메뉴 건너뛰기




Volumn 22, Issue 2, 2011, Pages 153-169

The role of CREB signaling in Alzheimer's disease and other cognitive disorders

Author keywords

aging; Alzheimer's disease; amyloid; cAMP response element binding protein (CREB); CREB regulated transcription coactivator (CRTC); dementia; gene expression; Huntington's disease; neurodegeneration

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN;

EID: 79954573504     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/RNS.2011.018     Document Type: Article
Times cited : (242)

References (187)
  • 1
    • 0030952362 scopus 로고    scopus 로고
    • Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory
    • DOI 10.1016/S0092-8674(00)81904-2
    • Abel, T., Nguyen, P.V., Barad, M., Deuel, T.A., Kandel, E.R., and Bourtchouladze, R. (1997). Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell 88, 615-626. (Pubitemid 27152404)
    • (1997) Cell , vol.88 , Issue.5 , pp. 615-626
    • Abel, T.1    Nguyen, P.V.2    Barad, M.3    Deuel, T.A.S.4    Kandel, E.R.5    Bourtchouladze, R.6
  • 2
    • 2942705826 scopus 로고    scopus 로고
    • +/- mice: A model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration
    • DOI 10.1016/j.neuron.2004.05.021, PII S0896627304003022
    • +/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its ameliora-tion. Neuron 42, 947-959. (Pubitemid 38798233)
    • (2004) Neuron , vol.42 , Issue.6 , pp. 947-959
    • Alarcon, J.M.1    Malleret, G.2    Touzani, K.3    Vronskaya, S.4    Ishii, S.5    Kandel, E.R.6    Barco, A.7
  • 4
    • 70349217960 scopus 로고    scopus 로고
    • Bipartite functions of the CREB co-activators selectively direct alternative splicing or transcriptional activation
    • Amelio, A.L., Caputi, M., and Conkright, M.D. (2009). Bipartite functions of the CREB co-activators selectively direct alternative splicing or transcriptional activation. EMBO J. 28, 2733-2747.
    • (2009) EMBO J. , vol.28 , pp. 2733-2747
    • Amelio, A.L.1    Caputi, M.2    Conkright, M.D.3
  • 6
    • 0030571016 scopus 로고    scopus 로고
    • Alterations of cAMP response element-binding activity in the aged rat brain in response to administration of rolipram, a cAMP-specific phosphodiesterase inhibitor
    • DOI 10.1016/0169-328X(96)00098-8
    • Asanuma, M., Nishibayashi, S., Iwata, E., Kondo, Y., Nakanishi, T., Vargas, M.G., and Ogawa, N. (1996). Alterations of cAMP response element-binding activity in the aged rat brain in response to administration of rolipram, a cAMP-specific phosphodiesterase inhibitor. Brain Res. Mol. Brain Res. 41, 210-215. (Pubitemid 26288163)
    • (1996) Molecular Brain Research , vol.41 , Issue.1-2 , pp. 210-215
    • Asanuma, M.1    Nishibayashi, S.2    Iwata, E.3    Kondo, Y.4    Nakanishi, T.5    Vargas, M.G.6    Ogawa, N.7
  • 7
    • 0020701770 scopus 로고
    • Morphological basis of long-term habituation and sensitization in Aplysia
    • Bailey, C.H. and Chen, M. (1983). Morphological basis of long-term habituation and sensitization in Aplysia. Science 220, 91-93. (Pubitemid 13161720)
    • (1983) Science , vol.220 , Issue.4592 , pp. 91-93
    • Bailey, C.H.1    Chen, M.2
  • 9
    • 0037705997 scopus 로고    scopus 로고
    • Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory?
    • Balschun, D., Wolfer, D.P., Gass, P., Mantamadiotis, T., Welzl, H., Schutz, G., Frey, J.U., and Lipp, H.P. (2003). Does cAMP response element-binding protein have a pivotal role in hip-pocampal synaptic plasticity and hippocampus-dependent mem-ory? J. Neurosci. 23, 6304-6314. (Pubitemid 36875632)
    • (2003) Journal of Neuroscience , vol.23 , Issue.15 , pp. 6304-6314
    • Balschun, D.1    Wolfer, D.P.2    Gass, P.3    Mantamadiotis, T.4    Welzl, H.5    Schutz, G.6    Frey, J.U.7    Lipp, H.-P.8
  • 11
    • 0032538271 scopus 로고    scopus 로고
    • CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation
    • DOI 10.1016/S0092-8674(00)81752-3
    • Bartsch, D., Casadio, A., Karl, K.A., Serodio, P., and Kandel, E.R. (1998). CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation. Cell 95, 211-223. (Pubitemid 28473782)
    • (1998) Cell , vol.95 , Issue.2 , pp. 211-223
    • Bartsch, D.1    Casadio, A.2    Karl, K.A.3    Serodio, P.4    Kandel, E.R.5
  • 12
    • 76449085569 scopus 로고    scopus 로고
    • γ-Secretases: From cell biology to therapeutic strategies
    • Bergmans, B.A. and De Strooper, B. (2010). γ-Secretases: from cell biology to therapeutic strategies. Lancet Neurol. 9, 215-226.
    • (2010) Lancet Neurol. , vol.9 , pp. 215-226
    • Bergmans, B.A.1    De Strooper, B.2
  • 13
    • 77950229880 scopus 로고    scopus 로고
    • Neural mechanisms of ageing and cognitive decline
    • Bishop, N.A., Lu, T., and Yankner, B.A. (2010). Neural mechanisms of ageing and cognitive decline. Nature 464, 529-535.
    • (2010) Nature , vol.464 , pp. 529-535
    • Bishop, N.A.1    Lu, T.2    Yankner, B.A.3
  • 14
    • 0030463470 scopus 로고    scopus 로고
    • 2+- and stimulus duration-dependent switch for hippocampal gene expression
    • DOI 10.1016/S0092-8674(00)81816-4
    • 2+-and stimulus duration-dependent switch for hippocampal gene expression. Cell 87, 1203-1214. (Pubitemid 27010104)
    • (1996) Cell , vol.87 , Issue.7 , pp. 1203-1214
    • Bito, H.1    Deisseroth, K.2    Tsien, R.W.3
  • 15
    • 10344262616 scopus 로고    scopus 로고
    • Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC Proteins
    • DOI 10.1016/j.cub.2004.11.002, PII S0960982204008565
    • Bittinger, M.A., McWhinnie, E., Meltzer, J., Iourgenko, V., Latario, B., Liu, X., Chen, C.H., Song, C., Garza, D., and Labow, M. (2004). Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. Curr. Biol. 14, 2156-2161. (Pubitemid 39623199)
    • (2004) Current Biology , vol.14 , Issue.23 , pp. 2156-2161
    • Bittinger, M.A.1    McWhinnie, E.2    Meltzer, J.3    Iourgenko, V.4    Latario, B.5    Liu, X.6    Chen, C.H.7    Song, C.8    Garza, D.9    Labow, M.10
  • 16
    • 0029059248 scopus 로고
    • Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotro-phin signals
    • Bonni, A., Ginty, D.D., Dudek, H., and Greenberg, M.E. (1995). Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotro-phin signals. Moll. Cell Neurosci. 6, 168-183.
    • (1995) Moll. Cell Neurosci. , vol.6 , pp. 168-183
    • Bonni, A.1    Ginty, D.D.2    Dudek, H.3    Greenberg, M.E.4
  • 17
    • 0028071507 scopus 로고
    • Deficient long-term memory in mice with a targeted mutation of the c-AMP-responsive element binding protein
    • Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G., and Silva, AJ. (1994). Deficient long-term memory in mice with a targeted mutation of the c-AMP-responsive element binding protein. Cell 79, 59-68.
    • (1994) Cell , vol.79 , pp. 59-68
    • Bourtchuladze, R.1    Frenguelli, B.2    Blendy, J.3    Cioffi, D.4    Schutz, G.5    Silva, A.J.6
  • 19
    • 0029021176 scopus 로고
    • Hippocampal long-term depression and depotentiation are defec-tive in mice carrying a targeted disruption of the gene encoding the RI β subunit of cAMP-dependent protein kinase
    • Brandon, E.P., Zhuo, M., Huang, YY, Qi, M., Gerhold, K.A., Burton, K.A., Kandel, E.R., McKnight, G.S., and Idzerda, R.L. (1995). Hippocampal long-term depression and depotentiation are defec-tive in mice carrying a targeted disruption of the gene encoding the RI β subunit of cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 92, 8851-8855.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8851-8855
    • Brandon, E.P.1    Zhuo, M.2    Huang, Y.Y.3    Qi, M.4    Gerhold, K.A.5    Burton, K.A.6    Kandel, E.R.7    McKnight, G.S.8    Idzerda, R.L.9
  • 20
    • 0345118873 scopus 로고    scopus 로고
    • Hippocampal CREB1 but not CREB2 is decreased in aged rats with spatial memory impairments
    • DOI 10.1016/j.nlm.2003.08.001
    • Brightwell, J J., Gallagher, M., and Colombo, P.J. (2004). Hippocampal CREB1 but not CREB2 is decreased in aged rats with spatial memory impairments. Neurobiol. Learn. Mem. 81, 19-26. (Pubitemid 37518336)
    • (2004) Neurobiology of Learning and Memory , vol.81 , Issue.1 , pp. 19-26
    • Brightwell, J.J.1    Gallagher, M.2    Colombo, P.J.3
  • 21
    • 0028787753 scopus 로고
    • Multiple pro-tein kinase A-regulated events are required for transcriptional induction by cAMP
    • Brindle, P., Nakajima, T., and Montminy, M. (1995). Multiple pro-tein kinase A-regulated events are required for transcriptional induction by cAMP. Proc. Natl. Acad. Sci. USA 92, 10521-10525.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 10521-10525
    • Brindle, P.1    Nakajima, T.2    Montminy, M.3
  • 22
    • 78651072485 scopus 로고    scopus 로고
    • CAMP-response element binding protein bind-ing protein gene transfer increases brain-derived neurotrophic factor levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease
    • Caccamo, A., Maldonado, M.A., Bokov, A.F., Majumder, S., and Oddo, S. (2010). cAMP-response element binding protein bind-ing protein gene transfer increases brain-derived neurotrophic factor levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. PNAS 107: 22687-22692.
