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Volumn 42, Issue 3, 2014, Pages 301-317

Herb-drug interactions: Challenges and opportunities for improved predictions

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; COMPUTER SIMULATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GOVERNMENT REGULATION; HERB-DRUG INTERACTIONS; HUMANS; LEGISLATION, DRUG; MILK THISTLE; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PLANT PREPARATIONS; SILYMARIN; STILBENES;

EID: 84893839263     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.055236     Document Type: Review
Times cited : (158)

References (202)
  • 3
    • 84879799217 scopus 로고    scopus 로고
    • Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death
    • Aires V, Limagne E, Cotte AK, Latruffe N, Ghiringhelli F, and Delmas D (2013) Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death. Mol Nutr Food Res 57:1170-1181.
    • (2013) Mol Nutr Food Res , vol.57 , pp. 1170-1181
    • Aires, V.1    Limagne, E.2    Cotte, A.K.3    Latruffe, N.4    Ghiringhelli, F.5    Delmas, D.6
  • 5
    • 77950676607 scopus 로고    scopus 로고
    • Involvement of breast cancer resistance protein (BCRP1/ABCG2) in the bioavailability and tissue distribution of trans-resveratrol in knockout mice
    • Alfaras I, Pérez M, Juan ME, Merino G, Prieto JG, Planas JM, and Alvarez AI (2010) Involvement of breast cancer resistance protein (BCRP1/ABCG2) in the bioavailability and tissue distribution of trans-resveratrol in knockout mice. J Agric Food Chem 58:4523-4528.
    • (2010) J Agric Food Chem , vol.58 , pp. 4523-4528
    • Alfaras, I.1    Pérez, M.2    Juan, M.E.3    Merino, G.4    Prieto, J.G.5    Planas, J.M.6    Alvarez, A.I.7
  • 11
    • 43949115541 scopus 로고    scopus 로고
    • Herbal medicine in the United States: Review of efficacy, safety, and regulation: Grand rounds at University of California, San Francisco Medical Center
    • Bent S (2008) Herbal medicine in the United States: review of efficacy, safety, and regulation: grand rounds at University of California, San Francisco Medical Center. J Gen Intern Med 23: 854-859.
    • (2008) J Gen Intern Med , vol.23 , pp. 854-859
    • Bent, S.1
  • 13
    • 0142131213 scopus 로고    scopus 로고
    • The conduct of in vitro and in vivo drug-drug interaction studies: A PhRMA perspective
    • Pharmaceutical Research and Manufacturers of America Drug Metabolism/ Clinical Pharmacology Technical Working Groups
    • Bjornsson TD, Callaghan JT, Einolf HJ, Fischer V, Gan L, Grimm S, Kao J, King SP, Miwa G, and Ni L, et al.; Pharmaceutical Research and Manufacturers of America Drug Metabolism/ Clinical Pharmacology Technical Working Groups (2003) The conduct of in vitro and in vivo drug-drug interaction studies: a PhRMA perspective. J Clin Pharmacol 43:443-469.
    • (2003) J Clin Pharmacol , vol.43 , pp. 443-469
    • Bjornsson, T.D.1    Callaghan, J.T.2    Einolf, H.J.3    Fischer, V.4    Gan, L.5    Grimm, S.6    Kao, J.7    King, S.P.8    Miwa, G.9    Ni, L.10
  • 14
    • 0141675108 scopus 로고    scopus 로고
    • Reference values for basic human anatomical and physiological characteristics for use in radiation protection
    • Boecker BB (2003) Reference values for basic human anatomical and physiological characteristics for use in radiation protection. Radiat Prot Dosimetry 105:571-574.
    • (2003) Radiat Prot Dosimetry , vol.105 , pp. 571-574
    • Boecker, B.B.1
  • 16
    • 84882789000 scopus 로고    scopus 로고
    • A systematic approach to evaluate herb-drug interaction mechanisms: Investigation of milk thistle extracts and eight isolated constituents as CYP3A inhibitors
    • Brantley SJ, Graf TN, Oberlies NH, and Paine MF (2013) A systematic approach to evaluate herb-drug interaction mechanisms: Investigation of milk thistle extracts and eight isolated constituents as CYP3A inhibitors. Drug Metab Dispos 41:1662-1670.
    • (2013) Drug Metab Dispos , vol.41 , pp. 1662-1670
    • Brantley, S.J.1    Graf, T.N.2    Oberlies, N.H.3    Paine, M.F.4
  • 17
    • 77249169919 scopus 로고    scopus 로고
    • Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations
    • Brantley SJ, Oberlies NH, Kroll DJ, and Paine MF (2010) Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations. J Pharmacol Exp Ther 332:1081-1087.
    • (2010) J Pharmacol Exp Ther , vol.332 , pp. 1081-1087
    • Brantley, S.J.1    Oberlies, N.H.2    Kroll, D.J.3    Paine, M.F.4
  • 20
    • 36549007414 scopus 로고    scopus 로고
    • Modulation of human cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) in Caco-2 cell monolayers by selected commercial-source milk thistle and goldenseal products
    • Budzinski JW, Trudeau VL, Drouin CE, Panahi M, Arnason JT, and Foster BC (2007) Modulation of human cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) in Caco-2 cell monolayers by selected commercial-source milk thistle and goldenseal products. Can J Physiol Pharmacol 85:966-978.
    • (2007) Can J Physiol Pharmacol , vol.85 , pp. 966-978
    • Budzinski, J.W.1    Trudeau, V.L.2    Drouin, C.E.3    Panahi, M.4    Arnason, J.T.5    Foster, B.C.6
  • 22
    • 79956004865 scopus 로고    scopus 로고
    • Nutraceuticals in the treatment of obsessive compulsive disorder (OCD): A review of mechanistic and clinical evidence
    • Camfield DA, Sarris J, and Berk M (2011) Nutraceuticals in the treatment of obsessive compulsive disorder (OCD): a review of mechanistic and clinical evidence. Prog Neuropsychopharmacol Biol Psychiatry 35:887-895.
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry , vol.35 , pp. 887-895
    • Camfield, D.A.1    Sarris, J.2    Berk, M.3
  • 24
    • 0034634252 scopus 로고    scopus 로고
    • Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4
    • Chan WK and Delucchi AB (2000) Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4. Life Sci 67:3103-3112.
    • (2000) Life Sci , vol.67 , pp. 3103-3112
    • Chan, W.K.1    Delucchi, A.B.2
  • 25
    • 70350128772 scopus 로고    scopus 로고
    • Herb-drug interaction of silymarin or silibinin on the pharmacokinetics of trazodone in rats
    • Chang JC, Wu YT, Lee WC, Lin LC, and Tsai TH (2009) Herb-drug interaction of silymarin or silibinin on the pharmacokinetics of trazodone in rats. Chem Biol Interact 182:227-232.
    • (2009) Chem Biol Interact , vol.182 , pp. 227-232
    • Chang, J.C.1    Wu, Y.T.2    Lee, W.C.3    Lin, L.C.4    Tsai, T.H.5
  • 26
    • 0035192944 scopus 로고    scopus 로고
    • Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: Evidence for mechanism-based inactivation of CYP1A2
    • Chang TK, Chen J, and Lee WB (2001) Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J Pharmacol Exp Ther 299:874-882.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 874-882
    • Chang, T.K.1    Chen, J.2    Lee, W.B.3
  • 28
    • 84874092834 scopus 로고    scopus 로고
    • Species differences in drug transporters and implications for translating preclinical findings to humans
    • Chu X, Bleasby K, and Evers R (2013) Species differences in drug transporters and implications for translating preclinical findings to humans. Expert Opin Drug Metab Toxicol 9:237-252.
    • (2013) Expert Opin Drug Metab Toxicol , vol.9 , pp. 237-252
    • Chu, X.1    Bleasby, K.2    Evers, R.3
  • 29
    • 0032862195 scopus 로고    scopus 로고
    • Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol
    • Ciolino HP and Yeh GC (1999) Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Mol Pharmacol 56:760-767.
    • (1999) Mol Pharmacol , vol.56 , pp. 760-767
    • Ciolino, H.P.1    Yeh, G.C.2
  • 30
    • 0032535055 scopus 로고    scopus 로고
    • Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor
    • Ciolino HP, Daschner PJ, and Yeh GC (1998) Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor. Cancer Res 58:5707-5712.
    • (1998) Cancer Res , vol.58 , pp. 5707-5712
    • Ciolino, H.P.1    Daschner, P.J.2    Yeh, G.C.3
  • 31
    • 84872543301 scopus 로고    scopus 로고
    • Lipid bilayer properties control membrane partitioning, binding, and transport of p-glycoprotein substrates
    • Clay AT and Sharom FJ (2013) Lipid bilayer properties control membrane partitioning, binding, and transport of p-glycoprotein substrates. Biochemistry 52:343-354.
    • (2013) Biochemistry , vol.52 , pp. 343-354
    • Clay, A.T.1    Sharom, F.J.2
  • 32
    • 79959910572 scopus 로고    scopus 로고
    • Population pharmacokinetic modeling of trans-resveratrol and its glucuronide and sulfate conjugates after oral and intravenous administration in rats
    • Colom H, Alfaras I, Maijó M, Juan ME, and Planas JM (2011) Population pharmacokinetic modeling of trans-resveratrol and its glucuronide and sulfate conjugates after oral and intravenous administration in rats. Pharm Res 28:1606-1621.
    • (2011) Pharm Res , vol.28 , pp. 1606-1621
    • Colom, H.1    Alfaras, I.2    Maijó, M.3    Juan, M.E.4    Planas, J.M.5
  • 33
    • 0034753042 scopus 로고    scopus 로고
    • Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2
    • Cui Y, König J, and Keppler D (2001) Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol Pharmacol 60:934-943.
