Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells

Immunobiology

Volumn 218, Issue 12, 2013, Pages 1452-1467

  Endale, Mehari ^a,e   Park, Seung Chun ^a   Kim, Suk ^b   Kim, Seung Hyung ^c   Yang, Yanyan ^d   Cho, Jae Youl ^d   Rhee, Man Hee ^a  

^a Kyungpook National University   (South Korea)

^b Gyeongsang National University   (South Korea)

^c Daejeon University   (South Korea)

^d Sungkyunkwan University   (South Korea)

^e CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Adaptor protein; Innate immunity; Protein kinases; Transcription factor

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYCLOOXYGENASE 2; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEME OXYGENASE 1; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROSTAGLANDIN E2; PROTEIN KINASE B; PROTEIN P85; QUERCETIN; STRESS ACTIVATED PROTEIN KINASE 1; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; IN VITRO STUDY; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; UPREGULATION;

(4-AMINO-5-(4-CHLOROPHENYL)-7-(DIMETHYLETHYL) PYRAZOLO [3,4-D]PYRIMIDINE; 2-(4-MORPHOLINYL)-8-PHENYL-1(4H)-BENZOPYRAN-4-1-HYDRO-CHLORIDE; ACTIVATOR PROTEIN-1; ADAPTOR-PROTEIN; AP-1; C-JUN N-TERMINAL KINASE; COX-2; CYCLOOXYGENASE-2; ERK1/2; EXTRACELLULAR SIGNAL REGULATED PROTEIN KINASE; GM-CSF; GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR; IKK; IL-1 RECEPTOR-ASSOCIATED KINASE 1; IL-1 RECEPTOR-ASSOCIATED KINASE 4; IL-1Β; IL-6; INDUCIBLE NITRIC OXIDE SYNTHASE; INHIBITOR OF NF-ΚB; INHIBITORY NF-ΚB KINASE; INNATE-IMMUNITY; INOS; INTERLEUKIN-1Β; INTERLEUKIN-6; IRAK-1; IRAK4; IΚB; JNK1/2; LY-294002; MAPK; MITOGEN-ACTIVATED PROTEIN KINASE; MYD88; MYELOID DIFFERENTIATION PRIMARY-RESPONSE PROTEIN 88; NF-ΚB; NITRIC OXIDE; NO; NUCLEAR FACTOR ΚB; PDK1; PGE(2); PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1; PI3K; PKB (AKT); PP2; PROSTAGLANDIN E(2); PROTEIN KINASE B; PROTEIN-KINASES; TAB1 AND 2; TAK1; TAK1-BINDING PROTEIN-1 AND -2; TNF RECEPTOR-ASSOCIATED FACTOR 6; TNF-Α; TRAF6; TRANSCRIPTION-FACTOR; TRANSFORMING-GROWTH-FACTOR-Β-ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR-Α;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYTOKINES; I-KAPPA B KINASE; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN BINDING; QUERCETIN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 84885930898     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2013.04.019     Document Type: Article

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