    • (2010) PNAS , vol.107 , pp. 22687-22692
    • Caccamo, A.1    Maldonado, M.A.2    Bokov, A.F.3    Majumder, S.4    Oddo, S.5
  • 24
    • 34147112878 scopus 로고    scopus 로고
    • Beta-amyloid causes downregulation of calcineurin in neurons through induction of oxidative stress
    • DOI 10.1016/j.nbd.2006.12.022, PII S0969996107000046
    • Celsi, F, Svedberg, M., Unger, C, Cotman, CW, Carri, M.T., Ottersen, O.P., Nordberg, A., and Torp, R. (2007). β-Amyloid causes downregulation of calcineurin in neurons through induc-tion of oxidative stress. Neurobiol. Dis. 26, 342-352. (Pubitemid 46561337)
    • (2007) Neurobiology of Disease , vol.26 , Issue.2 , pp. 342-352
    • Celsi, F.1    Svedberg, M.2    Unger, C.3    Cotman, C.W.4    Carri, M.T.5    Ottersen, O.P.6    Nordberg, A.7    Torp, R.8
  • 27
    • 77957343182 scopus 로고    scopus 로고
    • CREB binding protein is required for both short-term and long-term memory formation
    • Chen, G, Zou, X., Watanabe, H., van Deursen, J.M., and Shen, J. (2010). CREB binding protein is required for both short-term and long-term memory formation. J. Neurosci. 30, 13066-13077.
    • (2010) J. Neurosci. , vol.30 , pp. 13066-13077
    • Chen, G.1    Zou, X.2    Watanabe, H.3    Van Deursen, J.M.4    Shen, J.5
  • 28
    • 77957354074 scopus 로고    scopus 로고
    • Inhibition of phosphodiesterase-4 reverses memory deficits produced by A β25-35 or Aβ 1-40 peptide in rats
    • Cheng, Y.F., Wang, C, Lin, H.B., Li, Y.F., Huang, Y, Xu, J.P., and Zhang, H.T (2010). Inhibition of phosphodiesterase-4 reverses memory deficits produced by A β25-35 or Aβ 1-40 peptide in rats. Psychopharmacology (Berl.) 212, 181-191.
    • (2010) Psychopharmacology (Berl.) , vol.212 , pp. 181-191
    • Cheng, Y.F.1    Wang, C.2    Lin, H.B.3    Li, Y.F.4    Huang, Y.5    Xu, J.P.6    Zhang, H.T.7
  • 29
    • 70349767918 scopus 로고    scopus 로고
    • CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease
    • Choi, YS., Lee, B., Cho, H.Y, Reyes, I.B., Pu, X.A., Saido, TC, Hoyt, K.R., and Obrietan, K. (2009). CREB is a key regula-tor of striatal vulnerability in chemical and genetic models of Huntington's disease. Neurobiol. Dis. 36, 259-268.
    • (2009) Neurobiol. Dis. , vol.36 , pp. 259-268
    • Choi, Y.S.1    Lee, B.2    Cho, H.Y.3    Reyes, I.B.4    Pu, X.A.5    Saido, T.C.6    Hoyt, K.R.7    Obrietan, K.8
  • 30
    • 0027433708 scopus 로고
    • Phosphorylated CREB binds specifically to the nuclear protein CBP
    • DOI 10.1038/365855a0
    • Chrivia, J.C., Kwok, R.P.S., Lamb, N, Hagiwara, M., Montminy, M.R., and Goodman, R.H. (1993). Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-859. (Pubitemid 23341031)
    • (1993) Nature , vol.365 , Issue.6449 , pp. 855-859
    • Chrivia, J.C.1    Kwok, R.P.S.2    Lamb, N.3    Hagiwara, M.4    Montminy, M.R.5    Goodman, R.H.6
  • 31
    • 0037195561 scopus 로고    scopus 로고
    • Age-related changes in CREB binding protein immunoreactivity in the cerebral cortex and hippocampus of rats
    • DOI 10.1016/S0006-8993(02)03562-X, PII S000689930203562X
    • Chung, YH., Kim, EJ., Shin, CM., Joo, K.M., Kim, M.J., Woo, H.W, and Cha, C.I. (2002). Age-related changes in CREB bind-ing protein immunoreactivity in the cerebral cortex and hip-pocampus of rats. Brain Res. 956, 312-318. (Pubitemid 35351398)
    • (2002) Brain Research , vol.956 , Issue.2 , pp. 312-318
    • Chung, Y.H.1    Kim, E.J.2    Shin, C.M.3    Joo, K.M.4    Kim, M.J.5    Woo, H.W.6    Cha, C.I.7
  • 35
    • 34447260274 scopus 로고    scopus 로고
    • Rapid forgetting of social transmission of food preferences in aged rats: Relationship to hip-pocampal CREB activation
    • Countryman, R.A. and Gold, P.E. (2007). Rapid forgetting of social transmission of food preferences in aged rats: relationship to hip-pocampal CREB activation. Learn. Mem. 14, 350-358.
    • (2007) Learn. Mem. , vol.14 , pp. 350-358
    • Countryman, R.A.1    Gold, P.E.2
  • 36
    • 77954537925 scopus 로고    scopus 로고
    • Chronic caffeine consump-tion prevents memory disturbance in different animal models of memory decline
    • Cunha, R.A. and Agostinho, P.M. (2010). Chronic caffeine consump-tion prevents memory disturbance in different animal models of memory decline. J. Alzheimers Dis. 20 (Suppl. 1), S95-S116.
    • (2010) J. Alzheimers Dis. , vol.20 , Issue.SUPPL. 1
    • Cunha, R.A.1    Agostinho, P.M.2
  • 37
    • 0025277205 scopus 로고
    • Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
    • Dash, P.K., Hochner, B., and Kandel, E.R. (1990). Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation. Nature 345, 718-721.
    • (1990) Nature , vol.345 , pp. 718-721
    • Dash, P.K.1    Hochner, B.2    Kandel, E.R.3
  • 39
    • 50849087682 scopus 로고    scopus 로고
    • Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolip-ram in rats
    • de Lima, M.N., Presti-Torres, J., Garcia, V.A., Guimaraes, M.R., Scalco, F.S., Roesler, R., and Schroder, N. (2008). Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolip-ram in rats. Neuropharmacology 55, 788-792.
    • (2008) Neuropharmacology , vol.55 , pp. 788-792
    • De Lima, M.N.1    Presti-Torres, J.2    Garcia, V.A.3    Guimaraes, M.R.4    Scalco, F.S.5    Roesler, R.6    Schroder, N.7
  • 40
    • 33748932680 scopus 로고    scopus 로고
    • Brain plasticity and mental processes: Cajal again
    • DeFelipe, J. (2006). Brain plasticity and mental processes: Cajal again. Nat. Rev. Neurosci. 7, 811-817.
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 811-817
    • Defelipe, J.1
  • 41
    • 43649092175 scopus 로고    scopus 로고
    • Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease
    • DeMarch, Z., Giampa, C., Patassini, S., Bernardi, G, and Fusco, F.R. (2008). Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease. Neurobiol. Dis. 30, 375-387.