    • (2001) Mol Pharmacol , vol.60 , pp. 934-943
    • Cui, Y.1    König, J.2    Keppler, D.3
  • 34
    • 0032793959 scopus 로고    scopus 로고
    • OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
    • Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, and Kim RB (1999) OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos 27:866-871.
    • (1999) Drug Metab Dispos , vol.27 , pp. 866-871
    • Cvetkovic, M.1    Leake, B.2    Fromm, M.F.3    Wilkinson, G.R.4    Kim, R.B.5
  • 35
    • 20144372639 scopus 로고    scopus 로고
    • Milk thistle and prostate cancer: Differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells
    • Davis-Searles PR, Nakanishi Y, Kim NC, Graf TN, Oberlies NH, Wani MC, Wall ME, Agarwal R, and Kroll DJ (2005) Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells. Cancer Res 65:4448-4457.
    • (2005) Cancer Res , vol.65 , pp. 4448-4457
    • Davis-Searles, P.R.1    Nakanishi, Y.2    Kim, N.C.3    Graf, T.N.4    Oberlies, N.H.5    Wani, M.C.6    Wall, M.E.7    Agarwal, R.8    Kroll, D.J.9
  • 36
    • 84866085375 scopus 로고    scopus 로고
    • Botanical-drug interactions: A scientific perspective
    • de Lima Toccafondo Vieira M and Huang SM (2012) Botanical-drug interactions: a scientific perspective. Planta Med 78:1400-1415.
    • (2012) Planta Med , vol.78 , pp. 1400-1415
    • De Lima Toccafondo Vieira, M.1    Huang, S.M.2
  • 37
    • 0034491047 scopus 로고    scopus 로고
    • Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver
    • de Santi C, Pietrabissa A, Mosca F, and Pacifici GM (2000a) Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. Xenobiotica 30:1047-1054.
    • (2000) Xenobiotica , vol.30 , pp. 1047-1054
    • De Santi, C.1    Pietrabissa, A.2    Mosca, F.3    Pacifici, G.M.4
  • 38
    • 0033937909 scopus 로고    scopus 로고
    • Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum
    • De Santi C, Pietrabissa A, Spisni R, Mosca F, and Pacifici GM (2000b) Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum. Xenobiotica 30:609-617.
    • (2000) Xenobiotica , vol.30 , pp. 609-617
    • De Santi, C.1    Pietrabissa, A.2    Spisni, R.3    Mosca, F.4    Pacifici, G.M.5
  • 39
    • 15444370925 scopus 로고    scopus 로고
    • Herbal medicine in Europe-relaxing regulatory standards
    • De Smet PA (2005) Herbal medicine in Europe-relaxing regulatory standards. N Engl J Med 352:1176-1178.
    • (2005) N Engl J Med , vol.352 , pp. 1176-1178
    • De Smet, P.A.1
  • 42
    • 84893853791 scopus 로고
    • Dietary Supplement Health and Education Act
    • Dietary Supplement Health and Education Act (1994) Public Law 103-417, 103rd Congress.
    • (1994) Public Law 103-417, 103rd Congress
  • 44
    • 78650521620 scopus 로고    scopus 로고
    • Assessment of a dry extract from milk thistle (Silybum marianum) for interference with human liver cytochrome-P450 activities
    • Doehmer J, Weiss G, McGregor GP, and Appel K (2011) Assessment of a dry extract from milk thistle (Silybum marianum) for interference with human liver cytochrome-P450 activities. Toxicol In Vitro 25:21-27.
    • (2011) Toxicol in Vitro , vol.25 , pp. 21-27
    • Doehmer, J.1    Weiss, G.2    McGregor, G.P.3    Appel, K.4
  • 45
    • 33947233105 scopus 로고    scopus 로고
    • Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate
    • Ebert B, Seidel A, and Lampen A (2007) Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol Sci 96:227-236.
    • (2007) Toxicol Sci , vol.96 , pp. 227-236
    • Ebert, B.1    Seidel, A.2    Lampen, A.3
  • 46
    • 78650912735 scopus 로고    scopus 로고
    • Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy
    • Efferth T and Koch E (2011) Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy. Curr Drug Targets 12:122-132.
    • (2011) Curr Drug Targets , vol.12 , pp. 122-132
    • Efferth, T.1    Koch, E.2
  • 48
    • 34547730805 scopus 로고    scopus 로고
    • An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents
    • Etheridge AS, Black SR, Patel PR, So J, and Mathews JM (2007) An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Med 73:731-741.
    • (2007) Planta Med , vol.73 , pp. 731-741
    • Etheridge, A.S.1    Black, S.R.2    Patel, P.R.3    So, J.4    Mathews, J.M.5
  • 49
    • 79955690629 scopus 로고    scopus 로고
    • European Medicines Agency, European Medicines Agency, London, UK
    • European Medicines Agency (2012) Guideline on the Investigation of Drug Interactions, European Medicines Agency, London, UK.
    • (2012) Guideline on the Investigation of Drug Interactions
  • 50
    • 0141859150 scopus 로고    scopus 로고
    • Directive 2002/46/EC of the European Parliament and of the Council of 10 June 2002 on the approximation of the laws of the Member States relating to food supplements
    • European Parliament
    • European Parliament (2002) Directive 2002/46/EC of the European Parliament and of the Council of 10 June 2002 on the approximation of the laws of the Member States relating to food supplements. Official J Eur Union 183:51-57.
    • (2002) Official J Eur Union , vol.183 , pp. 51-57
  • 52
    • 0034065619 scopus 로고    scopus 로고
    • Regulatory issues relating to herbal products-part 1: Legislation in the European Union, North America, and Australia
    • Forte JS and Raman A (2000) Regulatory issues relating to herbal products-part 1: legislation in the European Union, North America, and Australia. J Med Food 3:23-39.
    • (2000) J Med Food , vol.3 , pp. 23-39
    • Forte, J.S.1    Raman, A.2
  • 53
    • 84863905251 scopus 로고    scopus 로고
    • Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: A randomized controlled trial
    • Silymarin in NASH and C Hepatitis (SyNCH) Study Group
    • Fried MW, Navarro VJ, Afdhal N, Belle SH, Wahed AS, Hawke RL, Doo E, Meyers CM, and Reddy KR; Silymarin in NASH and C Hepatitis (SyNCH) Study Group (2012) Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. JAMA 308:274-282.
    • (2012) JAMA , vol.308 , pp. 274-282
    • Fried, M.W.1    Navarro, V.J.2    Afdhal, N.3    Belle, S.H.4    Wahed, A.S.5    Hawke, R.L.6    Doo, E.7    Meyers, C.M.8    Reddy, K.R.9
  • 54
    • 36949011011 scopus 로고    scopus 로고
    • The effect of silymarin on oral nifedipine pharmacokinetics
    • Fuhr U, Beckmann-Knopp S, Jetter A, Lück H, and Mengs U (2007) The effect of silymarin on oral nifedipine pharmacokinetics. Planta Med 73:1429-1435.
    • (2007) Planta Med , vol.73 , pp. 1429-1435
    • Fuhr, U.1    Beckmann-Knopp, S.2    Jetter, A.3    Lück, H.4    Mengs, U.5
  • 55
    • 33749249528 scopus 로고    scopus 로고
    • Recommendations for reporting randomized controlled trials of herbal interventions: Explanation and elaboration
    • CONSORT Group
    • Gagnier JJ, Boon H, Rochon P, Moher D, Barnes J, and Bombardier C; CONSORT Group (2006) Recommendations for reporting randomized controlled trials of herbal interventions: Explanation and elaboration. J Clin Epidemiol 59:1134-1149.
    • (2006) J Clin Epidemiol , vol.59 , pp. 1134-1149
    • Gagnier, J.J.1    Boon, H.2    Rochon, P.3    Moher, D.4    Barnes, J.5    Bombardier, C.6
  • 57
    • 67149141758 scopus 로고    scopus 로고
    • Combined therapy of silymarin and desferrioxamine in patients with betathalassemia major: A randomized double-blind clinical trial
    • Gharagozloo M, Moayedi B, Zakerinia M, Hamidi M, Karimi M, Maracy M, and Amirghofran Z (2009) Combined therapy of silymarin and desferrioxamine in patients with betathalassemia major: a randomized double-blind clinical trial. Fundam Clin Pharmacol 23: 359-365.
    • (2009) Fundam Clin Pharmacol , vol.23 , pp. 359-365
    • Gharagozloo, M.1    Moayedi, B.2    Zakerinia, M.3    Hamidi, M.4    Karimi, M.5    Maracy, M.6    Amirghofran, Z.7
  • 58
    • 0037248470 scopus 로고    scopus 로고
    • Absorption of three wine-related polyphenols in three different matrices by healthy subjects
    • Goldberg DM, Yan J, and Soleas GJ (2003) Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem 36:79-87.
    • (2003) Clin Biochem , vol.36 , pp. 79-87
    • Goldberg, D.M.1    Yan, J.2    Soleas, G.J.3
  • 59
    • 0035899915 scopus 로고    scopus 로고
    • Herbal medicines today and the roots of modern pharmacology
    • Goldman P (2001) Herbal medicines today and the roots of modern pharmacology. Ann Intern Med 135:594-600.
