Transcriptional control of cognitive development

Current Opinion in Neurobiology

Volumn 15, Issue 1, 2005, Pages 21-28

  Hong, Elizabeth J ^a   West, Anne E ^a   Greenberg, Michael E ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; METHYL CPG BINDING PROTEIN 2;

COGNITIVE DEVELOPMENT; ENVIRONMENT; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HUMAN; MENTAL DEFICIENCY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 13844275314     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.conb.2005.01.002     Document Type: Review

References (60)

1. T.N. Wiesel Postnatal development of the visual cortex and the influence of environment Nature 299 1982 583 591
2. H.Y. Zoghbi Postnatal neurodevelopmental disorders: meeting at the synapse? Science 302 2003 826 830
3. J.K. Inlow, and L.L. Restifo Molecular and comparative genetics of mental retardation Genetics 166 2004 835 881
4. J.H. Rubinstein, and H. Taybi Broad thumbs and toes and facial abnormalities Am J Dis Child 105 1963 588 608
5. F. Petrij, R.H. Giles, H.G. Dauwerse, J.J. Saris, R.C. Hennekam, M. Masuno, N. Tommerup, G.J. van Ommen, R.H. Goodman, and D.J. Peters Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP Nature 376 1995 348 351
6. H.M. Chan, and N.B. La Thangue p300/CBP proteins: HATs for transcriptional bridges and scaffolds J Cell Sci 114 2001 2363 2373
7. W. Fischle, Y. Wang, and C.D. Allis Binary switches and modification cassettes in histone biology and beyond Nature 425 2003 475 479
8. B.E. Lonze, and D.D. Ginty Function and regulation of CREB family transcription factors in the nervous system Neuron 35 2002 605 623
9. S.C. Hu, J. Chrivia, and A. Ghosh Regulation of CBP-mediated transcription by neuronal calcium signaling Neuron 22 1999 799 808
10. S. Impey, A.L. Fong, Y. Wang, J.R. Cardinaux, D.M. Fass, K. Obrietan, G.A. Wayman, D.R. Storm, T.R. Soderling, and R.H. Goodman Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV Neuron 34 2002 235 244
11. Y. Tanaka, I. Naruse, T. Maekawa, H. Masuya, T. Shiroishi, and S. Ishii Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome Proc Natl Acad Sci USA 94 1997 10215 10220
12. Y. Oike, A. Hata, T. Mamiya, T. Kaname, Y. Noda, M. Suzuki, H. Yasue, T. Nabeshima, K. Araki, and K. Yamamura Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism Hum Mol Genet 8 1999 387 396
13. +/- mutant mice, some forms of long-term memory and l-LTP are impaired. Pharmacological inhibition of histone deacetylases potentiates l-LTP and restores the long-term memory deficit, suggesting a potential role for histone acetylation in neural plasticity and memory.
14. R. Bourtchouladze, R. Lidge, R. Catapano, J. Stanley, S. Gossweiler, D. Romashko, R. Scott, and T. Tully A mouse model of Rubinstein-Taybi syndrome: defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4 Proc Natl Acad Sci USA 100 2003 10518 10522
15. -/-} mutant mice are impaired in some forms of long-term memory, and the memory defect is reversible either by transgene suppression or by pharmacological inhibition of histone deacetylases, implicating the histone acetyltransferase activity of CBP in long-term memory function.
16. Y. Huang, J.J. Doherty, and R. Dingledine Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus J Neurosci 22 2002 8422 8428
17. ••].
18. ••] identify the Bdnf gene as a mammalian target of MeCP2 repression. Using chromatin immunoprecipitation, the authors found that MeCP2 is bound to rat Bdnf promoter III (homologous to mouse Bdnf promoter IV) in resting cortical neurons, and, in response to membrane depolarization and calcium influx, MeCP2 dissociates from the promoter, concurrent with induction of the Bdnf transcript. Taken together, these studies pioneer the concept that a methyl-binding protein such as MeCP2 can dynamically associate with its target promoters and thereby regulate gene induction, in contrast to the prevailing dogma that methyl-binding proteins primarily mediate long-term gene silencing.