    • (2008) Neurobiol. Dis. , vol.30 , pp. 375-387
    • Demarch, Z.1    Giampa, C.2    Patassini, S.3    Bernardi, G.4    Fusco, F.R.5
  • 42
    • 0037061683 scopus 로고    scopus 로고
    • Dynamic multiphosphorylation passwords for activity-dependent gene expression
    • DOI 10.1016/S0896-6273(02)00664-5
    • Deisseroth, K. and Tsien, R.W. (2002). Dynamic multiphosphoryla-tion passwords for activity-dependent gene expression. Neuron 34, 179-182. (Pubitemid 34442561)
    • (2002) Neuron , vol.34 , Issue.2 , pp. 179-182
    • Deisseroth, K.1    Tsien, R.W.2
  • 43
    • 0030059338 scopus 로고    scopus 로고
    • Signaling from synapse to nucleus: Postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity
    • DOI 10.1016/S0896-6273(00)80026-4
    • Deisseroth, K., Bito, H., and Tsien, R.W. (1996). Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron 16, 89-101. (Pubitemid 26044732)
    • (1996) Neuron , vol.16 , Issue.1 , pp. 89-101
    • Deisseroth, K.1    Bito, H.2    Tsien, R.W.3
  • 44
    • 0032510478 scopus 로고    scopus 로고
    • Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons
    • DOI 10.1038/32448
    • Deisseroth, K., Heist, E.K., and Tsien, R.W. (1998). Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature 392, 198-202. (Pubitemid 28162795)
    • (1998) Nature , vol.392 , Issue.6672 , pp. 198-202
    • Deisseroth, K.1    Heist, E.K.2    Tsien, R.W.3
  • 46
    • 0037775776 scopus 로고    scopus 로고
    • Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice
    • Dickey, C.A., Loring, J.F., Montgomery, J., Gordon, M.N., Eastman, P.S., and Morgan, D. (2003). Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice. J. Neurosci. 23, 5219-5226. (Pubitemid 36793250)
    • (2003) Journal of Neuroscience , vol.23 , Issue.12 , pp. 5219-5226
    • Dickey, C.A.1    Loring, J.F.2    Montgomery, J.3    Gordon, M.N.4    Eastman, P.S.5    Morgan, D.6
  • 47
    • 0035850819 scopus 로고    scopus 로고
    • Signaling to the nucleus by an L-type calcium channel- calmodulin complex through the MAP kinase pathway
    • DOI 10.1126/science.1063395
    • Dolmetsch, R.E., Pajvani, U., Fife, K., Spotts, J.M., and Greenberg, M.E. (2001). Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Science 294, 333-339. (Pubitemid 32963394)
    • (2001) Science , vol.294 , Issue.5541 , pp. 333-339
    • Dolmetsch, R.E.1    Pajvani, U.2    Fife, K.3    Spotts, J.M.4    Greenberg, M.E.5
  • 48
    • 33750361022 scopus 로고    scopus 로고
    • Aging of the brain, entropy, and Alzheimer disease
    • DOI 10.1212/01.wnl.0000240127.89601.83, PII 0000611420061024000011
    • Drachman, D.A. (2006). Aging of the brain, entropy, and Alzheimer disease. Neurology 67, 1340-1352. (Pubitemid 44632055)
    • (2006) Neurology , vol.67 , Issue.8 , pp. 1340-1352
    • Drachman, D.A.1
  • 50
    • 0033529082 scopus 로고    scopus 로고
    • Dendritic spine changes associ-ated with hippocampal long-term synaptic plasticity
    • Engert, F. and Bonhoeffer, T. (1999). Dendritic spine changes associ-ated with hippocampal long-term synaptic plasticity. Nature 399, 66-70.
    • (1999) Nature , vol.399 , pp. 66-70
    • Engert, F.1    Bonhoeffer, T.2
  • 54
    • 77956496045 scopus 로고    scopus 로고
    • Regulation of dendritic development by BDNF requires activation of CRTC1 by glutamate
    • Finsterwald, C., Fiumelli, H., Cardinaux, J.R., and Martin, J.L. (2010). Regulation of dendritic development by BDNF requires activation of CRTC1 by glutamate. J. Biol. Chem. 285, 28587-28595.
    • (2010) J. Biol. Chem. , vol.285 , pp. 28587-28595
    • Finsterwald, C.1    Fiumelli, H.2    Cardinaux, J.R.3    Martin, J.L.4
  • 55
    • 77955915549 scopus 로고    scopus 로고
    • Structural brain changes in aging: Courses, causes and cognitive consequences
    • Fjell, A.M. and Walhovd, K.B. (2010). Structural brain changes in aging: courses, causes and cognitive consequences. Rev. Neurosci. 21, 187-221.
    • (2010) Rev. Neurosci. , vol.21 , pp. 187-221
    • Fjell, A.M.1    Walhovd, K.B.2
  • 56
    • 0036320783 scopus 로고    scopus 로고
    • Calcium dysregulation in the aging brain
    • Foster, TC. and Kumar, A. (2002). Calcium dysregulation in the aging brain. Neuroscientist 8, 297-301. (Pubitemid 34824012)
    • (2002) Neuroscientist , vol.8 , Issue.4 , pp. 297-301
    • Foster, T.C.1    Kumar, A.2
  • 58
    • 0026071499 scopus 로고
    • CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription
    • Foulkes, N.S., Borrelli, E., and Sassone-Corsi, P. (1991). CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64, 739-749. (Pubitemid 121001161)
    • (1991) Cell , vol.64 , Issue.4 , pp. 739-749
    • Foulkes, N.S.1    Borrelli, E.2    Sassone-Corsi, P.3
  • 59
    • 33745048523 scopus 로고    scopus 로고
    • CREB-binding protein activation by presenilin 1 but not by its M146L mutant
    • DOI 10.1097/01.wnr.0000220137.06542.a0, PII 0000175620060626000014
    • Francis, Y.I., Stephanou, A., and Latchman, D.S. (2006). CREB-binding protein activation by presenilin 1 but not by its M146L mutant. Neuroreport 17, 917-921. (Pubitemid 43869959)
    • (2006) NeuroReport , vol.17 , Issue.9 , pp. 917-921
    • Francis, Y.I.1    Stephanou, A.2    Latchman, D.S.3
  • 60
    • 33847787591 scopus 로고    scopus 로고
    • Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells
    • DOI 10.1523/JNEUROSCI.5053-06.2007
    • Garzon, D. and Fahnestock, M. (2007). Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated neuroblastoma cells. J. Neurosci. 27, 2628-2635. (Pubitemid 46393608)
    • (2007) Journal of Neuroscience , vol.27 , Issue.10 , pp. 2628-2635
    • Garzon, D.J.1    Fahnestock, M.2
  • 62
    • 18344383860 scopus 로고    scopus 로고
    • Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock
    • DOI 10.1016/S0896-6273(02)00656-6
    • Gau, D., Lemberger, T, von Gall, C, Kretz, O., Le Minh, N., Gass, P., Schmid, W., Schibler, U., Korf, H.W., and Schutz, G (2002). Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock. Neuron 34, 245-253. (Pubitemid 34442567)
    • (2002) Neuron , vol.34 , Issue.2 , pp. 245-253
    • Gau, D.1    Lemberger, T.2    Von Gall, C.3    Kretz, O.4    Le Minh, N.5    Gass, P.6    Schmid, W.7    Schibler, U.8    Korf, H.W.9    Schutz, G.10
  • 63
    • 61449226493 scopus 로고    scopus 로고
    • Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington's disease
    • Giampà, C, Middei, S., Patassini, S., Borreca, A., Marullo, F, Laurenti, D., Bernardi, G, Ammassari-Teule, M., and Fusco, F.R. (2009). Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington's disease. Eur. J. Neurosci. 29, 902-910.
    • (2009) Eur. J. Neurosci. , vol.29 , pp. 902-910
    • Giampà, C.1    Middei, S.2    Patassini, S.3    Borreca, A.4    Marullo, F.5    Laurenti, D.6    Bernardi, G.7    Ammassari-Teule, M.8    Fusco, F.R.9
  • 65
    • 85047694516 scopus 로고    scopus 로고
    • Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment
    • DOI 10.1172/JCI200422831
    • Gong, B., Vitolo, O.V, Trinchese, F, Liu, S., Shelanski, M., and Arancio, O. (2004). Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. J. Clin. Invest. 114, 1624-1634. (Pubitemid 40385553)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.11 , pp. 1624-1634
    • Gong, B.1    Vitolo, O.V.2    Trinchese, F.3    Liu, S.4    Shelanski, M.5    Arancio, O.6
  • 66
    • 0024445798 scopus 로고
    • Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
    • DOI 10.1016/0092-8674(89)90013-5
    • Gonzalez, G.A. and Montminy, M.R. (1989). Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59, 675-680. (Pubitemid 19282874)
    • (1989) Cell , vol.59 , Issue.4 , pp. 675-680
    • Gonzalez, G.A.1    Montminy, M.R.2
  • 67
    • 0024499494 scopus 로고
    • A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence
    • DOI 10.1038/337749a0
    • Gonzalez, GA., Yamamoto, K.K., Fischer, W.H., Karr, D., Menzel, P., Biggs, W. 3rd., Vale, W.W., and Montminy, M.R. (1989). A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. Nature 337, 749-752. (Pubitemid 19064731)
    • (1989) Nature , vol.337 , Issue.6209 , pp. 749-752
    • Gonzalez, G.A.1    Yamamoto, K.K.2    Fischer, W.H.3    Karr, D.4    Menzel, P.5    Biggs III, W.6    Vale, W.W.7    Montminy, M.R.8
  • 68
    • 0034234237 scopus 로고    scopus 로고
    • CBP/p300 in cell growth, transformation, and development