    • (2001) Ann Intern Med , vol.135 , pp. 594-600
    • Goldman, P.1
  • 60
    • 33645307385 scopus 로고    scopus 로고
    • Effects of Silybum marianum on serum hepatitis C virus RNA, alanine aminotransferase levels and well-being in patients with chronic hepatitis C
    • Gordon A, Hobbs DA, Bowden DS, Bailey MJ, Mitchell J, Francis AJ, and Roberts SK (2006) Effects of Silybum marianum on serum hepatitis C virus RNA, alanine aminotransferase levels and well-being in patients with chronic hepatitis C. J Gastroenterol Hepatol 21:275-280.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 275-280
    • Gordon, A.1    Hobbs, D.A.2    Bowden, D.S.3    Bailey, M.J.4    Mitchell, J.5    Francis, A.J.6    Roberts, S.K.7
  • 61
    • 36949024949 scopus 로고    scopus 로고
    • Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (Milk Thistle) extract in support of preclinical in vivo studies for prostate cancer chemoprevention
    • Graf TN, Wani MC, Agarwal R, Kroll DJ, and Oberlies NH (2007) Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (Milk Thistle) extract in support of preclinical in vivo studies for prostate cancer chemoprevention. Planta Med 73:1495-1501.
    • (2007) Planta Med , vol.73 , pp. 1495-1501
    • Graf, T.N.1    Wani, M.C.2    Agarwal, R.3    Kroll, D.J.4    Oberlies, N.H.5
  • 62
    • 67649389519 scopus 로고    scopus 로고
    • The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: A perspective of the pharmaceutical research and manufacturers of America
    • Grimm SW, Einolf HJ, Hall SD, He K, Lim HK, Ling KH, Lu C, Nomeir AA, Seibert E, and Skordos KW, et al. (2009) The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of America. Drug Metab Dispos 37:1355-1370.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1355-1370
    • Grimm, S.W.1    Einolf, H.J.2    Hall, S.D.3    He, K.4    Lim, H.K.5    Ling, K.H.6    Lu, C.7    Nomeir, A.A.8    Seibert, E.9    Skordos, K.W.10
  • 63
    • 0042329468 scopus 로고    scopus 로고
    • Application of liquid chromatography-electrospray ionizationion trap mass spectrometry to investigate the metabolism of silibinin in human liver microsomes
    • Gunaratna C and Zhang T (2003) Application of liquid chromatography- electrospray ionizationion trap mass spectrometry to investigate the metabolism of silibinin in human liver microsomes. J Chromatogr B Analyt Technol Biomed Life Sci 794:303-310.
    • (2003) J Chromatogr B Analyt Technol Biomed Life Sci , vol.794 , pp. 303-310
    • Gunaratna, C.1    Zhang, T.2
  • 64
    • 31444435037 scopus 로고    scopus 로고
    • Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: Comparison of a milk thistle and black cohosh product to rifampin and clarithromycin
    • Gurley B, Hubbard MA, Williams DK, Thaden J, Tong Y, Gentry WB, Breen P, Carrier DJ, and Cheboyina S (2006a) Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin. J Clin Pharmacol 46:201-213.
    • (2006) J Clin Pharmacol , vol.46 , pp. 201-213
    • Gurley, B.1    Hubbard, M.A.2    Williams, D.K.3    Thaden, J.4    Tong, Y.5    Gentry, W.B.6    Breen, P.7    Carrier, D.J.8    Cheboyina, S.9
  • 65
    • 84866109213 scopus 로고    scopus 로고
    • Pharmacokinetic herb-drug interactions (part 1): Origins, mechanisms, and the impact of botanical dietary supplements
    • Gurley BJ (2012) Pharmacokinetic herb-drug interactions (part 1): origins, mechanisms, and the impact of botanical dietary supplements. Planta Med 78:1478-1489.
    • (2012) Planta Med , vol.78 , pp. 1478-1489
    • Gurley, B.J.1
  • 67
    • 7944225802 scopus 로고    scopus 로고
    • In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto
    • Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Carrier J, Khan IA, Edwards DJ, and Shah A (2004) In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Clin Pharmacol Ther 76:428-440.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 428-440
    • Gurley, B.J.1    Gardner, S.F.2    Hubbard, M.A.3    Williams, D.K.4    Gentry, W.B.5    Carrier, J.6    Khan, I.A.7    Edwards, D.J.8    Shah, A.9
  • 69
    • 83655197410 scopus 로고    scopus 로고
    • Role of transporters in drug interactions
    • Han HK (2011) Role of transporters in drug interactions. Arch Pharm Res 34:1865-1877.
    • (2011) Arch Pharm Res , vol.34 , pp. 1865-1877
    • Han, H.K.1
  • 70
    • 70350509161 scopus 로고    scopus 로고
    • Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers
    • Han Y, Guo D, Chen Y, Tan ZR, and Zhou HH (2009a) Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. Xenobiotica 39:694-699.
    • (2009) Xenobiotica , vol.39 , pp. 694-699
    • Han, Y.1    Guo, D.2    Chen, Y.3    Tan, Z.R.4    Zhou, H.H.5
  • 71
    • 68849120724 scopus 로고    scopus 로고
    • Effect of silymarin on the pharmacokinetics of losartan and its active metabolite E-3174 in healthy Chinese volunteers
    • Han Y, Guo D, Chen Y, Chen Y, Tan ZR, and Zhou HH (2009b) Effect of silymarin on the pharmacokinetics of losartan and its active metabolite E-3174 in healthy Chinese volunteers. Eur J Clin Pharmacol 65:585-591.
    • (2009) Eur J Clin Pharmacol , vol.65 , pp. 585-591
    • Han, Y.1    Guo, D.2    Chen, Y.3    Chen, Y.4    Tan, Z.R.5    Zhou, H.H.6
  • 72
    • 84871904912 scopus 로고    scopus 로고
    • Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2
    • Harper JN and Wright SH (2013) Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2. Am J Physiol Renal Physiol 304:F56-F67.
    • (2013) Am J Physiol Renal Physiol , vol.304
    • Harper, J.N.1    Wright, S.H.2
  • 75
    • 35648976075 scopus 로고    scopus 로고
    • Induction of hepatic cytochrome P450 enzymes: Methods, mechanisms, recommendations, and in vitro-in vivo correlations
    • Hewitt NJ, Lecluyse EL, and Ferguson SS (2007) Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations. Xenobiotica 37:1196-1224.
    • (2007) Xenobiotica , vol.37 , pp. 1196-1224
    • Hewitt, N.J.1    Lecluyse, E.L.2    Ferguson, S.S.3
  • 76
    • 0036226707 scopus 로고    scopus 로고
    • Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes
    • Hollenberg PF (2002) Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes. Drug Metab Rev 34:17-35.
    • (2002) Drug Metab Rev , vol.34 , pp. 17-35
    • Hollenberg, P.F.1
  • 77
    • 55849119571 scopus 로고    scopus 로고
    • Effects of resveratrol on the pharmacokinetics of diltiazem and its major metabolite, desacetyldiltiazem, in rats
    • Hong SP, Choi DH, and Choi JS (2008) Effects of resveratrol on the pharmacokinetics of diltiazem and its major metabolite, desacetyldiltiazem, in rats. Cardiovasc Ther 26:269-275.
    • (2008) Cardiovasc Ther , vol.26 , pp. 269-275
    • Hong, S.P.1    Choi, D.H.2    Choi, J.S.3
  • 79
    • 84863344719 scopus 로고    scopus 로고
    • PBPK as a tool in regulatory review
    • Huang SM (2012) PBPK as a tool in regulatory review. Biopharm Drug Dispos 33:51-52.
    • (2012) Biopharm Drug Dispos , vol.33 , pp. 51-52
    • Huang, S.M.1
  • 80
    • 33845618025 scopus 로고    scopus 로고
    • The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: A randomized, double-blind, placebo-controlled, clinical trial
    • Huseini HF, Larijani B, Heshmat R, Fakhrzadeh H, Radjabipour B, Toliat T, and Raza M (2006) The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phytother Res 20: 1036-1039.
    • (2006) Phytother Res , vol.20 , pp. 1036-1039
    • Huseini, H.F.1    Larijani, B.2    Heshmat, R.3    Fakhrzadeh, H.4    Radjabipour, B.5    Toliat, T.6    Raza, M.7
  • 81
    • 38749143669 scopus 로고    scopus 로고
    • Resveratrol (trans-resveratrol, 3,5,49-trihydroxy-transstilbene) glucuronidation exhibits atypical enzyme kinetics in various protein sources
    • Iwuchukwu OF and Nagar S (2008) Resveratrol (trans-resveratrol, 3,5,49-trihydroxy-transstilbene) glucuronidation exhibits atypical enzyme kinetics in various protein sources. Drug Metab Dispos 36:322-330.
    • (2008) Drug Metab Dispos , vol.36 , pp. 322-330
    • Iwuchukwu, O.F.1    Nagar, S.2
  • 82
    • 84858080543 scopus 로고    scopus 로고
    • Analytical method development for synthesized conjugated metabolites of trans-resveratrol, and application to pharmacokinetic studies
    • Iwuchukwu OF, Sharan S, Canney DJ, and Nagar S (2012) Analytical method development for synthesized conjugated metabolites of trans-resveratrol, and application to pharmacokinetic studies. J Pharm Biomed Anal 63:1-8.
    • (2012) J Pharm Biomed Anal , vol.63 , pp. 1-8
    • Iwuchukwu, O.F.1    Sharan, S.2    Canney, D.J.3    Nagar, S.4
  • 83
    • 79957563746 scopus 로고    scopus 로고
    • Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells
    • Iwuchukwu OF, Tallarida RJ, and Nagar S (2011) Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells. Life Sci 88:1047-1054.
