Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity

NeuroToxicology

Volumn 35, Issue 1, 2013, Pages 30-40

  Dewapriya, Pradeep ^a   Li, Yong Xin ^a   Himaya, S W A ^a   Pangestuti, Ratih ^a   Kim, Se Kwon ^a  

^a Pukyong National University   (South Korea)

Author keywords

Alzheimer's disease; Amyloid ; Neoechinulin A; Neuroinflammation; Pro inflammatory mediators; Reactive oxygen species

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; APOPTOSIS SIGNAL REGULATING KINASE 1; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOLE ALKALOID; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; NEOECHINULIN A; NUCLEAR FACTOR KAPPA B P50 SUBUNIT; PROSTAGLANDIN E2; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; MICROGLIA; MICROSPORUM; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PC12 CELL; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

AMYLOID BETA-PEPTIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CELL COMMUNICATION; CYCLOOXYGENASE 2; CYTOPROTECTION; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; INDOLE ALKALOIDS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; MAP KINASE KINASE KINASE 5; MICE; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PIPERAZINES; RATS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

MICROSPORUM;

EID: 84872463326     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2012.12.004     Document Type: Article

References (57)

1. Akashi S., Kimura T., Takeuchi T., Kuramochi K., Kobayashi S., Sugawara F., et al. Neoechinulin A impedes the progression of rotenone-induced cytotoxicity in PC12 cells. Biol Pharm Bull 2011, 34:243-248.
2. Amano T., Noda T. Improved detection of nitric oxide radical (NO) production in an activated macrophage culture with a radical scavenger, carboxy PTIO, and Griess reagent. FEBS Lett 1995, 368:425-428.
3. Bachstetter A.D., Xing B., Almeida L.D., Dimayuga E.R., Watterson D.M., Eldik L.J.V. Microglial p38a MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Ab). J Neuroinflamm 2011, 8:79.
4. Banati B.R. Neuropathological imaging: in vivo detection of glial activation as a measure of disease and adaptive change in the brain. Br Med Bull 2003, 65:121-131.
5. Block M.L., Hong J.S. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 2005, 76:77-98.
6. Brook M., Tchen C.M., Santalucia C.R., McIlrath J., Arthur J.S.C., Saklatvala J., et al. Post-translational regulation of tris-tetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways. Mol Cell Biol 2006, 26:2408-2418.
7. Casnati G., Pochini P., Ungaro R. Neoechinulin: a new isoprenyl indole metabolite from Aspergillus amstelodami Grazz. Chim Ital 1972, 103:141-151.
8. Choi J., Ha K.H., Byun M.S., Min S.Y., Park M.J., Park H.S., et al. Treatment with N-tosyl-l-phenylalanine chloromethyl ketone after the onset of collagen-induced arthritis reduces joint erosion and NF-kappaB activation. Eur J Pharmacol 2008, 595:108-113.
9. Collister K.A., Albensi B.C. Potential therapeutic targets in the NF-kappaB pathway for Alzheimer's disease. Drug News Perspect 2005, 18:623-629.
10. Das K.P., Freudenrich T.M., Mundy W.R. Assessment of PC12 cell differentiation and neurite growth: a comparison of morphological and neurochemical measure. Neurotoxicol Teratol 2004, 26:397-406.
11. Dhawan G., Floden M.A., Combs C.K. Amyloid-β oligomers stimulate microglia through a tyrosine kinase dependant mechanism. Neurobiol Aging 2011, 10.1016/j.neurobiolaging.2011.10.027.
