Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.

Molecular brain

Volumn 1, Issue , 2008, Pages 15-

  Yang, Ting ^a   Arslanova, Dilyara ^b   Gu, Yongli ^b   Augelli Szafran, Corinne ^b   Xia, Weiming ^b  

^a HARVARD UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DIPEPTIDE; HER6 PROTEIN, ZEBRAFISH; N (N (3,5 DIFLUOROPHENACETYL)ALANYL)PHENYLGLYCINE TERT BUTYL ESTER; N-(N-(3,5-DIFLUOROPHENACETYL)ALANYL)PHENYLGLYCINE TERT-BUTYL ESTER; NOTCH RECEPTOR; PROTEINASE INHIBITOR; RECOMBINANT PROTEIN; SECRETASE; ZEBRAFISH PROTEIN;

ANIMAL; ANIMAL EMBRYO; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; PHENOTYPE; PRENATAL DEVELOPMENT; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; ZEBRA FISH;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DIPEPTIDES; EMBRYO, NONMAMMALIAN; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; MUTATION; PHENOTYPE; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NOTCH; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 77950255854     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/1756-6606-1-15     Document Type: Article

References (0)