    • (2011) Life Sci , vol.88 , pp. 1047-1054
    • Iwuchukwu, O.F.1    Tallarida, R.J.2    Nagar, S.3
  • 85
    • 79961196568 scopus 로고    scopus 로고
    • Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases
    • Jancová P, Siller M, Anzenbacherová E, Kren V, Anzenbacher P, and Simánek V (2011) Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases. Xenobiotica 41:743-751.
    • (2011) Xenobiotica , vol.41 , pp. 743-751
    • Jancová, P.1    Siller, M.2    Anzenbacherová, E.3    Kren, V.4    Anzenbacher, P.5    Simánek, V.6
  • 86
    • 34548805504 scopus 로고    scopus 로고
    • Mechanism-based inactivation of cytochrome P450 enzymes: Chemical mechanisms, structure-activity relationships and relationship to clinical drugdrug interactions and idiosyncratic adverse drug reactions
    • Kalgutkar AS, Obach RS, and Maurer TS (2007) Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drugdrug interactions and idiosyncratic adverse drug reactions. Curr Drug Metab 8:407-447.
    • (2007) Curr Drug Metab , vol.8 , pp. 407-447
    • Kalgutkar, A.S.1    Obach, R.S.2    Maurer, T.S.3
  • 87
    • 33646498651 scopus 로고    scopus 로고
    • The quantitative prediction of in vivo enzyme-induction caused by drug exposure from in vitro information on human hepatocytes
    • Kato M, Chiba K, Horikawa M, and Sugiyama Y (2005) The quantitative prediction of in vivo enzyme-induction caused by drug exposure from in vitro information on human hepatocytes. Drug Metab Pharmacokinet 20:236-243.
    • (2005) Drug Metab Pharmacokinet , vol.20 , pp. 236-243
    • Kato, M.1    Chiba, K.2    Horikawa, M.3    Sugiyama, Y.4
  • 88
    • 56749149546 scopus 로고    scopus 로고
    • Patient disclosure about herb and supplement Use among Adults in the US
    • Kennedy J, Wang CC, and Wu CH (2008) Patient Disclosure about Herb and Supplement Use among Adults in the US. Evid Based Complement Alternat Med 5:451-456.
    • (2008) Evid Based Complement Alternat Med , vol.5 , pp. 451-456
    • Kennedy, J.1    Wang, C.C.2    Wu, C.H.3
  • 89
    • 80052671545 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic modeling: Methodology, applications, and limitations with a focus on its role in pediatric drug development
    • Khalil F and Läer S (2011) Physiologically based pharmacokinetic modeling: methodology, applications, and limitations with a focus on its role in pediatric drug development. J Biomed Biotechnol 2011:907461.
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 907461
    • Khalil, F.1    Läer, S.2
  • 90
    • 77649258953 scopus 로고    scopus 로고
    • Effects of silybinin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen in rats
    • Kim CS, Choi SJ, Park CY, Li C, and Choi JS (2010) Effects of silybinin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen in rats. Anticancer Res 30:79-85.
    • (2010) Anticancer Res , vol.30 , pp. 79-85
    • Kim, C.S.1    Choi, S.J.2    Park, C.Y.3    Li, C.4    Choi, J.S.5
  • 91
    • 79551684635 scopus 로고    scopus 로고
    • Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes
    • Kim E, Sy-Cordero A, Graf TN, Brantley SJ, Paine MF, and Oberlies NH (2011a) Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes. Planta Med 77:265-270.
    • (2011) Planta Med , vol.77 , pp. 265-270
    • Kim, E.1    Sy-Cordero, A.2    Graf, T.N.3    Brantley, S.J.4    Paine, M.F.5    Oberlies, N.H.6
  • 92
    • 79960439315 scopus 로고    scopus 로고
    • Resveratrol inhibits genistein-induced multi-drug resistance protein 2 (MRP2) expression in HepG2 cells
    • Kim JH, Chen C, and Tony Kong AN (2011b) Resveratrol inhibits genistein-induced multi-drug resistance protein 2 (MRP2) expression in HepG2 cells. Arch Biochem Biophys 512:160-166.
    • (2011) Arch Biochem Biophys , vol.512 , pp. 160-166
    • Kim, J.H.1    Chen, C.2    Tony Kong, A.N.3
  • 93
    • 0141974905 scopus 로고    scopus 로고
    • Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum)
    • Kim NC, Graf TN, Sparacino CM, Wani MC, and Wall ME (2003a) Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum). Org Biomol Chem 1:1684-1689.
    • (2003) Org Biomol Chem , vol.1 , pp. 1684-1689
    • Kim, N.C.1    Graf, T.N.2    Sparacino, C.M.3    Wani, M.C.4    Wall, M.E.5
  • 95
    • 84870539183 scopus 로고    scopus 로고
    • Characterization of organic anion transporting polypeptide (OATP) expression and its functional contribution to the uptake of substrates in human hepatocytes
    • Kimoto E, Yoshida K, Balogh LM, Bi YA, Maeda K, El-Kattan A, Sugiyama Y, and Lai Y (2013) Characterization of organic anion transporting polypeptide (OATP) expression and its functional contribution to the uptake of substrates in human hepatocytes. Mol Pharm 9:3535-3542.
    • (2013) Mol Pharm , vol.9 , pp. 3535-3542
    • Kimoto, E.1    Yoshida, K.2    Balogh, L.M.3    Bi, Y.A.4    Maeda, K.5    El-Kattan, A.6    Sugiyama, Y.7    Lai, Y.8
  • 96
    • 79956099278 scopus 로고    scopus 로고
    • Influence of non-steroidal antiinflammatory drugs on organic anion transporting polypeptide (OATP) 1B1-and OATP1B3-mediated drug transport
    • Kindla J, Müller F, Mieth M, Fromm MF, and König J (2011) Influence of non-steroidal antiinflammatory drugs on organic anion transporting polypeptide (OATP) 1B1-and OATP1B3-mediated drug transport. Drug Metab Dispos 39:1047-1053.
    • (2011) Drug Metab Dispos , vol.39 , pp. 1047-1053
    • Kindla, J.1    Müller, F.2    Mieth, M.3    Fromm, M.F.4    König, J.5
  • 97
    • 70349153908 scopus 로고    scopus 로고
    • Effect of membrane cholesterol on BSEP/Bsep activity: Species specificity studies for substrates and inhibitors
    • Kis E, Ioja E, Nagy T, Szente L, Herédi-Szabó K, and Krajcsi P (2009) Effect of membrane cholesterol on BSEP/Bsep activity: species specificity studies for substrates and inhibitors. Drug Metab Dispos 37:1878-1886.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1878-1886
    • Kis, E.1    Ioja, E.2    Nagy, T.3    Szente, L.4    Herédi-Szabó, K.5    Krajcsi, P.6
  • 98
    • 84876767096 scopus 로고    scopus 로고
    • Interaction of silymarin flavonolignans with organic anion transporting polypeptides (OATPs)
    • Kock K, Xie Y, Oberlies NH, Hawke RL, and Brouwer KL (2013) Interaction of silymarin flavonolignans with organic anion transporting polypeptides (OATPs). Drug Metab Dispos 41: 958-965.
    • (2013) Drug Metab Dispos , vol.41 , pp. 958-965
    • Kock, K.1    Xie, Y.2    Oberlies, N.H.3    Hawke, R.L.4    Brouwer, K.L.5
  • 99
    • 0031839670 scopus 로고    scopus 로고
    • Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'?
    • Kopp P (1998) Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? Eur J Endocrinol 138:619-620.
    • (1998) Eur J Endocrinol , vol.138 , pp. 619-620
    • Kopp, P.1
  • 100
    • 22044435364 scopus 로고    scopus 로고
    • Effect of silybin and its glycosides on the expression of cytochromes P450 1A2 and 3A4 in primary cultures of human hepatocytes
    • Kosina P, Maurel P, Ulrichová J, and Dvorák Z (2005) Effect of silybin and its glycosides on the expression of cytochromes P450 1A2 and 3A4 in primary cultures of human hepatocytes. J Biochem Mol Toxicol 19:149-153.
    • (2005) J Biochem Mol Toxicol , vol.19 , pp. 149-153
    • Kosina, P.1    Maurel, P.2    Ulrichová, J.3    Dvorák, Z.4
  • 101
    • 34249884261 scopus 로고    scopus 로고
    • Milk thistle nomenclature: Why it matters in cancer research and pharmacokinetic studies
    • Kroll DJ, Shaw HS, and Oberlies NH (2007) Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies. Integr Cancer Ther 6:110-119.
    • (2007) Integr Cancer Ther , vol.6 , pp. 110-119
    • Kroll, D.J.1    Shaw, H.S.2    Oberlies, N.H.3
  • 102
    • 51349132313 scopus 로고    scopus 로고
    • Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives
    • Kundu JK and Surh YJ (2008) Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives. Cancer Lett 269:243-261.
    • (2008) Cancer Lett , vol.269 , pp. 243-261
    • Kundu, J.K.1    Surh, Y.J.2
  • 103
    • 0026092176 scopus 로고
    • Metabolic enantiomeric interactions: The inhibition of human (S)-warfarin-7-hydroxylase by (R)-warfarin
    • Kunze KL, Eddy AC, Gibaldi M, and Trager WF (1991) Metabolic enantiomeric interactions: the inhibition of human (S)-warfarin-7-hydroxylase by (R)-warfarin. Chirality 3:24-29.
    • (1991) Chirality , vol.3 , pp. 24-29
    • Kunze, K.L.1    Eddy, A.C.2    Gibaldi, M.3    Trager, W.F.4
  • 104
    • 75649125625 scopus 로고    scopus 로고
    • A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL)
    • Ladas EJ, Kroll DJ, Oberlies NH, Cheng B, Ndao DH, Rheingold SR, and Kelly KM (2010) A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). Cancer 116:506-513.
