The reaction kinetics of 3-hydroxybenzoate 6-hydroxylase from rhodococcus jostii RHA1 provide an understanding of the para-hydroxylation enzyme catalytic cycle

Journal of Biological Chemistry

Volumn 288, Issue 49, 2013, Pages 35222-35236

  Sucharitakul, Jeerus ^a   Tongsook, Chanakan ^b   Pakotiprapha, Danaya ^b   Van Berkel, Willem J H ^c   Chaiyen, Pimchai ^b  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; HYDROXYLATION;

ENZYME CATALYTIC CYCLE; ENZYME REACTION; FLAVOENZYMES; HALF REACTIONS; HYDROXYLASES; PRODUCT RELEASE; RHODOCOCCUS; TRANSIENT KINETICS;

REACTION KINETICS;

3 HYDROXYBENZOATE 6 HYDROXYLASE; BACTERIAL ENZYME; OXYGEN; OXYGENASE; PEROXYFLAVIN; QUERCETIN; UNCLASSIFIED DRUG; 3-HYDROXYBENZOATE-6-HYDROXYLASE; BACTERIAL PROTEIN; MIXED FUNCTION OXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HYDROXYLATION; PRIORITY JOURNAL; PROTON TRANSPORT; RHODOCOCCUS; RHODOCOCCUS JOSTII; STEADY STATE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; KINETICS; METABOLISM; OXIDATION REDUCTION REACTION; SPECTROPHOTOMETRY;

RHODOCOCCUS JOSTII;

BACTERIAL PROTEINS; CATALYSIS; CATALYTIC DOMAIN; HYDROXYLATION; KINETICS; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; NAD; OXIDATION-REDUCTION; RHODOCOCCUS; SPECTROPHOTOMETRY;

EID: 84894312047     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.515205     Document Type: Article

References (83)

