Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila

Science

Volumn 313, Issue 5788, 2006, Pages 851-853

  Didelot, Gérard ^a,d   Molinari, Florence ^b   Tchénio, Paul ^c   Comas, Daniel ^a,e   Milhiet, Elodie ^c   Munnich, Arnold ^b   Colleaux, Laurence ^b   Preat, Thomas ^a  

^a CNRS   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c LABORATOIRE AIMÉ COTTON   (France)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

^e Glaxo Smith Kline   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DATA PROCESSING; ENZYMES; GENES; PATHOLOGY;

LONG-TERM MEMORY (LTM); NEUROTRYPSIN ORTHOLOG; PATHOPHYSIOLOGICAL CONSEQUENCES;

GENETIC ENGINEERING;

NEUROTRYPSIN; PROTEIN TEQUILA; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ENZYME; FLY; MEMORY; MENTAL HEALTH; MUSHROOM; MUTATION; PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; ASSOCIATIVE MEMORY; AUTOSOMAL RECESSIVE DISORDER; CONDITIONING; CONTROLLED STUDY; DROSOPHILA; GENE; GENE INACTIVATION; GENE MUTATION; GENE REPRESSION; INFORMATION PROCESSING; LONG TERM MEMORY; MENTAL DEFICIENCY; MUSHROOM BODY; NONHUMAN; PRIORITY JOURNAL; TEQ GENE;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CONDITIONING, CLASSICAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; LEARNING; MEMORY; MIFEPRISTONE; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; MUSHROOM BODIES; MUTATION; ODORS; RNA INTERFERENCE; RNA, MESSENGER; SERINE ENDOPEPTIDASES;

BASIDIOMYCOTA;

EID: 33747101309     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1127215     Document Type: Article

References (21)

1. F. Molinari et al., Science 298, 1779 (2002).
2. T. P. Gschwend, S. R. Krueger, S. V. Kozlov, D, P. Wolfer, P. Sonderegger, Mol. Cell. Neurosci. 9, 207 (1997).
3. J. K. Inlow, L. L. Restifo, Genetics 166, 835 (2004).
4. See supporting material on Science Online.
5. T. Tully, T. Preat, S. C. Boynton, M. Del Vecchio, Cell 79, 35 (1994).
6. S. T. Thibault et al., Nat. Genet. 36, 283 (2004).
7. J. R. Crittenden, E. M. Skoulakis, K. A. Han, D. Kalderon, R. L. Davis, Learn. Mem. 5, 38 (1998).
8. A. Pascual, T. Preat, Science 294, 1115 (2001).
9. G. Isabel, A. Pascual, T. Preat, Science 304, 1024 (2004).
10. G. Grenningloh, E. J. Rehm, C. S. Goodman, Cell 67, 45 (1991).
11. E. M. Skoulakis, D. Kalderon, R. L. Davis, Neuron 11, 197 (1993).
12. A. Piccin et al., Nucleic Acids Res. 29, E55 (2001).
13. T. Zars, R. Wolf, R. Davis, M. Heisenberg, Learn. Mem. 7, 18 (2000).
14. D. Comas, F. Petit, T. Preat, Nature 430, 460 (2004).
15. J. D. Armstrong, J. S. de Belle, Z. Wang, K. Kaiser, Learn. Mem. 5, 102 (1998).
16. J. Dubnau et al., Curr. Biol. 13, 286 (2003).
17. Z. Mao, G. Roman, L. Zong, R. L. Davis, Proc. Natl. Acad. Sci. U.S.A 101, 198 (2004).
18. S. Shiosaka, S. Yoshida, Neurosci. Res. 37, 85 (2000).
19. S. Shiosaka, Anat. Sci. Int. 79, 137 (2004).
20. F. Molinari, V. Meskanaite, A. Munnich, P. Sonderegger, L. Colleaux, Hum. Mol. Genet. 12 (suppl. 2), R195 (2003).
21. We thank Y. H. Belgacem, J.-R. Martin, and J. Neveu for help with cryostat sections; L. Kaiser for help with statistical analysis; J.-Y. Lallemand for providing major equipment; and members of our laboratories for fruitful discussions. Supported by the Agence Nationale pour la Recherche (L.C. and T.P.), the Fondation France Telecom (L.C.), the Fondation pour la Recherche Médicale (L.C. and T.P.), the Fondation Bettencourt Schueller (T.P.), the Fondation Schlumberger pour l'Enseignement et la Recherche (T.P.), and the Association pour la Recherche contre le Cancer (G.D.).