    • Goodman, R.H. and Smolik, S. (2000). CBP/p300 in cell growth, transformation, and development. Genes Dev. 14, 1553-1577. (Pubitemid 30460905)
    • (2000) Genes and Development , vol.14 , Issue.13 , pp. 1553-1577
    • Goodman, R.H.1    Smolik, S.2
  • 69
    • 0023034795 scopus 로고
    • Stimulation of neuronal acetylcholine receptors induces rapid gene transcription
    • Greenberg, M., Ziff, E., and Greene, L. (1986). Stimulation of neuronal acetylcholine receptors induces rapid gene transcription. Science 234, 80-83. (Pubitemid 17171550)
    • (1986) Science , vol.234 , Issue.4772 , pp. 80-83
    • Greenberg, M.E.1    Ziff, E.B.2    Greene, L.A.3
  • 70
    • 0035879067 scopus 로고    scopus 로고
    • Experience-dependent gene expression in the rat hippocampus after spatial learning: A comparison of the immediate-early genes Arc, c-fos, and zif268
    • Guzowski, J.F., Setlow, B., Wagner, E.K., and McGaugh, J.L. (2001). Experience-dependent gene expression in the rat hippocampus after spatial learning: a comparison of the immediate-early genes Arc, c-fos, and zif268. J. Neurosci. 21, 5089-5098. (Pubitemid 32622934)
    • (2001) Journal of Neuroscience , vol.21 , Issue.14 , pp. 5089-5098
    • Guzowski, J.F.1    Setlow, B.2    Wagner, E.K.3    McGaugh, J.L.4
  • 71
    • 25844525608 scopus 로고    scopus 로고
    • Mapping behaviorally relevant neural circuits with immediate-early gene expression
    • DOI 10.1016/j.conb.2005.08.018, PII S0959438805001364, Neuronal and Glial Cell Biology/New Technologies
    • Guzowski, J.F., Timlin, J.A., Roysam, B., McNaughton, B.L., Worley, P.F., and Barnes, CA. (2005). Mapping behaviorally rel-evant neural circuits with immediate-early gene expression. Curr. Opin. Neurobiol. 15, 599-606. (Pubitemid 41394406)
    • (2005) Current Opinion in Neurobiology , vol.15 , Issue.5 , pp. 599-606
    • Guzowski, J.F.1    Timlin, J.A.2    Roysam, B.3    McNaughton, B.L.4    Worley, P.F.5    Barnes, C.A.6
  • 72
    • 33747140419 scopus 로고    scopus 로고
    • Rubinstein-Taybi syndrome: Molecular findings and therapeutic approaches to improve cognitive dysfunction
    • DOI 10.1007/s00018-005-5555-8
    • Hallam, T.M. and Bourtchouladze, R. (2006). Rubinstein-Taybi syn-drome: molecular findings and therapeutic approaches to improve cognitive dysfunction. Cell. Mol. Life Sci. 63, 1725-1735. (Pubitemid 44223082)
    • (2006) Cellular and Molecular Life Sciences , vol.63 , Issue.15 , pp. 1725-1735
    • Hallam, T.M.1    Bourtchouladze, R.2
  • 75
    • 0036793859 scopus 로고    scopus 로고
    • Coffin-Lowry syndrome: Clinical and molecular features
    • Hanauer, A. and Young, I.D. (2002). Coffin-Lowry syndrome: clini-cal and molecular features. J. Med. Genet. 39, 705-713. (Pubitemid 35178719)
    • (2002) Journal of Medical Genetics , vol.39 , Issue.10 , pp. 705-713
    • Hanauer, A.1    Young, I.D.2
  • 76
    • 0035936640 scopus 로고    scopus 로고
    • Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation
    • Harum, K.H., Alemi, L., and Johnston, M.V. (2001). Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation. Neurology 56, 207-214. (Pubitemid 32095362)
    • (2001) Neurology , vol.56 , Issue.2 , pp. 207-214
    • Harum, K.H.1    Alemi, L.2    Johnston, M.V.3
  • 78
    • 0028170035 scopus 로고
    • CAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase
    • Huang, YY, Li, X.C., and Kandel, E.R. (1994). cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase. Cell 79, 69-79.
    • (1994) Cell , vol.79 , pp. 69-79
    • Huang, Y.Y.1    Li, X.C.2    Kandel, E.R.3
  • 79
    • 0031048406 scopus 로고    scopus 로고
    • Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents
    • DOI 10.1016/S0014-2999(96)00969-7, PII S0014299996009697
    • Imanishi, T., Sawa, A., Ichimaru, Y, Miyashiro, M., Kato, S., Yamamoto, T., and Ueki, S. (1997). Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents. Eur. J. Pharmacol. 321, 273-278. (Pubitemid 27105928)
    • (1997) European Journal of Pharmacology , vol.321 , Issue.3 , pp. 273-278
    • Imanishi, T.1    Sawa, A.2    Ichimaru, Y.3    Miyashiro, M.4    Kato, S.5    Yamamoto, T.6    Ueki, S.7
  • 80
    • 0029898252 scopus 로고    scopus 로고
    • Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hip-pocampus
    • Impey, S., Mark, M., Villacres, E.C., Poser, S., Chavkin, C, and Storm, D.R. (1996). Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hip-pocampus. Neuron 16, 973-982.
    • (1996) Neuron , vol.16 , pp. 973-982
    • Impey, S.1    Mark, M.2    Villacres, E.C.3    Poser, S.4    Chavkin, C.5    Storm, D.R.6
  • 84
    • 0032471366 scopus 로고    scopus 로고
    • Mutation analysis of the RSK2 gene in Coffin-Lowry patients: Extensive allelic heterogeneity and a high rate of de novo mutations
    • DOI 10.1086/302153
    • Jacquot, S., Merienne, K., De Cesare, D., Pannetier, S., Mandel, J.L., Sassone-Corsi, P., and Hanauer, A. (1998). Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic het-erogeneity and a high rate of de novo mutations. Am. J. Hum. Genet. 63, 1631-1640. (Pubitemid 30415725)
    • (1998) American Journal of Human Genetics , vol.63 , Issue.6 , pp. 1631-1640
    • Jacquot, S.1    Merienne, K.2    De Cesare, D.3    Pannetier, S.4    Mandel, J.-L.5    Sassone-Corsi, P.6    Hanauer, A.7
  • 85
    • 12244298155 scopus 로고    scopus 로고
    • Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein
    • DOI 10.1093/hmg/ddg002
    • Jiang, H., Nucifora, F.C. Jr., Ross, C.A., and DeFranco, D.B. (2003). Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein. Hum. Mol. Genet. 12, 1-12. (Pubitemid 36097710)
    • (2003) Human Molecular Genetics , vol.12 , Issue.1 , pp. 1-12
    • Haibing, J.1    Nucifora Jr., F.C.2    Ross, C.A.3    DeFranco, D.B.4
  • 86
    • 4043105520 scopus 로고    scopus 로고
    • Inducible repression of CREB function disrupts amygdala-dependent memory
    • DOI 10.1016/j.nlm.2004.05.008, PII S1074742704000644
    • Josselyn, S.A., Kida, S., and Silva, A.J. (2004). Inducible repres-sion of CREB function disrupts amygdala-dependent memory. Neurobiol. Learn. Mem. 82, 159-163. (Pubitemid 39070261)
    • (2004) Neurobiology of Learning and Memory , vol.82 , Issue.2 , pp. 159-163
    • Josselyn, S.A.1    Kida, S.2    Silva, A.J.3
  • 87
    • 0027416894 scopus 로고
    • Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons
    • DOI 10.1016/0896-6273(93)90331-K
    • Kaang, B.K., Kandel, E.R., and Grant, S.G. (1993). Activation of cAMP-responsive genes by stimuli that produce long-term facili-tation in Aplysia sensory neurons. Neuron 10, 427-435. (Pubitemid 23111734)
    • (1993) Neuron , vol.10 , Issue.3 , pp. 427-435
    • Kaang, B.-K.1    Kandel, E.R.2    Grant, S.G.N.3
  • 89
    • 0035798238 scopus 로고    scopus 로고
    • The molecular biology of memory storage: A dialogue between genes and synapses
    • DOI 10.1126/science.1067020
    • Kandel, E.R. (2001). The molecular biology of memory storage: a dialogue between genes and synapses. Science 294, 1030-1038. (Pubitemid 33041851)
    • (2001) Science , vol.294 , Issue.5544 , pp. 1030-1038
    • Kandel, E.R.1
  • 90
    • 0035940811 scopus 로고    scopus 로고
    • 3H-cAMP binding sites in rat hippocampus during maturation and aging
    • DOI 10.1016/S0304-3940(01)02358-8, PII S0304394001023588
    • 3 H-cAMP binding sites in rat hippocampus during maturation and aging. Neurosci. Lett. 315, 89-92. (Pubitemid 33050006)
    • (2001) Neuroscience Letters , vol.315 , Issue.1-2 , pp. 89-92
    • Karege, F.1    Lambercy, C.2    Schwald, M.3    Steimer, T.4    Cisse, M.5
  • 93
    • 34848895216 scopus 로고    scopus 로고
    • Calcineurin activity is required for depolarization-induced, CREB-dependent gene transcription in cortical neurons
    • DOI 10.1111/j.1471-4159.2007.04801.x
    • Kingsbury, T.J., Bambrick, L.L., Roby, CD., and Krueger, B.K. (2007). Calcineurin activity is required for depolarization-in-duced CREB-dependent gene transcription in cortical neurons. J. Neurochem. 103, 761-770. (Pubitemid 47498035)
    • (2007) Journal of Neurochemistry , vol.103 , Issue.2 , pp. 761-770
    • Kingsbury, T.J.1    Bambrick, L.L.2    Roby, C.D.3    Krueger, B.K.4
  • 94
    • 77950794366 scopus 로고    scopus 로고
    • Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease
    • Klevytska, A.M., Tebbenkamp, A.T., Savonenko, A.V., and Borchelt, D.R. (2010). Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease. J. Neuropathol. Exp. Neurol. 69, 396-404.