    • (2010) Cancer , vol.116 , pp. 506-513
    • Ladas, E.J.1    Kroll, D.J.2    Oberlies, N.H.3    Cheng, B.4    Ndao, D.H.5    Rheingold, S.R.6    Kelly, K.M.7
  • 106
  • 107
    • 84873340432 scopus 로고    scopus 로고
    • Effects of single or repeated silymarin administration on pharmacokinetics of risperidone and its major metabolite, 9-hydroxyrisperidone in rats
    • Lee KS, Chae SW, Park JH, Park JH, Choi JM, Rhie SJ, and Lee HJ (2013) Effects of single or repeated silymarin administration on pharmacokinetics of risperidone and its major metabolite, 9-hydroxyrisperidone in rats. Xenobiotica 43:303-310.
    • (2013) Xenobiotica , vol.43 , pp. 303-310
    • Lee, K.S.1    Chae, S.W.2    Park, J.H.3    Park, J.H.4    Choi, J.M.5    Rhie, S.J.6    Lee, H.J.7
  • 109
    • 64949088858 scopus 로고    scopus 로고
    • Effects of quercetin on the pharmacokinetics of Etoposide after oral or intravenous administration of etoposide in rats
    • Li X and Choi JS (2009) Effects of quercetin on the pharmacokinetics of Etoposide after oral or intravenous administration of etoposide in rats. Anticancer Res 29:1411-1415.
    • (2009) Anticancer Res , vol.29 , pp. 1411-1415
    • Li, X.1    Choi, J.S.2
  • 110
    • 84861916495 scopus 로고    scopus 로고
    • The role of ABC and SLC transporters in the pharmacokinetics of dietary and herbal phytochemicals and their interactions with xenobiotics
    • Li Y, Lu J, and Paxton JW (2012) The role of ABC and SLC transporters in the pharmacokinetics of dietary and herbal phytochemicals and their interactions with xenobiotics. Curr Drug Metab 13:624-639.
    • (2012) Curr Drug Metab , vol.13 , pp. 624-639
    • Li, Y.1    Lu, J.2    Paxton, J.W.3
  • 111
    • 0031794361 scopus 로고    scopus 로고
    • Inhibition and induction of cytochrome P450 and the clinical implications
    • Lin JH and Lu AY (1998) Inhibition and induction of cytochrome P450 and the clinical implications. Clin Pharmacokinet 35:361-390.
    • (1998) Clin Pharmacokinet , vol.35 , pp. 361-390
    • Lin, J.H.1    Lu, A.Y.2
  • 112
    • 48649109479 scopus 로고    scopus 로고
    • Food-drug interaction of (-)-epigallocatechin-3-gallate on the pharmacokinetics of irinotecan and the metabolite SN-38
    • Lin LC, Wang MN, and Tsai TH (2008) Food-drug interaction of (-)-epigallocatechin-3-gallate on the pharmacokinetics of irinotecan and the metabolite SN-38. Chem Biol Interact 174:177-182.
    • (2008) Chem Biol Interact , vol.174 , pp. 177-182
    • Lin, L.C.1    Wang, M.N.2    Tsai, T.H.3
  • 113
    • 84888065587 scopus 로고    scopus 로고
    • Herb supplement sales increase 5.5% in 2012: Herbal supplement sales rise for 9th consecutive year; Turmeric sales jump 40% in natural channel
    • Lindstrom A, Ooyen C, Lynch M, and Blumenthal M (2013) Herb supplement sales increase 5.5% in 2012: herbal supplement sales rise for 9th consecutive year; turmeric sales jump 40% in natural channel. HerbalGram 99:60-65.
    • (2013) HerbalGram , vol.99 , pp. 60-65
    • Lindstrom, A.1    Ooyen, C.2    Lynch, M.3    Blumenthal, M.4
  • 115
    • 43249110151 scopus 로고    scopus 로고
    • Metabolism and disposition of resveratrol in the isolated perfused rat liver: Role of Mrp2 in the biliary excretion of glucuronides
    • Maier-Salamon A, Hagenauer B, Reznicek G, Szekeres T, Thalhammer T, and Jäger W (2008) Metabolism and disposition of resveratrol in the isolated perfused rat liver: role of Mrp2 in the biliary excretion of glucuronides. J Pharm Sci 97:1615-1628.
    • (2008) J Pharm Sci , vol.97 , pp. 1615-1628
    • Maier-Salamon, A.1    Hagenauer, B.2    Reznicek, G.3    Szekeres, T.4    Thalhammer, T.5    Jäger, W.6
  • 116
    • 0036082463 scopus 로고    scopus 로고
    • Metabolism and disposition of resveratrol in rats: Extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model
    • Marier JF, Vachon P, Gritsas A, Zhang J, Moreau JP, and Ducharme MP (2002) Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J Pharmacol Exp Ther 302: 369-373.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 369-373
    • Marier, J.F.1    Vachon, P.2    Gritsas, A.3    Zhang, J.4    Moreau, J.P.5    Ducharme, M.P.6
  • 117
    • 33845473315 scopus 로고    scopus 로고
    • Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction
    • Martignoni M, Groothuis GM, and de Kanter R (2006) Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol 2:875-894.
    • (2006) Expert Opin Drug Metab Toxicol , vol.2 , pp. 875-894
    • Martignoni, M.1    Groothuis, G.M.2    De Kanter, R.3
  • 118
    • 84865623868 scopus 로고    scopus 로고
    • Silybum marianum (milk thistle) in the management and prevention of hepatotoxicity in a patient undergoing reinduction therapy for acute myelogenous leukemia
    • McBride A, Augustin KM, Nobbe J, and Westervelt P (2012) Silybum marianum (milk thistle) in the management and prevention of hepatotoxicity in a patient undergoing reinduction therapy for acute myelogenous leukemia. J Oncol Pharm Pract 18:360-365.
    • (2012) J Oncol Pharm Pract , vol.18 , pp. 360-365
    • McBride, A.1    Augustin, K.M.2    Nobbe, J.3    Westervelt, P.4
  • 119
    • 83955165411 scopus 로고    scopus 로고
    • Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line
    • Ménez C, Mselli-Lakhal L, Foucaud-Vignault M, Balaguer P, Alvinerie M, and Lespine A (2012) Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line. Biochem Pharmacol 83:269-278.
    • (2012) Biochem Pharmacol , vol.83 , pp. 269-278
    • Ménez, C.1    Mselli-Lakhal, L.2    Foucaud-Vignault, M.3    Balaguer, P.4    Alvinerie, M.5    Lespine, A.6
  • 120
    • 84866647386 scopus 로고    scopus 로고
    • Legalon® SIL: The antidote of choice in patients with acute hepatotoxicity from amatoxin poisoning
    • Mengs U, Pohl RT, and Mitchell T (2012) Legalon® SIL: the antidote of choice in patients with acute hepatotoxicity from amatoxin poisoning. Curr Pharm Biotechnol 13:1964-1970.
    • (2012) Curr Pharm Biotechnol , vol.13 , pp. 1964-1970
    • Mengs, U.1    Pohl, R.T.2    Mitchell, T.3
  • 121
    • 53049097296 scopus 로고    scopus 로고
    • Thiomethylstilbenes as inhibitors of CYP1A1, CYP1A2 and CYP1B1 activities
    • Mikstacka R, Baer-Dubowska W, Wieczorek M, and Sobiak S (2008) Thiomethylstilbenes as inhibitors of CYP1A1, CYP1A2 and CYP1B1 activities. Mol Nutr Food Res 52 (Suppl 1): S77-S83.
    • (2008) Mol Nutr Food Res , vol.52 , Issue.SUPPL. 1
    • Mikstacka, R.1    Baer-Dubowska, W.2    Wieczorek, M.3    Sobiak, S.4
  • 123
    • 0037813163 scopus 로고    scopus 로고
    • Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats
    • Miura D, Miura Y, and Yagasaki K (2003) Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats. Life Sci 73:1393-1400.
    • (2003) Life Sci , vol.73 , pp. 1393-1400
    • Miura, D.1    Miura, Y.2    Yagasaki, K.3
  • 124
    • 80051980858 scopus 로고    scopus 로고
    • Inhibitory effects of commonly used herbal extracts on UDPglucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities
    • Mohamed ME and Frye RF (2011) Inhibitory effects of commonly used herbal extracts on UDPglucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities. Drug Metab Dispos 39: 1522-1528.
    • (2011) Drug Metab Dispos , vol.39 , pp. 1522-1528
    • Mohamed, M.E.1    Frye, R.F.2
  • 125
    • 77956575028 scopus 로고    scopus 로고
    • Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity
    • Mohamed MF, Tseng T, and Frye RF (2010) Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity. Xenobiotica 40:663-669.
    • (2010) Xenobiotica , vol.40 , pp. 663-669
    • Mohamed, M.F.1    Tseng, T.2    Frye, R.F.3
  • 126
    • 43049183575 scopus 로고    scopus 로고
    • Localization of the Sodium-Taurocholate cotransporting polypeptide in membrane rafts and modulation of its activity by cholesterol in vitro
    • Molina H, Azocar L, Ananthanarayanan M, Arrese M, and Miquel JF (2008) Localization of the Sodium-Taurocholate cotransporting polypeptide in membrane rafts and modulation of its activity by cholesterol in vitro. Biochim Biophys Acta 1778:1283-1291.