19. Z. Guan, M. Giustetto, S. Lomvardas, J.H. Kim, M.C. Miniaci, J.H. Schwartz, D. Thanos, and E.R. Kandel Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure Cell 111 2002 483 493 This study performed using the mollusk Aplysia provides evidence that chromatin remodeling can take a role in the transcriptional program underlying long-term synaptic plasticity.
20. N.M. Tsankova, A. Kumar, and E.J. Nestler Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures J Neurosci 24 2004 5603 5610
21. R.E. Amir, I.B. Van den Veyver, M. Wan, C.Q. Tran, U. Francke, and H.Y. Zoghbi Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 Nat Genet 23 1999 185 188
22. M.D. Shahbazian, and H.Y. Zoghbi Molecular genetics of Rett syndrome and clinical spectrum of MECP2 mutations Curr Opin Neurol 14 2001 171 176
23. P.A. Wade Methyl CpG-binding proteins and transcriptional repression Bioessays 23 2001 1131 1137
24. R. Jaenisch, and A. Bird Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals Nat Genet 33 2003 245 254
25. A. Bird DNA methylation patterns and epigenetic memory Genes Dev 16 2002 6 21
26. J. Guy, B. Hendrich, M. Holmes, J.E. Martin, and A. Bird A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome Nat Genet 27 2001 322 326
27. R.Z. Chen, S. Akbarian, M. Tudor, and R. Jaenisch Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice Nat Genet 27 2001 327 331
28. M. Shahbazian, J. Young, L. Yuva-Paylor, C. Spencer, B. Antalffy, J. Noebels, D. Armstrong, R. Paylor, and H. Zoghbi Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3 Neuron 35 2002 243 254
29. C. Colantuoni, O.H. Jeon, K. Hyder, A. Chenchik, A.H. Khimani, V. Narayanan, E.P. Hoffman, W.E. Kaufmann, S. Naidu, and J. Pevsner Gene expression profiling in postmortem Rett Syndrome brain: differential gene expression and patient classification Neurobiol Dis 8 2001 847 865
30. M. Tudor, S. Akbarian, R.Z. Chen, and R. Jaenisch Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain Proc Natl Acad Sci USA 99 2002 15536 15541
31. M.M. Poo Neurotrophins as synaptic modulators Nat Rev Neurosci 2 2001 24 32
32. 2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism Neuron 20 1998 709 726
33. T. Timmusk, K. Palm, M. Metsis, T. Reintam, V. Paalme, M. Saarma, and H. Persson Multiple promoters direct tissue-specific expression of the rat BDNF gene Neuron 10 1993 475 489
34. D. Bruniquel, and R.H. Schwartz Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process Nat Immunol 4 2003 235 240 This study convincingly demonstrates the active and rapid demethylation of the interleukin 2 promoter in T-lymphocytes in response to activation, both in vitro and in vivo. Methylation status was assessed by the bisulfite sequencing method. The change in methylation was found to be required for transcriptional activation, as assessed using transfected reporter plasmids. Although an enzymatic activity that is able to demethylate DNA has not yet been definitively identified in mammalian cells, this study provides evidence that the removal of DNA methylation can be a key event in gene activation.
35. I. Stancheva, A.L. Collins, I.B. Van den Veyver, H. Zoghbi, and R.R. Meehan A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos Mol Cell 12 2003 425 435
36. U. Bellugi, L. Lichtenberger, D. Mills, A. Galaburda, and J.R. Korenberg Bridging cognition, the brain and molecular genetics: evidence from Williams syndrome Trends Neurosci 22 1999 197 207
37. H. Tager-Flusberg Fulfilling the promise of the cognitive neurosciences Neuron 43 2004 595 596
38. M. Tassabehji Williams-Beuren syndrome: a challenge for genotype-phenotype correlations Hum Mol Genet 12 2003 R229 R237
39. C.A. Morris, C.B. Mervis, H.H. Hobart, R.G. Gregg, J. Bertrand, G.J. Ensing, A. Sommer, C.A. Moore, R.J. Hopkin, and P.A. Spallone GTF2I hemizygosity implicated in mental retardation in Williams syndrome: genotype-phenotype analysis of five families with deletions in the Williams syndrome region Am J Med Genet 123A 2003 45 59
40. H. Hirota, R. Matsuoka, X.N. Chen, L.S. Salandanan, A. Lincoln, F.E. Rose, M. Sunahara, M. Osawa, U. Bellugi, and J.R. Korenberg Williams syndrome deficits in visual spatial processing linked to GTF2IRD1 and GTF2I on chromosome 7q11.23 Genet Med 5 2003 311 321