    • (2010) J. Neuropathol. Exp. Neurol. , vol.69 , pp. 396-404
    • Klevytska, A.M.1    Tebbenkamp, A.T.2    Savonenko, A.V.3    Borchelt, D.R.4
  • 95
    • 0037061719 scopus 로고    scopus 로고
    • CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events
    • DOI 10.1016/S0896-6273(02)00655-4
    • Kornhauser, J.M., Cowan, CW, Shaywitz, A.J., Dolmetsch, R.E., Griffith, E.C., Hu, L.S., Haddad, C, Xia, Z., and Greenberg, M.E. (2002). CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron 34, 221-233. (Pubitemid 34442565)
    • (2002) Neuron , vol.34 , Issue.2 , pp. 221-233
    • Kornhauser, J.M.1    Cowan, C.W.2    Shaywitz, A.J.3    Dolmetsch, R.E.4    Griffith, E.C.5    Hu, L.S.6    Haddad, C.7    Xia, Z.8    Greenberg, M.E.9
  • 96
    • 2942731425 scopus 로고    scopus 로고
    • CBP histone acetyltransferase activity is a critical component of memory consolidation
    • DOI 10.1016/j.neuron.2004.06.002, PII S0896627304003526
    • Korzus, E., Rosenfeld, M.G., and Mayford, M. (2004). CBP histone acetyltransferase activity is a critical component of memory con-solidation. Neuron 42, 961-972. (Pubitemid 38798234)
    • (2004) Neuron , vol.42 , Issue.6 , pp. 961-972
    • Korzus, E.1    Rosenfeld, M.G.2    Mayford, M.3
  • 98
    • 23944460541 scopus 로고    scopus 로고
    • Age-related disturbance of memory and CREB phosphorylation in CA1 area of hippocampus of rats
    • DOI 10.1016/j.brainres.2005.06.045, PII S0006899305008826
    • Kudo, K., Wati, H., Qiao, C, Arita, J., and Kanba, S. (2005). Age-related disturbance of memory and CREB phosphorylation in CA1 area of hippocampus of rats. Brain Res. 1054, 30-37. (Pubitemid 41188126)
    • (2005) Brain Research , vol.1054 , Issue.1 , pp. 30-37
    • Kudo, K.1    Wati, H.2    Qiao, C.3    Arita, J.4    Kanba, S.5
  • 100
    • 63349105631 scopus 로고    scopus 로고
    • Long-term administration of green tea catechins prevents age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic AMP-response element binding protein signaling cascade
    • Li, Q., Zhao, H.F., Zhang, Z.F., Liu, Z.G., Pei, X.R., Wang, J.B., Cai, MY., and Li, Y (2009a). Long-term administration of green tea catechins prevents age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic AMP-response element binding protein signaling cascade. Neuroscience 159, 1208-1215.
    • (2009) Neuroscience , vol.159 , pp. 1208-1215
    • Li, Q.1    Zhao, H.F.2    Zhang, Z.F.3    Liu, Z.G.4    Pei, X.R.5    Wang, J.B.6    Cai, M.Y.7    Li, Y.8
  • 101
    • 70149095473 scopus 로고    scopus 로고
    • Long-term green tea catechin administration pre-vents spatial learning and memory impairment in senescence-ac-celerated mouse prone-8 mice by decreasing Aβ1-42 oligomers and upregulating synaptic plasticity-related proteins in the hip-pocampus
    • Li, Q., Zhao, H.F., Zhang, Z.F., Liu, Z.G., Pei, X.R., Wang, J.B., and Li, Y (2009b). Long-term green tea catechin administration pre-vents spatial learning and memory impairment in senescence-ac-celerated mouse prone-8 mice by decreasing Aβ1-42 oligomers and upregulating synaptic plasticity-related proteins in the hip-pocampus. Neuroscience 163, 741-749.
    • (2009) Neuroscience , vol.163 , pp. 741-749
    • Li, Q.1    Zhao, H.F.2    Zhang, Z.F.3    Liu, Z.G.4    Pei, X.R.5    Wang, J.B.6    Li, Y.7
  • 102
    • 61449218839 scopus 로고    scopus 로고
    • TORC1 regulates activity-dependent CREB-target gene tran-scription and dendritic growth of developing cortical neurons
    • Li, S., Zhang, C, Takemori, H., Zhou, Y., and Xiong, Z.Q. (2009c). TORC1 regulates activity-dependent CREB-target gene tran-scription and dendritic growth of developing cortical neurons. J. Neurosci. 29, 2334-2343.
    • (2009) J. Neurosci. , vol.29 , pp. 2334-2343
    • Li, S.1    Zhang, C.2    Takemori, H.3    Zhou, Y.4    Xiong, Z.Q.5
  • 103
    • 0035155854 scopus 로고    scopus 로고
    • Selective changes of calcineurin (protein phosphatase 2B) activity in Alzheimer's disease cerebral cortex
    • DOI 10.1006/exnr.2000.7534
    • Lian, Q., Ladner, CJ., Magnuson, D., and Lee, J.M. (2001). Selective changes of calcineurin (protein phosphatase 2B) activity in Alzheimer's disease cerebral cortex. Exp. Neurol. 167, 158-165. (Pubitemid 32066418)
    • (2001) Experimental Neurology , vol.167 , Issue.1 , pp. 158-165
    • Lian, Q.1    Ladner, C.J.2    Magnuson, D.3    Lee, J.M.4
  • 104
    • 36448978859 scopus 로고    scopus 로고
    • Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain
    • DOI 10.1111/j.1471-4159.2007.04942.x
    • Liang, Z., Liu, F., Grundke-Iqbal, I., Iqbal, K., and Gong, C.X. (2007). Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain. J. Neurochem. 103, 2462-2470. (Pubitemid 350173577)
    • (2007) Journal of Neurochemistry , vol.103 , Issue.6 , pp. 2462-2470
    • Liang, Z.1    Liu, F.2    Grundke-Iqbal, I.3    Iqbal, K.4    Gong, C.-X.5
  • 106
    • 0037101970 scopus 로고    scopus 로고
    • Function and regulation of CREB family transcription factors in the nervous system
    • DOI 10.1016/S0896-6273(02)00828-0
    • Lonze, B.E. and Ginty, D.D. (2002). Function and regulation of CREB family transcription factors in the nervous system. Neuron 35, 605-623. (Pubitemid 35229980)
    • (2002) Neuron , vol.35 , Issue.4 , pp. 605-623
    • Lonze, B.E.1    Ginty, D.D.2
  • 107
    • 3042631024 scopus 로고    scopus 로고
    • Gene regulation and DNA damage in the ageing human brain
    • DOI 10.1038/nature02661
    • Lu, T., Pan, Y, Kao, S.Y, Li, C., Kohane, I., Chan, J., and Yankner, B.A. (2004). Gene regulation and DNA damage in the ageing human brain. Nature 429, 883-891. (Pubitemid 38843301)
    • (2004) Nature , vol.429 , Issue.6994 , pp. 883-891
    • Lu, T.1    Pan, Y.2    Kao, S.-Y.3    Li, C.4    Kohane, I.5    Chan, J.6    Yankner, B.A.7
  • 110
    • 58849110602 scopus 로고    scopus 로고
    • Brain region-specific gene expression activation required for reconsolidation and extinction of contextual fear memory
    • Mamiya, N., Fukushima, H., Suzuki, A., Matsuyama, Z., Homma, S., Frankland, P.W., and Kida, S. (2009). Brain region-specific gene expression activation required for reconsolidation and extinction of contextual fear memory. J. Neurosci. 29, 402-413.
    • (2009) J. Neurosci. , vol.29 , pp. 402-413
    • Mamiya, N.1    Fukushima, H.2    Suzuki, A.3    Matsuyama, Z.4    Homma, S.5    Frankland, P.W.6    Kida, S.7
  • 112
    • 0031444409 scopus 로고    scopus 로고
    • Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: A function for local protein synthesis in memory storage
    • DOI 10.1016/S0092-8674(00)80484-5
    • Martin, K.C., Casadio, A., Zhu, H., Yaping, E., Rose, J.C., Chen, M., Bailey, C.H., and Kandel, E.R. (1997). Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage. Cell 91, 927-938. (Pubitemid 28028772)
    • (1997) Cell , vol.91 , Issue.7 , pp. 927-938
    • Martin, K.C.1    Casadio, A.2    Zhu, H.3    Yaping, E.4    Rose, J.C.5    Chen, M.6    Bailey, C.H.7    Kandel, E.R.8
  • 113
    • 0035845567 scopus 로고    scopus 로고
    • Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB
    • DOI 10.1073/pnas.191152098
    • Mayr, B.M., Canettieri, G, and Montminy, M.R. (2001). Distinct effects of cAMP and mitogenic signals on CREB-binding pro-tein recruitment impart specificity to target gene activation via CREB. Proc. Natl. Acad. Sci. USA 98, 10936-10941. (Pubitemid 32878722)
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , Issue.19 , pp. 10936-10941
    • Mayr, B.M.1    Canettieri, G.2    Montminy, M.R.3
  • 116
    • 30344438257 scopus 로고    scopus 로고
    • Dysregulation of memory-related proteins in the hipppocampus of aged rats and their relation with cognitive impairment
    • DOI 10.1002/hipo.20099
    • Monti, B., Berteotti, C, and Contestabile, A. (2005). Dysregulation of memory-related proteins in the hippocampus of aged rats and their relation with cognitive impairment. Hippocampus 15, 1041-1049. (Pubitemid 43056992)
    • (2005) Hippocampus , vol.15 , Issue.8 , pp. 1041-1049
    • Monti, B.1    Berteotti, C.2    Constestabile, A.3
  • 117
    • 30944445595 scopus 로고    scopus 로고
    • Subchronic rolipram delivery activates hippocampal CREB and Arc, enhances retention and slows down extinction of conditioned fear
    • DOI 10.1038/sj.npp.1300813, PII 1300813
    • Monti, B., Berteotti, C, and Contestabile, A. (2006). Subchronic rolipram delivery activates hippocampal CREB and Arc, enhances retention and slows down extinction of conditioned fear. Neuropsychopharmacology 31, 278-286. (Pubitemid 43113393)
    • (2006) Neuropsychopharmacology , vol.31 , Issue.2 , pp. 278-286
    • Monti, B.1    Berteotti, C.2    Contestabile, A.3
  • 118
    • 0023198109 scopus 로고
    • Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene
    • DOI 10.1038/328175a0
    • Montminy, M.R. and Bilezikjian, L.M. (1987). Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. Nature 328, 175-178. (Pubitemid 17108220)
    • (1987) Nature , vol.328 , Issue.6126 , pp. 175-178
    • Montminy, M.R.1    Bilezikjian, L.M.2
  • 120
    • 0025938297 scopus 로고
    • L-type voltage-sensi-tive calcium channels mediate synaptic activation of immediate early genes
    • Murphy, T., Worley, P., and Baraban, J. (1991). L-type voltage-sensi-tive calcium channels mediate synaptic activation of immediate early genes. Neuron 7, 625-635.