12. Dossena A., Marchelli R., Pochini A. New metabolites of Aspergillus amstelodami related to the biogenesis of neoechinulin. J Chem Soc Chem Commun 1974, 771-772.
13. Eftekharzadeh B., Ramin M., Khodagholi F., Moradi S., Tabrizian K., Sharif R., et al. Inhibition of PKA attenuates memory deficits induced by β-amyloid (1-42) and decreases oxidative stress and NF-κB transcription factors. Behav Brain Res 2012, 226:301-308.
14. Everbroeck B.V., Dobbeleir I., Waele M.D., Leenheir D.E., Lübke U., Martin J.J., et al. Extracellular protein deposition correlates with glial activation and oxidative stress in Creutzfeldt-Jakob and Alzheimer's disease. Acta Neuropathol 2004, 108:194-200.
15. Fang F., Lue L.F., Yan S., Xu H., Luddy J.S., Chen D., et al. RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. FASEB J 2010, 24:1043-1055.
16. Feng Y., Wang X.P., Yang S.G., Wang Y.G., Zhang X., Du X.T., et al. Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation. Neurotoxicology 2009, 20:986-995.
17. Ferreira I.L., Bajouco L.M., Mota S.I., Auberson Y.P., Oliveira C.R., Rego A.C. Amyloid beta peptide 1-42 disturbs intracellular calcium haemostasis through activation of GluN2B-containing N-methyl-d-asparate receptors in cortical cultures. Cell Calcium 2012, 51:95-106.
18. Graeber M.B. Changing face of microglia. Science 2010, 330:783-788.
19. Harry G.J., Kaft A.D. Microglia in the developing brain: a potential target with lifetime effect. Neurotoxicology 2012, 33:191-206.
20. Hayes A., Thaker U., Iwatsubo T., Brown S.M.P., Mann D.M.A. Pathological relationships between microglial cell activity and tau and amyloid β protein in patients with Alzheimer's disease. Nerurosci Lett 2002, 331:171-174.
21. He F.Q., Qiu B.Y., Zhang X.H., Li T.K., Xie Q., Cui D.J., et al. Tetrandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-κB activation in a rat model of Alzheimer's disease induced by amyloid-β(1-42). Brain Res 2011, 1384:89-96.
22. Himaya S.W.A., Ryu B., Qian Z.J., Li Y., Kim S.K. 1-(5-bromo-2-hydroxy-4-methoxyphenol) ethanone [SE1] suppresses pro-inflammatory responses by blocking NF-κB and MAPK signalling pathways in activated microglia. Eur J Pharmacol 2011, 670:608-616.
23. Huo Y., Rangarajan P., Ling E.A., Dheen S.T. Dexamethasone inhibits the Nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia. BMC Neurosci 2011, 12:49.
24. Ii M., Sunamoto M., Ohnishi K., Ichimori Y. β-Amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity. Brain Res 1996, 720:93-100.
25. Ittner L.M., Gotz J. Amyloid-β and tau-a toxic pas de deux in Alzheimer's disease. Nat Rev Neurosci 2011, 12:67-72.
26. Kaminska B. MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta 2005, 1754:235-262.
27. Kim E.K., Choi E.J. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 2010, 1802:396-405.
28. Kimoto K., Aoki T., Shibata Y., Kamisuki S., Sugawara F., Kuramochi K., et al. Structure activity relationships of Neoechinulin A analogues with cytoprotection against peroxynitrite induced PC12 cell death. J Antibiot 2007, 60:614-621.
29. Kumar A., Negi G., Sharma S.S. Suppression of NF-κB and NF-κB regulated oxidative stress and neuroinflammation by BAY 11-7082 (IκB phosphorylation inhibitor) in experimental diabetic neuropathy. Biochimie 2012, 94:1158-1165.
30. Kumar S., Boehm J., Lee J.C. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov 2003, 2:717-726.
31. Lawrence T., Fong C. The resolution of inflammation: anti-inflammatory roles for NF-κB. Int J Biochem Cell Biol 2010, 4:519-523.
32. Lee J., Ryu H., Ferrante R., Morris S., Ratan R.R. Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox. Proc Natl Acad Sci USA 2003, 100:4843-4848.
