Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation

FASEB Journal

Volumn 21, Issue 13, 2007, Pages 3468-3478

  Reif, Raymond ^a   Sales, Susanne ^a   Hettwer, Stefan ^b   Dreier, Birgit ^a   Gisler, Claudio ^a   Wölfel, Jens ^a   Lüscher, Daniel ^a   Zurlinden, Andreas ^b   Stephan, Alexander ^a   Ahmed, Shaheen ^b   Baici, Antonio ^a   Ledermann, Birgit ^a   Kunz, Beat ^a   Sonderegger, Peter ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b NEUROTUNE AG   (Switzerland)

Author keywords

Cognitive function; Extracellular matrix; Nervous system; Serine peptidase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AGRIN; AMINO ACID; CALCIUM; NEUROTRYPSIN; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CENTRAL NERVOUS SYSTEM; CHEMICAL BOND; COGNITION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ASSAY; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; IN VITRO STUDY; MENTAL DEFICIENCY; MOUSE; MUTAGENESIS; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NONHUMAN; PATHOGENESIS; PH; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION;

AGRIN; AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; CELL LINE; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MENTAL RETARDATION; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTAGENESIS; SEQUENCE HOMOLOGY, AMINO ACID; SERINE ENDOPEPTIDASES; SYNAPSES;

MUS;

EID: 35948988507     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.07-8800com     Document Type: Article

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