    • (1991) Neuron , vol.7 , pp. 625-635
    • Murphy, T.1    Worley, P.2    Baraban, J.3
  • 121
    • 0000631273 scopus 로고    scopus 로고
    • The signal-dependent coactivator CBP is a nuclear target for pp90(RSK)
    • DOI 10.1016/S0092-8674(00)80119-1
    • Nakajima, T., Fukamizu, A., Takahashi, J., Gage, F.H., Fisher, T., Blenis, J., and Montminy, M.R. (1996). The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell 86, 465-474. (Pubitemid 26272086)
    • (1996) Cell , vol.86 , Issue.3 , pp. 465-474
    • Nakajima, T.1    Fukamizu, A.2    Takahashi, J.3    Gage, F.H.4    Fisher, T.5    Blenis, J.6    Montminy, M.R.7
  • 122
    • 77958485211 scopus 로고    scopus 로고
    • Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity
    • Nakatsu, Y, Sakoda, H., Kushiyama, A., Ono, H., Fujishiro, M., Horike, N., Yoneda, M., Ohno, H., Tsuchiya, Y, Kamata, H., et al. (2010). Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity. J. Biol. Chem. 285, 33018-33027.
    • (2010) J. Biol. Chem. , vol.285 , pp. 33018-33027
    • Nakatsu, Y.1    Sakoda, H.2    Kushiyama, A.3    Ono, H.4    Fujishiro, M.5    Horike, N.6    Yoneda, M.7    Ohno, H.8    Tsuchiya, Y.9    Kamata, H.10
  • 124
    • 0033018277 scopus 로고    scopus 로고
    • Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: Implications for a dominant-negative mechanism
    • Oike, Y, Hata, A., Mamiya, T, Kaname, T, Noda, Y, Suzuki, M., Yasue, H., Nabeshima, T, Araki, K., and Yamamura, K. (1999). Truncated CBP protein leads to classical Rubinstein-Taybi syn-drome phenotypes in mice: implications for a dominant-negative mechanism. Hum. Mol. Genet. 8, 387-396. (Pubitemid 29097326)
    • (1999) Human Molecular Genetics , vol.8 , Issue.3 , pp. 387-396
    • Oike, Y.1    Hata, A.2    Mamiya, T.3    Kaname, T.4    Noda, Y.5    Suzuki, M.6    Yasue, H.7    Nabeshima, T.8    Araki, K.9    Yamamura, K.-I.10
  • 125
    • 33745896544 scopus 로고    scopus 로고
    • Differential role for CBP and p300 CREB-binding domain in motor skill learning
    • DOI 10.1037/0735-7044.120.3.724
    • Oliveira, A.M., Abel, T, Brindle, P.K., and Wood, M.A. (2006). Differential role for CBP and p300 CREB-binding domain in motor skill learning. Behav. Neurosci. 120, 724-729. (Pubitemid 44050552)
    • (2006) Behavioral Neuroscience , vol.120 , Issue.3 , pp. 724-729
    • Oliveira, A.M.M.1    Abel, T.2    Brindle, P.K.3    Wood, M.A.4
  • 126
    • 34748917182 scopus 로고    scopus 로고
    • Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits
    • DOI 10.1101/lm.656907
    • Oliveira, A.M., Wood, M.A., McDonough, C.B., and Abel, T. (2007). Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits. Learn. Mem. 14, 564-572. (Pubitemid 47481689)
    • (2007) Learning and Memory , vol.14 , Issue.9 , pp. 564-572
    • Oliveira, A.M.M.1    Wood, M.A.2    McDonough, C.B.3    Abel, T.4
  • 129
  • 130
    • 0037171762 scopus 로고    scopus 로고
    • Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memory
    • DOI 10.1016/S0896-6273(02)00684-0
    • Pittenger, C, Huang, YY, Paletzki, R.F., Bourtchouladze, R., Scanlin, H., Vronskaya, S., and Kandel, E.R. (2002). Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memory. Neuron 34, 447-462. (Pubitemid 34465502)
    • (2002) Neuron , vol.34 , Issue.3 , pp. 447-462
    • Pittenger, C.1    Huang, Y.Y.2    Paletzki, R.F.3    Bourtchouladze, R.4    Scanlin, H.5    Vronskaya, S.6    Kandel, E.R.7
  • 131
    • 33846437448 scopus 로고    scopus 로고
    • Deletion of the Coffin-Lowry syndrome gene Rsk2 in mice is associated with impaired spatial learning and reduced control of exploratory behavior
    • DOI 10.1007/s10519-006-9116-1
    • Poirier, R., Jacquot, S., Vaillend, C, Soutthiphong, A.A., Libbey, M., Davis, S., Laroche, S., Hanauer, A., Welzl, H, Lipp, H.P., et al. (2007). Deletion of the Coffin-Lowry syndrome gene Rsk2 in mice is associated with impaired spatial learning and reduced control of exploratory behavior. Behav. Genet. 37, 31-50. (Pubitemid 46144051)
    • (2007) Behavior Genetics , vol.37 , Issue.1 , pp. 31-50
    • Poirier, R.1    Jacquot, S.2    Vaillend, C.3    Soutthiphong, A.A.4    Libbey, M.5    Davis, S.6    Laroche, S.7    Hanauer, A.8    Welzl, H.9    Lipp, H.-P.10    Wolfer, D.P.11
  • 132
    • 49149105430 scopus 로고    scopus 로고
    • Alteration of CREB phosphorylation and spatial memory deficits in aged 129T2/Sv mice
    • Porte, Y, Buhot, M.C., and Mons, N. (2008). Alteration of CREB phosphorylation and spatial memory deficits in aged 129T2/Sv mice. Neurobiol. Aging 29, 1533-1546.
    • (2008) Neurobiol. Aging , vol.29 , pp. 1533-1546
    • Porte, Y.1    Buhot, M.C.2    Mons, N.3
  • 133
    • 67649342620 scopus 로고    scopus 로고
    • Phosphodiesterase 5 inhibition improves synaptic func-tion, memory, and amyloid-β load in an Alzheimer's disease mouse model
    • Puzzo, D., Staniszewski, A., Deng, S.X., Privitera, L., Leznik, E., Liu, S., Zhang, H., Feng, Y., Palmeri, A., Landry, D.W., et al. (2009). Phosphodiesterase 5 inhibition improves synaptic func-tion, memory, and amyloid-β load in an Alzheimer's disease mouse model. J. Neurosci. 29, 8075-8086.
    • (2009) J. Neurosci. , vol.29 , pp. 8075-8086
    • Puzzo, D.1    Staniszewski, A.2    Deng, S.X.3    Privitera, L.4    Leznik, E.5    Liu, S.6    Zhang, H.7    Feng, Y.8    Palmeri, A.9    Landry, D.W.10
  • 134
    • 55049110911 scopus 로고    scopus 로고
    • A brief history of neuronal gene expression: Regulatory mechanisms and cellular consequences
    • Qiu, Z. and Ghosh, A. (2008). A brief history of neuronal gene expression: regulatory mechanisms and cellular consequences. Neuron 60, 449-455.
    • (2008) Neuron , vol.60 , pp. 449-455
    • Qiu, Z.1    Ghosh, A.2
  • 135
    • 33748944191 scopus 로고
    • Consideraciones generales sobre la mor-fología de la célula nerviosa
    • 273-275, 289-291
    • Ramón Y, Cajal, S. (1894). Consideraciones generales sobre la mor-fología de la célula nerviosa. La Veterinaria Española 37, 257-260, 273-275, 289-291.