33. Liu Y., Walter S., Stagi M., Cherny D., Letiembre M., Schaeffer W.S., et al. LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide. Brain 2005, 128:1778-1789.
34. 2+ influx. Neutotoxicology 2012, 33:59-69.
35. Maezawa I., Zimin P.I., Wulff H., Jin L.W. Amyloid-β protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J Biol Chem 2011, 286:3693-3706.
36. Maruyama K., Ohuchi T., Yoshida K., Shibata Y., Sugawara F., Arai T. Protective properties of neoechinulin A against SIN-1-induced neuronal cell death. J Biochem 2004, 136:81-87.
37. McGeer P.L., McGeer E.G. NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies. Neurobiol Aging 2007, 28:639-647.
38. Milatovic D., Montine T.J., Aschner M. Prostanoid signaling: dual role for prostaglandin E2 in neurotoxicity. Neurotoxicology 2011, 32:312-3199.
39. Mrak R.E. Microglia in Alzheimer brain: a neuropathological perspective. Int J Alzheimer's Dis 2012, 10.1155/2012/165021.
40. Nagano T., Kimura S.H., Takemura M. Prostagalanding E2 reduces amyloid β-induced phagocytosis in cultured rat microglia. Brain Res 2010, 1323:11-17.
41. Pan X.D., Zhu Y.G., Lin N., Zhang J., Ye Q.Y., Huang H.P., et al. Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease. Mol Neurodegener 2011, 6:45.
42. Parihar M.S., Hemnani T. Alzheimer's disease pathogenesis and therapeutic interventions. J Clin Neurosci 2004, 11:456-467.
43. Qin L., Liu Y., Cooper C., Liu B., Wilson B., Hong J.S. Microglia enhance β-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species. J Neurochem 2002, 83:973-983.
44. Ransohoff R.M. Microgliosis: the questions shape the answers. Nature Neurosci 2007, 10:1507-1509.
45. Resende R., Ferreiro E., Pereira C., Oliveira R.D. Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: involvement of endoplasmic reticulum calcium release in oligomer-induced cell death. Neuroscience 2008, 155:725-737.
46. Rivest S. Regulation of innate immune responses in the brain. Nat Rev Immunol 2009, 9:429-439.
47. Rogers R., Lue L.F. Microglial chemotaxis activation, and phagocytosis of amyloid β-peptide as linked phenomena in Alzheimer's disease. Neurochem Int 2001, 333-340.
48. Schilling T., Eder C. Amyloid-β-induced reactive oxygen species production and priming are differentially regulated by ion channels in microglia. J Cell Physiol 2011, 226:3295-3302.
49. Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001, 81:741-766.
50. Sondag C.M., Dhawan G., Combs C.K. Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia. J Neuroinflamm 2009, 6:1-13.
51. Strooper B.D., Woodgett J. Alzheimer's disease: mental plaque removal. Nature 2003, 423:392-393.
52. Ta L.E., Espeset L., Podratz J., Windebank A.J. Neurotoxicity of oxaliplatin and cisplatin for dorsal root ganglion neurons correlates with platinum-DNA binding. Neurotoxicology 2006, 992-1002.
53. Torreilles F., Tabcheh S.S., Guerin M., Torreilles J. Neurodegenerative disorders: the role of peroxynitrite. Brain Res Brain Res Rev 1999, 30:153-163.
54. Uttara B., Singh A.V., Zambon P., Mahajan R.T. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol 2009, 7:65-74.
55. Westerink R.H.S., Ewing A.G. The PC12 cell as model for neurosecretion. Acta Physiol 2008, 192:273-285.
56. Wyss-Coray T. Inflammation in Alzheimer's disease: driving force, bystander or beneficial response?. Nat Med 2006, 12:1005-1015.
57. Zhang D., Hu X., Qian L., Wilson B., Lee C., Flood P., et al. Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro. Toxicol Appl Pharmacol 2009, 238:64-70.