1. De Strooper, B., and Annaert, W. (2010) Novel research horizons for presenilins and -secretases in cell biology and disease. Annu. Rev. Cell Dev. Biol. 26, 235-260
2. Ho, A., and Shen, J. (2011) Presenilins in synaptic function and disease. Trends Mol. Med. 17, 617-624
3. Kopan, R., and Ilagan, M. X. (2004) -Secretase: proteasome of the membrane Nat. Rev. Mol. Cell Biol. 5, 499-504
4. Beckett, C., Nalivaeva, N. N., Belyaev, N. D., and Turner, A. J. (2012) Nuclear signalling by membrane protein intracellular domains: the AICD enigma. Cell. Signal. 24, 402-409
5. St George-Hyslop, P., and Fraser, P. E. (2012) Assembly of the presenilin -/-secretase complex. J. Neurochem. 120, SUPPL. 1, 84-88
6. Marambaud, P., Wen, P. H., Dutt, A., Shioi, J., Takashima, A., Siman, R., and Robakis, N. K. (2003) A CBP binding transcriptional repressor produced by the PS1/-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell 114, 635-645
7. Raurell, I., Codina, M., Casagolda, D., Del Valle, B., Baulida, J., de Herreros, A. G., and Duñach, M. (2008) -Secretase-dependent and -independent effects of presenilin1 on -catenin-Tcf-4 transcriptional activity. PLoS One 3, e4080
8. Francis, Y. I., Stephanou, A., and Latchman, D. S. (2006) CREB-binding protein activation by presenilin 1 but not by its M146L mutant. Neuroreport 17, 917-921
9. Saura, C. A., Choi, S. Y., Beglopoulos, V., Malkani, S., Zhang, D., Shankaranarayana Rao, B. S., Chattarji, S., Kelleher, R. J., 3rd, Kandel, E. R., Duff, K., Kirkwood, A., and Shen, J. (2004) Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42, 23-36
10. Vitolo, O. V., Sant'Angelo, A., Costanzo, V., Battaglia, F., Arancio, O., and Shelanski, M. (2002) Amyloid -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proc. Natl. Acad. Sci. U.S.A. 99, 13217-13221
11. Gong, B., Cao, Z., Zheng, P., Vitolo, O. V., Liu, S., Staniszewski, A., Moolman, D., Zhang, H., Shelanski, M., and Arancio, O. (2006) Ubiquitin hydrolase Uch-L1 rescues-amyloid-induced decreases in synaptic function and contextual memory. Cell 126, 775-788
12. España, J., Valero, J., Miñano-Molina, A. J., Masgrau, R., Martín, E., Guardia- Laguarta, C., Lleó, A., Giménez-Llort, L., Rodríguez-Alvarez, J., and Saura, C. A. (2010) -Amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1. J. Neurosci. 30, 9402-9410
13. Herreman, A., Hartmann, D., Annaert, W., Saftig, P., Craessaerts, K., Serneels, L., Umans, L., Schrijvers, V., Checler, F., Vanderstichele, H., Baekelandt, V., Dressel, R., Cupers, P., Huylebroeck, D., Zwijsen, A., Van Leuven, F., and De Strooper, B. (1999) Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc. Natl. Acad. Sci. U.S.A. 96, 11872-11877
14. Didelot, G., Molinari, F., Tchénio, P., Comas, D., Milhiet, E., Munnich, A., Colleaux, L., and Preat, T. (2006) Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila. Science 313, 851-853
15. Reif, R., Sales, S., Hettwer, S., Dreier, B., Gisler, C., Wölfel, J., Lüscher, D., Zurlinden, A., Stephan, A., Ahmed, S., Baici, A., Ledermann, B., Kunz, B., and Sonderegger, P. (2007) Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation. FASEB J. 21, 3468-3478
16. Molinari, F., Rio, M., Meskenaite, V., Encha-Razavi, F., Augé, J., Bacq, D., Briault, S., Vekemans, M., Munnich, A., Attié-Bitach, T., Sonderegger, P., and Colleaux, L. (2002) Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation. Science 298, 1779-1781
17. Merdes, G., Soba, P., Loewer, A., Bilic, M. V., Beyreuther, K., and Paro, R. (2004) Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J. 23, 4082-4095
18. Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., 3rd, and Nusse, R. (2003) Wnt proteins are lipidmodified and can act as stem cell growth factors. Nature 423, 448-452
19. Kang, D. E., Yoon, I. S., Repetto, E., Busse, T., Yermian, N., Ie, L., and Koo, E. H. (2005) Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in plateletderived growth factor signaling. J. Biol. Chem. 280, 31537-31547
20. Repetto, E., Yoon, I. S., Zheng, H., and Kang, D. E. (2007) Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway. J. Biol. Chem. 282, 31504-31516
21. Li, T., Ma, G., Cai, H., Price, D. L., and Wong, P. C. (2003) Nicastrin is required for assembly of presenilin/-secretase complexes to mediate Notch signaling and for processing and trafficking of-amyloid precursor protein in mammals. J. Neurosci. 23, 3272-3277