    • (2008) Biochim Biophys Acta , vol.1778 , pp. 1283-1291
    • Molina, H.1    Azocar, L.2    Ananthanarayanan, M.3    Arrese, M.4    Miquel, J.F.5
  • 127
  • 128
    • 37549031270 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: Effects of quercetin and EGCG on biochanin A disposition in rats
    • Moon YJ and Morris ME (2007) Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats. Mol Pharm 4: 865-872.
    • (2007) Mol Pharm , vol.4 , pp. 865-872
    • Moon, Y.J.1    Morris, M.E.2
  • 129
    • 0037311322 scopus 로고    scopus 로고
    • Effect of flavonoids on MRP1-mediated transport in Panc-1 cells
    • Nguyen H, Zhang S, and Morris ME (2003) Effect of flavonoids on MRP1-mediated transport in Panc-1 cells. J Pharm Sci 92:250-257.
    • (2003) J Pharm Sci , vol.92 , pp. 250-257
    • Nguyen, H.1    Zhang, S.2    Morris, M.E.3
  • 130
    • 0034251950 scopus 로고    scopus 로고
    • The alcohol-inducible form of cytochrome P450 (CYP 2E1): Role in toxicology and regulation of expression
    • Novak RF and Woodcroft KJ (2000) The alcohol-inducible form of cytochrome P450 (CYP 2E1): role in toxicology and regulation of expression. Arch Pharm Res 23:267-282.
    • (2000) Arch Pharm Res , vol.23 , pp. 267-282
    • Novak, R.F.1    Woodcroft, K.J.2
  • 131
    • 0032733974 scopus 로고    scopus 로고
    • Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes
    • Obach RS (1999) Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes. Drug Metab Dispos 27:1350-1359.
    • (1999) Drug Metab Dispos , vol.27 , pp. 1350-1359
    • Obach, R.S.1
  • 132
    • 0033917295 scopus 로고    scopus 로고
    • Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression
    • Obach RS (2000) Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther 294: 88-95.
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 88-95
    • Obach, R.S.1
  • 133
    • 0025055648 scopus 로고
    • Enzyme induction in the cytochrome P-450 system
    • Okey AB (1990) Enzyme induction in the cytochrome P-450 system. Pharmacol Ther 45: 241-298.
    • (1990) Pharmacol Ther , vol.45 , pp. 241-298
    • Okey, A.B.1
  • 134
    • 0033750995 scopus 로고    scopus 로고
    • Quercetin and resveratrol potently reduce estrogen sulfotransferase activity in normal human mammary epithelial cells
    • Otake Y, Nolan AL, Walle UK, and Walle T (2000) Quercetin and resveratrol potently reduce estrogen sulfotransferase activity in normal human mammary epithelial cells. J Steroid Biochem Mol Biol 73:265-270.
    • (2000) J Steroid Biochem Mol Biol , vol.73 , pp. 265-270
    • Otake, Y.1    Nolan, A.L.2    Walle, U.K.3    Walle, T.4
  • 135
    • 34249875093 scopus 로고    scopus 로고
    • Clinical relevance of the small intestine as an organ of drug elimination: Drug-fruit juice interactions
    • Paine MF and Oberlies NH (2007) Clinical relevance of the small intestine as an organ of drug elimination: drug-fruit juice interactions. Expert Opin Drug Metab Toxicol 3:67-80.
    • (2007) Expert Opin Drug Metab Toxicol , vol.3 , pp. 67-80
    • Paine, M.F.1    Oberlies, N.H.2
  • 136
    • 5444251235 scopus 로고    scopus 로고
    • In vitro interaction of the HIV protease inhibitor ritonavir with herbal constituents: Changes in P-gp and CYP3A4 activity
    • Patel J, Buddha B, Dey S, Pal D, and Mitra AK (2004) In vitro interaction of the HIV protease inhibitor ritonavir with herbal constituents: changes in P-gp and CYP3A4 activity. Am J Ther 11:262-277.
    • (2004) Am J Ther , vol.11 , pp. 262-277
    • Patel, J.1    Buddha, B.2    Dey, S.3    Pal, D.4    Mitra, A.K.5
  • 140
    • 0037666303 scopus 로고    scopus 로고
    • Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: Comparison with resveratrol and polyphenols from alcoholized beverages
    • Piver B, Berthou F, Dreano Y, and Lucas D (2003) Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. Life Sci 73:1199-1213.
    • (2003) Life Sci , vol.73 , pp. 1199-1213
    • Piver, B.1    Berthou, F.2    Dreano, Y.3    Lucas, D.4
  • 141
    • 84867099595 scopus 로고    scopus 로고
    • The bioavailability and distribution of transresveratrol are constrained by ABC transporters
    • Planas JM, Alfaras I, Colom H, and Juan ME (2012) The bioavailability and distribution of transresveratrol are constrained by ABC transporters. Arch Biochem Biophys 527:67-73.
    • (2012) Arch Biochem Biophys , vol.527 , pp. 67-73
    • Planas, J.M.1    Alfaras, I.2    Colom, H.3    Juan, M.E.4
  • 142
    • 34249915550 scopus 로고    scopus 로고
    • Advances in the use of milk thistle (Silybum marianum)
    • Post-White J, Ladas EJ, and Kelly KM (2007) Advances in the use of milk thistle (Silybum marianum). Integr Cancer Ther 6:104-109.
    • (2007) Integr Cancer Ther , vol.6 , pp. 104-109
    • Post-White, J.1    Ladas, E.J.2    Kelly, K.M.3
  • 143
    • 0033966128 scopus 로고    scopus 로고
    • A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery
    • Poulin P and Theil FP (2000) A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery. J Pharm Sci 89:16-35.
    • (2000) J Pharm Sci , vol.89 , pp. 16-35
    • Poulin, P.1    Theil, F.P.2
  • 144
    • 44949121637 scopus 로고    scopus 로고
    • Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
    • Rambaldi A, Jacobs BP, and Gluud C (2007) Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Cochrane Database Syst Rev (4):CD003620.
    • (2007) Cochrane Database Syst Rev , Issue.4
    • Rambaldi, A.1    Jacobs, B.P.2    Gluud, C.3
  • 145
    • 34547664909 scopus 로고    scopus 로고
    • Effect of silymarin on the oral bioavailability of ranitidine in healthy human volunteers
    • Rao BN, Srinivas M, Kumar YS, and Rao YM (2007) Effect of silymarin on the oral bioavailability of ranitidine in healthy human volunteers. Drug Metabol Drug Interact 22: 175-185.
    • (2007) Drug Metabol Drug Interact , vol.22 , pp. 175-185
    • Rao, B.N.1    Srinivas, M.2    Kumar, Y.S.3    Rao, Y.M.4
  • 146
    • 2942719062 scopus 로고    scopus 로고
    • Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes
    • Raucy JL, Lasker J, Ozaki K, and Zoleta V (2004) Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes. Toxicol Sci 79:233-241.
    • (2004) Toxicol Sci , vol.79 , pp. 233-241
    • Raucy, J.L.1    Lasker, J.2    Ozaki, K.3    Zoleta, V.4
  • 147
    • 34247556082 scopus 로고    scopus 로고
    • Mechanistic approaches to volume of distribution predictions: Understanding the processes
    • Rodgers T and Rowland M (2007) Mechanistic approaches to volume of distribution predictions: understanding the processes. Pharm Res 24:918-933.
    • (2007) Pharm Res , vol.24 , pp. 918-933
    • Rodgers, T.1    Rowland, M.2
  • 148
    • 80054778404 scopus 로고    scopus 로고
    • Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae)
    • Roth M, Araya JJ, Timmermann BN, and Hagenbuch B (2011) Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae). J Pharmacol Exp Ther 339:624-632.
    • (2011) J Pharmacol Exp Ther , vol.339 , pp. 624-632
    • Roth, M.1    Araya, J.J.2    Timmermann, B.N.3    Hagenbuch, B.4
  • 149
    • 0347357905 scopus 로고    scopus 로고
    • Regulatory issues concerning the safety, efficacy and quality of herbal remedies
    • Rousseaux CG and Schachter H (2003) Regulatory issues concerning the safety, efficacy and quality of herbal remedies. Birth Defects Res B Dev Reprod Toxicol 68:505-510.
    • (2003) Birth Defects Res B Dev Reprod Toxicol , vol.68 , pp. 505-510
    • Rousseaux, C.G.1    Schachter, H.2
  • 150
    • 79951765993 scopus 로고    scopus 로고
    • Physiologically-based pharmacokinetics in drug development and regulatory science
    • Rowland M, Peck C, and Tucker G (2011) Physiologically-based pharmacokinetics in drug development and regulatory science. Annu Rev Pharmacol Toxicol 51:45-73.
    • (2011) Annu Rev Pharmacol Toxicol , vol.51 , pp. 45-73
    • Rowland, M.1    Peck, C.2    Tucker, G.3
  • 152
    • 77649273305 scopus 로고    scopus 로고
    • Comparison of Silybum marianum (L.) Gaertn. with fluoxetine in the treatment of Obsessive-Compulsive Disorder
    • Sayyah M, Boostani H, Pakseresht S, and Malayeri A (2010) Comparison of Silybum marianum (L.) Gaertn. with fluoxetine in the treatment of Obsessive-Compulsive Disorder. Prog Neuropsychopharmacol Biol Psychiatry 34:362-365.
    • (2010) Prog Neuropsychopharmacol Biol Psychiatry , vol.34 , pp. 362-365
    • Sayyah, M.1    Boostani, H.2    Pakseresht, S.3    Malayeri, A.4
  • 153
    • 0026776782 scopus 로고
    • Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients
    • Schandalik R, Gatti G, and Perucca E (1992) Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients. Arzneimittelforschung 42:964-968.
