S., Meselhy M.R., Komatsu K. Simultaneous Determination of triterpene saponins in ginseng drugs by high-performance liquid chromatography. Chem Pharm Bull (Tokyo) 2004, 52:995-998.