22. Mahoney, M. B., Parks, A. L., Ruddy, D. A., Tiong, S. Y., Esengil, H., Phan, A. C., Philandrinos, P., Winter, C. G., Chatterjee, R., Huppert, K., Fisher, W. W., L'Archeveque, L., Mapa, F. A., Woo, W., Ellis, M. C., and Curtis, D. (2006) Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers. Genetics 172, 2309-2324
23. Gunawardena, S., and Goldstein, L. S. (2001) Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila. Neuron 32, 389-401
24. Stokin, G. B., Almenar-Queralt, A., Gunawardena, S., Rodrigues, E. M., Falzone, T., Kim, J., Lillo, C., Mount, S. L., Roberts, E. A., McGowan, E., Williams, D. S., and Goldstein, L. S. (2008) Amyloid precursor proteininduced axonopathies are independent of amyloid- peptides. Hum. Mol. Genet. 17, 3474-3486
25. Stephan, A., Mateos, J. M., Kozlov, S. V., Cinelli, P., Kistler, A. D., Hettwer, S., Rülicke, T., Streit, P., Kunz, B., and Sonderegger, P. (2008) Neurotrypsin cleaves agrin locally at the synapse. FASEB J. 22, 1861-1873
26. Jayadev, S., Case, A., Eastman, A. J., Nguyen, H., Pollak, J., Wiley, J. C., Möller, T., Morrison, R. S., and Garden, G. A. (2010) Presenilin 2 is the predominant -secretase in microglia and modulates cytokine release. PLoS One 5, e15743
27. Garcia-Bassets, I., Kwon, Y. S., Telese, F., Prefontaine, G. G., Hutt, K. R., Cheng, C. S., Ju, B. G., Ohgi, K. A., Wang, J., Escoubet-Lozach, L., Rose, D. W., Glass, C. K., Fu, X. D., and Rosenfeld, M. G. (2007) Histone methylation- dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell 128, 505-518
28. Wang, D., Garcia-Bassets, I., Benner, C., Li, W., Su, X., Zhou, Y., Qiu, J., Liu, W., Kaikkonen, M. U., Ohgi, K. A., Glass, C. K., Rosenfeld, M. G., and Fu, X. D. (2011) Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature 474, 390-394
29. Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T. K., Koche, R. P., Lee, W., Mendenhall, E., O'Donovan, A., Presser, A., Russ, C., Xie, X., Meissner, A., Wernig, M., Jaenisch, R., Nusbaum, C., Lander, E. S., and Bernstein, B. E. (2007) Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448, 553-560
30. Shen, Y., Yue, F., McCleary, D. F., Ye, Z., Edsall, L., Kuan, S., Wagner, U., Dixon, J., Lee, L., Lobanenkov, V. V., and Ren, B. (2012) A map of the cis-regulatory sequences in the mouse genome. Nature 488, 116-120
31. McLean, C. Y., Bristor, D., Hiller, M., Clarke, S. L., Schaar, B. T., Lowe, C. B., Wenger, A. M., and Bejerano, G. (2010)GREATimproves functional interpretation of cis-regulatory regions. Nat. Biotechnol. 28, 495-501
32. Boulianne, G. L., Livne-Bar, I., Humphreys, J. M., Liang, Y., Lin, C., Rogaev, E., and St George-Hyslop, P. (1997) Cloning and characterization of the Drosophila presenilin homologue. Neuroreport 8, 1025-1029
33. Hu, Y., Ye, Y., and Fortini, M. E. (2002) Nicastrin is required for -secretase cleavage of the Drosophila Notch receptor. Dev. Cell 2, 69-78
34. Hong, C. S., and Koo, E. H. (1997) Isolation and characterization of Drosophila presenilin homolog. Neuroreport 8, 665-668
35. Bogdanik, L. P., and Burgess, R. W. (2011) A valid mouse model of AGRIN-associated congenital myasthenic syndrome. Hum. Mol. Genet. 20, 4617-4633
36. Yang, T., Arslanova, D., Gu, Y., Augelli-Szafran, C., and Xia, W. (2008) Quantification of -secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein. Mol. Brain 1, 15
37. Barthet, G., Shioi, J., Shao, Z., Ren, Y., Georgakopoulos, A., and Robakis, N. K. (2011) Inhibitors of -secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates. FASEB J. 25, 2937-2946
38. Haapasalo, A., and Kovacs, D. M. (2011) The many substrates of presenilin/ -secretase. J. Alzheimers Dis. 25, 3-28
39. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., and Selkoe, D. J. (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and -secretase activity. Nature 398, 513-517
40. Yu, G., Chen, F., Nishimura, M., Steiner, H., Tandon, A., Kawarai, T., Arawaka, S., Supala, A., Song, Y. Q., Rogaeva, E., Holmes, E., Zhang, D. M., Milman, P., Fraser, P. E., Haass, C., and George-Hyslop, P. S. (2000) Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes. J. Biol. Chem. 275, 27348-27353
