Assembly of the presenilin γ-/ε-secretase complex

Journal of Neurochemistry

Volumn 120, Issue SUPPL. 1, 2012, Pages 84-88

  St George Hyslop, P ^a,b   Fraser, P E ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

alzheimer; gamma secretase; presenilin; tmp21

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; ASPARTIC PROTEINASE; BINDING PROTEIN; CD147 ANTIGEN; EPSILON SECRETASE; GAMMA SECRETASE; IMATINIB; NICASTRIN; NONSTEROID ANTIINFLAMMATORY AGENT; NOTCH RECEPTOR; PRESENILIN; PRESENILIN 1; PRESENILIN 2; PRESENILIN ENHANCER 2 PROTEIN; TRANSMEMBRANE TRAFFICKING PROTEIN 21; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; COMPLEX FORMATION; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; HUMANS; MEMBRANE PROTEINS; PEPTIDE HYDROLASES; PRESENILIN-1; PRESENILIN-2;

EID: 84655162703     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07505.x     Document Type: Review

References (37)

1. Alves Da Costa C., Sunyach C., Pardossi-Piquard R., Sevalle J., Vincent B., Boyer N., Kawarai T., Girardot N., St George-Hyslop P., and, Checler F., (2006) Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease. J. Neurosci. 26, 6377-6385.
2. Arawaka S., Hasegawa H., Tandon A., et al. (2002) The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein. J. Neurochem. 83, 1065-1071. (Pubitemid 35397116)
3. Capell A., Beher D., Prokop S., Steiner H., Kaether C., Shearman M. S., and, Haass C., (2005) Gamma-secretase complex assembly within the early secretory pathway. J. Biol. Chem. 280, 6471-6478. (Pubitemid 40341195)
4. Chen F., Hasegawa H., Schmitt-Ulms G., et al. (2006) TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature 440, 1208-1212.
5. Chen A. C., Guo L. Y., Ostaszewski B. L., Selkoe D. J., and, Lavoie M. J., (2010) Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. J. Biol. Chem. 285, 11378-11391.
6. Dolcini V., Dunys J., Sevalle J., Chen F., Guillot-Sestier M. V., St George-Hyslop P., Fraser P. E., and, Checler F., (2008) TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin. Biochem. Biophys. Res. Commun. 371, 69-74. (Pubitemid 351626931)
7. Francis R., Mcgrath G., Zhang J., et al. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma- secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell 3, 85-97. (Pubitemid 34778398)
8. Fukumori A., Fluhrer R., Steiner H., and, Haass C., (2010) Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis. J. Neurosci. 30, 7853-7862.
9. Gu Y., Chen F., Sanjo N., et al. (2003) APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes. J. Biol. Chem. 278, 7374-7380. (Pubitemid 36800741)
10. He G., Luo W., Li P., et al. (2010) Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. Nature 467, 95-98.
11. Kaether C., Scheuermann J., Fassler M., Zilow S., Shirotani K., Valkova C., Novak B., Kacmar S., Steiner H., and, Haass C., (2007) Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1. EMBO Rep. 8, 743-748. (Pubitemid 47202453)
12. Kim S. H., and, Sisodia S. S., (2005a) Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2. J. Biol. Chem. 280, 41953-41966. (Pubitemid 43023164)
13. Kim S. H., and, Sisodia S. S., (2005b) A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1. J. Biol. Chem. 280, 1992-2001.
14. Kukar T. L., Ladd T. B., Bann M. A., et al. (2008) Substrate-targeting gamma-secretase modulators. Nature 453, 925-929.
15. Lazarov V. K., Fraering P. C., Ye W., Wolfe M. S., Selkoe D. J., and, Li H., (2006) Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores. Proc. Natl. Acad. Sci. USA 103, 6889-6894.
16. Ma G., Li T., Price D. L., and, Wong P. C., (2005) APH-1 a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J. Neurosci. 25, 192-198. (Pubitemid 40110780)
17. Marambaud P., and, Robakis N. K., (2005) Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation. Genes Brain Behav. 4, 134-146. (Pubitemid 40559140)
18. Ogura T., Mio K., Hayashi I., et al. (2006) Three-dimensional structure of the gamma-secretase complex. Biochem. Biophys. Res. Commun. 343, 525-534.
19. Osenkowski P., Li H., Ye W., Li D., Aeschbach L., Fraering P. C., Wolfe M. S., and, Selkoe D. J., (2009) Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution. J. Mol. Biol. 385, 642-652.
20. Pardossi-Piquard R., Petit A., Kawarai T., et al. (2005) Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron 46, 541-554. (Pubitemid 40797380)
21. Pardossi-Piquard R., Bohm C., Chen F., Kanemoto S., Checler F., Schmitt-Ulms G., St George-Hyslop P., and, Fraser P. E., (2009a) TMP21 transmembrane domain regulates gamma-secretase cleavage. J. Biol. Chem. 284, 28634-28641.
22. Pardossi-Piquard R., Yang S. P., Kanemoto S., et al. (2009b) APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes. J. Biol. Chem. 284, 16298-16307.
23. Prokop S., Shirotani K., Edbauer D., Haass C., and, Steiner H., (2004) Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex. J. Biol. Chem. 279, 23255-23261. (Pubitemid 38685633)
24. Prokop S., Haass C., and, Steiner H., (2005) Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments. J. Neurochem. 94, 57-62. (Pubitemid 40911392)
25. Rogaev E. I., Sherrington R., Rogaeva E. A., et al. (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778.
26. Serneels L., Dejaegere T., Craessaerts K., et al. (2005) Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. Proc. Natl. Acad. Sci. USA 102, 1719-1724. (Pubitemid 40209234)
27. Sherrington R., Rogaev E. I., Liang Y., et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
28. Shirotani K., Edbauer D., Kostka M., Steiner H., and, Haass C., (2004) Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1. J. Neurochem. 89, 1520-1527. (Pubitemid 38802673)
29. Spasic D., Raemaekers T., Dillen K., Declerck I., Baert V., Serneels L., Fullekrug J., and, Annaert W., (2007) Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway. J. Cell Biol. 176, 629-640. (Pubitemid 46333978)
30. St George-Hyslop P., and, Schmitt-Ulms G., (2010) Alzheimer's disease: selectively tuning gamma-secretase. Nature 467, 36-37.
31. Steiner H., Winkler E., Edbauer D., Prokop S., Basset G., Yamasaki A., Kostka M., and, Haass C., (2002) PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. J. Biol. Chem. 277, 39062-39065. (Pubitemid 35190871)
32. Thathiah A., Spittaels K., Hoffmann M., et al. (2009) The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science 323, 946-951.
33. Vetrivel K. S., Kodam A., Gong P., Chen Y., Parent A. T., Kar S., and, Thinakaran G., (2008) Localization and regional distribution of p23/TMP21 in the brain. Neurobiol. Dis. 32, 37-49.
34. Wolfe M. S., Xia W., Ostaszewski B. L., Diehl T. S., Kimberly W. T., and, Selkoe D. S., (1999) Two transmembrane aspartates in presenilin 1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398, 513-517.
35. Yang D. S., Tandon A., Chen F., et al., (2002) Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. J. Biol. Chem. 277, 28135-28142. (Pubitemid 34966766)
36. Yu G., Nishimura M., Arawaka S., et al., (2000) Nicastrin modulates presenilin-mediated Notch/glp-1 signal transduction and betaAPP processing. Nature 407, 48-54.
37. Zhou S., Zhou H., Walian P. J., and, Jap B. K., (2005) CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production. Proc. Natl. Acad. Sci. USA 102, 7499-7504. (Pubitemid 40741000)