Inhibition of NF-κB activation is associated with anti-inflammatory and anti-apoptotic effects of Ginkgolide B in a mouse model of cerebral ischemia/reperfusion injury

European Journal of Pharmaceutical Sciences

Volumn 47, Issue 4, 2012, Pages 652-660

  Gu, Jin Hua ^a,b   Ge, Jian Bin ^a,c   Li, Mei ^a   Wu, Feng ^a,b   Zhang, Wei ^b   Qin, Zheng Hong ^a  

^a SOOCHOW UNIVERSITY   (China)

^b NANTONG MEDICAL COLLEGE   (China)

^c The Second People's Hospital of Nantong   (China)

Author keywords

Apoptosis; Cerebral ischemia reperfusion; Ginkgolide B; Inflammation; NF B

Indexed keywords

CASPASE 3; GINKGOLIDE B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; NEUROPROTECTIVE AGENT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN WATER; CELL ACTIVATION; CELLULAR DISTRIBUTION; CYTOKINE PRODUCTION; ENZYME ACTIVATION; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR DYSFUNCTION; MOUSE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPERFUSION INJURY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BRAIN; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GINKGOLIDES; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; LACTONES; MALE; MICE; MICE, INBRED ICR; MICROGLIA; NEUROPROTECTIVE AGENTS; NF-KAPPA B; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 84866125550     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.07.016     Document Type: Article

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