    • (1894) La Veterinaria Española , vol.37 , pp. 257-260
    • Ramón, Y.1    Cajal, S.2
  • 136
    • 0242460552 scopus 로고    scopus 로고
    • Dysregulation of protein kinase A signaling in the aged prefrontal cortex: New strategy for treating age-related cognitive decline
    • DOI 10.1016/S0896-6273(03)00694-9
    • Ramos, B.P., Birnbaum, S.G., Lindenmayer, I., Newton, S.S., Duman, R.S., and Arnsten, A.F. (2003). Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline. Neuron 40, 835-845. (Pubitemid 37431042)
    • (2003) Neuron , vol.40 , Issue.4 , pp. 835-845
    • Ramos, B.P.1    Birnbaum, S.G.2    Lindenmayer, I.3    Newton, S.S.4    Duman, R.S.5    Arnsten, A.F.T.6
  • 138
    • 34250814515 scopus 로고    scopus 로고
    • Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression
    • DOI 10.1038/sj.emboj.7601715, PII 7601715
    • Ravnskjaer, K., Kester, H., Liu, Y., Zhang, X., Lee, D., Yates, J.R. III, and Montminy, M. (2007). Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expres-sion. EMBO J. 26, 2880-2889. (Pubitemid 46975772)
    • (2007) EMBO Journal , vol.26 , Issue.12 , pp. 2880-2889
    • Ravnskjaer, K.1    Kester, H.2    Liu, Y.3    Zhang, X.4    Lee, D.5    Yates III, J.R.6    Montminy, M.7
  • 139
    • 77958524817 scopus 로고    scopus 로고
    • Dynamic epigenetic regulation in neurons: Enzymes, stimuli and signaling pathways
    • Riccio, A. (2010). Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways. Nat. Neurosci. 13, 1330-1337.
    • (2010) Nat. Neurosci. , vol.13 , pp. 1330-1337
    • Riccio, A.1
  • 140
    • 30744455255 scopus 로고    scopus 로고
    • A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons
    • DOI 10.1016/j.molcel.2005.12.006, PII S1097276505018484
    • Riccio, A., Alvania, R.S., Lonze, B.E., Ramanan, N., Kim, T., Huang, Y, Dawson, T.M., Snyder, S.H., and Ginty, D.D. (2006). A nitric oxide signaling pathway controls CREB-mediated gene expres-sion in neurons. Mol. Cell 21, 283-294. (Pubitemid 43099943)
    • (2006) Molecular Cell , vol.21 , Issue.2 , pp. 283-294
    • Riccio, A.1    Alvania, R.S.2    Lonze, B.E.3    Ramanan, N.4    Kim, T.5    Huang, Y.6    Dawson, T.M.7    Snyder, S.H.8    Ginty, D.D.9
  • 142
    • 32644461812 scopus 로고    scopus 로고
    • Rolipram reverses scopolamine-induced and time-dependent memory deficits in object recognition by different mechanisms of action
    • DOI 10.1016/j.nlm.2005.09.002, PII S1074742705000869
    • Rutten, K., Prickaerts, J., and Blokland, A. (2006). Rolipram reverses scopolamine-induced and time-dependent memory deficits in object recognition by different mechanisms of action. Neurobiol. Learn. Mem. 85, 132-138. (Pubitemid 43247839)
    • (2006) Neurobiology of Learning and Memory , vol.85 , Issue.2 , pp. 132-138
    • Rutten, K.1    Prickaerts, J.2    Blokland, A.3
  • 143
    • 43049118254 scopus 로고    scopus 로고
    • Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques
    • Rutten, K., Basile, J.L., Prickaerts, J., Blokland, A., and Vivian, J.A. (2008). Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques. Psychopharmacology (Berl.) 196, 643-648.
    • (2008) Psychopharmacology (Berl.) , vol.196 , pp. 643-648
    • Rutten, K.1    Basile, J.L.2    Prickaerts, J.3    Blokland, A.4    Vivian, J.A.5
  • 144
    • 0034657129 scopus 로고    scopus 로고
    • Developmentally regulated NMDA receptor-dependent dephosphorylation of cAMP response element-binding protein (CREB) in hippocampal neurons
    • Sala, C, Rudolph-Correia, S., and Sheng, M. (2000). Development-ally regulated NMDA receptor-dependent dephosphorylation of cAMP response element-binding protein (CREB) in hippocam-pal neurons. J. Neurosci. 20, 3529-3536. (Pubitemid 30266214)
    • (2000) Journal of Neuroscience , vol.20 , Issue.10 , pp. 3529-3536
    • Sala, C.1    Rudolph-Correia, S.2    Sheng, M.3
  • 145
    • 77249122985 scopus 로고    scopus 로고
    • Molecular network analysis suggests aberrant CREB-mediated gene regulation in the Alzheimer disease hippocampus
    • Satoh, J., Tabunoki, H., and Arima, K. (2009). Molecular network analysis suggests aberrant CREB-mediated gene regulation in the Alzheimer disease hippocampus. Dis. Markers 27, 239-252.
    • (2009) Dis. Markers , vol.27 , pp. 239-252
    • Satoh, J.1    Tabunoki, H.2    Arima, K.3
  • 147
    • 22544434621 scopus 로고    scopus 로고
    • Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice
    • DOI 10.1523/JNEUROSCI.1247-05.2005
    • Saura, C.A., Chen, G, Malkani, S., Choi, S.Y, Takahashi, R.H., Zhang, D., Gouras, GK., Kirkwood, A., Morris, R.G., and Shen, J. (2005). Conditional inactivation of presenilin-1 prevents amy-loid accumulation and temporarily rescues contextual and spa-tial working memory impairments in amyloid precursor protein transgenic mice. J. Neurosci. 25, 6755-6764. (Pubitemid 41023143)
    • (2005) Journal of Neuroscience , vol.25 , Issue.29 , pp. 6755-6764
    • Saura, C.A.1    Chen, G.2    Malkani, S.3    Choi, S.-Y.4    Takahashi, R.H.5    Zhang, D.6    Gouras, G.K.7    Kirkwood, A.8    Morris, R.G.M.9    Shen, J.10
  • 149
    • 77953061132 scopus 로고    scopus 로고
    • Dorsal hippocampal CREB is both necessary and sufficient for spatial memory
    • Sekeres, MJ., Neve, R.L., Frankland, P.W., and Josselyn, S.A. (2010). Dorsal hippocampal CREB is both necessary and sufficient for spatial memory. Learn. Mem. 17, 280-283.
    • (2010) Learn. Mem. , vol.17 , pp. 280-283
    • Sekeres, M.J.1    Neve, R.L.2    Frankland, P.W.3    Josselyn, S.A.4
  • 150
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • DOI 10.1126/science.1074069
    • Selkoe, D J. (2002). Alzheimer's disease is a synaptic failure. Science 298, 789-791. (Pubitemid 35231524)
    • (2002) Science , vol.298 , Issue.5594 , pp. 789-791
    • Selkoe, D.J.1
  • 151
    • 0025807509 scopus 로고
    • 2+-regulated transcription factor phosphorylated by calmodulin-dependent kinases
    • 2+-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science 252, 1427-1430. (Pubitemid 21917061)
    • (1991) Science , vol.252 , Issue.5011 , pp. 1427-1430
    • Sheng, M.1    Thompson, M.A.2    Greenberg, M.E.3
  • 153
    • 70350099049 scopus 로고    scopus 로고
    • Molecular and cellular approaches to memory allocation in neural circuits
    • Silva, AJ., Zhou, Y, Rogerson, T, Shobe, J., and Balaji, J. (2009). Molecular and cellular approaches to memory allocation in neural circuits. Science 326, 391-395.
    • (2009) Science , vol.326 , pp. 391-395
    • Silva, A.J.1    Zhou, Y.2    Rogerson, T.3    Shobe, J.4    Balaji, J.5
  • 154
    • 70349755717 scopus 로고    scopus 로고
    • Reversal of long-term dendritic spine alterations in Alzheimer disease models
    • Smith, D.L., Pozueta, J., Gong, B., Arancio, O., and Shelanski, M. (2009). Reversal of long-term dendritic spine alterations in Alzheimer disease models. Proc. Natl. Acad. Sci. USA 106, 16877-16882.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 16877-16882
    • Smith, D.L.1    Pozueta, J.2    Gong, B.3    Arancio, O.4    Shelanski, M.5
  • 157
    • 77952210244 scopus 로고    scopus 로고
    • Epigenetics and cognitive aging
    • Sweatt, J.D. (2010). Epigenetics and cognitive aging. Science 328, 701-702.
    • (2010) Science , vol.328 , pp. 701-702
    • Sweatt, J.D.1
  • 160
    • 0035907325 scopus 로고    scopus 로고
    • β-amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival is not compromised
    • Tong, L., Thornton, P.L., Balazs, R., and Cotman, CW. (2001). β-amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival is not compromised. J. Biol. Chem. 276, 17301-17306.
    • (2001) J. Biol. Chem. , vol.276 , pp. 17301-17306
    • Tong, L.1    Thornton, P.L.2    Balazs, R.3    Cotman, C.W.4
  • 164
    • 0019870922 scopus 로고
    • Phosphodiesterase inhibitors facilitate memory for passive avoidance conditioning
    • DOI 10.1016/S0163-1047(81)91424-2
    • Villiger, J.W. and Dunn, A.J. (1981). Phosphodiesterase inhibitors facilitate memory for passive avoidance conditioning. Behav. Neural Biol. 31, 354-359. (Pubitemid 11066626)
    • (1981) Behavioral and Neural Biology , vol.31 , Issue.3 , pp. 354-359
    • Villiger, J.W.1    Dunn, A.J.2
  • 165
    • 61349094140 scopus 로고    scopus 로고
    • Enhanced CREB-dependent gene expression increases the excitability of neurons in the basal amygdala and primes the consolidation of contextual and cued fear memory
    • Viosca, J., Lopez de Armentia, M., Jancic, D., and Barco, A. (2009a). Enhanced CREB-dependent gene expression increases the excitability of neurons in the basal amygdala and primes the consolidation of contextual and cued fear memory. Learn. Mem. 16, 193-197.