41. Capell, A., Grünberg, J., Pesold, B., Diehlmann, A., Citron, M., Nixon, R., Beyreuther, K., Selkoe, D. J., and Haass, C. (1998) The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J. Biol. Chem. 273, 3205-3211
42. Bentahir, M., Nyabi, O., Verhamme, J., Tolia, A., Horré, K., Wiltfang, J., Esselmann, H., and De Strooper, B. (2006) Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms. J. Neurochem. 96, 732-742
43. O'Brien, W. T., and Klein, P. S. (2009) Validating GSK3 as an in vivo target of lithium action. Biochem. Soc. Trans. 37, 1133-1138
44. Zhong, H., Zou, H., Semenov, M. V., Moshinsky, D., He, X., Huang, H., Li, S., Quan, J., Yang, Z., and Lin, S. (2009) Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling. Mol. Biosyst. 5, 1356-1360
45. Moon, R. T., Kohn, A. D., De Ferrari, G. V., and Kaykas, A. (2004) WNT and -catenin signalling: diseases and therapies. Nat. Rev. Genet. 5, 691-701
46. Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., Wei, S., Hao, W., Kilgore, J., Williams, N. S., Roth, M. G., Amatruda, J. F., Chen, C., and Lum, L. (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol. 5, 100-107
47. Chen, S., Cao, W., Yue, P., Hao, C., Khuri, F. R., and Sun, S. Y. (2011) Celecoxib promotes c-FLIP degradation through Akt-independent inhibition of GSK3. Cancer Res. 71, 6270-6281
48. Buttrick, G. J., and Wakefield, J. G. (2008) PI3-K and GSK-3: Akt-ing together with microtubules. Cell Cycle 7, 2621-2625
49. Hur, E. M., and Zhou, F. Q. (2010) GSK3 signalling in neural development. Nat. Rev. Neurosci. 11, 539-551
50. Hong, E. J., West, A. E., and Greenberg, M. E. (2005) Transcriptional control of cognitive development. Curr. Opin. Neurobiol. 15, 21-28
51. Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., and Sun, Y. E. (2003) DNA methylation-related chromatin remodeling in activity- dependent BDNF gene regulation. Science 302, 890-893
52. Gopisetty, G., Xu, J., Sampath, D., Colman, H., and Puduvalli, V. K. (2013) Epigenetic regulation of CD133/PROM1 expression in glioma stem cells by Sp1/myc and promoter methylation. Oncogene 32, 3119-3129
53. Tie, F., Banerjee, R., Stratton, C. A., Prasad-Sinha, J., Stepanik, V., Zlobin, A., Diaz, M. O., Scacheri, P. C., and Harte, P. J. (2009) CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing. Development 136, 3131-3141
54. Altarejos, J. Y., and Montminy, M. (2011) CREB and the CRTC co-activators: Sensors for hormonal and metabolic signals. Nat. Rev. 12, 141-151
55. Daniels, M. P. (2012) The role of agrin in synaptic development, plasticity and signaling in the central nervous system. Neurochem. Int. 61, 848-853
56. Gschwend, T. P., Krueger, S. R., Kozlov, S. V., Wolfer, D. P., and Sonderegger, P. (1997) Neurotrypsin, a novel multidomain serine protease expressed in the nervous system. Mol. Cell. Neurosci. 9, 207-219
57. Wolfer, D. P., Lang, R., Cinelli, P., Madani, R., and Sonderegger, P. (2001) Multiple roles of neurotrypsin in tissue morphogenesis and nervous system development suggested by the mRNA expression pattern. Mol. Cell. Neurosci. 18, 407-433
58. Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., Jaenisch, R., Wagschal, A., Feil, R., Schreiber, S. L., and Lander, E. S. (2006)Abivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315-326
59. Matsumoto-Miyai, K., Sokolowska, E., Zurlinden, A., Gee, C. E., Lüscher, D., Hettwer, S., Wölfel, J., Ladner, A. P., Ster, J., Gerber, U., Rülicke, T., Kunz, B., and Sonderegger, P. (2009) Coincident pre- and postsynaptic activation induces dendritic filopodia via neurotrypsin-dependent agrin cleavage. Cell 136, 1161-1171
60. Bolliger, M. F., Zurlinden, A., Lüscher, D., Bütikofer, L., Shakhova, O., Francolini, M., Kozlov, S. V., Cinelli, P., Stephan, A., Kistler, A. D., Rülicke, T., Pelczar, P., Ledermann, B., Fumagalli, G., Gloor, S. M., Kunz, B., and Sonderegger, P. (2010) Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction. J. Cell Sci. 123, 3944-3955
61. Zou, K., Hosono, T., Nakamura, T., Shiraishi, H., Maeda, T., Komano, H., Yanagisawa, K., and Michikawa, M. (2008) Novel role of presenilins in maturation and transport of integrin -1. Biochemistry 47, 3370-3378
62. Wolfe, M. S. (2012)-Secretase inhibitors and modulators for Alzheimer's disease. J. Neurochem. 120, SUPPL. 1, 89-98