41. C. Gagliardi, M.C. Bonaglia, A. Selicorni, R. Borgatti, and R. Giorda Unusual cognitive and behavioural profile in a Williams syndrome patient with atypical 7q11.23 deletion J Med Genet 40 2003 526 530
42. D.W. Kim, and B.H. Cochran Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter Mol Cell Biol 20 2000 1140 1148
43. A. Meyer-Lindenberg, P. Kohn, C.B. Mervis, J.S. Kippenhan, R.K. Olsen, C.A. Morris, and K.F. Berman Neural basis of genetically determined visuospatial construction deficit in Williams syndrome Neuron 43 2004 623 631
44. G.F. Marcus, and S.E. Fisher FOXP2 in focus: what can genes tell us about speech and language? Trends Cogn Sci 7 2003 257 262
45. C.S. Lai, S.E. Fisher, J.A. Hurst, F. Vargha-Khadem, and A.P. Monaco A forkhead-domain gene is mutated in a severe speech and language disorder Nature 413 2001 519 523
46. W. Shu, H. Yang, L. Zhang, M.M. Lu, and E.E. Morrisey Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors J Biol Chem 276 2001 27488 27497
47. R.J. Ferland, T.J. Cherry, P.O. Preware, E.E. Morrisey, and C.A. Walsh Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain J Comp Neurol 460 2003 266 279
48. K. Takahashi, F.C. Liu, K. Hirokawa, and H. Takahashi Expression of Foxp2, a gene involved in speech and language, in the developing and adult striatum J Neurosci Res 73 2003 61 72
49. I. Teramitsu, L.C. Kudo, S.E. London, D.H. Geschwind, and S.A. White Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction J Neurosci 24 2004 3152 3163
50. S. Haesler, K. Wada, A. Nshdejan, E.E. Morrisey, T. Lints, E.D. Jarvis, and C. Scharff FoxP2 expression in avian vocal learners and non-learners J Neurosci 24 2004 3164 3175 Using the songbird as an animal model of vocal learning, this study identifies a correlation between Foxp2 expression and brain regions of the songbird that are involved in vocal learning. In the striatal nucleus Area X, a crucial nucleus in the vocal learning circuit, Foxp2 expression in zebra finch or canary increases specifically during times when the animal's song pattern is unstable. This intriguing expression pattern suggests Foxp2 might be involved in the development or maturation of neuronal circuits underlying learned vocalizations.
51. F. Liegeois, T. Baldeweg, A. Connelly, D.G. Gadian, M. Mishkin, and F. Vargha-Khadem Language fMRI abnormalities associated with FOXP2 gene mutation Nat Neurosci 6 2003 1230 1237
52. K.E. Watkins, F. Vargha-Khadem, J. Ashburner, R.E. Passingham, A. Connelly, K.J. Friston, R.S. Frackowiak, M. Mishkin, and D.G. Gadian MRI analysis of an inherited speech and language disorder: structural brain abnormalities Brain 125 2002 465 478
53. F. Vargha-Khadem, K. Watkins, K. Alcock, P. Fletcher, and R. Passingham Praxic and nonverbal cognitive deficits in a large family with a genetically transmitted speech and language disorder Proc Natl Acad Sci USA 92 1995 930 933
54. K.E. Watkins, N.F. Dronkers, and F. Vargha-Khadem Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia Brain 125 2002 452 464
55. V1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism Cell 119 2004 19 31
56. J.H. Sitz, M. Tigges, K. Baumgartel, L.G. Khaspekov, and B. Lutz Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4 Mol Cell Biol 24 2004 5821 5834
57. X. Nan, H.H. Ng, C.A. Johnson, C.D. Laherty, B.M. Turner, R.N. Eisenman, and A. Bird Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex Nature 393 1998 386 389
58. Y. Tanaka, I. Naruse, T. Hongo, M. Xu, T. Nakahata, T. Maekawa, and S. Ishii Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein Mech Dev 95 2000 133 145
59. Y. Oike, N. Takakura, A. Hata, T. Kaname, M. Akizuki, Y. Yamaguchi, H. Yasue, K. Araki, K. Yamamura, and T. Suda Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis Blood 93 1999 2771 2779
60. A.E. West, E.C. Griffith, and M.E. Greenberg Regulation of transcription factors by neuronal activity Nat Rev Neurosci 3 2002 921 931