    • (2009) Learn. Mem. , vol.16 , pp. 193-197
    • Viosca, J.1    Lopez De Armentia, M.2    Jancic, D.3    Barco, A.4
  • 166
    • 61349111440 scopus 로고    scopus 로고
    • Chronic enhancement of CREB activity in the hippocampus interferes with the retrieval of spatial information
    • Viosca, J., Malleret, G., Bourtchouladze, R., Benito, E., Vronskava, S., Kandel, E.R., and Barco, A. (2009b). Chronic enhancement of CREB activity in the hippocampus interferes with the retrieval of spatial information. Learn. Mem. 16, 198-209.
    • (2009) Learn. Mem. , vol.16 , pp. 198-209
    • Viosca, J.1    Malleret, G.2    Bourtchouladze, R.3    Benito, E.4    Vronskava, S.5    Kandel, E.R.6    Barco, A.7
  • 167
    • 70449533656 scopus 로고    scopus 로고
    • Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contri-bution of p300 and CBP to Rubinstein-Taybi syndrome etiology
    • Viosca, J., Lopez-Atalaya, J.P., Olivares, R., Eckner, R., and Barco, A. (2010). Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: differential contri-bution of p300 and CBP to Rubinstein-Taybi syndrome etiology. Neurobiol. Dis. 37, 186-194.
    • (2010) Neurobiol. Dis. , vol.37 , pp. 186-194
    • Viosca, J.1    Lopez-Atalaya, J.P.2    Olivares, R.3    Eckner, R.4    Barco, A.5
  • 168
    • 0036792096 scopus 로고    scopus 로고
    • Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibil-ity by drugs that enhance cAMP signaling
    • Vitolo, O.V., Sant'Angelo, A., Costanzo, V., Battaglia, F., Arancio, O., and Shelanski, M. (2002). Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibil-ity by drugs that enhance cAMP signaling. Proc. Natl. Acad. Sci. USA 99, 13217-13221.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13217-13221
    • Vitolo, O.V.1    Sant'Angelo, A.2    Costanzo, V.3    Battaglia, F.4    Arancio, O.5    Shelanski, M.6
  • 169
    • 0029786309 scopus 로고    scopus 로고
    • Alternative exon splicing controls a translational switch from activator to repressor isoforms of transcription factor CREB during sper-matogenesis
    • Walker, W.H., Girardet, C, and Habener, J.F. (1996). Alternative exon splicing controls a translational switch from activator to repressor isoforms of transcription factor CREB during sper-matogenesis. J. Biol. Chem. 271, 20145-21050.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20145-21050
    • Walker, W.H.1    Girardet, C.2    Habener, J.F.3
  • 170
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
    • DOI 10.1038/416535a
    • Walsh, D.M., Klyubin, I., Fadeeva, J.V., Cullen, W.K., Anwyl, R., Wolfe, M.S., Rowan, MJ., and Selkoe, DJ. (2002). Naturally secreted oligomers of amyloid-β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539. (Pubitemid 34288854)
    • (2002) Nature , vol.416 , Issue.6880 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 172
    • 67649405067 scopus 로고    scopus 로고
    • Indirect regulation of prese-nilins in CREB-mediated transcription
    • Watanabe, H., Smith, MJ., Heilig, E., Beglopoulos, V., Kelleher, RJ. 3rd., and Shen, J. (2009). Indirect regulation of prese-nilins in CREB-mediated transcription. J. Biol. Chem. 284, 13705-13713.
    • (2009) J. Biol. Chem. , vol.284 , pp. 13705-13713
    • Watanabe, H.1    Smith, M.J.2    Heilig, E.3    Beglopoulos, V.4    Shen, J.5
  • 174
    • 46749094132 scopus 로고    scopus 로고
    • Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels
    • Williams, C.M., El Mohsen, M.A., Vauzour, D., Rendeiro, C., Butler, L.T., Ellis, J.A., Whiteman, M., and Spencer, J.P. (2008). Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radic. Biol. Med. 45, 295-305.
    • (2008) Free Radic. Biol. Med. , vol.45 , pp. 295-305
    • Williams, C.M.1    El Mohsen, M.A.2    Vauzour, D.3    Rendeiro, C.4    Butler, L.T.5    Ellis, J.A.6    Whiteman, M.7    Spencer, J.P.8
  • 175
    • 0035956978 scopus 로고    scopus 로고
    • Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway
    • DOI 10.1073/pnas.051634198
    • Wu, G.Y., Deisseroth, K., and Tsien, R.W (2001). Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calm-odulin kinase pathway and a slow, less sensitive mitogen-acti-vated protein kinase pathway. Proc. Natl. Acad. Sci. USA 98, 2808-2813. (Pubitemid 32209565)
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , Issue.5 , pp. 2808-2813
    • Wu, G.-Y.1    Deisseroth, K.2    Tsien, R.W.3
  • 178
    • 77955913748 scopus 로고    scopus 로고
    • Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: Reversal by procyanidins extracted from the lotus seedpod
    • Xu, J., Rong, S., Xie, B., Sun, Z., Deng, Q., Wu, H, Bao, W, Wang, D., Yao, P., Huang, F, et al. (2010). Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: reversal by procyanidins extracted from the lotus seedpod. J. Gerontol. A Biol. Sci. Med. Sci. 65, 933-940.
    • (2010) J. Gerontol. A Biol. Sci. Med. Sci. , vol.65 , pp. 933-940
    • Xu, J.1    Rong, S.2    Xie, B.3    Sun, Z.4    Deng, Q.5    Wu, H.6    Bao, W.7    Wang, D.8    Yao, P.9    Huang, F.10
  • 179
    • 0033541589 scopus 로고    scopus 로고
    • Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type
    • DOI 10.1016/S0006-8993(99)01220-2, PII S0006899399012202
    • Yamamoto-Sasaki, M., Ozawa, H., Saito, T., Rosler, M., and Riederer, P. (1999). Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type. Brain Res. 824, 300-303. (Pubitemid 29225538)
    • (1999) Brain Research , vol.824 , Issue.2 , pp. 300-303
    • Yamamoto-Sasaki, M.1    Ozawa, H.2    Saito, T.3    Rosler, M.4    Riederer, P.5
  • 181
    • 0028934097 scopus 로고
    • CREB as a memory modulator: Induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila
    • Yin, J.C., Del Vecchio, M., Zhou, H., and Tully, T. (1995). CREB as a memory modulator: induced expression of a dCREB2 activa-tor isoform enhances long-term memory in Drosophila. Cell 81, 107-115.
    • (1995) Cell , vol.81 , pp. 107-115
    • Yin, J.C.1    Del Vecchio, M.2    Zhou, H.3    Tully, T.4
  • 182
    • 0027983479 scopus 로고
    • Induction of a dominant nega-tive CREB transgene specifically blocks long-term memory in Drosophila
    • Yin, J.C., Wallach, J.S., Del Vecchio, M., Wilder, E.L., Zhou, H, Quinn, W.G., and Tully, T. (1994). Induction of a dominant nega-tive CREB transgene specifically blocks long-term memory in Drosophila. Cell 79, 49-58.
    • (1994) Cell , vol.79 , pp. 49-58
    • Yin, J.C.1    Wallach, J.S.2    Del Vecchio, M.3    Wilder, E.L.4    Zhou, H.5    Quinn, W.G.6    Tully, T.7
  • 183
    • 0034051217 scopus 로고    scopus 로고
    • Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism
    • DOI 10.1016/S0893-133X(00)00108-1, PII S0893133X00001081
    • Zhang, H.T., Crissman, A.M., Dorairaj, N.R., Chandler, LJ., and O'Donnell, J.M. (2000). Inhibition of cyclic AMP phospho-diesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism. Neuropsychopharmacology 23, 198-204. (Pubitemid 30406904)
    • (2000) Neuropsychopharmacology , vol.23 , Issue.2 , pp. 198-204
    • Zhang, H.-T.1    Crissman, A.M.2    Dorairaj, N.R.3    Chandler, L.J.4    O'Donnell, J.M.5
  • 184
    • 3242758203 scopus 로고    scopus 로고
    • Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus
    • DOI 10.1038/sj.npp.1300440
    • Zhang, H.T., Zhao, Y, Huang, Y, Dorairaj, N.R., Chandler, LJ., and O'Donnell, J.M. (2004). Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus. Neuropsychopharmacology 29, 1432-1439. (Pubitemid 38982235)
    • (2004) Neuropsychopharmacology , vol.29 , Issue.8 , pp. 1432-1439
    • Zhang, H.-T.1    Zhao, Y.2    Huang, Y.3    Dorairaj, N.R.4    Chandler, L.J.5    O'Donnell, J.M.6
  • 185
    • 67349199183 scopus 로고    scopus 로고
    • Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synap-tic plasticity-related proteins in hippocampus
    • Zhao, H., Li, Q., Pei, X., Zhang, Z., Yang, R., Wang, J., and Li, Y (2009). Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synap-tic plasticity-related proteins in hippocampus. Behav. Brain Res. 201, 311-317.
    • (2009) Behav. Brain Res. , vol.201 , pp. 311-317
    • Zhao, H.1    Li, Q.2    Pei, X.3    Zhang, Z.4    Yang, R.5    Wang, J.6    Li, Y.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.