63. Morohashi, Y., Kan, T., Tominari, Y., Fuwa, H., Okamura, Y., Watanabe, N., Sato, C., Natsugari, H., Fukuyama, T., Iwatsubo, T., and Tomita, T. (2006) C-terminal fragment of presenilin is the molecular target of a dipeptidic -secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)- L-alanyl]-S-phenylglycine t-butyl ester). J. Biol. Chem. 281, 14670-14676
64. Watanabe, H., Smith, M. J., Heilig, E., Beglopoulos, V., Kelleher, R. J., 3rd, and Shen, J. (2009) Indirect regulation of presenilins in CREB-mediated transcription. J. Biol. Chem. 284, 13705-13713
65. Ichiki, T. (2006) Role of cAMP response element binding protein in cardiovascular remodeling: good, bad, or both Arterioscler. Thromb. Vasc. Biol. 26, 449-455
66. Garcia-Bassets, I., and Wang, D. (2012) Cistrome plasticity and mechanisms of cistrome reprogramming. Cell Cycle 11, 3199-3210
67. Fiol, C. J., Williams, J. S., Chou, C. H., Wang, Q. M., Roach, P. J., and Andrisani, O. M. (1994) A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression. J. Biol. Chem. 269, 32187-32193
68. Horike, N., Sakoda, H., Kushiyama, A., Ono, H., Fujishiro, M., Kamata, H., Nishiyama, K., Uchijima, Y., Kurihara, Y., Kurihara, H., and Asano, T. (2008) AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3- and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver. J. Biol. Chem. 283, 33902-33910
69. Böer, U., Cierny, I., Krause, D., Heinrich, A., Lin, H., Mayr, G., Hiemke, C., and Knepel, W. (2008) Chronic lithium salt treatment reduces CRE/ CREB-directed gene transcription and reverses its upregulation by chronic psychosocial stress in transgenic reporter gene mice. Neuropsychopharmacology 33, 2407-2415
70. Tyson, D. R., Swarthout, J. T., Jefcoat, S. C., and Partridge, N. C. (2002) PTH induction of transcriptional activity of the cAMP response elementbinding protein requires the serine 129 site and glycogen synthase kinase- 3 activity, but not casein kinase II sites. Endocrinology 143, 674-682
71. Conlon, R. A., Reaume, A. G., and Rossant, J. (1995) Notch1 is required for the coordinate segmentation of somites. Development 121, 1533-1545
72. Donoviel, D. B., Hadjantonakis, A. K., Ikeda, M., Zheng, H., Hyslop, P. S., and Bernstein, A. (1999) Mice lacking both presenilin genes exhibit early embryonic patterning defects. Genes Dev. 13, 2801-2810
73. Handler, M., Yang, X., and Shen, J. (2000) Presenilin-1 regulates neuronal differentiation during neurogenesis. Development 127, 2593-2606
74. Wen, P. H., De Gasperi, R., Gama Sosa, M. A., and Elder, G. A. (2004) Neural progenitor cells do not differentiate prematurely in presenilin-1 null mutant mice. Neurosci. Lett. 371, 249-254
75. Gadadhar, A., Marr, R., and Lazarov, O. (2011) Presenilin-1 regulates neural progenitor cell differentiation in the adult brain. J. Neurosci. 31, 2615-2623
76. Kim, W. Y., and Shen, J. (2008) Presenilins are required for maintenance of neural stem cells in the developing brain. Mol. Neurodegener. 3, 2
77. Ahn, K., Shelton, C. C., Tian, Y., Zhang, X., Gilchrist, M. L., Sisodia, S. S., and Li, Y. M. (2010) Activation and intrinsic -secretase activity of presenilin 1. Proc. Natl. Acad. Sci. U.S.A. 107, 21435-21440
78. Shen, J., and Kelleher, R. J., 3rd (2007) The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc. Natl. Acad. Sci. U.S.A. 104, 403-409
79. De Strooper, B. (2007) Loss-of-function presenilin mutations in Alzheimer disease. Talking point on the role of presenilin mutations in Alzheimer disease. EMBO Rep. 8, 141-146
80. Tu, H., Nelson, O., Bezprozvanny, A., Wang, Z., Lee, S. F., Hao, Y. H., Serneels, L., De Strooper, B., Yu, G., and Bezprozvanny, I. (2006) Presenilins form ER Ca2- leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126, 981-993
81. Nelson, O., Tu, H., Lei, T., Bentahir, M., de Strooper, B., and Bezprozvanny, I. (2007) Familial Alzheimer disease-linked mutations specifically disrupt Ca2- leak function of presenilin 1. J. Clin. Investig. 117, 1230-1239
82. Kawamura, Y., Kikuchi, A., Takada, R., Takada, S., Sudoh, S., Shibamoto, S., Yanagisawa, K., and Komano, H. (2001) Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of -catenin phosphorylation. Eur. J. Biochem. 268, 3036-3041
83. Saura, C. A., and Valero, J. (2011) The role of CREB signaling in Alzheimer's disease and other cognitive disorders. Rev. Neurosci. 22, 153-169