Tissue plasminogen activator induces microglial inflammation via a noncatalytic molecular mechanism involving activation of mitogen-activated protein kinases and Akt signaling pathways and AnnexinA2 and Galectin-1 receptors

GLIA

Volumn 60, Issue 4, 2012, Pages 526-540

  Pineda, David ^a,b   Ampurdanés, Coral ^a   Medina, Manel G ^a   Serratosa, Joan ^c   Tusell, Josep Maria ^c   Saura, Josep ^d   Planas, Anna M ^c   Navarro, Pilar ^a  

^a HOSPITAL DEL MAR   (Spain)

^b CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^c INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Alzheimer's disease; ERK1 2; JNK; Microglial activation; Neuroinflammation; NO; p38; TNF

Indexed keywords

GALECTIN 1; LIPOCORTIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TISSUE PLASMINOGEN ACTIVATOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; ENZYME INHIBITION; GLIA CELL; INFLAMMATION; INTRACELLULAR SIGNALING; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMYLOID BETA-PEPTIDES; ANIMALS; ANNEXIN A2; CELLS, CULTURED; CEREBRAL CORTEX; DRUG INTERACTIONS; ENZYME INHIBITORS; GALECTIN 1; GENE KNOCKOUT TECHNIQUES; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; NEUROGLIA; NITRIC OXIDE; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; RNA, SMALL INTERFERING; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84856697436     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22284     Document Type: Article

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