    • (1992) Arzneimittelforschung , vol.42 , pp. 964-968
    • Schandalik, R.1    Gatti, G.2    Perucca, E.3
  • 154
    • 0028231599 scopus 로고
    • Pharmacokinetics of silybin following oral administration of silipide in patients with extrahepatic biliary obstruction
    • Schandalik R and Perucca E (1994) Pharmacokinetics of silybin following oral administration of silipide in patients with extrahepatic biliary obstruction. Drugs Exp Clin Res 20:37-42.
    • (1994) Drugs Exp Clin Res , vol.20 , pp. 37-42
    • Schandalik, R.1    Perucca, E.2
  • 155
    • 50049099550 scopus 로고    scopus 로고
    • The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity
    • Schrieber SJ, Wen Z, Vourvahis M, Smith PC, Fried MW, Kashuba AD, and Hawke RL (2008) The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity. Drug Metab Dispos 36: 1909-1916.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1909-1916
    • Schrieber, S.J.1    Wen, Z.2    Vourvahis, M.3    Smith, P.C.4    Fried, M.W.5    Kashuba, A.D.6    Hawke, R.L.7
  • 157
    • 84866442086 scopus 로고    scopus 로고
    • In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide
    • Sharan S, Iwuchukwu OF, Canney DJ, Zimmerman CL, and Nagar S (2012) In vivo-formed versus preformed metabolite kinetics of trans-resveratrol-3-sulfate and trans-resveratrol-3-glucuronide. Drug Metab Dispos 40:1993-2001.
    • (2012) Drug Metab Dispos , vol.40 , pp. 1993-2001
    • Sharan, S.1    Iwuchukwu, O.F.2    Canney, D.J.3    Zimmerman, C.L.4    Nagar, S.5
  • 158
    • 84855928270 scopus 로고    scopus 로고
    • Drug interactions with herbal medicines
    • Shi S and Klotz U (2012) Drug interactions with herbal medicines. Clin Pharmacokinet 51: 77-104.
    • (2012) Clin Pharmacokinet , vol.51 , pp. 77-104
    • Shi, S.1    Klotz, U.2
  • 159
    • 82455206245 scopus 로고    scopus 로고
    • Regulations applicable to plant food supplements and related products in the European Union
    • Silano V, Coppens P, Larrañaga-Guetaria A, Minghetti P, and Roth-Ehrang R (2011) Regulations applicable to plant food supplements and related products in the European Union. Food Funct 2:710-719.
    • (2011) Food Funct , vol.2 , pp. 710-719
    • Silano, V.1    Coppens, P.2    Larrañaga-Guetaria, A.3    Minghetti, P.4    Roth-Ehrang, R.5
  • 160
    • 0028930481 scopus 로고
    • [10] Mechanism-based enzyme inactivators
    • Silverman RB (1995) [10] Mechanism-based enzyme inactivators. Methods Enzymol 249: 240-283.
    • (1995) Methods Enzymol , vol.249 , pp. 240-283
    • Silverman, R.B.1
  • 161
    • 79961047423 scopus 로고    scopus 로고
    • Resveratrol and health-a comprehensive review of human clinical trials
    • Smoliga JM, Baur JA, and Hausenblas HA (2011) Resveratrol and health-a comprehensive review of human clinical trials. Mol Nutr Food Res 55:1129-1141.
    • (2011) Mol Nutr Food Res , vol.55 , pp. 1129-1141
    • Smoliga, J.M.1    Baur, J.A.2    Hausenblas, H.A.3
  • 162
    • 79959971542 scopus 로고    scopus 로고
    • Silymarin efficacy against influenza A virus replication
    • Song JH and Choi HJ (2011) Silymarin efficacy against influenza A virus replication. Phytomedicine 18:832-835.
    • (2011) Phytomedicine , vol.18 , pp. 832-835
    • Song, J.H.1    Choi, H.J.2
  • 163
    • 2442649042 scopus 로고    scopus 로고
    • Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases
    • Sridar C, Goosen TC, Kent UM, Williams JA, and Hollenberg PF (2004) Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases. Drug Metab Dispos 32:587-594.
    • (2004) Drug Metab Dispos , vol.32 , pp. 587-594
    • Sridar, C.1    Goosen, T.C.2    Kent, U.M.3    Williams, J.A.4    Hollenberg, P.F.5
  • 164
    • 0042679455 scopus 로고    scopus 로고
    • Isoform selectivity and kinetics of morphine 3-and 6-glucuronidation by human udp-glucuronosyltransferases: Evidence for atypical glucuronidation kinetics by UGT2B7
    • Stone AN, Mackenzie PI, Galetin A, Houston JB, and Miners JO (2003) Isoform selectivity and kinetics of morphine 3-and 6-glucuronidation by human udp-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7. Drug Metab Dispos 31:1086-1089.
    • (2003) Drug Metab Dispos , vol.31 , pp. 1086-1089
    • Stone, A.N.1    Mackenzie, P.I.2    Galetin, A.3    Houston, J.B.4    Miners, J.O.5
  • 165
    • 77952652033 scopus 로고    scopus 로고
    • Inhibitory effects of herbal extracts on breast cancer resistance protein (BCRP) and structure-inhibitory potency relationship of isoflavonoids
    • Tamaki H, Satoh H, Hori S, Ohtani H, and Sawada Y (2010) Inhibitory effects of herbal extracts on breast cancer resistance protein (BCRP) and structure-inhibitory potency relationship of isoflavonoids. Drug Metab Pharmacokinet 25:170-179.
    • (2010) Drug Metab Pharmacokinet , vol.25 , pp. 170-179
    • Tamaki, H.1    Satoh, H.2    Hori, S.3    Ohtani, H.4    Sawada, Y.5
  • 167
    • 33750535207 scopus 로고    scopus 로고
    • Atypical cytochrome p450 kinetics: Implications for drug discovery
    • Tracy TS (2006) Atypical cytochrome p450 kinetics: implications for drug discovery. Drugs R D 7:349-363.
    • (2006) Drugs R D , vol.7 , pp. 349-363
    • Tracy, T.S.1
  • 168
    • 0042905800 scopus 로고    scopus 로고
    • Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium
    • Troutman MD and Thakker DR (2003) Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res 20:1210-1224.
    • (2003) Pharm Res , vol.20 , pp. 1210-1224
    • Troutman, M.D.1    Thakker, D.R.2
  • 169
    • 84877333836 scopus 로고    scopus 로고
    • A review of potential harmful interactions between anticoagulant/ antiplatelet agents and Chinese herbal medicines
    • Tsai HH, Lin HW, Lu YH, Chen YL, and Mahady GB (2013) A review of potential harmful interactions between anticoagulant/antiplatelet agents and Chinese herbal medicines. PLoS ONE 8:e64255.
    • (2013) PLoS ONE , vol.8
    • Tsai, H.H.1    Lin, H.W.2    Lu, Y.H.3    Chen, Y.L.4    Mahady, G.B.5
  • 170
    • 79151477135 scopus 로고    scopus 로고
    • Reaction product affinity regulates activation of human sulfotransferase 1A1 PAP sulfation
    • Tyapochkin E, Kumar VP, Cook PF, and Chen G (2011) Reaction product affinity regulates activation of human sulfotransferase 1A1 PAP sulfation. Arch Biochem Biophys 506:137-141.
    • (2011) Arch Biochem Biophys , vol.506 , pp. 137-141
    • Tyapochkin, E.1    Kumar, V.P.2    Cook, P.F.3    Chen, G.4
  • 171
    • 0034501276 scopus 로고    scopus 로고
    • Herbal medicine: From the past to the future
    • Tyler VE (2000) Herbal medicine: from the past to the future. Public Health Nutr 3 (4A): 447-452.
    • (2000) Public Health Nutr , vol.3 , Issue.4 A , pp. 447-452
    • Tyler, V.E.1
  • 172
    • 52949103260 scopus 로고    scopus 로고
    • Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites
    • Uchaipichat V, Galetin A, Houston JB, Mackenzie PI, Williams JA, and Miners JO (2008) Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites. Mol Pharmacol 74:1152-1162.
    • (2008) Mol Pharmacol , vol.74 , pp. 1152-1162
    • Uchaipichat, V.1    Galetin, A.2    Houston, J.B.3    Mackenzie, P.I.4    Williams, J.A.5    Miners, J.O.6
  • 173
    • 61649084453 scopus 로고    scopus 로고
    • Trans-resveratrol-mediated inhibition of beta-oestradiol conjugation in MCF-7 cells stably expressing human sulfotransferases SULT1A1 or SULT1E1, and human liver microsomes
    • Ung D and Nagar S (2009) Trans-resveratrol-mediated inhibition of beta-oestradiol conjugation in MCF-7 cells stably expressing human sulfotransferases SULT1A1 or SULT1E1, and human liver microsomes. Xenobiotica 39:72-79.
    • (2009) Xenobiotica , vol.39 , pp. 72-79
    • Ung, D.1    Nagar, S.2
  • 174
    • 53049083034 scopus 로고    scopus 로고
    • Resveratrol modulates pyrogallol-induced changes in hepatic toxicity markers, xenobiotic metabolizing enzymes and oxidative stress
    • Upadhyay G, Singh AK, Kumar A, Prakash O, and Singh MP (2008) Resveratrol modulates pyrogallol-induced changes in hepatic toxicity markers, xenobiotic metabolizing enzymes and oxidative stress. Eur J Pharmacol 596:146-152.
    • (2008) Eur J Pharmacol , vol.596 , pp. 146-152
    • Upadhyay, G.1    Singh, A.K.2    Kumar, A.3    Prakash, O.4    Singh, M.P.5
  • 176
    • 0141993644 scopus 로고    scopus 로고
    • Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants
    • Václavíková R, Horský S, Simek P, and Gut I (2003) Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants. Naunyn Schmiedebergs Arch Pharmacol 368:200-209.
    • (2003) Naunyn Schmiedebergs Arch Pharmacol , vol.368 , pp. 200-209
    • Václavíková, R.1    Horský, S.2    Simek, P.3    Gut, I.4
  • 177
    • 63849152475 scopus 로고    scopus 로고
    • Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol
    • van de Wetering K, Burkon A, Feddema W, Bot A, de Jonge H, Somoza V, and Borst P (2009) Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol. Mol Pharmacol 75: 876-885.
    • (2009) Mol Pharmacol , vol.75 , pp. 876-885
    • Van De Wetering, K.1    Burkon, A.2    Feddema, W.3    Bot, A.4    De Jonge, H.5    Somoza, V.6    Borst, P.7
  • 179
    • 35648987166 scopus 로고    scopus 로고
    • Mechanism-based inactivation of human cytochrome P450 enzymes: Strategies for diagnosis and drug-drug interaction risk assessment
    • Venkatakrishnan K, Obach RS, and Rostami-Hodjegan A (2007) Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug-drug interaction risk assessment. Xenobiotica 37:1225-1256.
    • (2007) Xenobiotica , vol.37 , pp. 1225-1256
    • Venkatakrishnan, K.1    Obach, R.S.2    Rostami-Hodjegan, A.3
  • 180
    • 0033782925 scopus 로고    scopus 로고
    • Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures
    • Venkataramanan R, Ramachandran V, Komoroski BJ, Zhang S, Schiff PL, and Strom SC (2000) Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures. Drug Metab Dispos 28:1270-1273.
    • (2000) Drug Metab Dispos , vol.28 , pp. 1270-1273
    • Venkataramanan, R.1    Ramachandran, V.2    Komoroski, B.J.3    Zhang, S.4    Schiff, P.L.5    Strom, S.C.6
  • 182
  • 183
    • 4844223990 scopus 로고    scopus 로고
    • Resveratrol glucuronides as the metabolites of resveratrol in humans: Characterization, synthesis, and anti-HIV activity
    • Wang LX, Heredia A, Song H, Zhang Z, Yu B, Davis C, and Redfield R (2004) Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity. J Pharm Sci 93:2448-2457.
    • (2004) J Pharm Sci , vol.93 , pp. 2448-2457
    • Wang, L.X.1    Heredia, A.2    Song, H.3    Zhang, Z.4    Yu, B.5    Davis, C.6    Redfield, R.7
  • 184
    • 33846464175 scopus 로고    scopus 로고
    • Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: Potential involvement of ABCG2
    • Wang X and Morris ME (2007) Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2. Drug Metab Dispos 35:268-274.
    • (2007) Drug Metab Dispos , vol.35 , pp. 268-274
    • Wang, X.1    Morris, M.E.2
  • 185
    • 0037196119 scopus 로고    scopus 로고
    • An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice, and in wine
    • Wang Y, Catana F, Yang Y, Roderick R, and van Breemen RB (2002) An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice, and in wine. J Agric Food Chem 50:431-435.
    • (2002) J Agric Food Chem , vol.50 , pp. 431-435
    • Wang, Y.1    Catana, F.2    Yang, Y.3    Roderick, R.4    Van Breemen, R.B.5
  • 186
    • 9744267470 scopus 로고    scopus 로고
    • Modulation of P-glycoprotein function by St John's wort extract and its major constituents
    • Weber CC, Kressmann S, Fricker G, and Müller WE (2004) Modulation of P-glycoprotein function by St John's wort extract and its major constituents. Pharmacopsychiatry 37:292-298.
    • (2004) Pharmacopsychiatry , vol.37 , pp. 292-298
    • Weber, C.C.1    Kressmann, S.2    Fricker, G.3    Müller, W.E.4
  • 188
    • 37549005182 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract
    • Wen Z, Dumas TE, Schrieber SJ, Hawke RL, Fried MW, and Smith PC (2008) Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract. Drug Metab Dispos 36:65-72.
    • (2008) Drug Metab Dispos , vol.36 , pp. 65-72
    • Wen, Z.1    Dumas, T.E.2    Schrieber, S.J.3    Hawke, R.L.4    Fried, M.W.5    Smith, P.C.6
  • 189
    • 20344371723 scopus 로고    scopus 로고
    • Bioactivity and metabolism of transresveratrol orally administered to Wistar rats
    • Wenzel E, Soldo T, Erbersdobler H, and Somoza V (2005) Bioactivity and metabolism of transresveratrol orally administered to Wistar rats. Mol Nutr Food Res 49:482-494.
    • (2005) Mol Nutr Food Res , vol.49 , pp. 482-494
    • Wenzel, E.1    Soldo, T.2    Erbersdobler, H.3    Somoza, V.4
  • 190
    • 0026522216 scopus 로고
    • Study on dose-linearity of the pharmacokinetics of silibinin diastereomers using a new stereospecific assay
    • Weyhenmeyer R, Mascher H, and Birkmayer J (1992) Study on dose-linearity of the pharmacokinetics of silibinin diastereomers using a new stereospecific assay. Int J Clin Pharmacol Ther Toxicol 30:134-138.
    • (1992) Int J Clin Pharmacol Ther Toxicol , vol.30 , pp. 134-138
    • Weyhenmeyer, R.1    Mascher, H.2    Birkmayer, J.3
  • 191
    • 27644596457 scopus 로고    scopus 로고
    • Predicting in vivo drug interactions from in vitro drug discovery data
    • Wienkers LC and Heath TG (2005) Predicting in vivo drug interactions from in vitro drug discovery data. Nat Rev Drug Discov 4:825-833.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 825-833
    • Wienkers, L.C.1    Heath, T.G.2
  • 193
    • 84867328072 scopus 로고    scopus 로고
    • Mechanisms underlying food-drug interactions: Inhibition of intestinal metabolism and transport
    • Won CS, Oberlies NH, and Paine MF (2012) Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport. Pharmacol Ther 136:186-201.
    • (2012) Pharmacol Ther , vol.136 , pp. 186-201
    • Won, C.S.1    Oberlies, N.H.2    Paine, M.F.3
  • 194
    • 34548078783 scopus 로고    scopus 로고
    • Effect of silibinin on the pharmacokinetics of pyrazinamide and pyrazinoic acid in rats
    • Wu JW and Tsai TH (2007) Effect of silibinin on the pharmacokinetics of pyrazinamide and pyrazinoic acid in rats. Drug Metab Dispos 35:1603-1610.
    • (2007) Drug Metab Dispos , vol.35 , pp. 1603-1610
    • Wu, J.W.1    Tsai, T.H.2
  • 196
    • 0037273329 scopus 로고    scopus 로고
    • Liquid chromatography/ tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate
    • Yu C, Shin YG, Kosmeder JW, Pezzuto JM, and van Breemen RB (2003) Liquid chromatography/ tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun Mass Spectrom 17:307-313.
    • (2003) Rapid Commun Mass Spectrom , vol.17 , pp. 307-313
    • Yu, C.1    Shin, Y.G.2    Kosmeder, J.W.3    Pezzuto, J.M.4    Van Breemen, R.B.5
  • 197
    • 0043127383 scopus 로고    scopus 로고
    • Effect of the flavonoids biochanin A and silymarin on the Pglycoprotein-mediated transport of digoxin and vinblastine in human intestinal Caco-2 cells
    • Zhang S and Morris ME (2003a) Effect of the flavonoids biochanin A and silymarin on the Pglycoprotein-mediated transport of digoxin and vinblastine in human intestinal Caco-2 cells. Pharm Res 20:1184-1191.
    • (2003) Pharm Res , vol.20 , pp. 1184-1191
    • Zhang, S.1    Morris, M.E.2
  • 198
    • 0037371275 scopus 로고    scopus 로고
    • Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport
    • Zhang S and Morris ME (2003b) Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport. J Pharmacol Exp Ther 304:1258-1267.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1258-1267
    • Zhang, S.1    Morris, M.E.2
  • 199
    • 3242698924 scopus 로고    scopus 로고
    • Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport
    • Zhang S, Yang X, and Morris ME (2004) Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport. Pharm Res 21:1263-1273.
    • (2004) Pharm Res , vol.21 , pp. 1263-1273
    • Zhang, S.1    Yang, X.2    Morris, M.E.3
  • 200
    • 84862634533 scopus 로고    scopus 로고
    • Best practice in the use of physiologically based pharmacokinetic modeling and simulation to address clinical pharmacology regulatory questions
    • Zhao P, Rowland M, and Huang SM (2012) Best practice in the use of physiologically based pharmacokinetic modeling and simulation to address clinical pharmacology regulatory questions. Clin Pharmacol Ther 92:17-20.
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 17-20
    • Zhao, P.1    Rowland, M.2    Huang, S.M.3
  • 201
    • 84882754422 scopus 로고    scopus 로고
    • An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: A dose escalation study
    • Zhu HJ, Brinda BJ, Chavin KD, Bernstein HJ, Patrick KS, and Markowitz JS (2013) An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study. Drug Metab Dispos 41:1679-1685.
    • (2013) Drug Metab Dispos , vol.41 , pp. 1679-1685
    • Zhu, H.J.1    Brinda, B.J.2    Chavin, K.D.3    Bernstein, H.J.4    Patrick, K.S.5    Markowitz, J.S.6


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